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WO1998039027A3 - Sialyl lewis antigens as targets for immunotherapy - Google Patents

Sialyl lewis antigens as targets for immunotherapy Download PDF

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Publication number
WO1998039027A3
WO1998039027A3 PCT/US1998/004314 US9804314W WO9839027A3 WO 1998039027 A3 WO1998039027 A3 WO 1998039027A3 US 9804314 W US9804314 W US 9804314W WO 9839027 A3 WO9839027 A3 WO 9839027A3
Authority
WO
WIPO (PCT)
Prior art keywords
antigens
cancers
melanoma
immunotherapy
targets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/004314
Other languages
French (fr)
Other versions
WO1998039027A2 (en
Inventor
Mepur H Ravindranath
Donald L Morton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wayne Cancer Institute
Original Assignee
John Wayne Cancer Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wayne Cancer Institute filed Critical John Wayne Cancer Institute
Priority to AU65428/98A priority Critical patent/AU6542898A/en
Publication of WO1998039027A2 publication Critical patent/WO1998039027A2/en
Publication of WO1998039027A3 publication Critical patent/WO1998039027A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Sialyls Lewis (sLe) antigens are functionally important, immunogenic, tumorigenic or differentiation antigens and potential targets for both passive and active specific immunotherapy of melanoma and other cancers sharing these antigens. The present invention concerns the use of such antigens in vaccine formulations for the treatment of a variety of cancers and in particular melanoma. The B lymphocytes from the vaccine recipients will be used to harvest human monoclonal antibodies and use it as a drug for treatment of melanoma and other cancers.
PCT/US1998/004314 1997-03-05 1998-03-05 Sialyl lewis antigens as targets for immunotherapy Ceased WO1998039027A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU65428/98A AU6542898A (en) 1997-03-05 1998-03-05 Sialyl lewis antigens as targets for immunotherapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81128197A 1997-03-05 1997-03-05
US08/811,281 1997-03-05

Publications (2)

Publication Number Publication Date
WO1998039027A2 WO1998039027A2 (en) 1998-09-11
WO1998039027A3 true WO1998039027A3 (en) 1999-01-07

Family

ID=25206107

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/004314 Ceased WO1998039027A2 (en) 1997-03-05 1998-03-05 Sialyl lewis antigens as targets for immunotherapy

Country Status (2)

Country Link
AU (1) AU6542898A (en)
WO (1) WO1998039027A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9475874B2 (en) 2013-08-26 2016-10-25 MabVax Therapeutics, Inc. Nucleic acids encoding human antibodies to sialyl-lewisa

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* Cited by examiner, † Cited by third party
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WO2002045740A1 (en) * 2000-12-08 2002-06-13 Children's Memorial Hospital Compositions containing gangliosides for use in the treatment of skin disorders
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
EP1417965A1 (en) * 2002-11-07 2004-05-12 Vereniging Voor Christelijk Wetenschappelijk Onderwijs C-type lectin binding molecules, identification and uses thereof
JP4942664B2 (en) 2005-02-01 2012-05-30 モーフォシス アーゲー Libraries and methods for isolating antibodies
FR2919804B1 (en) * 2007-08-08 2010-08-27 Erytech Pharma COMPOSITION AND ANTI-TUMOR THERAPEUTIC VACCINE
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof
US10384796B2 (en) * 2012-04-04 2019-08-20 Commercial Aerospace Plane Pty Limited Aerospace plane system
WO2017041051A1 (en) 2015-09-04 2017-03-09 Sqz Biotechnologies Company Intracellular delivery of biomolecules to cells comprising a cell wall
CN109415741A (en) 2016-05-03 2019-03-01 Sqz生物技术公司 Intracellular delivery biomolecule is with inducing tolerance
KR102611270B1 (en) 2016-12-01 2023-12-08 리제너론 파마슈티칼스 인코포레이티드 Radiolabeled anti-PD-L1 antibody for immuno-PET imaging

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0508282A2 (en) * 1991-04-01 1992-10-14 Kyowa Hakko Kogyo Co., Ltd. Anti-idiotypic monoclonal antibodies
WO1992022565A1 (en) * 1991-06-10 1992-12-23 Alberta Research Council Modified sialyl lewisx compounds
WO1997027872A1 (en) * 1996-01-31 1997-08-07 President And Fellows Of Harvard College Immunomodulatory methods using oligosaccharides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0508282A2 (en) * 1991-04-01 1992-10-14 Kyowa Hakko Kogyo Co., Ltd. Anti-idiotypic monoclonal antibodies
WO1992022565A1 (en) * 1991-06-10 1992-12-23 Alberta Research Council Modified sialyl lewisx compounds
WO1997027872A1 (en) * 1996-01-31 1997-08-07 President And Fellows Of Harvard College Immunomodulatory methods using oligosaccharides

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CANCER IMMUNOLOGY, IMMUNOTHERAPY, (1998 FEB) 45 (6) 281-6 *
CANCER, (1997 MAY 1) 79 (9) 1686-97 *
DATABASE MEDLINE US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; KIEBER-EMMONS T ET AL: "Peptide mimicry of adenocarcinoma-associated carbohydrate antigens.", XP002083156 *
DATABASE MEDLINE US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; KUDRYASHOV V ET AL: "Immunogenicity of synthetic conjugates of Lewis(y) oligosaccharide with proteins in mice: towards the design of anticancer vaccines.", XP002083157 *
DATABASE MEDLINE US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; RAVINDRANATH M H ET AL: "Endothelial-selectin ligands sialyl Lewis (x) and sialyl Lewis (a) are differentiation antigens immunogenic in human melanoma.", XP002083158 *
HYBRIDOMA, (1997 FEB) 16 (1) 3-10 *
MAKINO K ET AL: "Expression of tumor-associated glycoantigen, sialyl Lewis (a), in human head and neck squamous cell carcinoma and its application to tumor immunotherapy.", JAPANESE JOURNAL OF CANCER RESEARCH, (1994 SEP) 85 (9) 887-91, XP002083154 *
RAVINDRANATH M H ET AL: "Ratio of IgG:IgM antibodies to sialyl Lewis (x) and GM3 correlates with tumor growth after immunization with melanoma-cell vaccine with different adjuvants in mice.", INTERNATIONAL JOURNAL OF CANCER, (1998 JAN 5) 75 (1) 117-24, XP002083155 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9475874B2 (en) 2013-08-26 2016-10-25 MabVax Therapeutics, Inc. Nucleic acids encoding human antibodies to sialyl-lewisa

Also Published As

Publication number Publication date
AU6542898A (en) 1998-09-22
WO1998039027A2 (en) 1998-09-11

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