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WO1998030254A3 - Sample collection and drug delivery apparatus for freely-moving tethered laboratory animals - Google Patents

Sample collection and drug delivery apparatus for freely-moving tethered laboratory animals Download PDF

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Publication number
WO1998030254A3
WO1998030254A3 PCT/US1998/000120 US9800120W WO9830254A3 WO 1998030254 A3 WO1998030254 A3 WO 1998030254A3 US 9800120 W US9800120 W US 9800120W WO 9830254 A3 WO9830254 A3 WO 9830254A3
Authority
WO
WIPO (PCT)
Prior art keywords
animal
freely
drug delivery
sample collection
laboratory animals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/000120
Other languages
French (fr)
Other versions
WO1998030254A2 (en
Inventor
Robert Wingfield Bonsal
Milburn Spencer Emery
Jay Michael Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/781,690 external-priority patent/US5865766A/en
Priority claimed from US08/781,695 external-priority patent/US5832878A/en
Application filed by Emory University filed Critical Emory University
Priority to JP53101998A priority Critical patent/JP2001509668A/en
Priority to EP98902398A priority patent/EP0977477A4/en
Priority to AU59075/98A priority patent/AU5907598A/en
Publication of WO1998030254A2 publication Critical patent/WO1998030254A2/en
Publication of WO1998030254A3 publication Critical patent/WO1998030254A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K29/00—Other apparatus for animal husbandry
    • A01K29/005—Monitoring or measuring activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/03—Housing for domestic or laboratory animals
    • A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K29/00—Other apparatus for animal husbandry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

A multichannel, multipurpose sample collection and drug delivery system for freely-moving laboratory animals (28) including several sampling and/or infusion devices mounted on a powered turntable (4) above the cage but out of the animal's sight. Rotation of the tether (2) as the animal (28) moves is detected by magnetic switches (133), which cause the turntable (4) to turn in the direction taken by the animal (28). Fluid or electrical swivels are entirely eliminated; the animal (28) experiences almost zero torque on the tether (2). As the swivel normally limits the number of fluid or electrical connections in traditional systems, eliminating the swivel removes this constraint. Multiple probes (70) can now be placed in alert, freely moving animals to sample several brain regions simultaneously.
PCT/US1998/000120 1997-01-10 1998-01-08 Sample collection and drug delivery apparatus for freely-moving tethered laboratory animals Ceased WO1998030254A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP53101998A JP2001509668A (en) 1997-01-10 1998-01-08 Free-moving, tethered sample collection and drug delivery device for laboratory animals
EP98902398A EP0977477A4 (en) 1997-01-10 1998-01-08 SAMPLING AND ACTIVE SUBSTANCE DELIVERY DEVICE FOR MOVABLE RESTRAINED ANIMALS
AU59075/98A AU5907598A (en) 1997-01-10 1998-01-08 Sample collection and drug delivery apparatus for freely-moving tethered laboratory animals

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/781,690 US5865766A (en) 1997-01-10 1997-01-10 Multichannel, multipurpose sample collection and drug delivery system for laboratory animals
US08/781,695 1997-01-10
US08/781,690 1997-01-10
US08/781,695 US5832878A (en) 1997-01-10 1997-01-10 Apparatus permitting tethered laboratory animals to move freely

Publications (2)

Publication Number Publication Date
WO1998030254A2 WO1998030254A2 (en) 1998-07-16
WO1998030254A3 true WO1998030254A3 (en) 1998-12-03

Family

ID=27119898

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000120 Ceased WO1998030254A2 (en) 1997-01-10 1998-01-08 Sample collection and drug delivery apparatus for freely-moving tethered laboratory animals

Country Status (4)

Country Link
EP (1) EP0977477A4 (en)
JP (1) JP2001509668A (en)
AU (1) AU5907598A (en)
WO (1) WO1998030254A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH694574A5 (en) * 2004-12-23 2005-04-15 Rcc Ltd Rat cage with an inner food rack, for laboratory animals, has closed side walls and base with a slit through the lid to take a tube from the infusion pump and shrouded catheter to the rat neck
EP2077092A3 (en) * 2007-10-29 2009-10-21 Taipei Veterans General Hospital System and Methods for Screening or Analyzing Targets
US9757037B2 (en) 2011-04-18 2017-09-12 Universite De Geneve In vivo bioluminescence monitoring apparatus
JP2014534864A (en) * 2011-10-28 2014-12-25 プレサージュ バイオサイエンシズ，インコーポレイテッド Drug delivery method
WO2017174557A2 (en) * 2016-04-04 2017-10-12 Brains Online Holding B.V. Use of push pull microdialysis in combination with shotgun proteomics for analyzing the proteome in extracellular space of brain
US11877558B2 (en) * 2019-12-20 2024-01-23 Novocure Gmbh Swivel assembly for actively limiting torsion of a cable, and systems and methods of using same
CN111134894B (en) * 2020-01-17 2022-02-22 上海长海医院 Sampling method for in vivo determination of continuous dynamic free drug concentration of canine prostate tissue
CN113040970B (en) * 2021-03-22 2022-07-08 陈相辉 Animal doctor uses medicine injection device
CN113693774B (en) * 2021-08-05 2024-02-27 国科赛赋河北医药技术有限公司 Protection device for monkey autonomous administration embedded pipeline

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3572552A (en) * 1969-07-25 1971-03-30 Perry W Guinn Diaphragm dispenser
US4444062A (en) * 1982-05-05 1984-04-24 Bennett John T Liquid transfer device
US4831887A (en) * 1986-01-14 1989-05-23 Thames Water Authority Automatic sampling machine
US4966579A (en) * 1988-05-21 1990-10-30 Fresenius Ag Apparatus for dosed continuous simultaneous infusion of a plurality of infusion solutions or medicaments
US5047009A (en) * 1987-09-22 1991-09-10 Vitreoretinal Development, Inc. Method and apparatus for ocular perfusion
US5211829A (en) * 1990-03-02 1993-05-18 Hitachi, Ltd. Analytical method and apparatus using capillary tube
US5213063A (en) * 1992-08-20 1993-05-25 Windsor Products, Inc. Animal tethering device
US5217432A (en) * 1991-12-31 1993-06-08 Abbott Laboratories Automated drug infusion manifold
US5279167A (en) * 1992-06-09 1994-01-18 Roger Peterson Method and apparatus for providing a sample for testing for volatile emissions
US5305712A (en) * 1992-11-30 1994-04-26 Allegheny-Singer Research Institute Animal tether system and method of use
US5463909A (en) * 1994-03-15 1995-11-07 Minnesota Mining And Manufacturing Company Runoff water sampler
US5470312A (en) * 1992-06-03 1995-11-28 Allergan, Inc. Irrigation/aspiration apparatus for surgical procedures
US5531679A (en) * 1994-03-14 1996-07-02 Schulman; Joseph H. Fluidic infusion system for catheter or probe
US5597734A (en) * 1993-08-27 1997-01-28 Dionex Corporation Ion chromatography using frequent regeneration of batch-type suppressor
US5607390A (en) * 1992-12-15 1997-03-04 Institute Of Neurology Dialysis probe

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3572552A (en) * 1969-07-25 1971-03-30 Perry W Guinn Diaphragm dispenser
US4444062A (en) * 1982-05-05 1984-04-24 Bennett John T Liquid transfer device
US4831887A (en) * 1986-01-14 1989-05-23 Thames Water Authority Automatic sampling machine
US5047009A (en) * 1987-09-22 1991-09-10 Vitreoretinal Development, Inc. Method and apparatus for ocular perfusion
US4966579A (en) * 1988-05-21 1990-10-30 Fresenius Ag Apparatus for dosed continuous simultaneous infusion of a plurality of infusion solutions or medicaments
US5211829A (en) * 1990-03-02 1993-05-18 Hitachi, Ltd. Analytical method and apparatus using capillary tube
US5217432A (en) * 1991-12-31 1993-06-08 Abbott Laboratories Automated drug infusion manifold
US5470312A (en) * 1992-06-03 1995-11-28 Allergan, Inc. Irrigation/aspiration apparatus for surgical procedures
US5279167A (en) * 1992-06-09 1994-01-18 Roger Peterson Method and apparatus for providing a sample for testing for volatile emissions
US5213063A (en) * 1992-08-20 1993-05-25 Windsor Products, Inc. Animal tethering device
US5305712A (en) * 1992-11-30 1994-04-26 Allegheny-Singer Research Institute Animal tether system and method of use
US5607390A (en) * 1992-12-15 1997-03-04 Institute Of Neurology Dialysis probe
US5597734A (en) * 1993-08-27 1997-01-28 Dionex Corporation Ion chromatography using frequent regeneration of batch-type suppressor
US5531679A (en) * 1994-03-14 1996-07-02 Schulman; Joseph H. Fluidic infusion system for catheter or probe
US5463909A (en) * 1994-03-15 1995-11-07 Minnesota Mining And Manufacturing Company Runoff water sampler

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0977477A4 *

Also Published As

Publication number Publication date
WO1998030254A2 (en) 1998-07-16
EP0977477A4 (en) 2001-09-05
JP2001509668A (en) 2001-07-24
EP0977477A2 (en) 2000-02-09
AU5907598A (en) 1998-08-03

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