[go: up one dir, main page]

WO1999045119A3 - Production of mycobacterial polypeptides by lactic acid bacteria - Google Patents

Production of mycobacterial polypeptides by lactic acid bacteria Download PDF

Info

Publication number
WO1999045119A3
WO1999045119A3 PCT/DK1999/000109 DK9900109W WO9945119A3 WO 1999045119 A3 WO1999045119 A3 WO 1999045119A3 DK 9900109 W DK9900109 W DK 9900109W WO 9945119 A3 WO9945119 A3 WO 9945119A3
Authority
WO
WIPO (PCT)
Prior art keywords
lactic acid
polypeptide
production
acid bacteria
mycobacterium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK1999/000109
Other languages
French (fr)
Other versions
WO1999045119A2 (en
Inventor
Carsten Loevstrup Jensen
Joergen Folkersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Statens Serum Institut SSI
Original Assignee
Statens Serum Institut SSI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Statens Serum Institut SSI filed Critical Statens Serum Institut SSI
Priority to AU26119/99A priority Critical patent/AU749672B2/en
Priority to JP2000534650A priority patent/JP2002505106A/en
Priority to CA002322505A priority patent/CA2322505A1/en
Priority to NZ507278A priority patent/NZ507278A/en
Priority to EP99906089A priority patent/EP1058731A2/en
Publication of WO1999045119A2 publication Critical patent/WO1999045119A2/en
Publication of WO1999045119A3 publication Critical patent/WO1999045119A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A method of producing in a recombinant lactic acid bacterium such as Lactococcus lactis a bioreactive polypeptide derived from mycobacteria belonging to the M. tuberculosis complex Mycobacterium tuberculosis, Mycobacterium africanum and Mycobacterium bovis or any other mycobacterial species. The lactic acid bacterially produced polypeptide is in the form of monomer or polymers of one or more polypeptide and it is useful as a diagnostic agent in delayed type hypersensitivity (DTH) skin tests in animals and humans and in vaccines. A bioreactive ESAT-6 homodimer polypeptide is described.
PCT/DK1999/000109 1998-03-06 1999-03-05 Production of mycobacterial polypeptides by lactic acid bacteria Ceased WO1999045119A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU26119/99A AU749672B2 (en) 1998-03-06 1999-03-05 Production of mycobacterial polypeptides by lactic acid bacteria
JP2000534650A JP2002505106A (en) 1998-03-06 1999-03-05 Production of Mycobacterial Polypeptides by Lactic Acid Bacteria
CA002322505A CA2322505A1 (en) 1998-03-06 1999-03-05 Production of mycobacterial polypeptides by lactic acid bacteria
NZ507278A NZ507278A (en) 1998-03-06 1999-03-05 Production of mycobacterial polypeptides by lactic acid bacteria
EP99906089A EP1058731A2 (en) 1998-03-06 1999-03-05 Production of mycobacterial polypeptides by lactic acid bacteria

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7710598P 1998-03-06 1998-03-06
DK0306/98 1998-03-06
US60/077,105 1998-03-06
DK30698 1998-03-06

Publications (2)

Publication Number Publication Date
WO1999045119A2 WO1999045119A2 (en) 1999-09-10
WO1999045119A3 true WO1999045119A3 (en) 1999-10-21

Family

ID=26063737

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1999/000109 Ceased WO1999045119A2 (en) 1998-03-06 1999-03-05 Production of mycobacterial polypeptides by lactic acid bacteria

Country Status (6)

Country Link
EP (1) EP1058731A2 (en)
JP (1) JP2002505106A (en)
AU (1) AU749672B2 (en)
CA (1) CA2322505A1 (en)
NZ (1) NZ507278A (en)
WO (1) WO1999045119A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6480999A (en) 1998-11-04 2000-05-22 Isis Innovation Limited Tuberculosis diagnostic test
ATE535600T1 (en) 2002-04-05 2011-12-15 Pasteur Institut IDENTIFICATION OF THE VIRULENCE-ASSOCIATED REGION RD1 ALLOWING THE DEVELOPMENT OF IMPROVED M. MICROTI VACCINES
WO2004067702A2 (en) * 2003-01-30 2004-08-12 The University Of Warwick Methods, oligonucleotides and kits for the identification of mycobacterium in a sample
GB0618127D0 (en) * 2006-09-14 2006-10-25 Isis Innovation Biomarker

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019093A1 (en) * 1992-03-19 1993-09-30 Institut Pasteur Peptide sequence capable of inducing a delayed-type hypersensitivity reaction in the presence of mycobacterium tuberculosis complex living bacteria, and applications
WO1995001441A1 (en) * 1993-07-02 1995-01-12 Statens Serumsinstitut Tuberculosis vaccine
WO1995001440A1 (en) * 1993-07-02 1995-01-12 Statens Seruminstitut Diagnostic skin test for tuberculosis
WO1998044119A1 (en) * 1997-04-02 1998-10-08 Statens Serum Institut NUCLEIC ACID FRAGMENTS AND POLYPEPTIDE FRAGMENTS DERIVED FROM $i(M. TUBERCULOSIS)
WO1999024577A1 (en) * 1997-11-10 1999-05-20 Statens Serum Institut NUCLEIC ACID FRAGMENTS AND POLYPEPTIDE FRAGMENTS DERIVED FROM $i(M. TUBERCULOSIS)

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019093A1 (en) * 1992-03-19 1993-09-30 Institut Pasteur Peptide sequence capable of inducing a delayed-type hypersensitivity reaction in the presence of mycobacterium tuberculosis complex living bacteria, and applications
WO1995001441A1 (en) * 1993-07-02 1995-01-12 Statens Serumsinstitut Tuberculosis vaccine
WO1995001440A1 (en) * 1993-07-02 1995-01-12 Statens Seruminstitut Diagnostic skin test for tuberculosis
WO1998044119A1 (en) * 1997-04-02 1998-10-08 Statens Serum Institut NUCLEIC ACID FRAGMENTS AND POLYPEPTIDE FRAGMENTS DERIVED FROM $i(M. TUBERCULOSIS)
WO1999024577A1 (en) * 1997-11-10 1999-05-20 Statens Serum Institut NUCLEIC ACID FRAGMENTS AND POLYPEPTIDE FRAGMENTS DERIVED FROM $i(M. TUBERCULOSIS)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARBOE, M. ET AL.: "Evidence for occurence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG", INFECTION AND IMMUNITY., vol. 64, no. 1, January 1996 (1996-01-01), WASHINGTON US, pages 16 - 22, XP002105205 *
MALIN, A.S. ET AL.: "Vaccinia expression of M. tuberculosis antigens is enhanced by a eukaryotic leader sequence", IMMUNOLOGY., vol. 89, no. suppl 1, 1996, L SCIENTIFIC PUBLICATIONS GB, XP002105206 *
SORENSEN, A.L. ET AL.: "Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis", INFECTION AND IMMUNITY., vol. 63, no. 5, May 1995 (1995-05-01), WASHINGTON US, pages 1710 - 1717, XP002105204 *

Also Published As

Publication number Publication date
EP1058731A2 (en) 2000-12-13
NZ507278A (en) 2003-10-31
CA2322505A1 (en) 1999-09-10
JP2002505106A (en) 2002-02-19
WO1999045119A2 (en) 1999-09-10
AU2611999A (en) 1999-09-20
AU749672B2 (en) 2002-07-04

Similar Documents

Publication Publication Date Title
Lauer et al. Heterogeneity of the species Lactobacillus acidophilus (Moro) Hansen and Moquot as revealed by biochemical characteristics and DNA-DNA hybridisation
Bollet et al. A simple method for the isolation of chromosomal DNA from gram positive or acid-fast bacteria
AU712143B2 (en) Bacteriocins
Hyronimus et al. Coagulin, a bacteriocin‐like inhibitory substance produced by Bacillus coagulans I4
ATE277181T1 (en) TUBERCULOSIS VACCINE
DE69839426T2 (en) NUCLEOTIDE SEQUENCES CODING FOR SECRETATED POLYPEPTIDES FROM MYCOBACTERIUM, VECTORS CONTAINING THEM, AND APPLICATIONS FOR DIAGNOSIS AND PREVENTION OF TUBERCULOSIS
Pastar et al. Identification and genetic characterization of a novel proteinase, PrtR, from the human isolate Lactobacillus rhamnosus BGT10
Olasupo et al. Occurrence of nisin Z production in Lactococcus lactis BFE 1500 isolated from wara, a traditional Nigerian cheese product
Gupta et al. Incidence of virulence in bacteriocin-producing enterococcal isolates
Mercenier et al. Genetic engineering of lactobacilli, leuconostocs and Streptococcus thermophilus
Patrick et al. Propionibacterium
WO1999045119A3 (en) Production of mycobacterial polypeptides by lactic acid bacteria
Enan et al. Characterization of probiotic lactic acid bacteria to be used as starter and protective cultures for dairy fermentations.
EP0369198A3 (en) Forage preservation
AR043607A1 (en) TEXTURING LACTIC BACTERIES
WO1995003417A3 (en) Homologously recombinant slow growing mycobacteria and uses therefor
DE137869T1 (en) DERIVED NISINE-PRODUCING MICRO-ORGANISMS, METHODS FOR THE PRODUCTION AND USE AND PRODUCTS OBTAINED THEREFORE.
Skeie et al. Interaction between starter bacteria and adjunct Lactobacillus plantarum INF15D on the degradation of citrate, asparagine and aspartate in a washed-curd cheese
FR2411001A1 (en) LYOPHILISATE OBTAINED AFTER ENZYMATIC DECOMPOSITION OF A DAIRY PRODUCT AND ITS PREPARATION PROCESS
PT1161562E (en) Deleted sequences in m. bovis bcg/m. bovis or m. tuberculosis, method for detecting mycobacteria using said sequences and vaccines
CA2481586A1 (en) Cheese capable of disinfecting helicobacter pylori
Tiwari et al. Characterization of a bacteriocin from Lactobacillus plantarum strain LR/14
Cosby et al. Formation, regeneration, and transfection of Lactobacillus plantarum protoplasts
El-Shafei et al. Isolation, screening and characterization of bacteriocin-producing lactic acid bacteria isolated from traditional fermented food
DE1492779C3 (en) Process for the manufacture of sour milk products

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AT AU AZ BA BB BG BR BY CA CH CN CU CZ CZ DE DE DK DK EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AT AU AZ BA BB BG BR BY CA CH CN CU CZ CZ DE DE DK DK EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2322505

Country of ref document: CA

Ref country code: CA

Ref document number: 2322505

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1999906089

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: KR

WWE Wipo information: entry into national phase

Ref document number: 26119/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 507278

Country of ref document: NZ

WWP Wipo information: published in national office

Ref document number: 1999906089

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: CA

WWG Wipo information: grant in national office

Ref document number: 26119/99

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 1999906089

Country of ref document: EP