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WO1999002985A1 - Dispositif portable permettant de detecter du liquide amniotique - Google Patents

Dispositif portable permettant de detecter du liquide amniotique Download PDF

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Publication number
WO1999002985A1
WO1999002985A1 PCT/US1998/011982 US9811982W WO9902985A1 WO 1999002985 A1 WO1999002985 A1 WO 1999002985A1 US 9811982 W US9811982 W US 9811982W WO 9902985 A1 WO9902985 A1 WO 9902985A1
Authority
WO
WIPO (PCT)
Prior art keywords
woman
amniotic fluid
mat
indicator
color
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/011982
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English (en)
Inventor
Lea T. Rosengreen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU78325/98A priority Critical patent/AU7832598A/en
Publication of WO1999002985A1 publication Critical patent/WO1999002985A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G01N31/221—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating pH value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/528—Atypical element structures, e.g. gloves, rods, tampons, toilet paper
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/0048—Devices for taking samples of body liquids for taking amniotic fluid samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0291—Instruments for taking cell samples or for biopsy for uterus

Definitions

  • the invention herein relates to identification of discharge of amniotic fluid by a pregnant woman More particularly it related to devices for differentiation of amniotic fluid discharged by a pregnant woman from other bodily fluids which may be discharged by the woman
  • amniotic fluid serves multiple functions, including cushioning the fetus from physical shock, see Sandier (ed ), AMNIOTIC FLUID AND ITS CLINICAL SIGNIFICANCE , (Marcel Dekker, Inc 1981)
  • Sandier ed
  • AMNIOTIC FLUID AND ITS CLINICAL SIGNIFICANCE a liquid-tight membrane within the amnion and also surrounding the fetus
  • the amniotic fluid serves multiple functions, including cushioning the fetus from physical shock, see Sandier (ed ), AMNIOTIC FLUID AND ITS CLINICAL SIGNIFICANCE , (Marcel Dekker, Inc 1981)
  • This occurrence of having "her water break" is usually one of the first indications that delivery is imminent
  • rupture of the amnion and discharge of the amniotic fluid is a very distinct and evident event with a relatively large amount of amniotic fluid being expelled, so that the woman knows immediately that she should contact her physician and prepare for delivery
  • amniotic fluid discharged by a woman during an earlier stage of her pregnancy, well before her anticipated due date for delivery can be a sign of fetal abnormality or some other problem with the progress of the pregnancy It is imperative at such time that the woman consult with her physician to identify whether the expulsion of amniotic fluid is benign, or whether it signifies some significant difficulty with the pregnancy
  • her delivery date is still some time off, and not being able to identify the discharged liquid
  • Nitrazine paper contains an indicator dye which when a sample of a woman's discharged bodily fluid is placed on the dye impregnated paper, turns to a color which is indicative of the pH of the fluid sample
  • an initial identification of the liquid as amniotic fluid can be made In practice, this is normally confirmed by use of more comprehensive tests, such as ferning, to unequivocally avoid confusion of amniotic fluid with identification of urine, perspiration or other bodily fluid
  • the device of the present invention is an absorbent pad or tampon intended to be worn by the pregnant woman within or at the exterior of her vagina, such that if amniotic fluid is leaked or otherwise discharged
  • the chemical indicator is a dye, and more preferably nitrazine or a related chemical ln another embodiment of the invention it involves a method for detection of rupture of the amnion of a pregnant woman which comprises providing a wearable device comprising an absorbent mat configured to be worn within or at the exterior of the vagina of the pregnant woman the mat containing an indicator responsive to the presence of amniotic fluid absorbed from the woman by the mat, in sufficient quantity to produce a first visual change in the appearance of the mat when amniotic fluid from the woman contacts the contained indicator within the mat the visual change produced by the indicator upon contact with amniotic fluid being different from a second visual change produced by the indicator upon contact with any other bodily fluid from the woman, having the device worn by the pregnant woman, and detecting by observing that the first visual change has occurred that amniotic fluid has been expelled by the pregnant woman into contact with the device the expulsion of amniotic fluid identifying rupture of the pregnant woman's amnion
  • a physician can determine the imminence of a pregnant's woman's delivery of his infant or detect the potential for there to be a fetal abnormality or other dysfunctional pregnancy
  • Figure 1 includes three perspective views (A, B and C) of a typical device of the present invention in the form of a vaginal tampon, illustrating schematically two examples of a visual change indicating that the tampon has absorbed amniotic fluid
  • Figure 2 includes two perspective views (A and B) of a device of the present invention in the form of a penneal pad, also illustrating schematically another example of a visual change indicating that the pad has absorbed amniotic fluid
  • Figure 3 includes two partial side elevation views (A and B) of two typical examples of a penneal pad of the present invention
  • the present invention is a device which enables a pregnant woman to determine immediately and by her own visual inspection whether or not a bodily fluid which she has discharged is or is not amniotic fluid
  • the device will also permit her to identify both amniotic fluid and other bodily fluid such as urine or perspiration which may be discharged
  • the device is an absorbent mat which is configured for the woman to wear either internally in the vagina, such as in the form of a tampon, or externally, such as in the form of a pad covering her penneal area and in particular, the external end of the vagina
  • the mat which is absorbent for expelled bodily fluids, is preloaded with an effective quantity of an indicator, commonly a dye, which when contacted with amniotic fluid reacts to produce a distinct and readily visible change in the appearance of the mat Most commonly, this visible change will be a change in color of that portion of the mat where the bodily fluid has been absorbed and contacted the indicator The color change may be from one color to another, or from an uncolored
  • Views B and C in Figure 1 illustrate two different versions of the tampon 2
  • View B the entire absorbent mat 6 is impregnated with the indicator
  • the discharged fluid which flows in the direction of the arrow 10, thus encounters interior end 12 of the tampon first, so that the bulk of the discharged fluid is absorbed starting adjacent to end 12 and tapering off over the length of the tampon 2 as the fluid is progressively absorbed, as indicated by the location of color 4 shown in View B
  • the indicator is impregnated into the mat 6 over only one or more discrete volumes 8, so that no color indication 4 appears until the discharged fluid passes through a portion of the mat 6 and reaches the impregnated volume 8, as indicated by the color 4 in View C
  • the configuration of View C will require less indicator, but will be less sensitive, especially to minor discharges since much or perhaps all of the discharged fluid may be absorbed by the upstream unimpregnated portion of the tampon 2 and therefore not reach the impregnated volume 8 to activate the indicator
  • Figure 1 also illustrates two optional features of the tampon 2
  • a non-reactive cap or zone 14 which is unaffected by liquid contact
  • the cap or zone 12 can absorb those residual liquids or fluids, thus removing them from possible competition for detection with subsequently discharged amniotic fluid, especially small quantity discharges
  • Figure 2 is similar to Figure 1 , except that the device is in the form of a pe ⁇ neal- or menstrual-type pad 18 as shown in View A
  • the indicator in this embodiment is incorporated throughout the mat 6 comprising the pad 18 Since the pad is worn externally and extends along the penneal area, it may be contacted by amniotic fluid, urine or perspiration discharged respectively from the vagina, urethra or sweat glands Thus when the woman discharges some fluid, the resulting color of the indicator will indicate which fluid it is While with very minor discharges, the location of the appearance of the color 4 may also give some indication of the identity of the discharged fluid, the tendency of the fluid to flow within the mat 6 usually makes location of little value in identifying the discharged fluid As with the tampon 2, sensing of liquid discharge will alert the woman to remove the pad 18 for visual examination, and observation of the color of the indicator will indicate to the woman whether she has discharged amniotic fluid and needs to contact her physician Usually the appearance of the pad 18, particularly with a small
  • the pad 18 is generally configured as a penneal pad, similar in configuration to common catamenial or menstrual pads
  • the pad 18 may be in a standalone form in which it is worn using a common support belt, or it may be in the form of an adhesive-backed pad which can be inserted in a woman's normal undergarment in the form of a crotch portion liner, or it may be an entire unitary panty-type garment with at least the crotch portion being made of the absorbent mat material 6
  • the pad 18 is shown as having an optional porous cover 20 on the surface of the mat 6 which contacts the wearer's penneal skin This cover 20 will be of a material which provides comfortable contact with the skin, and will be made of porous materials equivalent to those used for the body contact side of conventional menstrual pads
  • the one property which may be difference from menstrual pad covers, however, is that the cover 20 must be transparent, of a suitably light color or translucent
  • the embodiment illustrated in View B of Figure 3 is of a thin pad 18 in the form of a "panty liner "
  • a top cover 20' essentially equivalent to cover 20 in View A, having the same light color, transparency or translucency, but not necessarily being of the same material
  • a fluid impermeable layer 24 or the garment to which it will be attached may be of non- absorbent material
  • an adhesive layer 26 to permit adhesion of the pad 18 to the inside of the crotch portion of the wearer's panty, pantyhose or equivalent undergarment (not shown)
  • the adhesive in layer 26 will normally have sufficient adhesive strength to adhere well to the undergarment regardless of the wearer's movements, but to be removable from the undergarment with modest effort and no damage to the undergarment It will be recognized that a thin pad or the equivalent of a "light days” tampon will normally be all that is required "False alarms" normally occur only when a woman experiences a minor discharge of fluid
  • the penneal pad or tampon configuration will be preferred will depend on the choice of the woman and her doctor
  • the externally worn pad which covers the entire penneal area, will absorb and detect not only amniotic fluid expelled through the vagina, but also urine expelled through the urethra and perspiration expelled through the sweat glands Thus, identification of particular fluids may be made readily and unequivocally by the resultant color of the indicator
  • the tampon configuration being inserted into and retained in the vagina, is likely to detect only amniotic fluid and thus not be activated by the other discharged fluids such as urine or perspiration
  • Most women have a personal preference toward pads or tampons usually depending on the product they normally use for menstrual periods, and will in most cases wish to continue with the same type of product for amniotic fluid detection
  • the woman's physician may consider it advisable for the present device to be used only in the form of the external pad, rather than having a tampon within the vagina during the
  • Amniotic fluid can be readily differentiated from urine or perspiration by the pH of the respective liquids Typically, amniotic fluid will have a pH of about 7 0-7 3, decreasing slightly as pregnancy advances, See Sandier, supra, p 20 In contrast, typical pH for a woman's urine is approximately 5 8 and is approximately the same for perspiration, see Diem et al (eds ), SCIENTIFIC TABLES (7th edn , Geigy Pharm 1970), pp 662 and 679
  • nitrazine detector for differentiating these fluids will be the same nitrazine detector as is currently used in the nitrazine papers This material is described extensively in the literature as a dye It may also in some cases be referred to by the common name phenapthazine, or by the common names "nitrazine yellow” or “nitrazol,” although it is possible that such names might also be applied to compounds or compositions which are closely related to but not exactly the same as nitrazine Further, nitrazine or the "nitrazine-equivalent" materials are believed to include the dye compound 2,4-d ⁇ n ⁇ troan ⁇ l ⁇ ne - 1-naphthol-3,6-d ⁇ sulfon ⁇ c acid or the related sodium salt 3',6-d ⁇ sod ⁇ um 2,4-d ⁇ n ⁇ trobenzene-(1-azo-2')-naphthol-1'-d ⁇ sulphonate, see THE COLOUR INDEX, vol 5, p 4073, compound
  • nitrazine or other indicator chemicals in the pads, tampons, etc herein is only an initial screening test which permits the woman to make an quick determination that the fluid that she has expelled is likely to be amniotic fluid
  • the test is strongly indicative but not entirely conclusive More precise tests, commonly such as the ferning test, will thereafter be used by the medical personnel to confirm the presence of the amniotic fluid
  • the present invention is therefore not intended to be an absolute diagnostic device, but rather is intended to provide the pregnant woman with a rapid and readily identified indication to her from which she can to determine whether or not she needs to contact her physician or the hospital for further confirming tests
  • the pregnant woman can to make an appropriate judgment as to the need for physician contact and avoid a "false alarm "
  • nitrazine will be the preferred material, it will be recognized that there are other types of dyes and similar chemical indicators which function over an equivalent pH range or other range of change, and which have sufficient visible change, usually in the form of distinct color changes, to allow the woman to make the appropriate initial differentiation between absorbed amniotic fluid and absorbed urine or perspiration It is preferred that an indicator chosen have a gradual color change over the appropriate pH range, rather than having an abrupt color change over a very narrow pH range This is because the pH's of the various bodily fluids of interest do vary over known ranges as indicated above, such that a sharp cutoff point for color change will not necessarily adequately differentiate the different materials A gradual range of color change as with nitrazine, will allow for better differentiation of the different bodily fluids, notwithstanding that the actual pH of the fluids for any particular woman and at different stages of her pregnancy may vary slightly within their known ranges Thus, while nitrazine or the nitrazine analogs are preferred, it will be understood that other indicators of similar functionality for amniotic fluid,
  • the devices of the present invention will be available either through a woman's physician or hospital, or over the counter at pharmacies drugstores and similar establishments, in the same manner that pregnancy indicator kits for home use are currently available Since the present invention serves merely to provide a visual indication that amniotic fluid may be present, and does not affect the woman's body or the fetus in any manner, it is anticipated that the device will not require a physician's prescription to obtain While physicians may recommend to some or all of their patients that they use these devices, particularly as their anticipated delivery dates approach, it is also anticipated that a pregnant woman may herself choose to use these devices not only toward the end of her pregnancy, but also during earlier stages, such that she can be assured that amniotic fluid is not expelled during such earlier period of the pregnancy because of some physical or medical problem
  • the devices of the present invention are considered to be "one time use" pads or tampons, since once the indicator has been activated, the device cannot be reused
  • pads or tampons of the present invention will be worn by a pregnant woman from time to time during the last days of her pregnancy, as her delivery date approaches Normally the woman will not wear the devices continually, but rather use them only when she senses that she has or will begin some degree of fluid discharge
  • the actual amount of time of using the pads or tampons of the present invention will be determined by the woman and her physician If for instance, a woman has a prior history of having delivered previous children before the scheduled due date, the physician will likely recommend that the woman begin using the present devices at an earlier date, anticipating that her amnion will rupture well before her due date, thus indicating that her delivery is imminent, notwithstanding that her nominal due date is still some days off
  • physicians and other hospital personnel will recommend use of a device of the present type to any woman who presents herself to the physician or medical personnel with a "false alarm" as her delivery date approaches, in order to avoid further false alarms and be assured that when the actual rupture of the amni
  • Use of the present devices can also serve to aid the physician in determining the state of a woman's pregnancy and determining whether or not the date predicted for her delivery is accurate
  • the physician can then conduct sufficient other tests to determine whether or not the amniotic fluid detected was merely minor leakage such that the amnion has not fully ruptured but has merely developed minor benign leakage, or whether the delivery is imminent
  • the device of the present invention may be used at any stage of the a woman's pregnancy to aid in detecting potential problems with the pregnancy or fetal abnormalities If such is suspected, or if the woman has a prior history of such events, her physician may recommend that she use the present devices at the appropriate time in her pregnancy, and perhaps even throughout much of the pregnancy Thus the discharge of amniotic fluid at any time will be detected and the physician can conduct further diagnostic tests as appropriate

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  • Urology & Nephrology (AREA)
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  • General Physics & Mathematics (AREA)
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Abstract

Garniture absorbante ou tampon absorbant, qui permet à une femme enceinte de déterminer elle-même, avec une précision raisonnable, si elle a rejeté du liquide amniotique. La garniture ou le tampon, porté par la femme enceinte, contient un produit chimique détecteur ou indicateur qui provoque une modification visuelle (généralement un changement de couleur) au niveau de la garniture après un contact avec du liquide amniotique fuyant ou évacué d'une autre manière de l'amnios. La femme qui porte le dispositif peut, en observant ladite modification visuelle, savoir avec une certitude raisonnable si le liquide rejeté est du liquide amniotique et donc décider ou non d'appeler la personne qui la suit médicalement. De préférence, l'indicateur chimique est un colorant, idéalement de la nitrazine ou une substance voisine. En outre, grâce à cette invention, qui permet à la femme elle-même de détecter immédiatement un rejet de liquide amniotique, un médecin peut déterminer l'imminence de l'accouchement ou bien soupçonner l'éventualité d'une anomalie foetale ou d'une autre pathologie gravidique.
PCT/US1998/011982 1997-07-11 1998-06-10 Dispositif portable permettant de detecter du liquide amniotique Ceased WO1999002985A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU78325/98A AU7832598A (en) 1997-07-11 1998-06-10 Wearable amniotic fluid detection device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89145797A 1997-07-11 1997-07-11
US08/891,457 1997-07-11

Publications (1)

Publication Number Publication Date
WO1999002985A1 true WO1999002985A1 (fr) 1999-01-21

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000065096A1 (fr) * 1999-04-26 2000-11-02 The Procter & Gamble Company Protege-slip dote de capteur conçu pour predire le debut de la menstruation
GB2353357A (en) * 1999-08-14 2001-02-21 Inverclyde Biolog Amniotic fluid detection
US6342037B1 (en) 1998-06-29 2002-01-29 The Procter & Gamble Company Device having fecal component sensor
WO2002103356A1 (fr) * 2001-06-18 2002-12-27 Alexander Schoenfeld Article prophylactique a fonction preventive et diagnostique et methode d'utilisation et de fabrication associee
US6772708B2 (en) 2001-10-30 2004-08-10 The Procter And Gamble Company Wetness indicator having improved colorant retention
WO2004082485A1 (fr) * 2003-03-18 2004-09-30 Willett International Limited Dispositif permettant de detecter ou de surveiller de maniere non invasive une pathologie medicale chez un mammifere
US7159532B2 (en) 2002-02-19 2007-01-09 The Procter & Gamble Company Wetness indicator having improved colorant retention and durability
US7365238B2 (en) 2002-02-19 2008-04-29 The Procter And Gamble Company Absorbent article having a dehydration indicator
EP2045161A1 (fr) 2007-10-04 2009-04-08 Deere & Company Procédé et système pour évitement d'obstacle pour véhicule
US7718844B2 (en) 2004-06-30 2010-05-18 Kimberly-Clark Worldwide, Inc. Absorbent article having an interior graphic
WO2013008239A1 (fr) * 2011-07-14 2013-01-17 Mor Gideon Détection non invasive de méconium dans le liquide amniotique
US20140194847A1 (en) * 2014-01-14 2014-07-10 Lauren M. Adkins Tampon with nonpermeable cap
US10058306B2 (en) 2012-06-22 2018-08-28 Preprogen, LLC Method for obtaining fetal cells and fetal cellular components
US11788918B2 (en) 2020-06-18 2023-10-17 Trevillyan Labs, Llc Fluid detection fabric

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287153A (en) * 1978-09-20 1981-09-01 Towsend Marvin S Disposable article with non-leachable saline water indicator
US4357945A (en) * 1981-06-01 1982-11-09 Janko Albert B Device for testing and rupturing amniotic membrane
JPH05123324A (ja) * 1991-11-05 1993-05-21 Hakujiyuuji Kk 羊水の破水鑑別パツド
US5425377A (en) * 1994-08-25 1995-06-20 Caillouette; James C. pH measurement of body fluid
US5597700A (en) * 1994-04-28 1997-01-28 California Research, Llc Method for detecting free insulin-like growth-factor-binding protein 1 and a test device for detecting the ruptures of fetal membranes using the above method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287153A (en) * 1978-09-20 1981-09-01 Towsend Marvin S Disposable article with non-leachable saline water indicator
US4357945A (en) * 1981-06-01 1982-11-09 Janko Albert B Device for testing and rupturing amniotic membrane
JPH05123324A (ja) * 1991-11-05 1993-05-21 Hakujiyuuji Kk 羊水の破水鑑別パツド
US5597700A (en) * 1994-04-28 1997-01-28 California Research, Llc Method for detecting free insulin-like growth-factor-binding protein 1 and a test device for detecting the ruptures of fetal membranes using the above method
US5425377A (en) * 1994-08-25 1995-06-20 Caillouette; James C. pH measurement of body fluid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 9325, Derwent World Patents Index; AN 93-199764, XP002079894, YAZAKI KATSUMI: "Pad for detecting rupture of bag of amniotic fluid - comprises pH indicator sheet impregnated with bromo thymol blue" *

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342037B1 (en) 1998-06-29 2002-01-29 The Procter & Gamble Company Device having fecal component sensor
WO2000065096A1 (fr) * 1999-04-26 2000-11-02 The Procter & Gamble Company Protege-slip dote de capteur conçu pour predire le debut de la menstruation
WO2000065347A3 (fr) * 1999-04-26 2001-03-01 Procter & Gamble Dispositif pour diagnostics multiples de la sante de la femme
WO2000065348A3 (fr) * 1999-04-26 2001-04-05 Procter & Gamble Articles jetables et analogues comprenant un dispositif de detection
GB2353357A (en) * 1999-08-14 2001-02-21 Inverclyde Biolog Amniotic fluid detection
WO2002103356A1 (fr) * 2001-06-18 2002-12-27 Alexander Schoenfeld Article prophylactique a fonction preventive et diagnostique et methode d'utilisation et de fabrication associee
US6772708B2 (en) 2001-10-30 2004-08-10 The Procter And Gamble Company Wetness indicator having improved colorant retention
US7365238B2 (en) 2002-02-19 2008-04-29 The Procter And Gamble Company Absorbent article having a dehydration indicator
US6904865B2 (en) 2002-02-19 2005-06-14 The Procter And Gamble Company Wetness indicator having improved colorant retention and durability
US7159532B2 (en) 2002-02-19 2007-01-09 The Procter & Gamble Company Wetness indicator having improved colorant retention and durability
WO2004082485A1 (fr) * 2003-03-18 2004-09-30 Willett International Limited Dispositif permettant de detecter ou de surveiller de maniere non invasive une pathologie medicale chez un mammifere
US7718844B2 (en) 2004-06-30 2010-05-18 Kimberly-Clark Worldwide, Inc. Absorbent article having an interior graphic
EP2045161A1 (fr) 2007-10-04 2009-04-08 Deere & Company Procédé et système pour évitement d'obstacle pour véhicule
WO2013008239A1 (fr) * 2011-07-14 2013-01-17 Mor Gideon Détection non invasive de méconium dans le liquide amniotique
US9144520B2 (en) 2011-07-14 2015-09-29 Gideon Mor Noninvasive detection of meconium in amniotic fluid
US10058306B2 (en) 2012-06-22 2018-08-28 Preprogen, LLC Method for obtaining fetal cells and fetal cellular components
US10792018B2 (en) 2012-06-22 2020-10-06 Preprogen Llc Method for obtaining fetal cells and fetal cellular components
US20140194847A1 (en) * 2014-01-14 2014-07-10 Lauren M. Adkins Tampon with nonpermeable cap
US11788918B2 (en) 2020-06-18 2023-10-17 Trevillyan Labs, Llc Fluid detection fabric
US12123807B2 (en) 2020-06-18 2024-10-22 Trevillyan Labs, Llc Fluid detection fabric

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