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WO1999009042A3 - Microstructures for the manipulation of fluid samples - Google Patents

Microstructures for the manipulation of fluid samples Download PDF

Info

Publication number
WO1999009042A3
WO1999009042A3 PCT/US1998/016870 US9816870W WO9909042A3 WO 1999009042 A3 WO1999009042 A3 WO 1999009042A3 US 9816870 W US9816870 W US 9816870W WO 9909042 A3 WO9909042 A3 WO 9909042A3
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
fluid
elution
desired material
sample
Prior art date
Application number
PCT/US1998/016870
Other languages
French (fr)
Other versions
WO1999009042A2 (en
Inventor
Lee Allan Christel
Gregory T A Kovacs
William A Mcmillan
M Allen Northrup
Kurt E Petersen
Farzad Pourahmadi
Original Assignee
Cepheid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/910,434 external-priority patent/US6368871B1/en
Application filed by Cepheid filed Critical Cepheid
Priority to JP2000509721A priority Critical patent/JP2001515216A/en
Priority to AU89066/98A priority patent/AU745989B2/en
Priority to CA002301309A priority patent/CA2301309A1/en
Priority to EP98940889A priority patent/EP1003759A2/en
Publication of WO1999009042A2 publication Critical patent/WO1999009042A2/en
Publication of WO1999009042A3 publication Critical patent/WO1999009042A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B01F25/4323—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors
    • B01F25/43231—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors the channels or tubes crossing each other several times
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Structures Of Non-Positive Displacement Pumps (AREA)
  • Saccharide Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

The invention presents a microfluidic device and method for separating a desired material, such as nucleic acid, from other materials in a fluid sample. In a preferred embodiment, the device comprises a microfabricated chip (20) having an inlet port (28), an outlet port (30), and an extraction chamber (26) in fluid communication with the ports. The chamber (26) has internal attachment surfaces for capturing the desired material from the fluid sample as the sample flows continuously through the chamber. The captured material may then be eluted by forcing an elution fluid to flow through the chamber (26), thus releasing the material from the internal surfaces into the elution fluid. The flow-through design of the device allows target material from a relatively large volume of fluid sample to be concentrated into a much smaller volume of elution fluid. The internal surfaces are preferably formed by an array of columns (32) integrally formed with a wall of the chamber (26) and extending into the chamber (26). The collumns (32) provide a large surface area for capturing the desired material. The device also preferably includes an integrated heater (34) for increasing elution efficiency.
PCT/US1998/016870 1997-08-13 1998-08-13 Microstructures for the manipulation of fluid samples WO1999009042A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000509721A JP2001515216A (en) 1997-08-13 1998-08-13 Microstructure for manipulating fluid samples
AU89066/98A AU745989B2 (en) 1997-08-13 1998-08-13 Microstructures for the manipulation of fluid samples
CA002301309A CA2301309A1 (en) 1997-08-13 1998-08-13 Microstructures for the manipulation of fluid samples
EP98940889A EP1003759A2 (en) 1997-08-13 1998-08-13 Microstructures for the manipulation of fluid samples

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/910,434 1997-08-13
US08/910,434 US6368871B1 (en) 1997-08-13 1997-08-13 Non-planar microstructures for manipulation of fluid samples
US11545498A 1998-07-14 1998-07-14
US09/115,454 1998-07-14

Publications (2)

Publication Number Publication Date
WO1999009042A2 WO1999009042A2 (en) 1999-02-25
WO1999009042A3 true WO1999009042A3 (en) 1999-05-06

Family

ID=26813216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/016870 WO1999009042A2 (en) 1997-08-13 1998-08-13 Microstructures for the manipulation of fluid samples

Country Status (5)

Country Link
EP (1) EP1003759A2 (en)
JP (1) JP2001515216A (en)
AU (1) AU745989B2 (en)
CA (1) CA2301309A1 (en)
WO (1) WO1999009042A2 (en)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285411B1 (en) 1996-06-28 2007-10-23 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
US7349158B2 (en) 2002-09-12 2008-03-25 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7375890B2 (en) 2002-09-12 2008-05-20 Cyvera Corporation Method of manufacturing of a diffraction grating-based optical identification element
US7399643B2 (en) 2002-09-12 2008-07-15 Cyvera Corporation Method and apparatus for aligning microbeads in order to interrogate the same
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7602952B2 (en) 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder
US9174222B2 (en) 2005-04-05 2015-11-03 The General Hospital Corporation Devices and method for enrichment and alteration of cells and other particles
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9212977B2 (en) 2005-01-18 2015-12-15 Biocept, Inc. Cell separation using microchannel having patterned posts
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US9268983B2 (en) 2003-01-22 2016-02-23 Illumina, Inc. Optical system and method for reading encoded microbeads
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681871A (en) * 1995-05-24 1997-10-28 Johnson & Johnson Vision Products, Inc. Method for preparing ultraviolet radiation absorbing contact lenses
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6440725B1 (en) * 1997-12-24 2002-08-27 Cepheid Integrated fluid manipulation cartridge
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
JP2002525587A (en) 1998-08-28 2002-08-13 フェビット フェラリウス バイオテクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング Method and apparatus for measuring an analyte in a sample
WO2000061198A1 (en) * 1999-04-12 2000-10-19 Hitachi Chemical Co., Ltd. Method of producing probe arrays for biological materials using fine particles
US20050100943A1 (en) 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
DE60022025T2 (en) * 1999-05-28 2006-06-29 Cepheid, Sunnyvale APPENDIX FOR BREAKING CELLS
EP1181098B2 (en) * 1999-05-28 2011-07-06 Cepheid Cartridge for conducting a chemical reaction
DE19927534B4 (en) * 1999-06-16 2008-01-31 Merck Patent Gmbh Apparatus for sample application
DE50006164D1 (en) * 1999-07-02 2004-05-27 Clondiag Chip Tech Gmbh MICROCHIP MATRIX DEVICE FOR THE REPRODUCTION AND CHARACTERIZATION OF NUCLEIC ACIDS
AU5967900A (en) * 1999-07-21 2001-02-13 Dako A/S A method of controlling the temperature of a specimen in or on a solid support member
WO2001013088A1 (en) * 1999-08-13 2001-02-22 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
GB2355717A (en) 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
SE0001768D0 (en) * 2000-05-12 2000-05-12 Helen Andersson Microfluidic flow cell for manipulation of particles
DE10051396A1 (en) * 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh An integrated synthesis and identification of an analyte, comprises particles immobilized at a carrier to be coupled to receptors in a structured pattern to give receptor arrays for biochemical reactions
SE0004296D0 (en) * 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
JP3538777B2 (en) * 2001-03-26 2004-06-14 独立行政法人産業技術総合研究所 Microchemical reactor
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
EP1390624A1 (en) 2001-04-25 2004-02-25 President And Fellows Of Harvard College Fluidic switches and method for controlling flow in fluidic systems
WO2002087729A1 (en) * 2001-04-30 2002-11-07 Battelle Memorial Institute Apparatus and method for separation/purification of fluids utilizing rapidly cycled thermal swing
US6811695B2 (en) 2001-06-07 2004-11-02 Nanostream, Inc. Microfluidic filter
US7318912B2 (en) 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
US6881315B2 (en) 2001-08-03 2005-04-19 Nec Corporation Fractionating apparatus having colonies of pillars arranged in migration passage at interval and process for fabricating pillars
DE10150549A1 (en) * 2001-10-12 2003-04-17 Roche Diagnostics Gmbh Separation module, useful for the separation of corpuscles from blood, comprises two channels from a junction with a faster flow in one channel taking most of the particles, and a slower flow with few particles through the other channel
AU2002352746A1 (en) * 2001-11-15 2003-06-10 Arryx, Inc. Sample chip
SE0202399D0 (en) * 2001-12-11 2002-08-13 Thomas Laurell Device and method usable for integrated sequential separation and enrichment of proteins
US7749442B2 (en) 2001-12-14 2010-07-06 Arkray, Inc. Sample measuring device
KR100408871B1 (en) * 2001-12-20 2003-12-11 삼성전자주식회사 Method of separation or filtration by carbon nanotube in biochip
DE10163476A1 (en) * 2001-12-21 2003-10-30 Siemens Ag Arrangement for separating a component from a fluid
JP2005164242A (en) * 2001-12-28 2005-06-23 Cluster Technology Co Ltd Microchip for electrophoresis
US7867757B2 (en) 2001-12-28 2011-01-11 Norchip As Fluid manipulation in a microfabricated reaction chamber systems
US6814859B2 (en) 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
FR2839660B1 (en) 2002-05-17 2005-01-21 Commissariat Energie Atomique MICROREACTOR, PROCESS FOR PREPARING THE SAME, AND METHOD FOR REALIZING BIOCHEMICAL OR BIOLOGICAL REACTION
EP1380337B1 (en) * 2002-07-12 2012-11-14 Tosoh Corporation Fine channel device and a chemically operating method for fluid using the device
US7183104B1 (en) 2002-08-23 2007-02-27 Duane Morris Llp Separator and particle detection system
FR2846957B1 (en) * 2002-11-13 2005-09-30 Commissariat Energie Atomique MICRO-SYSTEM FILLING MICROBALLS AND PROCESS FOR OBTAINING THE SAME
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
JPWO2004051231A1 (en) * 2002-11-29 2006-04-06 日本電気株式会社 Separation apparatus and separation method
JP2004354364A (en) * 2002-12-02 2004-12-16 Nec Corp Fine particle manipulating unit, chip mounted with the same and detector, and method for separating, capturing and detecting protein
CN1739016A (en) * 2002-12-02 2006-02-22 日本电气株式会社 Liquid switches, microchips and mass spectrometry systems using them
GB0303524D0 (en) * 2003-02-15 2003-03-19 Sec Dep For The Home Departmen Improvements in and relating to the handling of dna
JPWO2004097393A1 (en) * 2003-04-28 2006-07-13 松下電器産業株式会社 Filter and biosensor equipped with the filter
JP4348676B2 (en) 2003-06-03 2009-10-21 富士フイルム株式会社 Micro chemical equipment
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
DE10334238A1 (en) * 2003-07-28 2005-02-24 Robert Bosch Gmbh Sensor inlet channel
US7731906B2 (en) * 2003-07-31 2010-06-08 Handylab, Inc. Processing particle-containing samples
FR2865806B1 (en) * 2004-01-30 2007-02-02 Commissariat Energie Atomique ON-CHIP LABORATORY COMPRISING A MICRO-FLUIDIC NETWORK AND A COPLANAR ELECTRONEBULATING NOSE
EP1730519B8 (en) * 2004-02-26 2010-09-22 DELTA Dansk Elektronik, Lys og Akustik Method, chip and system for collection of biological particles
WO2005108620A2 (en) * 2004-05-03 2005-11-17 Handylab, Inc. Processing polynucleotide-containing samples
WO2005123242A1 (en) * 2004-06-15 2005-12-29 Nec Corporation Structural body, chip using the structural body, and method of controlling lyophilic/lyophobic properties
JPWO2005124332A1 (en) * 2004-06-15 2008-07-31 日本電気株式会社 Electrophoresis chip, electrophoresis apparatus, and electrophoresis method
JP4735119B2 (en) * 2004-08-09 2011-07-27 日本精工株式会社 Reactor and production method thereof
JP4591759B2 (en) * 2004-11-05 2010-12-01 横河電機株式会社 Micro electrochemical reactor
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
EP2423667B1 (en) 2004-12-03 2021-03-03 Cytonome/ST, LLC Particle processing system
US7560417B2 (en) 2005-01-13 2009-07-14 Wisconsin Alumni Research Foundation Method and apparatus for parallel synthesis of chain molecules such as DNA
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
ES2437845T3 (en) 2005-01-18 2014-01-14 Biocept, Inc. Cell separation using a microchannel that has pillars with a configuration
JPWO2006098370A1 (en) * 2005-03-16 2008-08-28 日本電気株式会社 DELAY CIRCUIT, MICROCHIP HAVING ADJUSTING MECHANISM FOR EFFECTIVE PASSING TIME OF PATH, AND METHOD FOR MANUFACTURING THE SAME
EP1712284B1 (en) * 2005-04-15 2012-10-10 Samsung Electronics Co., Ltd. Cell separation method using hydrophobic solid supports
JP2006300860A (en) * 2005-04-25 2006-11-02 Kyocera Corp Micro chemical chip
KR101306214B1 (en) * 2005-10-24 2013-09-09 미쓰이 가가쿠 가부시키가이샤 Microchip device
EP2001990B1 (en) 2006-03-24 2016-06-29 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2007124105A2 (en) 2006-04-21 2007-11-01 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
JP4759451B2 (en) * 2006-06-16 2011-08-31 株式会社日立ソリューションズ Pretreatment chip for biological material and pretreatment chip system
WO2008002882A2 (en) 2006-06-26 2008-01-03 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
US20100005867A1 (en) * 2006-07-17 2010-01-14 Agilent Technologies, Inc. Temperature adjustment of a fluidic sample within a fluidic device
JP5173165B2 (en) * 2006-08-14 2013-03-27 東京エレクトロン株式会社 Chromatography column and method for producing the same
US8158411B2 (en) 2006-08-21 2012-04-17 Samsung Electronics Co., Ltd. Method of separating microorganism using nonplanar solid substrate and device for separating microorganism using the same
US7919278B2 (en) * 2006-08-21 2011-04-05 Samsung Electronics Co., Ltd. Method of amplifying nucleic acid from a cell using a nonplanar solid substrate
JP5190571B2 (en) * 2006-08-31 2013-04-24 独立行政法人物質・材料研究機構 Manufacturing method and manufacturing apparatus of micro pillar array element
EP2091647A2 (en) 2006-11-14 2009-08-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2008085991A2 (en) 2007-01-08 2008-07-17 U.S. Genomics, Inc. Reaction chamber
KR20100036263A (en) * 2007-05-23 2010-04-07 엔테그리스, 아이엔씨. Articles comprising wettable structured surfaces
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8357296B2 (en) 2007-09-24 2013-01-22 Emd Millipore Corporation Centrifugal filter
EP2072101A1 (en) * 2007-12-21 2009-06-24 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Multiple connected channel micro evaporator
WO2009117167A1 (en) 2008-01-02 2009-09-24 Blood Cell Storage, Inc. Devices and processes for nucleic acid extraction
JP5331798B2 (en) * 2008-04-19 2013-10-30 ブラザー工業株式会社 Inspection target receptacle and inspection device provided with the inspection target receptacle
KR101102532B1 (en) * 2008-07-10 2012-01-03 삼성전자주식회사 A reagent cartridge, a microfluidic device including the reagent cartridge, a manufacturing method thereof, and a sample analysis method using the same
US8361716B2 (en) 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
GB0818609D0 (en) 2008-10-10 2008-11-19 Univ Hull apparatus and method
RU2009120627A (en) 2009-05-29 2010-12-10 Корнинг Инкорпорейтед (US) MICRO-LIQUID FLOW CONTROLLED DEVICES
CA2764678C (en) 2009-06-04 2017-12-12 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
JP5585204B2 (en) * 2010-05-18 2014-09-10 大日本印刷株式会社 Microchip and manufacturing method thereof
AU2011315951B2 (en) 2010-10-15 2015-03-19 Lockheed Martin Corporation Micro fluidic optic design
BR112013026451B1 (en) 2011-04-15 2021-02-09 Becton, Dickinson And Company system and method to perform molecular diagnostic tests on several samples in parallel and simultaneously amplification in real time in plurality of amplification reaction chambers
WO2012159063A2 (en) 2011-05-19 2012-11-22 Blood Cell Strorage, Inc. Gravity flow fluidic device for nucleic acid extraction
US9304070B2 (en) 2011-07-13 2016-04-05 Emd Millipore Corporation All-in-one sample preparation device and method
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
CA2863637C (en) 2012-02-03 2021-10-26 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
HU230238B1 (en) * 2013-02-05 2015-10-28 NORMA Instruments Zártkörűen Működő Részvénytársaság Measuring unit for determining physical characteristics of liquid samples
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
SG11201703057TA (en) * 2014-10-17 2017-05-30 Water Optics Technology Pte Ltd A method and device for concentrating particles in a fluid sample
JP6937774B2 (en) 2016-03-14 2021-09-22 ルシラ ヘルス インコーポレイテッド Systems and methods for performing biological assays
DK3430378T3 (en) 2016-03-14 2022-10-24 Lucira Health Inc DEVICES AND METHODS FOR MODIFICATION OF OPTICAL PROPERTIES
AU2017232344B2 (en) 2016-03-14 2022-08-04 Pfizer Inc. Selectively vented biological assay devices and associated methods
CN107779387A (en) * 2016-08-30 2018-03-09 广州康昕瑞基因健康科技有限公司 Gene sequencing reaction cell
US11384327B2 (en) 2016-11-01 2022-07-12 California Institute Of Technology Microfluidic devices and methods for purifying rare antigen-specific T cell populations
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
EP3682225A4 (en) 2017-09-14 2021-06-09 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
EP3775834A4 (en) * 2018-07-09 2021-03-17 Hewlett-Packard Development Company, L.P. Analyte capturing devices with fluidic ejection devices
CN109100525B (en) * 2018-09-08 2023-07-28 重庆科技学院 Using method of paper-based microfluidic chip for multi-channel detection
AU2020232685B2 (en) * 2019-03-05 2024-12-19 Pfizer Inc. Bubble-free liquid filling of fluidic chambers
FR3097626B1 (en) * 2019-06-20 2021-07-09 Exoes Thermoregulation system with a rechargeable source of electricity
WO2021117204A1 (en) * 2019-12-12 2021-06-17 株式会社島津製作所 Chromatography system
CN111569962A (en) * 2020-05-21 2020-08-25 浙江大学 A protein enrichment method based on dielectrophoresis and a rapid detection system for multiple biological probes
CN114590475B (en) * 2020-12-07 2023-11-17 京东方科技集团股份有限公司 A liquid storage release device
CN112452367B (en) * 2020-12-10 2022-02-22 深圳先进技术研究院 Double-layer micropore chip, preparation method of double-layer micropore chip and biological device
BE1029473B1 (en) * 2021-06-08 2023-01-16 Pharmafluidics Generic design for microfluidic device
US20230330675A1 (en) * 2022-04-15 2023-10-19 Hewlett-Packard Development Company, L.P. Microfluidic structures with interior pillars
WO2024007489A1 (en) * 2022-07-05 2024-01-11 中科合肥智慧农业协同创新研究院 On-site rapid detection device for soil organic matter, and detection method thereof
EP4559568A1 (en) * 2023-11-24 2025-05-28 Sartorius BIA Separations d.o.o. Mixing unit, a mixing system comprising two or more mixing units , a method for mixing two or more fluids and a lysis system

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0323829A2 (en) * 1988-01-04 1989-07-12 E.I. Du Pont De Nemours And Company Multiple stage affinity process for isolation of specific cells from a cell mixture
WO1996010747A1 (en) * 1994-09-30 1996-04-11 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
WO1996012541A1 (en) * 1994-10-22 1996-05-02 Central Research Laboratories Limited Method and apparatus for diffusive transfer between immiscible fluids
WO1996014933A1 (en) * 1994-11-14 1996-05-23 Trustees Of The University Of Pennsylvania Mesoscale devices for analysis of motile cells
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0323829A2 (en) * 1988-01-04 1989-07-12 E.I. Du Pont De Nemours And Company Multiple stage affinity process for isolation of specific cells from a cell mixture
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
WO1996010747A1 (en) * 1994-09-30 1996-04-11 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
WO1996012541A1 (en) * 1994-10-22 1996-05-02 Central Research Laboratories Limited Method and apparatus for diffusive transfer between immiscible fluids
WO1996014933A1 (en) * 1994-11-14 1996-05-23 Trustees Of The University Of Pennsylvania Mesoscale devices for analysis of motile cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BURNS M A ET AL: "MICROFABRICATED STRUCTURES FOR INTEGRATED DNA ANALYSIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 93, May 1996 (1996-05-01), pages 5556 - 5561, XP002058000 *

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285411B1 (en) 1996-06-28 2007-10-23 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
US9528142B2 (en) 2001-02-14 2016-12-27 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7399643B2 (en) 2002-09-12 2008-07-15 Cyvera Corporation Method and apparatus for aligning microbeads in order to interrogate the same
US7375890B2 (en) 2002-09-12 2008-05-20 Cyvera Corporation Method of manufacturing of a diffraction grating-based optical identification element
US7349158B2 (en) 2002-09-12 2008-03-25 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US9268983B2 (en) 2003-01-22 2016-02-23 Illumina, Inc. Optical system and method for reading encoded microbeads
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US7602952B2 (en) 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US9212977B2 (en) 2005-01-18 2015-12-15 Biocept, Inc. Cell separation using microchannel having patterned posts
US9174222B2 (en) 2005-04-05 2015-11-03 The General Hospital Corporation Devices and method for enrichment and alteration of cells and other particles
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US11845081B2 (en) 2007-07-13 2023-12-19 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip
US9480983B2 (en) 2011-09-30 2016-11-01 Becton, Dickinson And Company Unitized reagent strip
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder

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