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WO1998019708A3 - Method for enhancing the solubility of substantially water-insoluble compounds - Google Patents

Method for enhancing the solubility of substantially water-insoluble compounds Download PDF

Info

Publication number
WO1998019708A3
WO1998019708A3 PCT/US1997/019831 US9719831W WO9819708A3 WO 1998019708 A3 WO1998019708 A3 WO 1998019708A3 US 9719831 W US9719831 W US 9719831W WO 9819708 A3 WO9819708 A3 WO 9819708A3
Authority
WO
WIPO (PCT)
Prior art keywords
solubility
water
enhancing
compounds
substantially water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/019831
Other languages
French (fr)
Other versions
WO1998019708A2 (en
Inventor
David H Donabedian
Lawrence Marlin
Elke M A Clark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Union Carbide Chemicals and Plastics Technology LLC
Original Assignee
Union Carbide Chemicals and Plastics Technology LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Carbide Chemicals and Plastics Technology LLC filed Critical Union Carbide Chemicals and Plastics Technology LLC
Priority to EP97950577A priority Critical patent/EP0891190A2/en
Publication of WO1998019708A2 publication Critical patent/WO1998019708A2/en
Publication of WO1998019708A3 publication Critical patent/WO1998019708A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)

Abstract

Methods for enhancing the water-solubility of substantially water-insoluble compounds are disclosed by combining such compounds with a water-soluble polymer, e.g., polyalkylene oxide polymer or a cellulose ether, having a molecular weight of from about 50,000 to 7,000,000 grams/per gram in an amount effective to enhance the water-solubility of the compound in an acidic environment, e.g., pH less than about 5. Compositions comprising the compounds having enhanced water solubility are also disclosed.
PCT/US1997/019831 1996-11-04 1997-10-31 Method for enhancing the solubility of substantially water-insoluble compounds Ceased WO1998019708A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP97950577A EP0891190A2 (en) 1996-11-04 1997-10-31 Method for enhancing the solubility of substantially water-insoluble compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3028296 1996-11-04
US60/030,282 1996-11-04

Publications (2)

Publication Number Publication Date
WO1998019708A2 WO1998019708A2 (en) 1998-05-14
WO1998019708A3 true WO1998019708A3 (en) 1998-08-20

Family

ID=21853450

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/019831 Ceased WO1998019708A2 (en) 1996-11-04 1997-10-31 Method for enhancing the solubility of substantially water-insoluble compounds

Country Status (3)

Country Link
EP (1) EP0891190A2 (en)
CN (1) CN1211928A (en)
WO (1) WO1998019708A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1150959T3 (en) 1999-12-08 2008-06-02 Pharmacia Corp Solid state form of Celecoxib which has increased bioavailability
US6818566B2 (en) 2002-10-18 2004-11-16 The Boc Group, Inc. Thermal activation of fluorine for use in a semiconductor chamber
EP2838564A4 (en) 2012-04-19 2015-12-02 Purdue Research Foundation ALPHA-D-GLUCANES HIGHLY RAMIFIED

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012523A1 (en) * 1978-11-20 1980-06-25 American Home Products Corporation Therapeutic compositions with enhanced bioavailability and process for their preparation
EP0315964A1 (en) * 1987-11-11 1989-05-17 Laboratoires Pharmascience A novel pharmaceutical composition comprising exifone and water-soluble polymer
WO1996032097A1 (en) * 1995-04-14 1996-10-17 Pharma Pass Solid compositions containing polyethyleneoxide and a non-amorphous active principle
WO1998011879A1 (en) * 1996-09-19 1998-03-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012523A1 (en) * 1978-11-20 1980-06-25 American Home Products Corporation Therapeutic compositions with enhanced bioavailability and process for their preparation
EP0315964A1 (en) * 1987-11-11 1989-05-17 Laboratoires Pharmascience A novel pharmaceutical composition comprising exifone and water-soluble polymer
WO1996032097A1 (en) * 1995-04-14 1996-10-17 Pharma Pass Solid compositions containing polyethyleneoxide and a non-amorphous active principle
WO1998011879A1 (en) * 1996-09-19 1998-03-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter

Also Published As

Publication number Publication date
EP0891190A2 (en) 1999-01-20
CN1211928A (en) 1999-03-24
WO1998019708A2 (en) 1998-05-14

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