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WO1998009985B1 - Peptides anti-inflammatoires et leurs utilisations - Google Patents

Peptides anti-inflammatoires et leurs utilisations

Info

Publication number
WO1998009985B1
WO1998009985B1 PCT/IL1997/000295 IL9700295W WO9809985B1 WO 1998009985 B1 WO1998009985 B1 WO 1998009985B1 IL 9700295 W IL9700295 W IL 9700295W WO 9809985 B1 WO9809985 B1 WO 9809985B1
Authority
WO
WIPO (PCT)
Prior art keywords
arg
glu
peptide
pro
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL1997/000295
Other languages
English (en)
Other versions
WO1998009985A2 (fr
WO1998009985A3 (fr
Filing date
Publication date
Priority claimed from US08/864,301 external-priority patent/US6126939A/en
Application filed filed Critical
Priority to EP97937794A priority Critical patent/EP0927191A2/fr
Priority to JP10512435A priority patent/JP2001500492A/ja
Priority to AU40301/97A priority patent/AU4030197A/en
Priority to IL12852997A priority patent/IL128529A0/xx
Priority to CA002264285A priority patent/CA2264285A1/fr
Publication of WO1998009985A2 publication Critical patent/WO1998009985A2/fr
Publication of WO1998009985A3 publication Critical patent/WO1998009985A3/fr
Publication of WO1998009985B1 publication Critical patent/WO1998009985B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne des peptides représentés par les formules ci-après: (i) Xaa - Yaa - Arg, dans laquelle Xaa est un résidu d'acide aminé et Yaa est Glu ou Xaa est absent et Yaa est un résidu d'acide aminé à l'exception de Pro; (ii) Arg - Yaa - Xaa, dans laquelle Xaa est un résidu d'acide aminé et Yaa est Glu ou Xaa est absent et Yaa est un résidu d'acide aminé à l'exception d'Asn; (iii) Xaa - Arg - Yaa, dans laquelle Xaa est un résidu d'acide aminé et Yaa est Glu; et (iv) Yaa - Arg - Xaa, dans laquelle Xaa est un résidu d'acide aminé et Yaa est Glu. L'invention concerne également des dérivés desdits peptides, ces peptides et dérivés exerçant un effet inhibiteur sur la migration des macrophages et/ou sur l'activité phagocytique des macrophages. En outre, les peptides et dérivés exercent un effet inhibiteur sur la capacité des macrophages et des cellules T à adhérer à la matrice extracellulaire et/ou la fibronectine. Les peptides et dérivés ont un effet inhibiteur sur la réaction immunitaire humorale et/ou cellulaire. L'invention concerne également des procédés d'utilisation desdits peptides et dérivés et des compositions les contenant, utilisés pour inhiber des inflammations, dont l'inflammation d'une articulation, du système nerveux central, de points de lésions spécifiques du système nerveux central ou d'autres sites immunitaires privilégiés.
PCT/IL1997/000295 1996-09-03 1997-09-03 Peptides anti-inflammatoires et leurs utilisations Ceased WO1998009985A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP97937794A EP0927191A2 (fr) 1996-09-03 1997-09-03 Peptides anti-inflammatoires et leurs utilisations
JP10512435A JP2001500492A (ja) 1996-09-03 1997-09-03 抗炎症性ペプチドおよびその使用
AU40301/97A AU4030197A (en) 1996-09-03 1997-09-03 Anti-inflammatory peptides and uses thereof
IL12852997A IL128529A0 (en) 1996-09-03 1997-09-03 Anti-inflammatory peptides and uses thereof
CA002264285A CA2264285A1 (fr) 1996-09-03 1997-09-03 Peptides anti-inflammatoires et leurs utilisations

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US2537696P 1996-09-03 1996-09-03
US75314196A 1996-11-20 1996-11-20
US08/864,301 1997-05-28
US60/025,376 1997-05-28
US08/864,301 US6126939A (en) 1996-09-03 1997-05-28 Anti-inflammatory dipeptide and pharmaceutical composition thereof
US08/753,141 1997-05-28

Publications (3)

Publication Number Publication Date
WO1998009985A2 WO1998009985A2 (fr) 1998-03-12
WO1998009985A3 WO1998009985A3 (fr) 1998-05-07
WO1998009985B1 true WO1998009985B1 (fr) 1998-06-18

Family

ID=27362525

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1997/000295 Ceased WO1998009985A2 (fr) 1996-09-03 1997-09-03 Peptides anti-inflammatoires et leurs utilisations

Country Status (7)

Country Link
US (1) US6126939A (fr)
EP (1) EP0927191A2 (fr)
JP (1) JP2001500492A (fr)
AU (1) AU4030197A (fr)
CA (1) CA2264285A1 (fr)
IL (1) IL128529A0 (fr)
WO (1) WO1998009985A2 (fr)

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US7442778B2 (en) 2004-09-24 2008-10-28 Amgen Inc. Modified Fc molecules

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