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WO1998011437B1 - Bibliotheques de marquage d'affinite avec groupes partants marques - Google Patents

Bibliotheques de marquage d'affinite avec groupes partants marques

Info

Publication number
WO1998011437B1
WO1998011437B1 PCT/US1997/016435 US9716435W WO9811437B1 WO 1998011437 B1 WO1998011437 B1 WO 1998011437B1 US 9716435 W US9716435 W US 9716435W WO 9811437 B1 WO9811437 B1 WO 9811437B1
Authority
WO
WIPO (PCT)
Prior art keywords
affinity
group
amino acid
composition
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/016435
Other languages
English (en)
Other versions
WO1998011437A1 (fr
Filing date
Publication date
Application filed filed Critical
Priority to AU43518/97A priority Critical patent/AU4351897A/en
Publication of WO1998011437A1 publication Critical patent/WO1998011437A1/fr
Publication of WO1998011437B1 publication Critical patent/WO1998011437B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne des procédés et des compositions permettant d'identifier des composés présentant une affinité vis à vis d'un site cible. Selon ledit procédé, le groupe à affinité est un groupe partant provenant d'une fonctionnalité réactive pouvant former une liaison covalente avec le site cible. Il est possible de combiner le composé comprenant le site cible avec la bibliothèque et de procéder à un dosage concernant la composition obtenue des groupes partants. Les groupes partants présentant la concentration la plus élevée peuvent être identifiés comme les groupes ayant la plus haute affinité de liaison vis à vis du site cible. Les composés sélectionnés peuvent ensuite être utilisés pour marquer la molécule cible, en particulier lorsque la molécule cible est trouvée naturellement dans un mélange complexe, tel qu'un liquide physiologique, par exemple le sang. Grâce à un marquage d'affinité in vivo, la durée de vie d'entités physiologiquement actives peut être grandement prolongée par le fait qu'elles se lient à des composants du sang à longue vie. L'entité liée par covalence peut également servir d'antagoniste ou d'agoniste de protéines de liaison particulières ou bien d'inhibiteur enzymatique.
PCT/US1997/016435 1996-09-16 1997-09-16 Bibliotheques de marquage d'affinite avec groupes partants marques Ceased WO1998011437A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU43518/97A AU4351897A (en) 1996-09-16 1997-09-16 Affinity labeling libraries with tagged leaving groups

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71475496A 1996-09-16 1996-09-16
US08/714,754 1996-09-16

Publications (2)

Publication Number Publication Date
WO1998011437A1 WO1998011437A1 (fr) 1998-03-19
WO1998011437B1 true WO1998011437B1 (fr) 1998-06-11

Family

ID=24871322

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/016435 Ceased WO1998011437A1 (fr) 1996-09-16 1997-09-16 Bibliotheques de marquage d'affinite avec groupes partants marques

Country Status (3)

Country Link
US (1) US6403324B1 (fr)
AU (1) AU4351897A (fr)
WO (1) WO1998011437A1 (fr)

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Publication number Priority date Publication date Assignee Title
DE69839946D1 (de) 1997-11-07 2008-10-09 Conjuchem Biotechnologies Inc Methoden zum Screening von Affinitätsmarker-Bibliotheken
EP1199566B1 (fr) * 1997-11-07 2008-08-27 ConjuChem Biotechnologies Inc. Méthodes de criblage de bibliothèques de marqueurs à affinité
DE69942578D1 (de) 1998-05-22 2010-08-26 Univ R Bifunktionelle moleküle sowie darauf basierende therapien.
US6335155B1 (en) 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US6919178B2 (en) 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
US20040266673A1 (en) * 2002-07-31 2004-12-30 Peter Bakis Long lasting natriuretic peptide derivatives
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
US20090175821A1 (en) * 1999-05-17 2009-07-09 Bridon Dominique P Modified therapeutic peptides with extended half-lives in vivo
ATE252601T1 (de) 1999-05-17 2003-11-15 Conjuchem Inc Lang wirkende insulinotrope peptide
US6514500B1 (en) 1999-10-15 2003-02-04 Conjuchem, Inc. Long lasting synthetic glucagon like peptide {GLP-!}
US6887470B1 (en) * 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6887842B1 (en) 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
EP1229924A4 (fr) 1999-11-19 2004-12-15 Univ Leland Stanford Junior Molecules bifonctionnelles ciblees et therapies basees sur celles-ci
US7220552B1 (en) 1999-11-19 2007-05-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
US20010051348A1 (en) 2000-01-28 2001-12-13 Lee Chee Wee Novel ligands and methods for preparing same
AU2001224349A1 (en) * 2000-04-10 2001-10-23 The Scripps Research Institute Proteomic analysis
DK1360202T3 (da) 2001-02-16 2008-09-22 Conjuchem Biotechnologies Inc Langvarigt glucagon-lignende peptid 2 (GLP-2) til behandling af gastrointestinale sygdomme og lidelser
DE602004027000D1 (de) * 2003-01-17 2010-06-17 Advanced Proteome Therapeutics Verfahren zur Identifizierung aktivierter Polymer-Komplexe zur sekundären Stellen-spezifischen Modifikation von Protein Ziel-Gruppen.
PL2100904T3 (pl) * 2004-04-23 2011-05-31 Conjuchem Biotechnologies Inc Stała faza do zastosowania w sposobie oczyszczania koniugatów albuminy
WO2007053946A1 (fr) * 2005-11-09 2007-05-18 Conjuchem Biotechnologies Inc. Procede de traitement du diabete et/ou de l'obesite en reduisant les effets secondaires nauseeux au moyen d'un peptide insulinotrope conjugue a de l'albumine
CN101384623B (zh) * 2005-12-22 2013-07-24 常山凯捷健生物药物研发（河北）有限公司 白蛋白与治疗剂的预成型偶联物的制备方法
US20090099074A1 (en) * 2007-01-10 2009-04-16 Conjuchem Biotechnologies Inc. Modulating food intake
WO2009075859A2 (fr) * 2007-12-11 2009-06-18 Conjuchem Biotechnologies Inc. Formulation de conjugués de peptides insulinotropes

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US5266684A (en) 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US5874239A (en) * 1993-07-30 1999-02-23 Affymax Technologies N.V. Biotinylation of proteins
EP0639585A1 (fr) 1993-08-20 1995-02-22 Banyu Pharmaceutical Co., Ltd. Inhibiteur d'élastase
US5571681A (en) 1994-03-10 1996-11-05 The Scripps Research Institute Chemical event selection by suicide substrate conjugates
US5738996A (en) 1994-06-15 1998-04-14 Pence, Inc. Combinational library composition and method
US5834318A (en) 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins

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