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WO1998023759A3 - Identification d'inhibiteurs empechant l'acces de la telomerase aux terminaisons chromosomiques - Google Patents

Identification d'inhibiteurs empechant l'acces de la telomerase aux terminaisons chromosomiques Download PDF

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Publication number
WO1998023759A3
WO1998023759A3 PCT/US1997/021272 US9721272W WO9823759A3 WO 1998023759 A3 WO1998023759 A3 WO 1998023759A3 US 9721272 W US9721272 W US 9721272W WO 9823759 A3 WO9823759 A3 WO 9823759A3
Authority
WO
WIPO (PCT)
Prior art keywords
telomerase
identification
inhibitors
prevent access
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/021272
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English (en)
Other versions
WO1998023759A2 (fr
WO1998023759A9 (fr
Inventor
Victoria Lundblad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Priority to CA002272989A priority Critical patent/CA2272989A1/fr
Priority to JP52474398A priority patent/JP2001507570A/ja
Priority to AU56868/98A priority patent/AU5686898A/en
Priority to EP97953039A priority patent/EP0942991A2/fr
Publication of WO1998023759A2 publication Critical patent/WO1998023759A2/fr
Publication of WO1998023759A9 publication Critical patent/WO1998023759A9/fr
Publication of WO1998023759A3 publication Critical patent/WO1998023759A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne de nouvelles protéines associées à la télomérase, ainsi que des procédés servant à isoler les gènes codant ces protéines. De nouveaux procédés de criblage permettent d'isoler des gènes supplémentaires associés à la télomérase, d'exprimer et de caractériser leurs produits de protéines. L'identification d'interactions entre protéines nécessaires au fonctionnement in vivo de la télomérase constitue la base d'un nouveau procédé de criblage afin de rechercher des agents anti-tumeur.
PCT/US1997/021272 1996-11-26 1997-11-26 Identification d'inhibiteurs empechant l'acces de la telomerase aux terminaisons chromosomiques Ceased WO1998023759A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002272989A CA2272989A1 (fr) 1996-11-26 1997-11-26 Identification d'inhibiteurs empechant l'acces de la telomerase aux terminaisons chromosomiques
JP52474398A JP2001507570A (ja) 1996-11-26 1997-11-26 染色体末端へのテロメラーゼのアクセスを阻害する阻害剤の同定
AU56868/98A AU5686898A (en) 1996-11-26 1997-11-26 Identification of inhibitors that prevent access of telomerase to chrom osomal terminus
EP97953039A EP0942991A2 (fr) 1996-11-26 1997-11-26 Identification d'inhibiteurs empechant l'acces de la telomerase aux terminaisons chromosomiques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75669396A 1996-11-26 1996-11-26
US08/756,693 1996-11-26

Publications (3)

Publication Number Publication Date
WO1998023759A2 WO1998023759A2 (fr) 1998-06-04
WO1998023759A9 WO1998023759A9 (fr) 1998-09-17
WO1998023759A3 true WO1998023759A3 (fr) 1998-12-17

Family

ID=25044649

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/021272 Ceased WO1998023759A2 (fr) 1996-11-26 1997-11-26 Identification d'inhibiteurs empechant l'acces de la telomerase aux terminaisons chromosomiques

Country Status (6)

Country Link
EP (1) EP0942991A2 (fr)
JP (1) JP2001507570A (fr)
KR (1) KR20000057258A (fr)
AU (1) AU5686898A (fr)
CA (1) CA2272989A1 (fr)
WO (1) WO1998023759A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12428678B2 (en) 2016-07-01 2025-09-30 Carlsberg A/S Method to screen for a mutant within a population of organisms by applying a pooling and splitting approach

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
WO1998014592A2 (fr) 1996-10-01 1998-04-09 Geron Corporation Transcriptase inverse de la telomerase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
AU3456099A (en) 1998-03-31 1999-10-18 Geron Corporation Methods and compositions for eliciting an immune response to a telomerase antigen
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
KR20010096991A (ko) * 2000-04-19 2001-11-08 임정빈 텔로머레이즈의 프로모터에 특정하게 결합하는더블유티이1 절편, 그 유전자, 발현벡터 및 그것을 이용한세포성장 억제 방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996012811A2 (fr) * 1994-10-20 1996-05-02 Arch Development Corporation Constituants de levure-telomerase et leurs procedes d'utilisation
WO1998014592A2 (fr) * 1996-10-01 1998-04-09 Geron Corporation Transcriptase inverse de la telomerase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996012811A2 (fr) * 1994-10-20 1996-05-02 Arch Development Corporation Constituants de levure-telomerase et leurs procedes d'utilisation
WO1998014592A2 (fr) * 1996-10-01 1998-04-09 Geron Corporation Transcriptase inverse de la telomerase

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BERGER S.L. & KIMMEL A.R., EDS: "Guide to molecular cloning techniques", 1987, ACADEMIC PRESS, SAN DIEGO, USA, XP002071178 *
DATABASE EMBL SEQUENCES EMBL, Heidelberg, FRG; 1 November 1996 (1996-11-01), JOHNSTON M. ET AL.: "Chromosome XII cosmid 8543", XP002071416 *
DATABASE EMBL SEQUENCES EMBL, Heidelberg, FRG; 30 January 1995 (1995-01-30), ZEHNER J.E. & PRINGLE J.R.: "S. cerevisiae BUD6 gene", XP002071417 *
GLOVER D.M. & HAMES B.D., EDS.: "DNA cloning 2, a practical approach: Expression Systems", 1995, OXFORD UNIVERSITY PRESS, OXFORD, UK, XP002071179 *
LINGNER J. ET AL.: "Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity", PROC. NATL. ACAD. SCI. USA, vol. 94, - October 1997 (1997-10-01), pages 11190 - 11195, XP002071046 *
LUNDBLAD V. & SZOSTAK J.W.: "A mutant with a defect in telomere elongation leads to secescence in yeast", CELL, vol. 57, 19 May 1989 (1989-05-19), pages 633 - 643, XP002071176 *
NUGENT C.I. ET AL.: "Cdc13p: a single-strand telomeric binding protein with a dual role in yeast telomere maintenance", SCIENCE, vol. 274, 11 October 1996 (1996-10-11), pages 249 - 252, XP002071050 *
STRATAGENE CATALOG 1995: "Two-hybrid vectors", p34 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12428678B2 (en) 2016-07-01 2025-09-30 Carlsberg A/S Method to screen for a mutant within a population of organisms by applying a pooling and splitting approach

Also Published As

Publication number Publication date
WO1998023759A2 (fr) 1998-06-04
EP0942991A2 (fr) 1999-09-22
CA2272989A1 (fr) 1998-06-04
AU5686898A (en) 1998-06-22
JP2001507570A (ja) 2001-06-12
KR20000057258A (ko) 2000-09-15

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