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WO1998039358B1 - Lipides cationiques oligomeres - Google Patents

Lipides cationiques oligomeres

Info

Publication number
WO1998039358B1
WO1998039358B1 PCT/US1998/004344 US9804344W WO9839358B1 WO 1998039358 B1 WO1998039358 B1 WO 1998039358B1 US 9804344 W US9804344 W US 9804344W WO 9839358 B1 WO9839358 B1 WO 9839358B1
Authority
WO
WIPO (PCT)
Prior art keywords
cationic lipids
oligomeric cationic
oligomeric
present
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/004344
Other languages
English (en)
Other versions
WO1998039358A9 (fr
WO1998039358A1 (fr
Filing date
Publication date
Priority claimed from US08/812,775 external-priority patent/US5877220A/en
Application filed filed Critical
Priority to AU66879/98A priority Critical patent/AU6687998A/en
Publication of WO1998039358A1 publication Critical patent/WO1998039358A1/fr
Publication of WO1998039358B1 publication Critical patent/WO1998039358B1/fr
Publication of WO1998039358A9 publication Critical patent/WO1998039358A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

La présente invention concerne de nouveaux lipides cationiques oligomères. La présente invention concerne également des compositions de ces nouveaux lipides cationiques avec des macromolécules anioniques, des méthodes d'interférence avec une expression de protéines dans une cellule faisant appel à ces compositions, ainsi qu'une trousse destinée à leur préparation.
PCT/US1998/004344 1997-03-06 1998-03-05 Lipides cationiques oligomeres Ceased WO1998039358A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66879/98A AU6687998A (en) 1997-03-06 1998-03-05 Oligomeric cationic lipids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/812,775 US5877220A (en) 1997-03-06 1997-03-06 Amide-based oligomeric cationic lipids
US08/812,775 1997-03-06

Publications (3)

Publication Number Publication Date
WO1998039358A1 WO1998039358A1 (fr) 1998-09-11
WO1998039358B1 true WO1998039358B1 (fr) 1998-11-26
WO1998039358A9 WO1998039358A9 (fr) 1999-02-25

Family

ID=25210592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/004344 Ceased WO1998039358A1 (fr) 1997-03-06 1998-03-05 Lipides cationiques oligomeres

Country Status (3)

Country Link
US (1) US5877220A (fr)
AU (1) AU6687998A (fr)
WO (1) WO1998039358A1 (fr)

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AU3366901A (en) * 1999-12-30 2001-07-16 Novartis Ag Novel colloid synthetic vectors for gene therapy
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
US6686461B1 (en) * 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
WO2001070685A2 (fr) 2000-03-22 2001-09-27 Solulink, Incorporated Agents de reticulation bifonctionnels a base d'hydrazine et de carbonyle
EP1448586A4 (fr) * 2001-11-02 2006-03-01 Intradigm Corp Procedes therapeutiques pour vehicules d'administration d'acides nucleiques
EP2338478B1 (fr) 2002-06-28 2014-07-23 Protiva Biotherapeutics Inc. Méthode de préparation de liposomes
WO2005026372A1 (fr) 2003-09-15 2005-03-24 Protiva Biotherapeutics, Inc. Composes conjugues lipidiques polyethyleneglycol-dialkyloxypropyle et utilisations de ces composes
US7158353B2 (en) * 2003-11-06 2007-01-02 Seagate Technology Llc Magnetoresistive sensor having specular sidewall layers
EA010060B1 (ru) * 2003-12-17 2008-06-30 Вайет Конъюгаты иммуногенных пептидных носителей и способы их получения
US8227403B2 (en) * 2003-12-17 2012-07-24 Wyeth Llc A-β immunogenic peptide carrier conjugates and methods of producing same
ATE536418T1 (de) 2004-06-07 2011-12-15 Protiva Biotherapeutics Inc Lipidverkapselte interferenz-rna
AU2005306533B2 (en) * 2004-11-17 2012-05-31 Arbutus Biopharma Corporation siRNA silencing of apolipoprotein B
CA2628300C (fr) 2005-11-02 2018-04-17 Protiva Biotherapeutics, Inc. Molecules d'arnsi modifiees et utilisations de celles-ci
WO2009082817A1 (fr) * 2007-12-27 2009-07-09 Protiva Biotherapeutics, Inc. Silençage de l'expression de la polo-like kinase à l'aide d'un arn interférent
CA3044134A1 (fr) * 2008-01-02 2009-07-09 Arbutus Biopharma Corporation Compositions et procedes ameliores pour la delivrance d'acides nucleiques
PL2279254T3 (pl) 2008-04-15 2017-11-30 Protiva Biotherapeutics Inc. Nowe preparaty lipidowe do dostarczania kwasów nukleinowych
WO2010042877A1 (fr) 2008-10-09 2010-04-15 Tekmira Pharmaceuticals Corporation Lipides aminés améliorés et procédés d'administration d'acides nucléiques
CA2750561C (fr) 2009-01-26 2017-10-10 Protiva Biotherapeutics, Inc. Compositions et procedes d'inactivation de l'expression de l'apolipoproteine c-iii
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
WO2011000106A1 (fr) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Lipides cationiques et procédés améliorés pour l'administration d'agents thérapeutiques
US8283333B2 (en) 2009-07-01 2012-10-09 Protiva Biotherapeutics, Inc. Lipid formulations for nucleic acid delivery
US8716464B2 (en) * 2009-07-20 2014-05-06 Thomas W. Geisbert Compositions and methods for silencing Ebola virus gene expression
WO2011084721A2 (fr) * 2009-12-21 2011-07-14 Agave Pharma Inc Molécule cationique et procédé d'utilisation
US8455455B1 (en) 2010-03-31 2013-06-04 Protiva Biotherapeutics, Inc. Compositions and methods for silencing genes involved in hemorrhagic fever
WO2012000104A1 (fr) 2010-06-30 2012-01-05 Protiva Biotherapeutics, Inc. Systèmes non liposomaux pour une administration d'acide nucléique
US8466122B2 (en) 2010-09-17 2013-06-18 Protiva Biotherapeutics, Inc. Trialkyl cationic lipids and methods of use thereof
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
EP4295895A3 (fr) 2017-05-11 2024-03-27 Tc1 Llc Interconnexion thermique pour pompe à sang implantable
AU2021385572A1 (en) 2020-11-25 2023-06-22 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids, and related methods of use
WO2023230587A2 (fr) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Nanoparticules lipidiques pour l'administration d'acides nucléiques et leurs procédés d'utilisation

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