WO1998003510B1 - - Google Patents

Info

Publication number: WO1998003510B1
Authority: WO; WIPO (PCT)
Prior art keywords: compound; stereoisomeric forms; ome; isomers; dimethyl
Prior art date: 1997-07-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

PCT/US1997/013072

Other languages

English (en)

Other versions

WO1998003510A1 (fr

Filing date

1997-07-23

Publication date

1998-04-02

1997-07-23 Priority to UA99010100A priority Critical patent/UA73913C2/uk

1997-07-23 Priority to PL97331523A priority patent/PL195762B1/pl

1997-07-23 Priority to RO99-00078A priority patent/RO121272B1/ro

1997-07-23 Priority to NZ333777A priority patent/NZ333777A/en

1997-07-23 Priority to JP50723398A priority patent/JP4704521B2/ja

1997-07-23 Priority to BR9710544A priority patent/BR9710544A/pt

1997-07-23 Priority to HU0500549A priority patent/HU229024B1/hu

1997-07-23 Priority to CA002259583A priority patent/CA2259583C/fr

1997-07-23 Priority to EA199900158A priority patent/EA004403B1/ru

1997-07-23 Priority to SI9720045A priority patent/SI9720045B/sl

1997-07-23 Priority to IL12787197A priority patent/IL127871A0/xx

1997-07-23 Priority to DE69738197T priority patent/DE69738197T2/de

1997-07-23 Priority to EEP199900019A priority patent/EE04316B1/xx

1997-07-23 Priority to SK97-99A priority patent/SK286461B6/sk

1997-07-23 Priority to DK97936222T priority patent/DK0915880T3/da

1997-07-23 Application filed filed Critical

1997-07-23 Priority to IL15016397A priority patent/IL150163A0/xx

1997-07-23 Priority to KR1019997000568A priority patent/KR100548853B1/ko

1997-07-23 Priority to AU38942/97A priority patent/AU747708B2/en

1997-07-23 Priority to EP97936222A priority patent/EP0915880B1/fr

1997-07-23 Priority to HU0102187A priority patent/HU228962B1/hu

1998-01-29 Publication of WO1998003510A1 publication Critical patent/WO1998003510A1/fr

1998-04-02 Publication of WO1998003510B1 publication Critical patent/WO1998003510B1/en

1998-12-30 Priority to IL127871A priority patent/IL127871A/en

1999-01-20 Priority to LVP-99-13A priority patent/LV12292B/en

1999-01-21 Priority to NO19990264A priority patent/NO315610B3/no

1999-01-24 Anticipated expiration legal-status Critical

2002-03-12 Priority to AU23236/02A priority patent/AU773039C/en

2002-06-11 Priority to IL150163A priority patent/IL150163A/en

2004-10-12 Priority to IL164513A priority patent/IL164513A/en

Status Ceased legal-status Critical Current

Links

PCT/US1997/013072 1996-07-24 1997-07-23 Azolo triazines et pyrimidines Ceased WO1998003510A1 (fr)

Priority Applications (26)

Application Number	Priority Date	Filing Date	Title
DK97936222T DK0915880T3 (da)	1996-07-24	1997-07-23	Azolotriaziner og pyrimidiner
RO99-00078A RO121272B1 (ro)	1996-07-24	1997-07-23	Azolotriazine şi pirimidine
NZ333777A NZ333777A (en)	1996-07-24	1997-07-23	(1,5-a) pyrazolo and triazole triazines and pyrimidines
JP50723398A JP4704521B2 (ja)	1996-07-24	1997-07-23	アゾロトリアジン類およびアゾロピリミジン類
BR9710544A BR9710544A (pt)	1996-07-24	1997-07-23	M-todo de tratamento composto e composi-Æo farmac-utica
HU0500549A HU229024B1 (en)	1996-07-24	1997-07-23	Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof
CA002259583A CA2259583C (fr)	1996-07-24	1997-07-23	Azolo triazines et pyrimidines
EA199900158A EA004403B1 (ru)	1996-07-24	1997-07-23	Производные пиразолотриазинов, фармацевтические композиции, содержащие их, способы лечения
SI9720045A SI9720045B (sl)	1996-07-24	1997-07-23	Azolo triazini in pirimidini
IL12787197A IL127871A0 (en)	1996-07-24	1997-07-23	Azolo triazines and pyrimidines
DE69738197T DE69738197T2 (de)	1996-07-24	1997-07-23	Azolotriazine und pyrimidine
EEP199900019A EE04316B1 (et)	1996-07-24	1997-07-23	Asolotriasiinid ja -pürimidiinid, neid sisaldavadfarmatseutilised kompositsioonid ning nende kasutamine ravimite valmistamiseks
SK97-99A SK286461B6 (sk)	1996-07-24	1997-07-23	[1,5-a]-Pyrazolo-1,3,5-triazíny, ich použitie a farmaceutické kompozície na ich báze
UA99010100A UA73913C2 (en)	1996-07-24	1997-07-23	Azolo triazines and pyrimidines
AU38942/97A AU747708B2 (en)	1996-07-24	1997-07-23	Azolo triazines and pyrimidines
PL97331523A PL195762B1 (pl)	1996-07-24	1997-07-23	Związki [1,5-a]pirazolo-1,3,5-triazynowe, środek farmaceutyczny i zastosowanie związków [1,5-a]pirazolo-1,3,5-triazynowych do wytwarzania leku
KR1019997000568A KR100548853B1 (ko)	1996-07-24	1997-07-23	아졸로 트리아진 및 피리미딘
IL15016397A IL150163A0 (en)	1996-07-24	1997-07-23	Azolo triazines and pyrimidines
EP97936222A EP0915880B1 (fr)	1996-07-24	1997-07-23	Azolo triazines et pyrimidines
HU0102187A HU228962B1 (en)	1996-07-24	1997-07-23	Azolo triazines, pharmaceutical compositions containing them and use of the compounds
IL127871A IL127871A (en)	1996-07-24	1998-12-30	PHARMACEUTICAL COMPOSITIONS CONTAINING CRF ANTAGONIST 3-ARYL-PYRAZOLO (AND 1,2,3-TRIAZOLO) [1,5-a]-1,3,5-TRIAZINE DERIVATIVES AND SOME NEW SUCH DERIVATIVES
LVP-99-13A LV12292B (en)	1996-07-24	1999-01-20	TRIANGLE AND PYRIMIDINES AZOL-DERIVATIVES
NO19990264A NO315610B3 (no)	1996-07-24	1999-01-21	Azolotriaziner og -pyrimidiner
AU23236/02A AU773039C (en)	1996-07-24	2002-03-12	Azolo triazines and pyrimidines
IL150163A IL150163A (en)	1996-07-24	2002-06-11	PHARMACEUTICAL COMPOSITIONS COMPRISING PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND SOME NOVEL SUCH COMPOUNDS
IL164513A IL164513A (en)	1996-07-24	2004-10-12	Pyrazolopyrimidines, pharmaceutical compositions containing them and their use in the preparation of medicaments

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US68604796A	1996-07-24	1996-07-24
US2329096P	1996-07-24	1996-07-24
US08/686,047		1996-07-24
US60/023,290		1996-07-24

Publications (2)

Publication Number	Publication Date
WO1998003510A1 WO1998003510A1 (fr)	1998-01-29
WO1998003510B1 true WO1998003510B1 (fr)	1998-04-02

Family

ID=26696934

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/US1997/013072 Ceased WO1998003510A1 (fr)	1996-07-24	1997-07-23	Azolo triazines et pyrimidines

Country Status (17)

Country	Link
EP (2)	EP0915880B1 (fr)
KR (1)	KR100548853B1 (fr)
AR (1)	AR007994A1 (fr)
AT (1)	ATE375344T1 (fr)
AU (1)	AU747708B2 (fr)
CZ (1)	CZ2005613A3 (fr)
DE (1)	DE69738197T2 (fr)
DK (1)	DK0915880T3 (fr)
EA (1)	EA006626B1 (fr)
ES (1)	ES2294800T3 (fr)
HK (1)	HK1052693A1 (fr)
HU (2)	HU228962B1 (fr)
LV (1)	LV12292B (fr)
PT (1)	PT915880E (fr)
RO (1)	RO121272B1 (fr)
TW (2)	TW542827B (fr)
WO (1)	WO1998003510A1 (fr)

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US7094782B1 (en)	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
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DK1129096T3 (da)	1998-11-12	2003-09-15	Neurocrine Biosciences Inc	CRF-receptorantagonister og fremgangsmåder, der er relateret dertil
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PL354784A1 (en)	1999-09-30	2004-02-23	Neurogen Corporation	Certain alkylene diamine-substituted heterocycles
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IL148905A0 (en) *	1999-09-30	2002-09-12	Neurogen Corp Pfizer Inc	Certain alkylene diamine-substituted pyrazolo{1,5,-a}-1,5-pyrimidines and pyrazolo{1,5,-a}-1,3,5-triazines
CA2398956A1 (fr) *	2000-02-14	2001-08-16	Japan Tobacco Inc.	Composition pharmaceutique pour la prophylaxie ou le traitement du stress post-operatoire
EP1301511A2 (fr) *	2000-07-14	2003-04-16	Bristol-Myers Squibb Pharma Company	Imidazo 1,2-a]pyrazines destinees au traitement d'affections neurologiques
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MXPA03010324A (es)	2001-05-14	2004-02-17	Bristol Myers Squibb Pharma Co	PIRAZINONAS, PIRIDINAS Y PIRIMIDINAS SUBSTITUIDAS COMO LIGANDOS DEL FACTOR DE LIBERACIoN DE CORTICOTROPINA.
US6894045B2 (en)	2001-07-12	2005-05-17	Bristol-Myers Squibb Pharma Company	Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands
WO2003006015A1 (fr)	2001-07-13	2003-01-23	Bristol-Myers Squibb Pharma Company	Thiazoles et oxazoles substitutes utilises comme ligands hormonaux de liberation de la corticotrophine
AU2002340405A1 (en)	2001-11-20	2003-06-10	Bristol-Myers Squibb Pharma Company	3,7-dihydro-purine-2,6-dione derivatives as crf receptor ligands
ES2245772T3 (es)	2002-03-07	2006-01-16	Smithkline Beecham Corporation	Derivados de pirazolopirimidina y pirazolotriazina y composiciones farmaceuticas que los contienen.
WO2003091226A1 (fr)	2002-04-26	2003-11-06	Eli Lilly And Company	Derives de triazole en tant qu'antagonistes des recepteurs de la tachykinine
FR2842809A1 (fr) *	2002-07-26	2004-01-30	Greenpharma Sas	NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
FR2850653A1 (fr) *	2003-02-04	2004-08-06	Univ Pasteur	Derives de pyrazolotriazine, procede de preparation et utilisations
US7329658B2 (en)	2003-02-06	2008-02-12	Pfizer Inc	Cannabinoid receptor ligands and uses thereof
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US7112585B2 (en)	2003-04-18	2006-09-26	Bristol-Myers Squibb Company	Pyrimidine derivatives as corticotropin releasing factor inhibitors
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US7208596B2 (en)	2003-11-25	2007-04-24	Bristol-Myers Squibb Pharma Company	Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
AR046967A1 (es)	2003-12-22	2006-01-04	Sb Pharmco Inc	Compuesto de pirazol[1,5-a]pirimidina, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
GB0519957D0 (en)	2005-09-30	2005-11-09	Sb Pharmco Inc	Chemical compound
WO2007013673A1 (fr) *	2005-07-29	2007-02-01	Astellas Pharma Inc.	Hétérocycles fusionnés en tant qu’inhibiteurs de lck
US8030304B2 (en) *	2006-09-20	2011-10-04	Eli Lilly And Company	Thiazole pyrazolopyrimidines CRF1 receptor antagonists
US8110580B2 (en)	2006-09-20	2012-02-07	Eli Lilly And Company	Thiophene pyrazolopyrimidine compounds
AR064491A1 (es)	2006-12-22	2009-04-08	Astex Therapeutics Ltd	Derivados de imidazo[1, 2-a]pirimidina, un proceso para su preparacion, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por las quinasas fgfr.
CN101679409B (zh)	2006-12-22	2014-11-26	Astex治疗学有限公司	双环杂环衍生化合物、其医药组合物和其用途
EP2522351B1 (fr) *	2007-06-13	2017-09-06	Research Development Foundation	Traitement et prévention de tauopathies et de l'amyloïdose de bêta-amyloïde en modulant la signalisation de récepteur CRF
GB0720041D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New Compounds
GB0720038D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New compounds
GB0810902D0 (en)	2008-06-13	2008-07-23	Astex Therapeutics Ltd	New compounds
EP2417138B1 (fr)	2009-04-09	2019-11-27	Merck Sharp & Dohme Corp.	Dérivés pyrazolo [1, 5-a] pyrimidine en tant qu'inhibiteurs de mtor
GB0906470D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
GB0906472D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
EP2264035A1 (fr) *	2009-06-04	2010-12-22	Merz Pharma GmbH & Co. KGaA	B antagonistes de la glycine
WO2012178125A1 (fr)	2011-06-22	2012-12-27	Vertex Pharmaceuticals Incorporated	Composés inhibiteurs de la kinase atr
DK2760453T3 (en)	2011-09-30	2016-08-15	Ipsen Pharma Sas	Macrocyclic LRRK2 kinase inhibitors
GB201210686D0 (en)	2012-06-15	2012-08-01	Holsboermaschmeyer Neurochemie Gmbh	V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
EP3610890A1 (fr)	2012-11-14	2020-02-19	The Johns Hopkins University	Procédés et compositions de traitement de la schizophrénie
US8871754B2 (en)	2012-11-19	2014-10-28	Irm Llc	Compounds and compositions for the treatment of parasitic diseases
ME03042B (fr)	2012-11-19	2018-10-20	Novartis Ag	Composés et compositions pour le traitement de maladies parasitaires
ES2884030T3 (es)	2012-12-07	2021-12-10	Vertex Pharma	2-amino-N-(piperidin-1-il-piridin-3-il)pirazolo[1,5alfa]pirimidin-3-carboxamida como inhibidor de ATR quinasa
EP2968237A4 (fr)	2013-03-15	2016-08-31	Univ Johns Hopkins	Procédés et compositions pour améliorer la fonction cognitive
CA2904767C (fr)	2013-03-15	2022-06-21	Agenebio, Inc.	Procedes et compositions pour ameliorer la fonction cognitive
GB201310782D0 (en)	2013-06-17	2013-07-31	Max Planck Innovation Gmbh	Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms
US10160760B2 (en)	2013-12-06	2018-12-25	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of ATR kinase
PL3152212T3 (pl)	2014-06-05	2020-06-15	Vertex Pharmaceuticals Inc.	Radioznakowane pochodne związku 2-amino-6-fluoro-n-[5-fluoro-piridyn-3-ylo]-pirazolo[1,5-a]pirymidino-3-karboksamidu przydatne jako inhibitor kinazy atr, wytwarzanie tego związku i jego różnych postaci stałych
SI3157566T1 (sl)	2014-06-17	2019-08-30	Vertex Pharmaceuticals Incorporated	Postopek za zdravljenje raka z uporabo kombinacije inhibitorjev CHK1 in ATR
CA2960777A1 (fr)	2014-09-17	2016-03-24	Oncodesign S.A.	Inhibiteurs macrocycliques de kinases lrrk2
CA2966259A1 (fr)	2014-11-03	2016-05-12	Bayer Pharma Aktiengesellschaft	Piperidinylpyrazolopyrimidinones et leur utilisation
EA034167B8 (ru)	2015-05-22	2021-04-27	Эйджинбайо, Инк.	Фармацевтические композиции леветирацетама пролонгированного высвобождения
CA3000684A1 (fr)	2015-09-30	2017-04-06	Vertex Pharmaceuticals Incorporated	Methode de traitement du cancer utilisant une association d'agents endommageant l'adn et d'inhibiteurs de l'atr
MX2019012431A (es) *	2017-04-21	2020-08-03	Ikena Oncology Inc	Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
CN110996943A (zh)	2017-08-14	2020-04-10	云杉生物科学公司	促肾上腺皮质激素释放因子受体拮抗剂
CN111511745B (zh) *	2018-02-06	2022-05-27	江苏恒瑞医药股份有限公司	吡唑并[1，5-a][1，3，5]三嗪-2-胺类衍生物、其制备方法及其应用
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1997
- 1997-07-23 WO PCT/US1997/013072 patent/WO1998003510A1/fr not_active Ceased
- 1997-07-23 ES ES97936222T patent/ES2294800T3/es not_active Expired - Lifetime
- 1997-07-23 EP EP97936222A patent/EP0915880B1/fr not_active Expired - Lifetime
- 1997-07-23 EA EA200301042A patent/EA006626B1/ru not_active IP Right Cessation
- 1997-07-23 PT PT97936222T patent/PT915880E/pt unknown
- 1997-07-23 DE DE69738197T patent/DE69738197T2/de not_active Expired - Lifetime
- 1997-07-23 HU HU0102187A patent/HU228962B1/hu unknown
- 1997-07-23 KR KR1019997000568A patent/KR100548853B1/ko not_active Expired - Fee Related
- 1997-07-23 CZ CZ2005-613A patent/CZ2005613A3/cs unknown
- 1997-07-23 AU AU38942/97A patent/AU747708B2/en not_active Expired
- 1997-07-23 HU HU0500549A patent/HU229024B1/hu unknown
- 1997-07-23 DK DK97936222T patent/DK0915880T3/da active
- 1997-07-23 AT AT97936222T patent/ATE375344T1/de active
- 1997-07-23 RO RO99-00078A patent/RO121272B1/ro unknown
- 1997-07-23 EP EP07015514A patent/EP1908764A1/fr not_active Withdrawn
- 1997-07-24 AR ARP970103368A patent/AR007994A1/es unknown
- 1997-07-25 TW TW086110640A patent/TW542827B/zh not_active IP Right Cessation
- 1997-07-25 TW TW092105694A patent/TWI238164B/zh not_active IP Right Cessation
1999
- 1999-01-20 LV LVP-99-13A patent/LV12292B/en unknown
2003
- 2003-07-02 HK HK03104703.7A patent/HK1052693A1/zh unknown

Publication	Publication Date	Title
WO1998003510B1 (fr)	1998-04-02
CA2165819A1 (fr)	1995-11-02	Derives de dc-89
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