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WO1998029744A3 - Method to classify gene products - Google Patents

Method to classify gene products Download PDF

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Publication number
WO1998029744A3
WO1998029744A3 PCT/US1997/023762 US9723762W WO9829744A3 WO 1998029744 A3 WO1998029744 A3 WO 1998029744A3 US 9723762 W US9723762 W US 9723762W WO 9829744 A3 WO9829744 A3 WO 9829744A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
collection
methods
gene products
contained
Prior art date
Application number
PCT/US1997/023762
Other languages
French (fr)
Other versions
WO1998029744A2 (en
Inventor
Lawrence M Kauvar
Hugo O Villar
Original Assignee
Terrapin Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terrapin Tech Inc filed Critical Terrapin Tech Inc
Priority to AU59020/98A priority Critical patent/AU5902098A/en
Publication of WO1998029744A2 publication Critical patent/WO1998029744A2/en
Publication of WO1998029744A3 publication Critical patent/WO1998029744A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Methods for classifying large numbers of proteins contained in a collection of interest are described. The collection may represent the repertoire of proteins encoded by the genome of an organism including a higher organism or those expressed by a particular tissue or type of cell. Classification is based on ability to bind ligands contained in a panel representative of the range of physiological interactions. The methods of the invention may also be used to evaluate relative binding of proteins in a set of proteins with respect to a physiologically significant ligand so as to permit the modification of specificity of a desired ligand/receptor interaction.
PCT/US1997/023762 1997-01-03 1997-12-23 Method to classify gene products WO1998029744A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59020/98A AU5902098A (en) 1997-01-03 1997-12-23 Method to classify gene products

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78536097A 1997-01-03 1997-01-03
US08/785,360 1997-01-03

Publications (2)

Publication Number Publication Date
WO1998029744A2 WO1998029744A2 (en) 1998-07-09
WO1998029744A3 true WO1998029744A3 (en) 1998-11-12

Family

ID=25135248

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/023762 WO1998029744A2 (en) 1997-01-03 1997-12-23 Method to classify gene products

Country Status (2)

Country Link
AU (1) AU5902098A (en)
WO (1) WO1998029744A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9816514D0 (en) * 1998-07-29 1998-09-30 Smithkline Beecham Plc Novel method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006121A1 (en) * 1991-09-18 1993-04-01 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
WO1995018969A1 (en) * 1994-01-06 1995-07-13 Terrapin Technologies, Inc. Surrogates for targets and improved reference panels

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006121A1 (en) * 1991-09-18 1993-04-01 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
WO1995018969A1 (en) * 1994-01-06 1995-07-13 Terrapin Technologies, Inc. Surrogates for targets and improved reference panels

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
H. BRIEM ET AL.: "Molecular similarity based on DOCK-generated fingerprints", JOURNAL OF MEDICINAL CHEMISTRY., vol. 39, no. 17, 1996, WASHINGTON US, pages 3401 - 3408, XP002078005 *
M. J. MAHAN ET AL.: "Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 92, January 1995 (1995-01-01), WASHINGTON US, pages 669 - 673, XP002078004 *
S. LI ET AL.: "A computer screening approach to immunoglobulin superfamily structures and interactions: Discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 94, January 1997 (1997-01-01), WASHINGTON US, pages 73 - 78, XP000619663 *

Also Published As

Publication number Publication date
AU5902098A (en) 1998-07-31
WO1998029744A2 (en) 1998-07-09

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