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WO1998037181A3 - Telomerase catalytic subunit gene and encoded protein - Google Patents

Telomerase catalytic subunit gene and encoded protein Download PDF

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Publication number
WO1998037181A3
WO1998037181A3 PCT/US1998/003404 US9803404W WO9837181A3 WO 1998037181 A3 WO1998037181 A3 WO 1998037181A3 US 9803404 W US9803404 W US 9803404W WO 9837181 A3 WO9837181 A3 WO 9837181A3
Authority
WO
WIPO (PCT)
Prior art keywords
catalytic subunit
malignancy
telomerase
encoded protein
subunit gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/003404
Other languages
French (fr)
Other versions
WO1998037181A2 (en
Inventor
Christopher M Counter
Matthew Meyerson
Robert A Weinberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whitehead Institute for Biomedical Research
Original Assignee
Whitehead Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Institute for Biomedical Research filed Critical Whitehead Institute for Biomedical Research
Publication of WO1998037181A2 publication Critical patent/WO1998037181A2/en
Publication of WO1998037181A3 publication Critical patent/WO1998037181A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Isolated DNA encoding the catalytic subunit of a eukaryotic telomerase holoenzyme, such as the catalytic subunit of a yeast or human telomerase holoenzyme; the RNA transcript, which is expressed in primary human tumors, cancer cell lines and telomerase-positive tissues; and the encoded catalytic subunit protein. Methods of assessing cells for malignancy or an increased likelihood of progression to malignancy and methods of diagnosing or aiding in the diagnosis of development of malignancy in an individual are also described.
PCT/US1998/003404 1997-02-20 1998-02-20 Telomerase catalytic subunit gene and encoded protein Ceased WO1998037181A2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US3875097P 1997-02-20 1997-02-20
US60/038,750 1997-02-20
US4715197P 1997-05-20 1997-05-20
US60/047,151 1997-05-20
US5454997P 1997-08-01 1997-08-01
US60/054,549 1997-08-01
US5576297P 1997-08-14 1997-08-14
US60/055,762 1997-08-14
US6432297P 1997-10-30 1997-10-30
US60/064,322 1997-10-30

Publications (2)

Publication Number Publication Date
WO1998037181A2 WO1998037181A2 (en) 1998-08-27
WO1998037181A3 true WO1998037181A3 (en) 1999-02-18

Family

ID=27534674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/003404 Ceased WO1998037181A2 (en) 1997-02-20 1998-02-20 Telomerase catalytic subunit gene and encoded protein

Country Status (1)

Country Link
WO (1) WO1998037181A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517971B1 (en) 1996-10-01 2009-04-14 Geron Corporation Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity
US7560437B2 (en) 1996-10-01 2009-07-14 Geron Corporation Nucleic acid compositions for eliciting an immune response against telomerase reverse transcriptase
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0861334B2 (en) 1995-11-16 2008-04-09 Michael W. Dahm Method of quantifying tumour cells in a body fluid and a suitable test kit
US6777203B1 (en) 1997-11-19 2004-08-17 Geron Corporation Telomerase promoter driving expression of therapeutic gene sequences
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
WO1998059040A2 (en) * 1997-06-20 1998-12-30 Bayer Aktiengesellschaft Human catalytic telomerase sub-unit and its diagnostic and therapeutic use
AU748442B2 (en) * 1997-07-01 2002-06-06 Cambia Vertebrate telomerase genes and proteins and uses thereof
EP1571215A3 (en) * 1997-07-01 2007-10-31 Cambia Biosystems LLC Vertebrate telomerase genes and proteins and uses thereof
US7378244B2 (en) 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
AU1606999A (en) * 1997-11-26 1999-06-15 Albert Einstein College Of Medicine Of Yeshiva University Mouse telomerase reverse transcriptase
US6608188B1 (en) 1998-01-08 2003-08-19 Chugai Seiyaku Kabushiki Kaisha CRT-1 gene having reverse transcriptase motif
DE19804372A1 (en) * 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Method for the quantitative determination of tumor cells in a body fluid and suitable test kits
US6639057B1 (en) 1998-03-26 2003-10-28 Kyowa Hakko Kogyo Co., Ltd. Monoclonal antibody against human telomerase catalytic subunit
AU3456099A (en) 1998-03-31 1999-10-18 Geron Corporation Methods and compositions for eliciting an immune response to a telomerase antigen
US6337200B1 (en) * 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
ATE347904T1 (en) 1998-10-29 2007-01-15 Dana Farber Cancer Inst Inc CANCER IMMUNOTHERAPY AND CANCER DIAGNOSIS USING UNIVERSAL TUMOR-ASSOCIATED ANTIGENS INCLUDING HTERT
US6825397B1 (en) 1998-11-09 2004-11-30 Pioneer Hi-Bred International, Inc. LEC1 trancriptional activator nucleic acids and methods of use thereof
AU2156600A (en) * 1998-11-25 2000-06-13 Cold Spring Harbor Laboratory Methods and reagents for increasing proliferative capacity and preventing replicative senescence
KR100801764B1 (en) * 1999-09-17 2008-02-05 레뉴런 리미티드 Conditional Immortalization of Cells
US6399384B1 (en) 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
US6492171B2 (en) 2000-05-16 2002-12-10 Isis Pharmaceuticals, Inc. Antisense modulation of TERT expression
WO2002016555A2 (en) * 2000-08-17 2002-02-28 University Of Wales College Of Medicine Htert-immortalised cell lines, their preparation and use
US7078491B1 (en) * 2000-09-21 2006-07-18 Amgen Inc. Selective binding agents of telomerase
GB0125773D0 (en) * 2001-10-26 2001-12-19 Reneuron Ltd Constructs
US20050089895A1 (en) * 2003-08-13 2005-04-28 Cheung Siu T. Compositions and methods for prognosis and therapy of liver cancer
AU2007306368B2 (en) 2006-10-12 2012-05-03 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Telomerase reverse transcriptase fusion protein, nucleotides encoding it, and uses thereof
US10689652B2 (en) 2013-10-02 2020-06-23 The Regents Of The University Of California Methods for immortalization of epithelial cells
US10870851B2 (en) 2015-10-06 2020-12-22 The Regents Of The University Of California Non-coding RNAs linked to immortality and associated methods and compositions

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023572A1 (en) * 1992-05-13 1993-11-25 University Of Texas Southwestern Medical Center At Dallas Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
WO1996001835A1 (en) * 1994-07-07 1996-01-25 Geron Corporation Mammalian telomerase
WO1996012811A2 (en) * 1994-10-20 1996-05-02 Arch Development Corporation Yeast telomerase components and methods using them
WO1998001542A1 (en) * 1996-07-08 1998-01-15 The Regents Of The University Of California Human telomerase
GB2317891A (en) * 1996-10-01 1998-04-08 Geron Corp hTRT, the reverse transcriptase subunit of human telomerase
WO1998021343A1 (en) * 1996-11-15 1998-05-22 Amgen Inc. Genes encoding telomerase proteins

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023572A1 (en) * 1992-05-13 1993-11-25 University Of Texas Southwestern Medical Center At Dallas Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
WO1996001835A1 (en) * 1994-07-07 1996-01-25 Geron Corporation Mammalian telomerase
WO1996012811A2 (en) * 1994-10-20 1996-05-02 Arch Development Corporation Yeast telomerase components and methods using them
WO1998001542A1 (en) * 1996-07-08 1998-01-15 The Regents Of The University Of California Human telomerase
GB2317891A (en) * 1996-10-01 1998-04-08 Geron Corp hTRT, the reverse transcriptase subunit of human telomerase
WO1998021343A1 (en) * 1996-11-15 1998-05-22 Amgen Inc. Genes encoding telomerase proteins

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
COUNTER C M ET AL: "The catalytic subunit of yeast telomerase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 94, no. 17, 1997, WASHINGTON US, pages 9202 - 9207, XP002071610 *
GREIDER C W: "TELOMERE LENGTH REGULATION", ANNUAL REVIEW OF BIOCHEMISTRY, vol. 65, 1996, PALO ALTO US, pages 337 - 365, XP002056801 *
HARRINGTON L ET AL: "HUMAN TELOMERASE CONTAINS EVOLUTIONARILY CONSERVED CATALYTIC AND STRUCTURAL SUBUNITS", GENES AND DEVELOPMENT, vol. 11, no. 23, 1 December 1997 (1997-12-01), COLD SPRING HARBOUR US, pages 3109 - 3115, XP002061269 *
LENDVAY T S ET AL: "Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes", GENETICS, vol. 144, no. 4, 1996, BETHESDA US, pages 1399 - 1412, XP002071608 *
LINGNER J ET AL: "Reverse transcriptase motifs in the catalytic subunit of telomerase", SCIENCE., vol. 276, no. 5312, 25 April 1997 (1997-04-25), LANCASTER, PA US, pages 561 - 567, XP002071609 *
MEYERSON M ET AL: "HEST2, THE PUTATIVE HUMAN TELOMERASE CATALYTIC SUBUNIT GENE, IS UP-REGULATED IN TUMOR CELLS AND DURING IMMORTALIZATION", CELL, vol. 90, no. 4, 22 August 1997 (1997-08-22), NA US, pages 785 - 795, XP002056804 *
NAKAMURA T M ET AL: "TELOMERASE CATALYTIC SUBUNIT HOMOLOGS FROM FISSION YEAST AND HUMAN", SCIENCE., vol. 277, 15 August 1997 (1997-08-15), LANCASTER, PA US, pages 955 - 959, XP002056803 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517971B1 (en) 1996-10-01 2009-04-14 Geron Corporation Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity
US7560437B2 (en) 1996-10-01 2009-07-14 Geron Corporation Nucleic acid compositions for eliciting an immune response against telomerase reverse transcriptase
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase

Also Published As

Publication number Publication date
WO1998037181A2 (en) 1998-08-27

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