[go: up one dir, main page]

WO1999000346A8 - Synthese de compositions de dihydrohonokiol - Google Patents

Synthese de compositions de dihydrohonokiol

Info

Publication number
WO1999000346A8
WO1999000346A8 PCT/US1998/013265 US9813265W WO9900346A8 WO 1999000346 A8 WO1999000346 A8 WO 1999000346A8 US 9813265 W US9813265 W US 9813265W WO 9900346 A8 WO9900346 A8 WO 9900346A8
Authority
WO
WIPO (PCT)
Prior art keywords
dihydrohonokiol
synthesis
compositions
disclosed
homologs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/013265
Other languages
English (en)
Other versions
WO1999000346A1 (fr
Inventor
William B Stavinoha
Neera Satsangi
Rajiv K Satsangi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Priority to JP50574599A priority Critical patent/JP2002507211A/ja
Priority to CA002297723A priority patent/CA2297723A1/fr
Priority to AU81689/98A priority patent/AU8168998A/en
Priority to EP98931609A priority patent/EP0991614A1/fr
Publication of WO1999000346A1 publication Critical patent/WO1999000346A1/fr
Anticipated expiration legal-status Critical
Publication of WO1999000346A8 publication Critical patent/WO1999000346A8/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne la synthèse et l'utilisation du composé anxiolytique dihydrohonokiol, ses dérivés, ses analogues et ses homologues. L'invention concerne également un procédé anxiolytique destiné à un mammifère.
PCT/US1998/013265 1997-06-26 1998-06-26 Synthese de compositions de dihydrohonokiol Ceased WO1999000346A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP50574599A JP2002507211A (ja) 1997-06-26 1998-06-26 ジヒドロホノキオール組成物の合成
CA002297723A CA2297723A1 (fr) 1997-06-26 1998-06-26 Synthese de compositions de dihydrohonokiol
AU81689/98A AU8168998A (en) 1997-06-26 1998-06-26 Synthesis of dihydrohonokiol compositions
EP98931609A EP0991614A1 (fr) 1997-06-26 1998-06-26 Synthese de compositions de dihydrohonokiol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5084597P 1997-06-26 1997-06-26
US60/050,845 1997-06-26

Publications (2)

Publication Number Publication Date
WO1999000346A1 WO1999000346A1 (fr) 1999-01-07
WO1999000346A8 true WO1999000346A8 (fr) 2000-02-17

Family

ID=21967834

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/013265 Ceased WO1999000346A1 (fr) 1997-06-26 1998-06-26 Synthese de compositions de dihydrohonokiol

Country Status (5)

Country Link
EP (1) EP0991614A1 (fr)
JP (1) JP2002507211A (fr)
AU (1) AU8168998A (fr)
CA (1) CA2297723A1 (fr)
WO (1) WO1999000346A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1140756A2 (fr) * 1998-12-31 2001-10-10 The Board Of Regents, The University Of Texas System Synthese de compositions a base de dihydrohonokiol
US20050070537A1 (en) * 2002-10-10 2005-03-31 Chris Rundfeldt Use of dihydroimidazolones for the treatment of dogs
JP2008542192A (ja) * 2005-02-23 2008-11-27 アービサー ジャック エル． 増殖の障害の治療用のホノキオール誘導体
CN101279901B (zh) * 2007-12-25 2011-08-17 四川大学 和厚朴酚系列衍生物及其制备方法和用途
EP2423181A1 (fr) 2010-07-28 2012-02-29 Prous Institute For Biomedical Research S.A. Dérivés de biphényldiol substitués à cible multiple
EP2986587B1 (fr) 2013-04-17 2023-11-22 Sharon Anavi-Goffer Ligands du récepteur cb2 pour le traitement de troubles psychiatriques
US9820988B2 (en) 2014-03-24 2017-11-21 Boehringer Ingelheim Vetmedica Gmbh Treatment of epileptic disorders in feline animals
US11897910B2 (en) 2015-06-11 2024-02-13 The Medical College Of Wisconsin, Inc. Mito-honokiol compounds and methods of synthesis and use thereof
WO2016201188A1 (fr) * 2015-06-11 2016-12-15 The Medical College Of Wisconsin, Inc. Composés mito-honokiol et leurs procédés de synthèse et d'utilisation
US10053406B2 (en) 2015-10-23 2018-08-21 Colgate-Palmolive Company Synthesis of honokiol
WO2021026285A1 (fr) * 2019-08-06 2021-02-11 Kirkland Justin Formulations comprenant du dihydrohonokiol
CN112125805B (zh) * 2020-09-11 2022-10-18 北京红惠新医药科技有限公司 水溶性厚朴酚衍生物及和厚朴酚衍生物和其中间体的制备方法、和相关的单羟基保护中间体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5995229A (ja) * 1982-11-24 1984-06-01 Tsumura Juntendo Inc 新規ハイドロオキシビフエニル化合物
KR900012875A (ko) * 1989-02-08 1990-09-03 오스카 아끼히꼬 비페닐 유도체, 신경세포 변성수복 또는 보호제 및 여기에 사용되는 폐닐유도체의 제조방법
US5449682A (en) * 1990-02-13 1995-09-12 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted benzyl element

Also Published As

Publication number Publication date
WO1999000346A1 (fr) 1999-01-07
EP0991614A1 (fr) 2000-04-12
JP2002507211A (ja) 2002-03-05
CA2297723A1 (fr) 1999-01-07
AU8168998A (en) 1999-01-19

Similar Documents

Publication Publication Date Title
AU2959995A (en) Stereochemical wortmannin derivatives
PL330635A1 (en) Inhibitor of cytokin production, triazepin compound and intermediate compounds used for obtaining the last mentioned one
AU4677199A (en) Multibinding inhibitors of topoisomerase
HUP0004250A3 (en) Hydroxyacetic ester derivatives, preparation method and use as synthesis intermediates
WO1999000346A8 (fr) Synthese de compositions de dihydrohonokiol
PL329153A1 (en) Derivatives of pyrrolopyrolone as inhibitors of neutropil elastase
AU5235299A (en) Spectral topography of mammalian matter
AU5652698A (en) (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors
AU2001269063A1 (en) Shortened synthesis of 3,3-diarylpropylamine derivatives
AU3255097A (en) Novel (n)-alkoxyadenine derivatives acting as cytokine inhibitors
WO2000040532A3 (fr) Synthese de compositions a base de dihydrohonokiol
WO1998017230A3 (fr) Nouveaux derives de 1,7,7-trimethyl-bicyclo[2.2.1]heptane
AU6250298A (en) Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones
AU5737498A (en) Method for the preparation of alpha-bromo-lactam derivatives
AU4415797A (en) New pde iv inhibitors: "bis-compounds"
AU4498799A (en) Method of preparing 5- or 8-bromoisoquinoline derivatives
AUPP342298A0 (en) Hydraulic fastening of components
HUP0003857A3 (en) Method for preparing alkyloxy furanone-amine derivatives, compounds obtained by said method and use of said compounds
AU5115598A (en) Novel pentaerythritol derivatives, preparation and use thereof and intermediates for the synthesis thereof
AU5210298A (en) Methods for the preparation of benzophenone derivatives
AU4997199A (en) Process for the synthesis of benzopyran derivatives
AU7177496A (en) Piperidinylethylamide derivatives as serotonergic agents
AU9231898A (en) Protease-deficient strains of (pichia methanolica)
AU1357597A (en) Substituted ethyl alpha,alpha - diarylmethyl ether derivatives
AU2335097A (en) Addition of amine to improve paraformaldehyde

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1998931609

Country of ref document: EP

ENP Entry into the national phase in:

Ref document number: 2297723

Country of ref document: CA

Ref country code: CA

Ref document number: 2297723

Kind code of ref document: A

Format of ref document f/p: F

AK Designated states

Kind code of ref document: C1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i
WWP Wipo information: published in national office

Ref document number: 1998931609

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1998931609

Country of ref document: EP