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WO1999033481A3 - Process using the growth factor igf-i in the manufacture of compositions that are useful in the treatment of cerebellar ataxia - Google Patents

Process using the growth factor igf-i in the manufacture of compositions that are useful in the treatment of cerebellar ataxia Download PDF

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Publication number
WO1999033481A3
WO1999033481A3 PCT/EP1998/008532 EP9808532W WO9933481A3 WO 1999033481 A3 WO1999033481 A3 WO 1999033481A3 EP 9808532 W EP9808532 W EP 9808532W WO 9933481 A3 WO9933481 A3 WO 9933481A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
useful
treatment
administration
igf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1998/008532
Other languages
French (fr)
Other versions
WO1999033481A2 (en
Inventor
Aleman Ignacio Torres
Garcia Ana Ma Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Research Systems ARS Holding NV
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Priority to AU24182/99A priority Critical patent/AU2418299A/en
Priority to EP98966697A priority patent/EP1039924A2/en
Publication of WO1999033481A2 publication Critical patent/WO1999033481A2/en
Publication of WO1999033481A3 publication Critical patent/WO1999033481A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Process using the growth factor IGF-I in the manufacture of compositions that are useful for the treatement of cerebellar ataxia. The invention which is claimed is a treatment for curing experimental ataxia which, because of the characteristics of the animal model used, may turn out to be useful in human beings. Ataxia is a neurological deficit for which there is no cure at present. The application of the IGF-I composition is by peripheral administration, which eliminates all the complications derived from the intracerebral administration which has been carried out until now for growth factors in the treatment of brain diseases. The effects obtained from the administration of IGF-I can also be achieved by the administration of compositions that increase the circulating levels thereof, for example compositions containing GHRH and/or GH.
PCT/EP1998/008532 1997-12-26 1998-12-22 Process using the growth factor igf-i in the manufacture of compositions that are useful in the treatment of cerebellar ataxia Ceased WO1999033481A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU24182/99A AU2418299A (en) 1997-12-26 1998-12-22 Process using the growth factor igf-i in the manufacture of compositions that are useful in the treatment of cerebellar ataxia
EP98966697A EP1039924A2 (en) 1997-12-26 1998-12-22 Process using the growth factor igf-1 in the manufacture of compositions that are useful in the treatment of cerebellar ataxia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9702702A ES2146530B1 (en) 1997-12-26 1997-12-26 USE OF THE IGF-I GROWTH FACTOR IN THE MANUFACTURE OF USEFUL COMPOSITIONS IN THE TREATMENT OF CEREBELAR ATAXY.
ES9702702 1997-12-26

Publications (2)

Publication Number Publication Date
WO1999033481A2 WO1999033481A2 (en) 1999-07-08
WO1999033481A3 true WO1999033481A3 (en) 1999-09-10

Family

ID=8301638

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/008532 Ceased WO1999033481A2 (en) 1997-12-26 1998-12-22 Process using the growth factor igf-i in the manufacture of compositions that are useful in the treatment of cerebellar ataxia

Country Status (6)

Country Link
EP (1) EP1039924A2 (en)
AR (1) AR014196A1 (en)
AU (1) AU2418299A (en)
ES (1) ES2146530B1 (en)
WO (1) WO1999033481A2 (en)
ZA (1) ZA9811896B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2343214A1 (en) * 1998-09-03 2000-03-16 Chris Edward Williams Neuroprotection
ES2207387B1 (en) * 2002-02-28 2005-07-16 Consejo Sup. Investig. Cientificas CHEMICAL COMPOSITION OF IGF-I FOR THE TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4747825A (en) * 1984-06-29 1988-05-31 Ferring Laboratories, Inc. Apparatus and methodology for pulsed administration of growth promoting agents
US5093317A (en) * 1989-06-05 1992-03-03 Cephalon, Inc. Treating disorders by application of insulin-like growth factor
US5492891A (en) * 1991-09-05 1996-02-20 Novo Nordisk A/S Method for treatment of patients with chronic liver disease
US5633228A (en) * 1992-06-12 1997-05-27 Cephalon, Inc., Prevention and treatment of peripheral neuropathy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4747825A (en) * 1984-06-29 1988-05-31 Ferring Laboratories, Inc. Apparatus and methodology for pulsed administration of growth promoting agents
US5093317A (en) * 1989-06-05 1992-03-03 Cephalon, Inc. Treating disorders by application of insulin-like growth factor
US5492891A (en) * 1991-09-05 1996-02-20 Novo Nordisk A/S Method for treatment of patients with chronic liver disease
US5633228A (en) * 1992-06-12 1997-05-27 Cephalon, Inc., Prevention and treatment of peripheral neuropathy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FERNANDEZ A M ET AL: "Insulin-like growth factor I restores motor coordination in a rat model o cerebellar ataxia.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1998 FEB 3) 95 (3) 1253-8, XP002102483 *
FERNANDEZ, A. M. ET AL: "Insulin - like growth factor modulates functional recovery in a rat model of cerebellar ataxia.", MEETING INFO.: 27TH ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE NEW ORLEANS, LOUISIANA, USA OCTOBER 25-30, 1997 *
SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 23, no. 1-2, 1997, pages 1451, XP002102591 *

Also Published As

Publication number Publication date
AR014196A1 (en) 2001-02-07
ZA9811896B (en) 1999-06-28
EP1039924A2 (en) 2000-10-04
ES2146530B1 (en) 2001-04-16
AU2418299A (en) 1999-07-19
ES2146530A1 (en) 2000-08-01
WO1999033481A2 (en) 1999-07-08

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