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WO1999058671A3 - Homologues du gene d'assurance de longevite des levures, lag1, d'origine humaine ou issus de nematodes - Google Patents

Homologues du gene d'assurance de longevite des levures, lag1, d'origine humaine ou issus de nematodes Download PDF

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Publication number
WO1999058671A3
WO1999058671A3 PCT/US1999/010160 US9910160W WO9958671A3 WO 1999058671 A3 WO1999058671 A3 WO 1999058671A3 US 9910160 W US9910160 W US 9910160W WO 9958671 A3 WO9958671 A3 WO 9958671A3
Authority
WO
WIPO (PCT)
Prior art keywords
lag1
human
nematode
methods
providing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/010160
Other languages
English (en)
Other versions
WO1999058671A9 (fr
WO1999058671A2 (fr
Inventor
S Michal Jazwinski
Paul Kirchman
James Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Publication of WO1999058671A2 publication Critical patent/WO1999058671A2/fr
Publication of WO1999058671A9 publication Critical patent/WO1999058671A9/fr
Anticipated expiration legal-status Critical
Publication of WO1999058671A3 publication Critical patent/WO1999058671A3/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • C07K14/43545—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention se rapporte à des acides nucléiques de LAG1 d'origine humaine ou issus de nématodes et aux polypeptides codés et exprimés par ces acides nucléiques, ainsi qu'aux vecteurs et cellules hôtes associés. La présente invention concerne de l'ADN et de l'ARN antisens. Elle se rapporte également à des procédés permettant d'accroître la longévité et la tolérance au stress de cellules eucaryotes et consistant à fournir à ces cellules des polypeptides de LAG1 d'origine humaine ou issus de nématodes. Les procédés permettant de fournir à une cellule des polypeptides de LAG1 consistent à surexprimer le gène LAG1 endogène, ou à introduire dans la cellule un vecteur d'expression contenant la région appropriée de codage de LAG1. Il est possible de mettre en oeuvre ces procédés sur des cellules mammaliennes, et notamment sur des cellules humaines. La présente invention se rapporte également à des compositions pharmaceutiques permettant la mise en oeuvre de ces procédés.
PCT/US1999/010160 1998-05-08 1999-05-10 Homologues du gene d'assurance de longevite des levures, lag1, d'origine humaine ou issus de nematodes Ceased WO1999058671A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7501498A 1998-05-08 1998-05-08
US09/075,014 1998-05-08

Publications (3)

Publication Number Publication Date
WO1999058671A2 WO1999058671A2 (fr) 1999-11-18
WO1999058671A9 WO1999058671A9 (fr) 2000-03-09
WO1999058671A3 true WO1999058671A3 (fr) 2000-11-09

Family

ID=22123003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/010160 Ceased WO1999058671A2 (fr) 1998-05-08 1999-05-10 Homologues du gene d'assurance de longevite des levures, lag1, d'origine humaine ou issus de nematodes

Country Status (1)

Country Link
WO (1) WO1999058671A2 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000382A1 (fr) * 1990-06-15 1992-01-09 Carnegie Institution Of Washington Gdf-1
WO1995033834A1 (fr) * 1994-06-03 1995-12-14 Research Corporation Technologies, Inc. Lag1: un gene pour augmenter la longevite des cellules eucaryotiques
WO1998005761A1 (fr) * 1996-08-07 1998-02-12 The General Hospital Corporation Polypeptides age-1 et molecules et methodes associees
WO1998017823A1 (fr) * 1996-10-21 1998-04-30 Mcgill University CONSERVATION STRUCTURELLE ET FONCTIONNELLE DU GENE D'HORLOGE clk-1 CHEZ $i(C. ELEGANS)
WO1999006558A1 (fr) * 1997-07-30 1999-02-11 Incyte Pharmaceuticals, Inc. Homologues proteiques d'assurance de longevite humaine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000382A1 (fr) * 1990-06-15 1992-01-09 Carnegie Institution Of Washington Gdf-1
WO1995033834A1 (fr) * 1994-06-03 1995-12-14 Research Corporation Technologies, Inc. Lag1: un gene pour augmenter la longevite des cellules eucaryotiques
WO1998005761A1 (fr) * 1996-08-07 1998-02-12 The General Hospital Corporation Polypeptides age-1 et molecules et methodes associees
WO1998017823A1 (fr) * 1996-10-21 1998-04-30 Mcgill University CONSERVATION STRUCTURELLE ET FONCTIONNELLE DU GENE D'HORLOGE clk-1 CHEZ $i(C. ELEGANS)
WO1999006558A1 (fr) * 1997-07-30 1999-02-11 Incyte Pharmaceuticals, Inc. Homologues proteiques d'assurance de longevite humaine

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
D'MELLO, NOEL P. ET AL: "Cloning and characterization of LAG1, a longevity - assurance gene in yeast", J. BIOL. CHEM. (1994), 269(22), 15451-9, XP002127185 *
HEKIMI S ET AL: "Molecular genetics of life span in C. elegans: how much does it teach us?", TRENDS IN GENETICS,NL,ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, vol. 14, no. 1, January 1998 (1998-01-01), pages 14-20, XP004101479, ISSN: 0168-9525 *
HODES R ET AL: "Longevity assurance genes: how do they influence aging and life span?", JOURNAL OF THE AMERICAN GERIATRICS SOCIETY,US,ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY, vol. 44, no. 8, 1996, pages 988-991, XP002084173, ISSN: 0002-8614 *
JIANG, JAMES C. ET AL: "Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human", GENOME RES. (1998), 8(12), 1259-1272, XP002127187 *
KIRCHMAN, PAUL A. ET AL: "LAG1 and LAC1 are homologous genes involved in determining the replicative life span of the budding yeast, Saccharomyces cerevisiae.", FASEB JOURNAL, (1996) VOL. 10, NO. 6, PP. A1517. MEETING INFO.: JOINT MEETING OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, THE AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY AND THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS NEW ORLEANS,, XP002127186 *
LEE S -J: "EXPRESSION OF GROWTH/DIFFERENTIATION FACTOR 1 IN THE NERVOUS SYSTEM: CONSERVATION OF A BICISTRONIC STRUCTURE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 88, no. 10, 1991, pages 4520-4524, XP000561931, ISSN: 0027-8424 *
WILSON R. ET AL.: "AC Q17870", EMBL DATABASE, 1 November 1996 (1996-11-01), Heidelberg, XP002127184 *

Also Published As

Publication number Publication date
WO1999058671A9 (fr) 2000-03-09
WO1999058671A2 (fr) 1999-11-18

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