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WO1999032080A3 - Procede d'immobilisation ciblee de l'inhibiteur de thrombogenese hirudine sur des surfaces en polymere - Google Patents

Procede d'immobilisation ciblee de l'inhibiteur de thrombogenese hirudine sur des surfaces en polymere Download PDF

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Publication number
WO1999032080A3
WO1999032080A3 PCT/DE1998/003727 DE9803727W WO9932080A3 WO 1999032080 A3 WO1999032080 A3 WO 1999032080A3 DE 9803727 W DE9803727 W DE 9803727W WO 9932080 A3 WO9932080 A3 WO 9932080A3
Authority
WO
WIPO (PCT)
Prior art keywords
hirudine
immobilization
functional groups
polymer surfaces
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1998/003727
Other languages
German (de)
English (en)
Other versions
WO1999032080A2 (fr
Inventor
Hartwig Hoecker
Joerg Lahann
Wilhelm Pluester
Doris Klee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19857904A external-priority patent/DE19857904A1/de
Application filed by Individual filed Critical Individual
Priority to DE19881935T priority Critical patent/DE19881935D2/de
Priority to AU26086/99A priority patent/AU2608699A/en
Publication of WO1999032080A2 publication Critical patent/WO1999032080A2/fr
Publication of WO1999032080A3 publication Critical patent/WO1999032080A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
    • A61L33/128—Other specific proteins or polypeptides not covered by A61L33/122 - A61L33/126
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un procédé permettant d'immobiliser l'inhibiteur de la thrombogénèse hirudine sur des surfaces en polymère d'objets médicaux, destinés à une utilisation extracorporelle et/ou intracorporelle, par interaction de groupes fonctionnels de l'hirudine avec des groupes fonctionnels correspondants des polymères, directement ou par l'intermédiaire de systèmes espaceurs appropriés. Selon ce procédé, il est proposé qu'au cours d'une étape de traitement à exécuter avant l'immobilisation, on modifie l'environnement chimique et/ou spatial de groupes fonctionnels de l'hirudine pour obtenir de celle-ci une sélectivité d'immobilisation, et qu'après l'immobilisation, on mette fin à la modification de l'environnement chimique et/ou spatial. Grâce à la procédure proposée, les groupes fonctionnels nécessaires à l'activité de la thrombine ne sont pas liés lors de l'immobilisation et restent donc à disposition, après l'immobilisation, pour les interactions avec la thrombine. On obtient ainsi un effet élevé antithrombogène et/ou empêchant la formation de thrombocytes de l'huridine lié auxdites surfaces.
PCT/DE1998/003727 1997-12-19 1998-12-18 Procede d'immobilisation ciblee de l'inhibiteur de thrombogenese hirudine sur des surfaces en polymere Ceased WO1999032080A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19881935T DE19881935D2 (de) 1997-12-19 1998-12-18 Verfahren zur gezielten Immobilisierung des Thromobogeneseinhibitors Hirudin auf Polymeroberflächen
AU26086/99A AU2608699A (en) 1997-12-19 1998-12-18 Device for targeted immobilization of the thrombogenic inhibitor hirudine on polymer surfaces

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19756508.5 1997-12-19
DE19756508 1997-12-19
DE19857904.7 1998-12-16
DE19857904A DE19857904A1 (de) 1997-12-19 1998-12-16 Verfahren zur gezielten Immobilisierung des Thrombogeneseinhibitors Hirudin auf Polymeroberflächen

Publications (2)

Publication Number Publication Date
WO1999032080A2 WO1999032080A2 (fr) 1999-07-01
WO1999032080A3 true WO1999032080A3 (fr) 1999-10-14

Family

ID=26042607

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1998/003727 Ceased WO1999032080A2 (fr) 1997-12-19 1998-12-18 Procede d'immobilisation ciblee de l'inhibiteur de thrombogenese hirudine sur des surfaces en polymere

Country Status (3)

Country Link
AU (1) AU2608699A (fr)
DE (1) DE19881935D2 (fr)
WO (1) WO1999032080A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0367489A2 (fr) * 1988-11-01 1990-05-09 Baxter International Inc. Matériaux antithrombosiques et leur méthode de préparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0367489A2 (fr) * 1988-11-01 1990-05-09 Baxter International Inc. Matériaux antithrombosiques et leur méthode de préparation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PHANEUF M D ET AL: "Covalent linkage of recombinant hirudin to poly(ethylene terephthalate) (Dacron): creation of a novel antithrombin surface", BIOMATERIALS, vol. 18, no. 10, 1 May 1997 (1997-05-01), pages 755-765, XP004063791, ISSN: 0142-9612 *
SEIFERT B.,ROMANIUK P., GROTH TH.: "Covalent immobilization of hirudin improves the haemocompatibility of polylactide-polyglycolide in vitro", BIOMATERIALS, vol. 18, no. 22, November 1997 (1997-11-01), pages 1495 - 1502, XP002112162 *
TESSER G.I., BALVERT-GEERS I.C.: "The methylsulfonylethoxycarbonyl group, a new and versatile amino protective function", INT.J.PEPTIDE PROTEIN RESEARCH, vol. 7, no. 4, 1975, pages 295 - 305, XP002112163 *

Also Published As

Publication number Publication date
WO1999032080A2 (fr) 1999-07-01
DE19881935D2 (de) 2001-01-04
AU2608699A (en) 1999-07-12

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