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WO1999011621A3 - Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents - Google Patents

Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents Download PDF

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Publication number
WO1999011621A3
WO1999011621A3 PCT/US1998/017955 US9817955W WO9911621A3 WO 1999011621 A3 WO1999011621 A3 WO 1999011621A3 US 9817955 W US9817955 W US 9817955W WO 9911621 A3 WO9911621 A3 WO 9911621A3
Authority
WO
WIPO (PCT)
Prior art keywords
thiourea
useful
cholesterol levels
increasing hdl
atherosclerotic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/017955
Other languages
French (fr)
Other versions
WO1999011621A2 (en
Inventor
Amedeo Arturo Failli
Jay Scott Shumsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Priority to AU92110/98A priority Critical patent/AU9211098A/en
Publication of WO1999011621A2 publication Critical patent/WO1999011621A2/en
Publication of WO1999011621A3 publication Critical patent/WO1999011621A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds are provided which have formula (I) wherein R is (II), (III), (IV) or (V), wherein R?7, R8, R9, R10 and R11¿ are each, independently, hydrogen, halogen, or lower alkyl of 1-6 carbon atoms; R?1 and R12¿ are each, independently, hydrogen or lower alkyl of 1-6 carbon atoms; and R?2, R3, R4, R5 and R6¿ are each, independently, hydrogen, halogen or lower alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof.
PCT/US1998/017955 1997-09-03 1998-08-31 Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents Ceased WO1999011621A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU92110/98A AU9211098A (en) 1997-09-03 1998-08-31 Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92264897A 1997-09-03 1997-09-03
US08/922,648 1997-09-03

Publications (2)

Publication Number Publication Date
WO1999011621A2 WO1999011621A2 (en) 1999-03-11
WO1999011621A3 true WO1999011621A3 (en) 1999-07-01

Family

ID=25447377

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/017955 Ceased WO1999011621A2 (en) 1997-09-03 1998-08-31 Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents

Country Status (4)

Country Link
AR (1) AR017047A1 (en)
AU (1) AU9211098A (en)
WO (1) WO1999011621A2 (en)
ZA (1) ZA987970B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA76977C2 (en) * 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557438A1 (en) * 1974-12-20 1976-06-24 Leo Pharm Prod Ltd N-SUBSTITUTED N "CYANO-N'PYRIDYLGUANIDINE COMPOUNDS
EP0001979A1 (en) * 1977-10-08 1979-05-30 Shudo, Koichi, Prof. Dr. N-(2-chloro-4-pyridyl)-N'-phenylureas, methods for their preparation and plant growth regulators containing them
US4387106A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas
DD223445A1 (en) * 1984-03-18 1985-06-12 Neubauer T Paedagog Hochschule PROCESS FOR THE PREPARATION OF THIROUS FUEL DERIVATIVES
CA2072704A1 (en) * 1991-07-01 1993-01-02 Gary Mark Coppola N-phenylthiourea derivatives and pharmaceutical use thereof
JPH0612447A (en) * 1992-03-31 1994-01-21 Toshiba Corp Summary writing device
WO1996018617A1 (en) * 1994-12-12 1996-06-20 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
WO1996040673A1 (en) * 1995-06-07 1996-12-19 Sugen, Inc. Novel urea- and thiourea-type compounds

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557438A1 (en) * 1974-12-20 1976-06-24 Leo Pharm Prod Ltd N-SUBSTITUTED N "CYANO-N'PYRIDYLGUANIDINE COMPOUNDS
EP0001979A1 (en) * 1977-10-08 1979-05-30 Shudo, Koichi, Prof. Dr. N-(2-chloro-4-pyridyl)-N'-phenylureas, methods for their preparation and plant growth regulators containing them
US4387106A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas
DD223445A1 (en) * 1984-03-18 1985-06-12 Neubauer T Paedagog Hochschule PROCESS FOR THE PREPARATION OF THIROUS FUEL DERIVATIVES
CA2072704A1 (en) * 1991-07-01 1993-01-02 Gary Mark Coppola N-phenylthiourea derivatives and pharmaceutical use thereof
EP0528146A1 (en) * 1991-07-01 1993-02-24 Sandoz Ltd. N-phenylthiourea derivatives and pharmaceutical use thereof
JPH0612447A (en) * 1992-03-31 1994-01-21 Toshiba Corp Summary writing device
WO1996018617A1 (en) * 1994-12-12 1996-06-20 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
WO1996040673A1 (en) * 1995-06-07 1996-12-19 Sugen, Inc. Novel urea- and thiourea-type compounds

Non-Patent Citations (28)

* Cited by examiner, † Cited by third party
Title
ACTA POL. PHARM. (1978), 35(5), 615-18 ;ISSN: 0001-6837 *
ACTA POL. PHARM. (1989), 46(2), 101-13;, 1989 *
CHEMICAL ABSTRACTS, vol. 112, no. 23, 4 June 1990, Columbus, Ohio, US; abstract no. 216860, WISTEROWICZ, KRYSTYNA ET AL: "Pyrazine derivatives. XXVI. Synthesis and tuberculostatic activity of N-pyrazinylthioureas" XP002087696 *
CHEMICAL ABSTRACTS, vol. 120, no. 7, 14 February 1994, Columbus, Ohio, US; abstract no. 71433, YONOVA, P. A. ET AL: "Physiological effects of ureas and thioureas. Synthesis and cytokinin activity of 1-(4-fluorophenyl)-3-pyridyl-2-ureas and thioureas" XP002100743 *
CHEMICAL ABSTRACTS, vol. 127, no. 20, 17 November 1997, Columbus, Ohio, US; abstract no. 277898, HEINISCH, G. ET AL: "Complete assignment of the 13C NMR spectra of diazinyl-substituted ureas and thioureas" XP002100742 *
CHEMICAL ABSTRACTS, vol. 70, no. 5, 3 February 1969, Columbus, Ohio, US; abstract no. 19884, NOVIKOV, E. G. ET AL: "The reaction of 3- and 4-aminopyridines with isocyanates and isothiocyanates" XP002100748 *
CHEMICAL ABSTRACTS, vol. 74, no. 25, 21 June 1971, Columbus, Ohio, US; abstract no. 141216, FUJIKAWA, FUKUJIRO ET AL: "Chemotherapeutic agents against Mycobacterium tuberculosis. XXVI. Synthesis and antituberculous activity of phenylthiourea, p-ethoxyphenylthiourea, and 3-bromo-4-ethoxyphenylthiourea derivatives" XP002087697 *
CHEMICAL ABSTRACTS, vol. 75, no. 3, 19 July 1971, Columbus, Ohio, US; abstract no. 20217, MINAMI, SHINSAKU ET AL: "Thiourea derivatives" XP002100747 *
CHEMICAL ABSTRACTS, vol. 81, no. 15, 14 October 1974, Columbus, Ohio, US; abstract no. 91314, LESIAK, TADEUSZ ET AL: "New derivatives of thiourea" XP002100746 *
CHEMICAL ABSTRACTS, vol. 85, no. 25, 20 December 1976, Columbus, Ohio, US; abstract no. 192015, KASHYAP, B. C. ET AL: "Ionization constants of some N-aryl-N'-(5-halo-2-pyridyl)thioureas" XP002087698 *
CHEMICAL ABSTRACTS, vol. 90, no. 13, 26 March 1979, Columbus, Ohio, US; abstract no. 97342, GUPTA, R. C. ET AL: "Biologically active thiazolidinone" XP002100745 *
CHEMICAL ABSTRACTS, vol. 91, no. 15, 8 October 1979, Columbus, Ohio, US; abstract no. 117865, FOKS, HENRYK ET AL: "Pyrazine derivatives. XI. Synthesis and antitubercular activity of pyrazineurea and pyrazinethiourea derivatives" XP002100744 *
DATABASE CHEMABS Chemical Abstacts Service; XP002100754 *
DATABASE CHEMABS Chemical Abstracts Service; XP002100752 *
DATABASE CHEMABS Chemical Abstracts Service; XP002100753 *
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DATABASE CHEMABS Chemical Abstracts Service; XP002100757 *
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DATABASE CHEMICAL ABSTRACTS Chemical Abstracts Service, Columbus; XP002087700 *
HEINISCH, GOTTFRIED ET AL: "Synthesis of N-aryl-N'-heteroaryl-substituted urea and thiourea derivatives and evaluation of their anticonvulsant activity", ARCH. PHARM. (WEINHEIM, GER.) (1997), 330(7), 207-210, 1997, XP002087695 *
J. INDIAN CHEM. SOC. (1978), 55(8), 832-4 CODEN: JICSAH;ISSN: 0019-4522 *
KHIM. GETEROTSIKL. SOEDIN. (1968), (2), 281-3 *
MAGN. RESON. CHEM. (1997), 35(9), 653-655 ;ISSN: 0749-1581 *
PHYSIOL. BIOCHEM. CYTOKININS PLANTS, SYMP. (1992), MEETING DATE 1990, 219-21. EDITOR(S): KAMINEK, MIROSLAV;MOK, DAVID W. S.; ZAZIMALOVA, EVA. PUBLISHER: SPB ACAD. PUBL., THE HAGUE, NETH. *
REV. ROUM. CHIM. (1976), 21(6), 903-10, 1976 *
ROCZ. CHEM. (1974), 48(2), 317-20 CODEN: ROCHAC *
YAKUGAKU ZASSHI (1971), 91(2), 159-65, 1971 *

Also Published As

Publication number Publication date
ZA987970B (en) 2000-05-31
WO1999011621A2 (en) 1999-03-11
AR017047A1 (en) 2001-08-22
AU9211098A (en) 1999-03-22

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