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WO1998033887B1 - Facteur-8 de differenciation de croissance - Google Patents

Facteur-8 de differenciation de croissance

Info

Publication number
WO1998033887B1
WO1998033887B1 PCT/US1998/002479 US9802479W WO9833887B1 WO 1998033887 B1 WO1998033887 B1 WO 1998033887B1 US 9802479 W US9802479 W US 9802479W WO 9833887 B1 WO9833887 B1 WO 9833887B1
Authority
WO
WIPO (PCT)
Prior art keywords
gdf
transgene
animal
expression
transgenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/002479
Other languages
English (en)
Other versions
WO1998033887A1 (fr
Filing date
Publication date
Priority claimed from US08/795,071 external-priority patent/US5994618A/en
Application filed filed Critical
Priority to AU62742/98A priority Critical patent/AU6274298A/en
Publication of WO1998033887A1 publication Critical patent/WO1998033887A1/fr
Publication of WO1998033887B1 publication Critical patent/WO1998033887B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne un animal transgénique non humain qui appartient à l'une des espèces du groupe comprenant les aviens, les bovins, les ovins et les porcins, et qui comporte un transgène entraînant la rupture de la production et/ou de l'activité du facteur-8 de différenciation de croissance (GDF-8) chromosomique intégré aux cellules germinales de l'animal. On décrit aussi des procédés relatifs à l'élaboration de ce type d'animal, et des procédés de traitement pour les animaux, ainsi que pour les êtres humains, consistant en un processus par anticorps ou par antisens sur le facteur GDF-8. Les animaux qui reçoivent ce traitement présentent la caractéristique d'une augmentation de tissu musculaire.
PCT/US1998/002479 1997-02-05 1998-02-05 Facteur-8 de differenciation de croissance Ceased WO1998033887A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62742/98A AU6274298A (en) 1997-02-05 1998-02-05 Growth differentiation factor-8

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/795,071 1997-02-05
US08/795,071 US5994618A (en) 1997-02-05 1997-02-05 Growth differentiation factor-8 transgenic mice
US84791097A 1997-04-28 1997-04-28
US08/847,910 1997-04-28
US86244597A 1997-05-23 1997-05-23
US08/862,445 1997-05-23

Publications (2)

Publication Number Publication Date
WO1998033887A1 WO1998033887A1 (fr) 1998-08-06
WO1998033887B1 true WO1998033887B1 (fr) 1998-09-11

Family

ID=27419913

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/002479 Ceased WO1998033887A1 (fr) 1997-02-05 1998-02-05 Facteur-8 de differenciation de croissance

Country Status (3)

Country Link
US (1) US20080311584A1 (fr)
AU (1) AU6274298A (fr)
WO (1) WO1998033887A1 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6607884B1 (en) 1993-03-19 2003-08-19 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-8
EP0690873B1 (fr) 1993-03-19 2003-06-11 The Johns Hopkins University School Of Medicine Facteur gde8 de differentiation de croissance
US6465239B1 (en) * 1993-03-19 2002-10-15 The John Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species
US7393682B1 (en) 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
US7566768B1 (en) 1995-10-26 2009-07-28 The Johns Hopkins University School Of Medicine Promyostatin peptides and methods of using same
US5994618A (en) 1997-02-05 1999-11-30 Johns Hopkins University School Of Medicine Growth differentiation factor-8 transgenic mice
US7332575B2 (en) 1994-03-18 2008-02-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species
US6008434A (en) 1994-07-08 1999-12-28 Johns Hopkins University School Of Medicine Growth differentiation factor-11 transgenic mice
WO1999002667A1 (fr) * 1997-07-14 1999-01-21 University Of Liege Mutation du gene de la myostatine a l'origine de l'hypertrophie musculaire chez les mammiferes
US6103466A (en) * 1997-07-14 2000-08-15 University Of Liege Double-muscling in mammals
US6891082B2 (en) * 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
US6696260B1 (en) 1997-08-01 2004-02-24 The Johns Hopkins University School Of Medicine Methods to identify growth differentiation factor (GDF) binding proteins
US6656475B1 (en) * 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
GB2333706A (en) * 1998-02-02 1999-08-04 Merck & Co Inc Method for increasing muscle mass in animals
AU2586199A (en) * 1998-02-05 1999-08-23 Johns Hopkins University School Of Medicine, The Growth differentiation factor-8
US6369201B1 (en) * 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
JP4544742B2 (ja) * 1998-05-06 2010-09-15 メタモーフイクス・インコーポレーテツド Ｇｄｆ−８の阻害による糖尿病の処置法
AU5483599A (en) * 1998-08-14 2000-03-06 Board Of Regents, The University Of Texas System Calcineurin-dependent control of skeletal muscle fiber type
NZ513642A (en) * 1999-01-21 2004-02-27 Metamorphix Inc Growth differentiation factor inhibitors and uses therefor
US6284882B1 (en) 1999-06-10 2001-09-04 Abbott Laboratories Myostatin gene promoter and inhibition of activation thereof
ZA200003786B (en) 1999-07-30 2002-01-21 Pfizer Prod Inc Myostatin regulatory region, nucleotide sequence determination and methods for its use.
WO2001053350A1 (fr) 2000-01-18 2001-07-26 Agresearch Limited Myostatine et mimetiques de ces derniers
AU2001284843A1 (en) * 2000-08-14 2002-02-25 Iogenetics, Llc Fatty liver disease resistant bovines
US7037501B2 (en) 2001-01-04 2006-05-02 Regents Of The University Of Minnesota Myostatin immnoconjugate
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
AU2012204098B2 (en) * 2001-04-24 2014-05-15 The Johns Hopkins University Use of follistatin to increase muscle mass
US7320789B2 (en) 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
BR0307871A (pt) 2002-02-21 2005-04-12 Wyeth Corp Proteìnas contendo domìnio de folistatina
IL163525A0 (en) 2002-02-21 2005-12-18 Wyeth Corp A follistatin domain containing protein
US7261893B2 (en) 2002-10-22 2007-08-28 Wyeth Neutralizing antibodies against GDF-8 and uses therefor
US7785587B2 (en) 2003-06-02 2010-08-31 Wyeth Therapeutic methods for muscular or neuromuscular disorders
NZ547593A (en) 2003-12-31 2009-09-25 Schering Plough Ltd Neutralizing epitope-based growth enhancing vaccine
WO2006036074A1 (fr) 2004-09-30 2006-04-06 Orico Limited Isoforme de myostatine
CA2594276A1 (fr) 2004-12-30 2006-07-13 Schering-Plough Ltd. Vaccins favorisant la croissance a base d'epitopes neutralisants
NZ538097A (en) * 2005-02-07 2006-07-28 Ovita Ltd Method and compositions for improving wound healing
HUE025240T2 (en) 2005-08-19 2016-03-29 Wyeth Llc Anti-GDF-8 antagonist antibodies and their use in the treatment of ALS and other disorders associated with GDF-8
GB2433320B (en) * 2005-12-16 2009-10-07 Norwegian University Of Life S Diagnostic method
EP1798292A1 (fr) * 2005-12-19 2007-06-20 Nutreco Nederland B.V. Procédé pour augmenter la production de viande de dindon
JP2009545313A (ja) 2006-08-03 2009-12-24 オリコ・リミテッド ミオスタチンアンタゴニスト
CN100450545C (zh) * 2006-08-03 2009-01-14 中国医学科学院基础医学研究所 肌肉生长抑制素在制备抗肿瘤药物中的应用
CN102653764B (zh) * 2012-04-26 2014-03-19 天津农学院 在牛mstn基因中引入移码突变的方法
NZ702269A (en) 2012-06-15 2017-07-28 Pfizer Improved antagonist antibodies against gdf-8 and uses therefor
WO2014043344A1 (fr) 2012-09-13 2014-03-20 Bristol-Myers Squibb Company Protéines à domaine d'échafaudage à base de fibronectine qui se lient à la myostatine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585479A (en) * 1992-07-24 1996-12-17 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ELAM-I RNA
US5716806A (en) * 1995-06-05 1998-02-10 Human Genome Sciences, Inc. Human inositiol monophosphatase H1 polynucleotides
US5756295A (en) * 1994-12-05 1998-05-26 Takeda Chemical Industries, Ltd. DNA primer and a method for screening DNAS
JP4484967B2 (ja) * 1995-06-06 2010-06-16 ベス イスラエル ディーコネス メディカル センター Ｄｎａ診断試験の方法及び装置
US6103466A (en) * 1997-07-14 2000-08-15 University Of Liege Double-muscling in mammals

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