WO1998003533B1 - Oligonucleotides anti-sens utilises comme agents antibacteriens - Google Patents
Oligonucleotides anti-sens utilises comme agents antibacteriensInfo
- Publication number
- WO1998003533B1 WO1998003533B1 PCT/US1997/012961 US9712961W WO9803533B1 WO 1998003533 B1 WO1998003533 B1 WO 1998003533B1 US 9712961 W US9712961 W US 9712961W WO 9803533 B1 WO9803533 B1 WO 9803533B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bacterium
- genus
- bacteria
- oligonucleotides
- streptococcus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
Cette invention se rapporte à un nouveau procédé qui démontre l'utilisation thérapeutique d'oligonucléotides résistants aux nucléases pour traiter les animaux souffrant d'une infection causée par une bactérie pathogène. Ce procédé consiste à intégrer: (1) des procédés de sélection de l'oligonucléotide correct; (2) la synthèse et la purification d'oligonucléotides résistants aux nucléases, et (3) des procédés d'analyse in vitro d'oligonucléotides antimicrobiens potentiels. Les oligonucléotides décrits peuvent comporter des squelettes, des restes de sucres, des bases ou des mélanges modifiés et ont été soumis à une purification, ce qui produit des oligonucléotides capables d'inhiber la croissance d'un large spectre d'espèces bactériennes cliniquement pertinentes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU38118/97A AU3811897A (en) | 1996-07-24 | 1997-07-23 | Antisense oligonucleotides as antibacterial agents |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68557596A | 1996-07-24 | 1996-07-24 | |
| US08/685,575 | 1996-07-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998003533A1 WO1998003533A1 (fr) | 1998-01-29 |
| WO1998003533B1 true WO1998003533B1 (fr) | 1998-04-02 |
Family
ID=24752791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/012961 Ceased WO1998003533A1 (fr) | 1996-07-24 | 1997-07-23 | Oligonucleotides anti-sens utilises comme agents antibacteriens |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU3811897A (fr) |
| WO (1) | WO1998003533A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7601336B2 (en) | 1997-06-13 | 2009-10-13 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2325013A1 (fr) * | 1998-04-13 | 1999-10-21 | Isis Pharmaceuticals Inc. | Identification de cibles genetiques destinees a etre modulees par des oligonucleotides et formation d'oligonucleotides destines a subir une modulation genique |
| US7321828B2 (en) | 1998-04-13 | 2008-01-22 | Isis Pharmaceuticals, Inc. | System of components for preparing oligonucleotides |
| US6548651B1 (en) | 1998-11-11 | 2003-04-15 | Pantheco A/S | Modified peptide nucleic acid (PNA) molecules |
| DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| US6211349B1 (en) * | 1998-12-30 | 2001-04-03 | Oligos Etc., Inc. | Protonated/acidified nucleic acids and methods of use |
| US7868162B2 (en) | 1998-12-30 | 2011-01-11 | Lakewood-Amedex, Inc. | Antimicrobial and antiviral compounds and methods for their use |
| US6627215B1 (en) | 1998-12-30 | 2003-09-30 | Oligos Etc. Inc. | Devices for improved wound management |
| US6211162B1 (en) * | 1998-12-30 | 2001-04-03 | Oligos Etc. Inc. | Pulmonary delivery of protonated/acidified nucleic acids |
| US6720139B1 (en) | 1999-01-27 | 2004-04-13 | Elitra Pharmaceuticals, Inc. | Genes identified as required for proliferation in Escherichia coli |
| IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
| WO2001019979A1 (fr) * | 1999-09-14 | 2001-03-22 | Merck & Co., Inc. | Gene murc et enzyme de pseudomonas aeruginosa |
| WO2001034810A2 (fr) | 1999-11-09 | 2001-05-17 | Elitra Pharmaceuticals, Inc. | Genes indispensables a une proliferation microbienne et antisens a cet egard |
| EP1246912A2 (fr) * | 1999-11-18 | 2002-10-09 | GeneSense Technologies Inc. | SEQUENCES OLIGONUCLEOTIDIQUES ANTISENS DERIVEES DES GENES i groEL /i ET i groES /i COMME INHIBITEURS DE MICRO-ORGANISMES |
| US6677153B2 (en) | 1999-11-29 | 2004-01-13 | Avi Biopharma, Inc. | Antisense antibacterial method and composition |
| JP2003518946A (ja) * | 2000-01-04 | 2003-06-17 | エイブイアイ バイオファーマ， インコーポレイテッド | アンチセンス抗細菌性細胞分裂組成物、およびその方法 |
| IT1317720B1 (it) | 2000-01-07 | 2003-07-15 | Chiesi Farma Spa | Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani. |
| IT1317846B1 (it) | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
| DZ3358A1 (fr) | 2000-05-22 | 2001-11-29 | Chiesi Farma Spa | Formulations en solution pharmaceutiques pour inhalateurs-doseurs sous pression |
| US6824979B2 (en) | 2000-12-21 | 2004-11-30 | East Carolina University | Catabolite repression control (Crc) gene and Pseudomonas virulence |
| TR200401980T4 (tr) | 2001-07-02 | 2004-09-21 | Chiesi Farmaceutici S.P.A. | Aerosol olarak uygulama için en uygun hale getirilmiş tobramisin formülasyonu |
| CA2453362A1 (fr) | 2001-07-10 | 2003-01-23 | Oligos Etc. Inc. | Compositions pharmacologiques contenant des oligonucleotides et leur utilisation |
| EP1595531A1 (fr) | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Formulation d'une solution pharmaceutique stable pour aérosols doseurs sous pression |
| CA2571593C (fr) | 2004-07-02 | 2015-04-21 | Avi Biopharma, Inc. | Technique et compose antibacterien antisens |
| WO2009067243A2 (fr) | 2007-11-20 | 2009-05-28 | Isis Pharmaceuticals Inc. | Modulation de l'expression de cd40 |
| GB201408623D0 (en) | 2014-05-15 | 2014-07-02 | Santaris Pharma As | Oligomers and oligomer conjugates |
| WO2016196897A1 (fr) | 2015-06-04 | 2016-12-08 | Sarepta Therapeutics, Inc. | Procédés et composés pour le traitement de maladies et d'états pathologiques associés aux lymphocytes |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5294533A (en) * | 1988-07-05 | 1994-03-15 | Baylor College Of Medicine | Antisense oligonucleotide antibiotics complementary to the macromolecular synthesis operon, methods of treating bacterial infections and methods for identification of bacteria |
| GB9505438D0 (en) * | 1995-03-17 | 1995-05-03 | Sod Conseils Rech Applic | Antisense oligonucleotides |
-
1997
- 1997-07-23 AU AU38118/97A patent/AU3811897A/en not_active Abandoned
- 1997-07-23 WO PCT/US1997/012961 patent/WO1998003533A1/fr not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7601336B2 (en) | 1997-06-13 | 2009-10-13 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
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