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WO1999063979A3 - Inhibition of δ-9-desaturase activity by saponins - Google Patents

Inhibition of δ-9-desaturase activity by saponins Download PDF

Info

Publication number
WO1999063979A3
WO1999063979A3 PCT/US1999/012304 US9912304W WO9963979A3 WO 1999063979 A3 WO1999063979 A3 WO 1999063979A3 US 9912304 W US9912304 W US 9912304W WO 9963979 A3 WO9963979 A3 WO 9963979A3
Authority
WO
WIPO (PCT)
Prior art keywords
saponins
inhibition
desaturase activity
methods
saponin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/012304
Other languages
French (fr)
Other versions
WO1999063979A2 (en
Inventor
Sambasiva R Chavali
R Armour Forse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP99927180A priority Critical patent/EP1100511A2/en
Priority to AU44149/99A priority patent/AU4414999A/en
Publication of WO1999063979A2 publication Critical patent/WO1999063979A2/en
Publication of WO1999063979A3 publication Critical patent/WO1999063979A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Compositions comprising a saponin or a saponin metabolite, such as dietary supplements and nutritional solutions, are described for use as inhibitors of Δ-9-desaturase enzyme. Methods for inhibiting the activity of Δ-9-desaturase enzyme and methods for treating obesity, diabetes and atherosclerosis are also described.
PCT/US1999/012304 1998-06-08 1999-06-03 Inhibition of δ-9-desaturase activity by saponins Ceased WO1999063979A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99927180A EP1100511A2 (en) 1998-06-08 1999-06-03 Inhibition of delta-9-desaturase activity by saponins
AU44149/99A AU4414999A (en) 1998-06-08 1999-06-03 Inhibition of delta-9-desaturase activity by saponins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9311398A 1998-06-08 1998-06-08
US09/093,113 1998-06-08

Publications (2)

Publication Number Publication Date
WO1999063979A2 WO1999063979A2 (en) 1999-12-16
WO1999063979A3 true WO1999063979A3 (en) 2000-03-16

Family

ID=22237219

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/012304 Ceased WO1999063979A2 (en) 1998-06-08 1999-06-03 Inhibition of δ-9-desaturase activity by saponins

Country Status (3)

Country Link
EP (1) EP1100511A2 (en)
AU (1) AU4414999A (en)
WO (1) WO1999063979A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2398940C (en) 2000-02-24 2012-02-21 Xenon Genetics, Inc. Methods and compositions using stearoyl-coa desaturase to identify triglyceride reducing therapeutic agents
US7232662B2 (en) 2000-09-26 2007-06-19 Xenon Pharmaceuticals Inc. Methods and compositions employing a novel stearoyl-CoA desaturase-hSCD5
US7132529B2 (en) 2001-07-30 2006-11-07 Isis Pharmaceuticals, Inc. Antisense modulation of stearoyl-CoA desaturase expression
US20050043256A1 (en) 2001-07-30 2005-02-24 Isis Pharmaceuticals, Inc. Antisense modulation of stearoyl-CoA desaturase expression
JP4494198B2 (en) * 2004-12-28 2010-06-30 クラシエホームプロダクツ株式会社 Pancreatic lipase inhibitor, lipolysis inhibitor, and fatty liver preventive or therapeutic agent
GT200600046A (en) * 2005-02-09 2006-09-25 COMBINATION THERAPY
CN117777121A (en) 2016-10-24 2024-03-29 詹森药业有限公司 Compounds and their uses
IL304017A (en) 2017-01-06 2023-08-01 Yumanity Therapeutics Inc Methods for the treatment of neurological disorders
WO2019084157A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Compounds and uses thereof
KR20210005593A (en) 2018-03-23 2021-01-14 유마니티 테라퓨틱스, 인크. Compounds and uses thereof
AU2020212034A1 (en) 2019-01-24 2021-09-16 Janssen Pharmaceutica Nv Compounds and uses thereof
EA202192047A1 (en) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. COMPOUNDS AND THEIR APPLICATIONS

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54135210A (en) * 1978-04-07 1979-10-20 Shigeru Yuuchi Tumor treating agent
JPS55122724A (en) * 1979-03-13 1980-09-20 Res Inst For Prod Dev Antidiabetic agent
JPS60172926A (en) * 1984-02-15 1985-09-06 Osaka Chem Lab Healthy food
JPS6124597A (en) * 1984-07-12 1986-02-03 Yamanouchi Pharmaceut Co Ltd Antidiabetic agent
JPH07267977A (en) * 1994-03-31 1995-10-17 I T Bi S:Kk Glycoside from fruit essence of panax shinseng, production thereof, production of health food thereform
JPH0859496A (en) * 1994-08-16 1996-03-05 Minoru Morimoto Method for producing extract by inoculating mushroom spawn on ginseng culture medium, culturing the spawn and subsequently extracting the culture medium and mushroom mycelium
WO1997018824A1 (en) * 1995-11-22 1997-05-29 Cheil Je Dang Co. Vasodilating composition

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54135210A (en) * 1978-04-07 1979-10-20 Shigeru Yuuchi Tumor treating agent
JPS55122724A (en) * 1979-03-13 1980-09-20 Res Inst For Prod Dev Antidiabetic agent
JPS60172926A (en) * 1984-02-15 1985-09-06 Osaka Chem Lab Healthy food
JPS6124597A (en) * 1984-07-12 1986-02-03 Yamanouchi Pharmaceut Co Ltd Antidiabetic agent
JPH07267977A (en) * 1994-03-31 1995-10-17 I T Bi S:Kk Glycoside from fruit essence of panax shinseng, production thereof, production of health food thereform
JPH0859496A (en) * 1994-08-16 1996-03-05 Minoru Morimoto Method for producing extract by inoculating mushroom spawn on ginseng culture medium, culturing the spawn and subsequently extracting the culture medium and mushroom mycelium
WO1997018824A1 (en) * 1995-11-22 1997-05-29 Cheil Je Dang Co. Vasodilating composition

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
CHAVALI ET AL.: "Decreased production of Interleukin-1-beta, Prostaglandin-E2 and Thromboxane B2, and elevated levels of interleukin-6 and -10 are associated with increased survival during endotoxic shock in mice consuming diets enriched with sesame seed oil supplemented with Qil-A saponin", INT. ARCH. ALLERGY IMMUNOL., vol. 114, no. 2, October 1997 (1997-10-01), pages 153 - 160, XP000853999 *
CHAVALI ET AL.: "Dietary alpha-linolenic acid increases TNF-alpha and decreases IL-6, Il-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega-6 and omega-3 fatty acids in mice", PROSTAGLANDINS LEUKOTR. ESSENTIAL FATTY ACIDS, vol. 58, no. 3, March 1998 (1998-03-01), pages 185 - 191, XP000856146 *
DATABASE WPI Week 197948, Derwent World Patents Index; AN 1979-86683b, XP002127157 *
DATABASE WPI Week 198045, Derwent World Patents Index; AN 1980-79615c, XP002127156 *
DATABASE WPI Week 198542, Derwent World Patents Index; AN 1985-259594, XP002127155 *
DATABASE WPI Week 199550, Derwent World Patents Index; AN 1995-390277, XP002127154 *
DATABASE WPI Week 199619, Derwent World Patents Index; AN 1996-184705, XP002127158 *
NAKABAYASHI A. ET AL.: "Alpha-tocopherol enhances the hypocholesterolemic action od sesamin in rats", INT. J. VITAMIN NUTR. RES., vol. 65, no. 3, 1995, pages 162 - 168, XP000856322 *
NORMAN ET AL.: "Licorice-derived compounds inhibit linoleic aicd (C:18:2 omega-6) desaturation in soybean chloroplasts", FEBS LETT., vol. 368, no. 1, 10 July 1995 (1995-07-10), pages 135 - 138, XP002127153 *
PATENT ABSTRACTS OF JAPAN vol. 0, no. 0 *
SHIMIZU ET AL.: "Sesamin is a potent and specific inhibitor of delta-5 desaturase in polyunsaturated fatty acid biosynthesis", LIPIDS, vol. 26, no. 7, 1991, pages 512 - 516, XP002910626 *

Also Published As

Publication number Publication date
WO1999063979A2 (en) 1999-12-16
AU4414999A (en) 1999-12-30
EP1100511A2 (en) 2001-05-23

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