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WO1998039359B1 - Dimeric cationic lipids on dicystine basis - Google Patents

Dimeric cationic lipids on dicystine basis

Info

Publication number
WO1998039359B1
WO1998039359B1 PCT/US1998/004349 US9804349W WO9839359B1 WO 1998039359 B1 WO1998039359 B1 WO 1998039359B1 US 9804349 W US9804349 W US 9804349W WO 9839359 B1 WO9839359 B1 WO 9839359B1
Authority
WO
WIPO (PCT)
Prior art keywords
cationic lipids
dicystine
basis
dimeric cationic
alk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/004349
Other languages
French (fr)
Other versions
WO1998039359A1 (en
Filing date
Publication date
Priority claimed from US08/812,771 external-priority patent/US6034135A/en
Application filed filed Critical
Priority to CA002281915A priority Critical patent/CA2281915A1/en
Priority to DE69815075T priority patent/DE69815075T2/en
Priority to EP98910189A priority patent/EP0968227B1/en
Priority to AU64488/98A priority patent/AU732333B2/en
Publication of WO1998039359A1 publication Critical patent/WO1998039359A1/en
Publication of WO1998039359B1 publication Critical patent/WO1998039359B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

The present invention provides novel dimeric cationic lipids. The present invention further provides compositions of these lipids with anionic or polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.

Claims

AMENDED CLAIMS[received by the International Bureau on 25 September 1998 (25.09.98); original claim 1 amended; remaining claims unchanged (1 page)]
1. A compound of the formula
Z - S - S - Z wherein Z is
Figure imgf000003_0001
wherein (a) n is 0, 1 or 2; (b) R- is hydroxy, a glyceryl moiety or a lipophilic moiety;
!c) R2 is
(i) -NH- [alk-- H]nl- wherein nl is an integer from 0 to 2 and alk: is an alkylene group of 2 to S carbon atoms;
(ϋ) -[W n2- wherein n2 is an integer from 0 to 3 and each W: is an independently selected amino acid residue;
Figure imgf000003_0002
wherein R4 is hydrogen, alkyl of 1 to 18 carbon atoms optionally mono-, di- or tri-substituted with Y1# Y2 and/or Y3 ;
PCT/US1998/004349 1997-03-06 1998-03-05 Dimeric cationic lipids on dicystine basis Ceased WO1998039359A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002281915A CA2281915A1 (en) 1997-03-06 1998-03-05 Dimeric cationic lipids on dicystine basis
DE69815075T DE69815075T2 (en) 1997-03-06 1998-03-05 DICYSTINE-BASED DIMERATION CATIONIC LIPIDS
EP98910189A EP0968227B1 (en) 1997-03-06 1998-03-05 Dimeric cationic lipids on dicystine basis
AU64488/98A AU732333B2 (en) 1997-03-06 1998-03-05 Dimeric cationic lipids on dicystine basis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/812,771 US6034135A (en) 1997-03-06 1997-03-06 Dimeric cationic lipids
US08/812,771 1997-03-06

Publications (2)

Publication Number Publication Date
WO1998039359A1 WO1998039359A1 (en) 1998-09-11
WO1998039359B1 true WO1998039359B1 (en) 1998-11-26

Family

ID=25210580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/004349 Ceased WO1998039359A1 (en) 1997-03-06 1998-03-05 Dimeric cationic lipids on dicystine basis

Country Status (6)

Country Link
US (1) US6034135A (en)
EP (1) EP0968227B1 (en)
AU (1) AU732333B2 (en)
CA (1) CA2281915A1 (en)
DE (1) DE69815075T2 (en)
WO (1) WO1998039359A1 (en)

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