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WO1998030680A3 - Special catalytic domains of CDC25C phosphatase - Google Patents

Special catalytic domains of CDC25C phosphatase Download PDF

Info

Publication number
WO1998030680A3
WO1998030680A3 PCT/US1998/000018 US9800018W WO9830680A3 WO 1998030680 A3 WO1998030680 A3 WO 1998030680A3 US 9800018 W US9800018 W US 9800018W WO 9830680 A3 WO9830680 A3 WO 9830680A3
Authority
WO
WIPO (PCT)
Prior art keywords
cdc25c
catalytic domains
special catalytic
cdc25c phosphatase
phosphatase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/000018
Other languages
French (fr)
Other versions
WO1998030680A2 (en
Inventor
Martin R Deibel
Anne F Vosters
Anthony W Yem
Keith D Watenpaugh
Musiri N Janakiraman
Luis A Parodi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Priority to AU60149/98A priority Critical patent/AU6014998A/en
Publication of WO1998030680A2 publication Critical patent/WO1998030680A2/en
Publication of WO1998030680A3 publication Critical patent/WO1998030680A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention discloses novel forms of catalytic macro molecules that are related to cdc25C, a cell cycle specific phosphatase. These special domains of cdc25C, and the method of making them, are especially useful.
PCT/US1998/000018 1997-01-13 1998-01-09 Special catalytic domains of cdc25c phosphatase Ceased WO1998030680A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU60149/98A AU6014998A (en) 1997-01-13 1998-01-09 Special catalytic domains of cdc25c phosphatase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3518897P 1997-01-13 1997-01-13
US60/035,188 1997-01-13

Publications (2)

Publication Number Publication Date
WO1998030680A2 WO1998030680A2 (en) 1998-07-16
WO1998030680A3 true WO1998030680A3 (en) 1998-09-17

Family

ID=21881186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000018 Ceased WO1998030680A2 (en) 1997-01-13 1998-01-09 Special catalytic domains of cdc25c phosphatase

Country Status (2)

Country Link
AU (1) AU6014998A (en)
WO (1) WO1998030680A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7548500A (en) * 1999-09-22 2001-04-24 Canbas Co., Ltd. Compositions and methods for inhibiting g2 cell cycle arrest and sensitizing cells to dna damaging agents
WO2001044467A2 (en) * 1999-12-14 2001-06-21 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Method for obtaining human cdc25 phosphatases and method for identifying human cdc25 phosphatase modulators

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
B. BARATTE ET AL.: "Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis inducing p34cdc2/cyclin Bcdc13 protein kinase", ANTICANCER RESEARCH, vol. 12, 1992, pages 873 - 880, XP002069498 *
J.B.A MILLAR ET AL.: "p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast", EMBO JOURNAL, vol. 10, no. 13, 1991, pages 4301 - 4309, XP002069499 *
M.S. LEE ET AL: "cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2", MOLECULAR BIOLOGY OF THE CELL, vol. 3, 1992, pages 73 - 84, XP002069497 *
T. ORIGUCHI ET AL.: "Dnacin A1 and Dnacin B1 are antitmor antibiotics that inhibit cdc25B phosphatase activity", BIOCHEMICAL PHARMACOLOGY, vol. 48, no. 11, 1994, pages 2139 - 2141, XP002038482 *

Also Published As

Publication number Publication date
AU6014998A (en) 1998-08-03
WO1998030680A2 (en) 1998-07-16

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