[go: up one dir, main page]

WO1998011238A3 - Protease m, a novel serine protease - Google Patents

Protease m, a novel serine protease Download PDF

Info

Publication number
WO1998011238A3
WO1998011238A3 PCT/US1997/016175 US9716175W WO9811238A3 WO 1998011238 A3 WO1998011238 A3 WO 1998011238A3 US 9716175 W US9716175 W US 9716175W WO 9811238 A3 WO9811238 A3 WO 9811238A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease
nucleic acid
acid molecules
expression vectors
tumor cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/016175
Other languages
French (fr)
Other versions
WO1998011238A9 (en
WO1998011238A2 (en
Inventor
Anthony Anisowicz
Ruth Sager
Georgia Sotiropoulou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Priority to AU44807/97A priority Critical patent/AU4480797A/en
Publication of WO1998011238A2 publication Critical patent/WO1998011238A2/en
Publication of WO1998011238A3 publication Critical patent/WO1998011238A3/en
Publication of WO1998011238A9 publication Critical patent/WO1998011238A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Isolated nucleic acid molecules encoding a novel serine protease, Protease M, is disclosed. Protease M is downregulated in metastatic mammary epithelial tumor cells, as well as other tumor cells, and is upregulated in senescent cells. In addition to isolated nucleic acid molecules, the invention provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Protease M gene has been introduced or disrupted. The invention further provides isolated Protease M proteins, fusion proteins, antigenic peptides and anti-Protease M antibodies. Diagnostic assays, drug screening assays, and therapeutic methods utilizing compositions of the invention are also provided.
PCT/US1997/016175 1996-09-13 1997-09-11 Protease m, a novel serine protease Ceased WO1998011238A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU44807/97A AU4480797A (en) 1996-09-13 1997-09-11 Protease m, a novel serine protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2530196P 1996-09-13 1996-09-13
US60/025,301 1996-09-13

Publications (3)

Publication Number Publication Date
WO1998011238A2 WO1998011238A2 (en) 1998-03-19
WO1998011238A3 true WO1998011238A3 (en) 1998-06-04
WO1998011238A9 WO1998011238A9 (en) 1998-07-09

Family

ID=21825221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/016175 Ceased WO1998011238A2 (en) 1996-09-13 1997-09-11 Protease m, a novel serine protease

Country Status (2)

Country Link
AU (1) AU4480797A (en)
WO (1) WO1998011238A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1092767T3 (en) * 1998-07-02 2006-11-27 Fuso Pharmaceutical Ind Serine protease-specific monoclonal antibodies and their use
US6322962B1 (en) * 1998-08-14 2001-11-27 Board Of Regents, The University Of Texas System Sterol-regulated Site-1 protease and assays of modulators thereof
JP2001054399A (en) 1999-08-18 2001-02-27 Fuji Photo Film Co Ltd Judgement of effectiveness of drug having protease inhibiting action
CN1298014A (en) * 1999-11-29 2001-06-06 上海博容基因开发有限公司 Human ATP-dependent serine proteolytic enzyme 48 as one new kind of polypeptide and polynucleotides encoding this polypeptide
CN1322833A (en) * 2000-05-09 2001-11-21 上海博德基因开发有限公司 New polypeptide human ATP dependent serine proteinase 18 and its encoding polynucleotides
WO2002003787A2 (en) * 2000-07-06 2002-01-17 Deltagen, Inc. Transgenic mice containing targeted gene disruptions
CA2360219A1 (en) 2000-10-27 2002-04-27 Mount Sinai Hospital Method for detecting alzheimer's disease
WO2002035232A2 (en) * 2000-10-27 2002-05-02 Mount Sinai Hospital Method for detecting ovarian cancer based on human kallikrein 6 (hk6)
WO2003034068A1 (en) * 2001-10-16 2003-04-24 Mount Sinai Hospital Localization of disorders associated with kallikreins
JP2005505303A (en) * 2001-10-16 2005-02-24 マウント・サイナイ・ホスピタル How to detect ovarian cancer
EP1448152A4 (en) * 2001-10-31 2006-06-07 Millennium Pharm Inc Methods and compositions for the treatment and diagnosis of pain disorders using 2047
CA2486619A1 (en) 2002-05-21 2003-12-04 Mayo Foundation For Medical Education And Research Methods and materials for treating inflammatory conditions

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005188A1 (en) * 1988-11-11 1990-05-17 Pharmaceutical Proteins Limited A genetic construct of which protein-coding dna comprises introns and is designed for protein production in transgenic animals
EP0576152A1 (en) * 1992-05-28 1993-12-29 Eli Lilly And Company Protease and related DNA compounds
EP0652014A1 (en) * 1993-11-10 1995-05-10 National Institute Of Immunology Treatment of prostatic hypertrophy
WO1996026280A1 (en) * 1995-02-21 1996-08-29 Basf Aktiengesellschaft NOVEL CYSTEINE PROTEASE RELATED TO INTERLEUKIN-1β CONVERTING ENZYME

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005188A1 (en) * 1988-11-11 1990-05-17 Pharmaceutical Proteins Limited A genetic construct of which protein-coding dna comprises introns and is designed for protein production in transgenic animals
EP0576152A1 (en) * 1992-05-28 1993-12-29 Eli Lilly And Company Protease and related DNA compounds
EP0652014A1 (en) * 1993-11-10 1995-05-10 National Institute Of Immunology Treatment of prostatic hypertrophy
WO1996026280A1 (en) * 1995-02-21 1996-08-29 Basf Aktiengesellschaft NOVEL CYSTEINE PROTEASE RELATED TO INTERLEUKIN-1β CONVERTING ENZYME

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANISOWICZ A ET AL: "A novel protease homolog differentially expressed in breast and ovarian cancer", MOLECULAR MEDICINE (CAMBRIDGE), 2 (5).30 SEP 1996. 624-636., XP002060076 *
HAGEN HE ET AL: "Simulium damnosum s.l.: identification of inducible serine proteases following an Onchocerca infection by differential display reverse transcription PCR.", EXP PARASITOL, NOV 1995, 81 (3) P249-54, UNITED STATES, XP002060075 *
VIHINEN M: "Modeling of prostate specific antigen and human glandular kallikrein structures.", BIOCHEM BIOPHYS RES COMMUN, NOV 15 1994, 204 (3) P1251-6, UNITED STATES, XP002060074 *

Also Published As

Publication number Publication date
WO1998011238A2 (en) 1998-03-19
AU4480797A (en) 1998-04-02

Similar Documents

Publication Publication Date Title
WO1999066025A3 (en) Mtbx protein and nucleic acid molecules and uses therefor
WO2002070652A3 (en) Novel molecules of the card-related protein family and uses thereof
ATE366814T1 (en) GL50 MOLECULES, AND USES THEREOF
EP1009752A4 (en) Novel molecules of the tango-77 related protein family and uses thereof
WO2000052047A3 (en) Human dickkopf-related protein and nucleic acid molecules and uses therefor
AU3217100A (en) Methods of use of a novel lysyl oxidase-related protein
WO2002044354A3 (en) Molecules of the card-related protein family and uses thereof
WO2001000826A3 (en) Novel molecules of the card-related protein family and uses thereof
WO1998011238A3 (en) Protease m, a novel serine protease
WO2000019988A8 (en) NOVEL Th2-SPECIFIC MOLECULES AND USES THEREOF
WO1997014797A3 (en) Cystatin m, a novel cysteine proteinase inhibitor
WO2001061005A3 (en) Molecules of the pyrin domain protein family and uses thereof
WO2000012544A3 (en) Novel irap-bp polypeptide and nucleic acid molecules and uses therefor
WO2001018216A3 (en) 26176, a novel calpain protease and uses thereof
WO2002061049A3 (en) Novel molecules of the pyrin/nbs/lrr protein family and uses thereof
WO2000008045A3 (en) Novel molecules of the tango-93-related protein family and uses thereof
WO2001030971A3 (en) Novel molecules and the card-related protein family and uses thereof
WO1999054437A3 (en) Novel molecules of the t125-related protein family and uses thereof
WO2001077151A3 (en) Fdrg proteins and nucleic acid molecules and uses therefor
WO2003029434A3 (en) Novel molecules of the hkid-1-related protein family and uses thereof
WO2002085939A8 (en) Novel molecules of the card-related protein family and uses thereof
WO2001059065A3 (en) Novel molecules of the card-related protein family and uses thereof
WO2001073074A3 (en) 18806, a novel trypsin serine protease-like molecule and uses thereof
WO2000018890A3 (en) Protein phosphatase molecules and uses therefor
WO2001083523A3 (en) Stmst protein and nucleic acid molecules and uses therefor

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
COP Corrected version of pamphlet

Free format text: PAGES 1/8 AND 4/8-8/8, DRAWINGS, REPLACED BY NEW PAGES 1/8 AND 4/8-8/8; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998513895

Format of ref document f/p: F

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA