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WO1998040390A3 - Oligosaccharides et leurs derives et procede chimio-enzymatique permettant de les preparer - Google Patents

Oligosaccharides et leurs derives et procede chimio-enzymatique permettant de les preparer Download PDF

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Publication number
WO1998040390A3
WO1998040390A3 PCT/EP1998/001096 EP9801096W WO9840390A3 WO 1998040390 A3 WO1998040390 A3 WO 1998040390A3 EP 9801096 W EP9801096 W EP 9801096W WO 9840390 A3 WO9840390 A3 WO 9840390A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligosaccharides
stereo
derivatives
addition
aglycone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1998/001096
Other languages
German (de)
English (en)
Other versions
WO1998040390A2 (fr
Inventor
Wolf-Dieter Fessner
Michael Petersen
Michael Arthur Papadopoulos
Gerd Osswald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU68242/98A priority Critical patent/AU6824298A/en
Publication of WO1998040390A2 publication Critical patent/WO1998040390A2/fr
Publication of WO1998040390A3 publication Critical patent/WO1998040390A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne de nouvelles oligosaccharides et leurs dérivés, ainsi qu'un procédé général de préparation stéréodivergente d'oligosaccharides à partir de glycosides simples aisément accessibles, à partir de la part aglycone desquels une autre unité saccharide est créée de manière stéréosélective par réactions de prolongement de chaîne. A cet effet, il est prévu une addition chimique (optionnelle) d'un équivalent aldéhyde à une liaison double C=X dans l'aglycone, suivie d'une addition enzymatique diastéréosélective d'un donneur aldol nucléophile à l'aldéhyde glycosylé en présence de différentes aldolases stéréospécifiques. Les oligosaccharides obtenues qui portent une unité cétose supplémentaire à l'extrémité réductrice, en cas d'utilisation d'aldolases DHAP-dépendantes, ainsi que leurs esters de phosphate correspondants et leurs dérivés appropriés, s'utilisent comme constituants ou précurseurs de principes actifs pharmaceutiques.
PCT/EP1998/001096 1997-03-11 1998-02-26 Oligosaccharides et leurs derives et procede chimio-enzymatique permettant de les preparer Ceased WO1998040390A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU68242/98A AU6824298A (en) 1997-03-11 1998-02-26 Oligosaccharides and the derivatives thereof, chemo-enzymatic method for the production thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1997109787 DE19709787A1 (de) 1997-03-11 1997-03-11 Oligosaccaride und deren Derivate sowie ein chemo-enzymatisches Verfahren zu deren Herstellung
DE19709787.1 1997-03-11

Publications (2)

Publication Number Publication Date
WO1998040390A2 WO1998040390A2 (fr) 1998-09-17
WO1998040390A3 true WO1998040390A3 (fr) 1999-01-14

Family

ID=7822840

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/001096 Ceased WO1998040390A2 (fr) 1997-03-11 1998-02-26 Oligosaccharides et leurs derives et procede chimio-enzymatique permettant de les preparer

Country Status (3)

Country Link
AU (1) AU6824298A (fr)
DE (1) DE19709787A1 (fr)
WO (1) WO1998040390A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7932236B2 (en) 2004-11-09 2011-04-26 Seneb Biosciences, Inc. Glycolipids

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MXPA04001831A (es) 2001-08-29 2004-07-08 Neose Technologies Inc Nuevos derivados sinteticos de gangliosidos y composiciones de los mismos.
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
NZ542148A (en) * 2003-03-06 2008-05-30 Neose Technologies Inc Methods and compositions for the enzymatic synthesis of gangliosides
CA2522345A1 (fr) 2003-04-09 2004-11-18 Neose Technologies, Inc. Methode de glycopegylation et proteines/peptides produits au moyen de ces methodes
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20080300173A1 (en) 2004-07-13 2008-12-04 Defrees Shawn Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
JP5948627B2 (ja) 2004-10-29 2016-07-20 レイショファーム ゲーエムベーハー 線維芽細胞成長因子（ｆｇｆ）のリモデリングと糖質ペグ化
ES2449195T3 (es) 2005-01-10 2014-03-18 Ratiopharm Gmbh Factor estimulante de colonias de granulocitos glicopegilado
US20070154992A1 (en) 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (fr) 2005-11-03 2007-05-18 Neose Technologies, Inc. Purification de sucre de nucleotide en utilisant des membranes
JP2009544327A (ja) 2006-07-21 2009-12-17 ノヴォ ノルディスク アー／エス Ｏ−結合型グリコシル化配列によるペプチドのグリコシル化
WO2008057683A2 (fr) 2006-10-03 2008-05-15 Novo Nordisk A/S Méthodes de purification de conjugués de polypeptides
JP2010523582A (ja) 2007-04-03 2010-07-15 バイオジェネリクス アクチェンゲゼルシャフト グリコｐｅｇ化ｇ−ｃｓｆを用いた治療方法
CA2690611C (fr) 2007-06-12 2015-12-08 Novo Nordisk A/S Procede ameliore pour la production de sucres de nucleotide
JP5619630B2 (ja) 2008-02-27 2014-11-05 ノボ・ノルデイスク・エー／エス 結合型第ｖｉｉｉ因子分子
US20120035120A1 (en) 2009-03-25 2012-02-09 Seneb Biosciences, Inc. Glycolipids as treatment for disease
FR2999076B1 (fr) * 2012-12-07 2015-03-20 Oreal Nouveaux composes c-xylosides carboxyles et utilisation en cosmetique.
JP6292438B2 (ja) * 2013-12-05 2018-03-14 ナガセケムテックス株式会社 二糖類化合物、変性オルガノポリシロキサン化合物及び界面活性剤
CN110869024A (zh) * 2017-06-05 2020-03-06 旗舰创业创新五公司 多生物剂及其使用方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0426176A2 (fr) * 1989-11-02 1991-05-08 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt 5-(alpha-D-glucopyranosyloxyméthyl)-furan-2-carboxaldehyde, ces dérivés, leurs produits en découlant et procédé pour la préparation de ces composés et leur utilisation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0426176A2 (fr) * 1989-11-02 1991-05-08 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt 5-(alpha-D-glucopyranosyloxyméthyl)-furan-2-carboxaldehyde, ces dérivés, leurs produits en découlant et procédé pour la préparation de ces composés et leur utilisation

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Title
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EYRISCH, OLIVER ET AL: "Disaccharide mimetics by enzymic tandem aldol additions", 1995, ANGEW. CHEM., INT. ED. ENGL. (1995), 34(15), 1639-41 CODEN: ACIEAY;ISSN: 0570-0833, XP002083668 *
KLEIN, JOACHIM ET AL: "New amphiphilic copolymers derived from hydrophobically modified vinyl saccharides", 1995, CAN. J. CHEM. (1995), 73(11), 1941-7 CODEN: CJCHAG;ISSN: 0008-4042, XP002083661 *
LICHTENTHALER, FRIEDER W. ET AL: ".alpha.-D-Glucopyranosyl-D-fructoses: distribution of furanoid and pyranoid tautomers in water, dimethyl sulfoxide, and pyridine. Studies on ketoses. Part 4", 1990, J. CHEM. SOC., PERKIN TRANS. 2 (1990), (8), 1489-97 CODEN: JCPKBH;ISSN: 0300-9580, XP002083664 *
LICHTENTHALER, FRIEDER W. ET AL: "5-(.alpha.-D-Glucosyloxymethyl)furfural: preparation from isomaltulose and exploration of its ensuing chemistry", 1993, LIEBIGS ANN. CHEM. (1993), (9), 967-74 CODEN: LACHDL;ISSN: 0170-2041, XP002083663 *
LICHTENTHALER, FRIEDER W. ET AL: "Disaccharide building blocks from isomaltulose: glucosyl-.alpha.(1.fwdarw.5)-D-arabinonic acid and ensuing products", 1993, LIEBIGS ANN. CHEM. (1993), (9), 975-80 CODEN: LACHDL;ISSN: 0170-2041, XP002083662 *
REUBEN, JACQUES: "Molecular structure as reflected in the carbon-13 NMR spectra of oligosaccharides with partially deuterated hydroxyls", 1985, J. AM. CHEM. SOC. (1985), 107(6), 1747-55 CODEN: JACSAT;ISSN: 0002-7863, XP002083666 *
THIEM, JOACHIM ET AL: "Synthesis and reactions of leucrose and its exocyclic glycal", 1990, CARBOHYDR. RES. (1990), 205, 333-45 CODEN: CRBRAT;ISSN: 0008-6215, XP002083946 *
WAGNER, R. ET AL: "Silicon-modified carbohydrate surfactants. I. Synthesis of siloxanyl moieties containing straight-chained glycosides and amides", 1996, APPL. ORGANOMET. CHEM. (1996), 10(6), 421-435 CODEN: AOCHEX;ISSN: 0268-2605, XP002083660 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7932236B2 (en) 2004-11-09 2011-04-26 Seneb Biosciences, Inc. Glycolipids

Also Published As

Publication number Publication date
AU6824298A (en) 1998-09-29
WO1998040390A2 (fr) 1998-09-17
DE19709787A1 (de) 1998-09-17

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