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WO1998009665A3 - Iontophoretic method of using phenylephrine to improve the effect of local anesthetics - Google Patents

Iontophoretic method of using phenylephrine to improve the effect of local anesthetics Download PDF

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Publication number
WO1998009665A3
WO1998009665A3 PCT/US1997/015410 US9715410W WO9809665A3 WO 1998009665 A3 WO1998009665 A3 WO 1998009665A3 US 9715410 W US9715410 W US 9715410W WO 9809665 A3 WO9809665 A3 WO 9809665A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenylephrine
improve
effect
local anesthetics
iontophoretic method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/015410
Other languages
French (fr)
Other versions
WO1998009665A2 (en
Inventor
Philip G Green
Wallace Ring
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Priority to AU41751/97A priority Critical patent/AU4175197A/en
Publication of WO1998009665A2 publication Critical patent/WO1998009665A2/en
Publication of WO1998009665A3 publication Critical patent/WO1998009665A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

An iontophoretic patch and method capable of increasing the duration or intensity of iontophoretically administered local anesthesia.
PCT/US1997/015410 1996-09-04 1997-09-03 Iontophoretic method of using phenylephrine to improve the effect of local anesthetics Ceased WO1998009665A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU41751/97A AU4175197A (en) 1996-09-04 1997-09-03 Iontophoretic method of using phenylephrine to improve the effect of local anesthetics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70755696A 1996-09-04 1996-09-04
US08/707,556 1996-09-04

Publications (2)

Publication Number Publication Date
WO1998009665A2 WO1998009665A2 (en) 1998-03-12
WO1998009665A3 true WO1998009665A3 (en) 1998-05-14

Family

ID=24842180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/015410 Ceased WO1998009665A2 (en) 1996-09-04 1997-09-03 Iontophoretic method of using phenylephrine to improve the effect of local anesthetics

Country Status (2)

Country Link
AU (1) AU4175197A (en)
WO (1) WO1998009665A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070078372A1 (en) * 2005-09-30 2007-04-05 Vyteris, Inc. Iontophoresis Drug Delivery Formulation Providing Acceptable Sensation and Dermal Anesthesia

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448299A2 (en) * 1990-03-15 1991-09-25 Becton, Dickinson and Company Composition for increased skin concentration of active agents by iontophoresis
WO1994023748A1 (en) * 1993-04-08 1994-10-27 The University Of Queensland Administration of vaso-active agent and therapeutic agent
WO1995009032A1 (en) * 1993-09-30 1995-04-06 Becton, Dickinson And Company Iontophoretic drug delivery system and method
US5534242A (en) * 1994-05-02 1996-07-09 Henry; Richard A. Lidocaine-vasoconstrictor aerosol preparation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448299A2 (en) * 1990-03-15 1991-09-25 Becton, Dickinson and Company Composition for increased skin concentration of active agents by iontophoresis
WO1994023748A1 (en) * 1993-04-08 1994-10-27 The University Of Queensland Administration of vaso-active agent and therapeutic agent
WO1995009032A1 (en) * 1993-09-30 1995-04-06 Becton, Dickinson And Company Iontophoretic drug delivery system and method
US5534242A (en) * 1994-05-02 1996-07-09 Henry; Richard A. Lidocaine-vasoconstrictor aerosol preparation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 107, no. 18, 2 November 1987, Columbus, Ohio, US; abstract no. 161563, SHOKICHI T. ET AL: "Effect of various adrenergic agents on lidocaine absorption and duration of anesthesia" XP002056658 *
DAS GUPTA V. ET AL: "Chemical stabilities of lidocaine hydrochloride and phenylephrine hydrochloride in aqueous solution", J. CLIN. HOSP. PHARM., vol. 11, no. 6, 1986, pages 449 - 452, XP002056657 *
GANGAROSA L.P. ET AL: "Conductivity of drugs used for iontophoresis", J. PHARM. SCIENCES, vol. 67, no. 10, 1978, pages 1439 - 1443, XP002056655 *
SHOKICHI T. ET AL: "Effect of various adrenergic agents on lidocaine absorption and duration of anesthesia", BYOIN YAKUGAKU, vol. 13, no. 3, 1987, pages 152 - 156 *
SINGH P. ET AL: "Effects of vasoconstriction on dermal pharmacokinetics and local tissue distribution of compounds", J. PHARM. SCIENCES, vol. 83, no. 6, 1994, pages 783 - 791, XP002056656 *

Also Published As

Publication number Publication date
AU4175197A (en) 1998-03-26
WO1998009665A2 (en) 1998-03-12

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