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WO1999022005A3 - Heparan sulfate d-glucosaminyl 3-o-sulfotransferases, an uses therefor - Google Patents

Heparan sulfate d-glucosaminyl 3-o-sulfotransferases, an uses therefor Download PDF

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Publication number
WO1999022005A3
WO1999022005A3 PCT/US1998/022597 US9822597W WO9922005A3 WO 1999022005 A3 WO1999022005 A3 WO 1999022005A3 US 9822597 W US9822597 W US 9822597W WO 9922005 A3 WO9922005 A3 WO 9922005A3
Authority
WO
WIPO (PCT)
Prior art keywords
glucosaminyl
heparan sulfate
sulfotransferases
uses therefor
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/022597
Other languages
French (fr)
Other versions
WO1999022005A2 (en
WO1999022005B1 (en
Inventor
Robert D Rosenberg
Nicholas W Shworak
Jian Liu
Linda M S Fritze
John J Schwartz
Lijuan Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Priority to AU11997/99A priority Critical patent/AU1199799A/en
Publication of WO1999022005A2 publication Critical patent/WO1999022005A2/en
Publication of WO1999022005A3 publication Critical patent/WO1999022005A3/en
Publication of WO1999022005B1 publication Critical patent/WO1999022005B1/en
Priority to US09/557,262 priority patent/US6861254B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Disclosed are novel isolated nucleic acids and substancially pure protein preparations for naturally occurring and synthetic or chimeric heparan sulfate D-glucosaminyl 3-O-sulfo-transferases (3-OSTs). Also disclosed are uses for these genes and proteins, including uses for the modification and sequencing of glycosaminoglycans.
PCT/US1998/022597 1997-10-24 1998-10-23 Heparan sulfate d-glucosaminyl 3-o-sulfotransferases, an uses therefor Ceased WO1999022005A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU11997/99A AU1199799A (en) 1997-10-24 1998-10-23 Heparan sulfate d-glucosaminyl 3-(o)-sulfotransferases, an uses therefor
US09/557,262 US6861254B1 (en) 1997-10-24 2000-04-24 Heparan sulfate D-glucosaminyl 3-O-sulfotransferases, and uses therefor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6276297P 1997-10-24 1997-10-24
US60/062,762 1997-10-24
US6543797P 1997-10-31 1997-10-31
US60/065,437 1997-10-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/557,262 Continuation US6861254B1 (en) 1997-10-24 2000-04-24 Heparan sulfate D-glucosaminyl 3-O-sulfotransferases, and uses therefor

Publications (3)

Publication Number Publication Date
WO1999022005A2 WO1999022005A2 (en) 1999-05-06
WO1999022005A3 true WO1999022005A3 (en) 1999-10-07
WO1999022005B1 WO1999022005B1 (en) 1999-11-11

Family

ID=26742665

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/022597 Ceased WO1999022005A2 (en) 1997-10-24 1998-10-23 Heparan sulfate d-glucosaminyl 3-o-sulfotransferases, an uses therefor

Country Status (2)

Country Link
AU (1) AU1199799A (en)
WO (1) WO1999022005A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6977248B1 (en) * 1999-08-25 2005-12-20 Massachusetts Institute Of Technology Pharmaceutical preparations for the inhibition of herpes simplex virus 1 entry
WO2001013910A2 (en) * 1999-08-25 2001-03-01 Massachusetts Institute Of Technology Pharmaceutical preparations for the inhibition of herpes simplex virus 1 entry
US6420150B1 (en) 2000-11-27 2002-07-16 Pe Corporation (Ny) Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
GB0111637D0 (en) * 2001-05-12 2001-07-04 Astrazeneca Ab Methods
WO2003018840A1 (en) * 2001-08-23 2003-03-06 Sumitomo Chemical Company, Limited Method of evaluating degree of canceration of mammal-origin specimen
AU2003247808A1 (en) * 2002-07-05 2004-01-23 Anders Malmstrom Purified and isolated heparan sulfate 3-o-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same
US7166763B2 (en) 2003-02-10 2007-01-23 Trustees Of Dartmouth College Mouse model of myxomatous valvular disease
MX2021008479A (en) * 2019-01-15 2021-10-13 Optimvia Llc Engineered aryl sulfate-dependent enzymes.
WO2021007429A1 (en) * 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
EP4453192A1 (en) * 2021-12-21 2024-10-30 University of Copenhagen Improved heparan sulfate and methods of making the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993025659A1 (en) * 1992-06-16 1993-12-23 University Of Massachusetts Medical Center Glycosaminoglycan specific sulfotransferases
GB2295012A (en) * 1994-10-29 1996-05-15 Cancer Res Campaign Tech Sequence analysis of polysaccharides with exoglycosidases, following partial depolymerisation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993025659A1 (en) * 1992-06-16 1993-12-23 University Of Massachusetts Medical Center Glycosaminoglycan specific sulfotransferases
GB2295012A (en) * 1994-10-29 1996-05-15 Cancer Res Campaign Tech Sequence analysis of polysaccharides with exoglycosidases, following partial depolymerisation

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002106186, Database accession no. F07258 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002106187, Database accession no. W89350 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002106188, Database accession no. N71828 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002106189, Database accession no. T75445 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002106190, Database accession no. F13088 *
EMEST11 DATABASE Accession number AA460705 13-JUN-1997 (Rel. 52, Created) Hillier L. et al. *
EMEST18 DATABASE Accession number AA407647 04-MAY-1997 (Rel. 51, Created) Ko M.S.H. et al. *
EMEST19 DATABASE Accession number AA041885 05-SEP-1996 (Rel. 49, Created) glycosaminoglycan N-acetylglucosaminyl N-deacetylase Marra M. et al. *
ERIKSSON I ET AL: "cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin.", J BIOL CHEM, APR 8 1994, 269 (14) P10438-43, UNITED STATES, XP002094359 *
LIU J ET AL: "Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase.", J BIOL CHEM, OCT 25 1996, 271 (43) P27072-82, UNITED STATES, XP002094357 *
SHWORAK NW ET AL: "Cell-free synthesis of anticoagulant heparan sulfate reveals a limiting converting activity that modifies an excess precursor pool.", J BIOL CHEM, OCT 25 1996, 271 (43) P27063-71, UNITED STATES, XP002094360 *
SHWORAK NW ET AL: "Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase.", J BIOL CHEM, OCT 31 1997, 272 (44) P28008-19, UNITED STATES, XP002094361 *
SHWORAK, NICHOLAS W. (1) ET AL: "Control of the synthesis of anticoagulant heparan sulfate: Molecular cloning and expression of the rate limiting enzyme, 3 - O - sulfotransferase.", CIRCULATION, (10/21/97) VOL. 96, NO. 8 SUPPL., PP. I412. MEETING INFO.: 70TH SCIENTIFIC SESSIONS OF THE AMERICAN HEART ASSOCIATION ORLANDO, FLORIDA, USA NOVEMBER 9-12, 1997 ABSTRACT 2300, XP002094358 *

Also Published As

Publication number Publication date
AU1199799A (en) 1999-05-17
WO1999022005A2 (en) 1999-05-06
WO1999022005B1 (en) 1999-11-11

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