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WO1998003184A1 - Derives de levane, leur preparation, leur composition et leurs applications, y compris d'ordre medical et alimentaire - Google Patents

Derives de levane, leur preparation, leur composition et leurs applications, y compris d'ordre medical et alimentaire Download PDF

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Publication number
WO1998003184A1
WO1998003184A1 PCT/US1997/013782 US9713782W WO9803184A1 WO 1998003184 A1 WO1998003184 A1 WO 1998003184A1 US 9713782 W US9713782 W US 9713782W WO 9803184 A1 WO9803184 A1 WO 9803184A1
Authority
WO
WIPO (PCT)
Prior art keywords
levan
derivative
molecular weight
daltons
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/013782
Other languages
English (en)
Other versions
WO1998003184A9 (fr
Inventor
Earl J. Roberts
Per J. Garegg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CLARKE-GAREGG MARGARET A
SUGAR PROCESSING RESEARCH INSTITUTE Inc
Original Assignee
CLARKE-GAREGG MARGARET A
SUGAR PROCESSING RESEARCH INSTITUTE Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CLARKE-GAREGG MARGARET A, SUGAR PROCESSING RESEARCH INSTITUTE Inc filed Critical CLARKE-GAREGG MARGARET A
Priority to AU40529/97A priority Critical patent/AU4052997A/en
Publication of WO1998003184A1 publication Critical patent/WO1998003184A1/fr
Publication of WO1998003184A9 publication Critical patent/WO1998003184A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates

Definitions

  • the value of x varies from 0 to 2 and wherein the sulfate is present in an amount of 0.2 to 3 sulfates per fructose ring.
  • the value of n ranges from about 1250 to 1550.
  • the weight range of components for levan acetates are preferably: C from 43% to 47%

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nouveaux dérivés de la lévane, qui est le β-(2-⊃6)polymère du fructose, dotés de caractéristiques uniques. La matière de départ à base de lévane présente une masse moléculaire bien plus élevée que la lévane ordinaire, de l'ordre d'au moins 1 x 106 Daltons, et de préférence d'environ 2 x 106 Daltons, dans une plage de distribution étroite. Les nouveaux dérivés de lévane sont caractérisés en ce qu'ils comprennent des liaisons glycosidiques β-(2-⊃6) prédominantes entre les motifs monomères de D-fructofuranoside. En ce qui concerne les dérivés hydrosolubles, ils présentent une masse moléculaire élevée de l'ordre d'environ 500,000 Daltons. Parmi les dérivés préférés on compte les sulfates, les phosphates et les acétates qui peuvent être présents en une teneur comprise entre 0,2 et 3 par noyau de fructose. Ces dérivés de lévane se prêtent à de nombreuses utilisations nouvelles. Ils peuvent ainsi être utilisés comme inhibiteurs de la prolifération des cellules des muscles lisses, comme agents anti-SIDA, comme excipients dans la fabrication de pilules et comme agents de gélification de l'eau. Ils peuvent également être utilisés pour la cicatrisation à des fins médicales et à des fins dermatologiques, comme matériaux de bourrage sous-cutanés à des fins médicales ou dentaires et dans le traitement des pis enflammés et des mammites chez le bétail, en médecine vétérinaire. Lorsque la lévane est elle-même réticulée par l'épichlorhydrine, elle agit comme agent filmogène pour produire des films minces en matière plastique.
PCT/US1997/013782 1996-07-19 1997-07-18 Derives de levane, leur preparation, leur composition et leurs applications, y compris d'ordre medical et alimentaire Ceased WO1998003184A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40529/97A AU4052997A (en) 1996-07-19 1997-07-18 Levan derivatives, their preparation, composition and applications including medical and food applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2220696P 1996-07-19 1996-07-19
US60/022,206 1996-07-19

Publications (2)

Publication Number Publication Date
WO1998003184A1 true WO1998003184A1 (fr) 1998-01-29
WO1998003184A9 WO1998003184A9 (fr) 1998-05-28

Family

ID=21808384

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/013782 Ceased WO1998003184A1 (fr) 1996-07-19 1997-07-18 Derives de levane, leur preparation, leur composition et leurs applications, y compris d'ordre medical et alimentaire

Country Status (2)

Country Link
AU (1) AU4052997A (fr)
WO (1) WO1998003184A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011120904A2 (fr) 2010-03-29 2011-10-06 Ferring B.V. Composition pharmaceutique à dissolution rapide
WO2013037708A1 (fr) 2011-09-16 2013-03-21 Ferring B.V. Composition pharmaceutique à dissolution rapide
WO2014079922A1 (fr) 2012-11-21 2014-05-30 Ferring B.V. Composition pour libération immédiate et prolongée
WO2018098291A1 (fr) * 2016-11-23 2018-05-31 Hppe, Llc Compositions de polysaccharide réticulé et mélanges de béton contenant ces dernières
US20190153561A1 (en) * 2016-06-20 2019-05-23 Hppe, Llc Enhanced binders for iron ore pelleting and cement adhesive materials

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547863A (en) * 1989-08-14 1996-08-20 The United States Of America As Represented By The Secretary Of The Agriculture Production of fructan (levan) polyfructose polymers using bacillus polymyxa

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547863A (en) * 1989-08-14 1996-08-20 The United States Of America As Represented By The Secretary Of The Agriculture Production of fructan (levan) polyfructose polymers using bacillus polymyxa

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DERWENT ABSTRACT, Accession Number 73-36342U/26, FARBWERKE HOECHST AG; & DE,A,2 162 343, (7326), 16 December 1971. *
J. AGRIC. FOOD CHEM., 1990, Vol. 38, No. 2, HAN et al., "Production and Characterization of Microbial Levan", pages 393-396. *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011120904A2 (fr) 2010-03-29 2011-10-06 Ferring B.V. Composition pharmaceutique à dissolution rapide
WO2013037708A1 (fr) 2011-09-16 2013-03-21 Ferring B.V. Composition pharmaceutique à dissolution rapide
WO2014079922A1 (fr) 2012-11-21 2014-05-30 Ferring B.V. Composition pour libération immédiate et prolongée
US20190153561A1 (en) * 2016-06-20 2019-05-23 Hppe, Llc Enhanced binders for iron ore pelleting and cement adhesive materials
WO2018098291A1 (fr) * 2016-11-23 2018-05-31 Hppe, Llc Compositions de polysaccharide réticulé et mélanges de béton contenant ces dernières
US10793473B2 (en) 2016-11-23 2020-10-06 Hppe, Llc Crosslinked polysaccharide compositions and concrete blends containing the same

Also Published As

Publication number Publication date
AU4052997A (en) 1998-02-10

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