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WO1997039348A1 - Systeme de transport de lames - Google Patents

Systeme de transport de lames Download PDF

Info

Publication number
WO1997039348A1
WO1997039348A1 PCT/US1997/005301 US9705301W WO9739348A1 WO 1997039348 A1 WO1997039348 A1 WO 1997039348A1 US 9705301 W US9705301 W US 9705301W WO 9739348 A1 WO9739348 A1 WO 9739348A1
Authority
WO
WIPO (PCT)
Prior art keywords
belts
treads
objects
slides
pair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/005301
Other languages
English (en)
Inventor
Marshall S. Levine
Daniel S. Levine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alpha Scientific Corp
Original Assignee
Alpha Scientific Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpha Scientific Corp filed Critical Alpha Scientific Corp
Priority to AU26008/97A priority Critical patent/AU2600897A/en
Publication of WO1997039348A1 publication Critical patent/WO1997039348A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G37/00—Combinations of mechanical conveyors of the same kind, or of different kinds, of interest apart from their application in particular machines or use in particular manufacturing processes
    • B65G37/005—Combinations of mechanical conveyors of the same kind, or of different kinds, of interest apart from their application in particular machines or use in particular manufacturing processes comprising two or more co-operating conveying elements with parallel longitudinal axes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00039—Transport arrangements specific to flat sample substrates, e.g. pusher blade
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0418—Plate elements with several rows of samples
    • G01N2035/0425—Stacks, magazines or elevators for plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0474—Details of actuating means for conveyors or pipettes
    • G01N2035/0482—Transmission
    • G01N2035/0484—Belt or chain

Definitions

  • This invention relates to the field of materials handling, and, in particular, provides an apparatus and method for transporting objects, such as microscope slides, along a vertical path.
  • the primary purpose of the present invention is to integrate dis ⁇ parate components of laboratory equipment, so that the components can cooperate as a unified, fully automated system.
  • the in ⁇ vention provides means for transporting microscope slides between a first device which automatically creates a blood smear, and a second device used to stain the slides, wherein the first and second devices are spaced apart vertically from each other.
  • the invention makes it possible for the smear maker and the staining device to work automatically and inde ⁇ pendently, because the slides can be transported reliably from one device to the other without manual intervention.
  • the present invention comprises a pair of opposed belts, the belts having external treads.
  • the belts are arranged vertically, so that the external treads define horizontally-oriented shelves which are capable of holding slides, or other objects, in a generally horizontal orientation.
  • the movements of the belts are preferably synchronized such that the slides continue to be conveyed in their horizontal orientation while the belts move.
  • Microscope slides, cradled between the treads of opposite belts, are transported vertically from, for example, a smearing apparatus at one level to a staining apparatus at a lower level.
  • the present invention also includes means for synchronization and buffering between different components which operate operate at different and sometimes random rates.
  • the invention can provide processing of its own, such as the drying of slides.
  • the invention also includes a device for loading a slide onto the transport mechanism.
  • a carriage having an attached tongue, moves horizontally along a shaft.
  • the tongue defines a flat surface, prefer ⁇ ably with lips at its ends, for holding the slide.
  • the carriage moves, the tongue delivers the slide to the belts by moving into the space between opposing treads, and thereby allowing the slide to become supported by the pair of treads.
  • the carriage then retracts the tongue, preferably after the belts have moved slightly so that the slide will not be affected by the retraction.
  • the invention therefore has the primary object of providing an appa ⁇ ratus and method for transporting microscope slides in a vertical direc ⁇ tion.
  • the invention has the further object of providing means for cradling microscope slides without disturbing the integrity of the specimen con ⁇ tained on the slides, or of identifying indicia imprinted on the slides.
  • the invention has the further object of providing means for handling microscope slides very gently, by cradling them in a soft rubber-like support.
  • the invention has the further object of providing an interim storage means for slides, so that slides can be efficiently transported between two devices which process slides at differing rates.
  • the invention has the further object of providing a means for syn ⁇ chronization such that slides can be passed from one device to another when the devices operate at different or random rates.
  • the invention has the further object of reducing the cost of trans ⁇ porting and processing microscope slides.
  • the invention has the further object of providing a method and appa ⁇ ratus for loading slides onto, and discharging slides from, a vertical transport mechanism.
  • the invention has the further object of providing a method and appa ⁇ ratus for inverting or flipping slides as they are discharged from a ver ⁇ tical transport device.
  • Figure 1 provides an elevational view of the slide transport device of the present invention.
  • Figure 2 is a cross-sectional view taken along the lines 2-2 of Fig ⁇ ure 1.
  • Figure 3 is a partial elevational view of the slide transport device of the present invention, showing the preferred apparatus for insertion of slides.
  • Figure 4 is a cross-sectional view, taken along the lines 4-4 of Figure 3, further illustrating the apparatus for insertion of slides.
  • Figure 5 provides a partial elevational view, similar to that of Figure 3, showing a slide being lifted off of the tongue which has car ⁇ ried the slide to the transport device of the present invention.
  • Figure 6 provides a cross-sectional view, taken along the line 6-6 of Figure 5.
  • Figure 7 provides an elevational view of an alternative form of the present invention, showing a pair of belts in a tilted arrangement, for transporting slides along a tilted path.
  • Figure 8 provides a cut-away perspective view of an assembly includ ⁇ ing the transport device of the present invention in conjunction with an automated smearing apparatus.
  • Figure 9 provides a cut-away perspective view of an assembly includ- ing the transport device of the present invention in conjunction with both an automated smearing apparatus and an automated staining device.
  • Figure 10 provides a fragmentary elevational view of another embodi ⁇ ment of the present invention, which embodiment includes a mechanism for automatically turning slides upside-down after they have been ejected from the transport device.
  • Figures 11, 12, and 13 provide diagrams illustrating successive stages in the operation of the device of Figure 10.
  • the slide transport device of the present in ⁇ vention includes a pair of belts 1 and 2 arranged in a generally vertical orientation.
  • Belt 1 has a pair of sprocket pulleys 3 and 4 which mesh with the corresponding inner treads 13 on the inside surface of the belt.
  • Belt 1 also has a plurality of outer treads 7, located on the outer sur ⁇ face of the belt.
  • Belt 2 is identical to belt 1, having sprocket pulleys 5 and 6, inner treads 14, and outer treads 8.
  • the belts are preferably made of rubber, or a rubber-like material, or of some other compliant material. The invention is not limited to rubber or rubber substitutes.
  • the belts are spaced apart from each other, as shown, so that slides 9 can be inserted between them.
  • the distance between the belts is greater than a dimension of the slides, so as to allow the slides to fit easily between the belts.
  • the distance between the outer treads must be less than a dimension of the slides, so that each slide can be supported by a pair of outer treads.
  • the movement of the outer treads around the pulleys facilitates the loading of slides into, and the discharge of slides from, the transport mechanism.
  • the outer treads are spaced farther away from each other when they are traveling around the pulleys, than when they are moving along straight paths. For example, at the bottom of Figure 1, one can see that the movement of the outer treads around the pulleys releases the slides from the transport device, because the treads become separated by a distance greater than the length of the slides.
  • the belts are generally par ⁇ allel to the path of travel of the slide. If one desires to move the slides along a path which is tilted, the belts can be tilted at the re ⁇ quired angle, and pulleys can be adjusted so as to position the treads such that they maintain the slides in a horizontal orientation.
  • Figure 7 shows this alternative embodiment, in which the belts are oblique rela ⁇ tive to the path of the slide.
  • the belts 1 and 2 can trans ⁇ port a slide both vertically and horizontally. The amount of horizontal travel is generally less than the amount of vertical travel.
  • the outer treads located on adjacent surfaces of the belts are still synchroni d. due to the synchronization of the movements of the pulleys, so as to maintain the slides in a horizontal orientation.
  • a striker bar 11 may be positioned in the vicinity of the bottom of the device, as shown, to cause the slides to rotate as they fall.
  • Figure 2 shows slides 9 as they are cradled by the outer treads 8 of belt 2.
  • the width of belt 2 is less than the width of the slide.
  • the width of the belt can be made equal to, or larger than, the width of the slide. It is also possible to have a plurality of narrow belts, provided that the treads of each of the narrow belts are syn ⁇ chronized.
  • the preferred means for synchronizing the belts is simply to make all of the pulleys of equal diameter, and to make them turn at the same rate.
  • the pulleys can therefore be adjusted, on a one-time basis, so that the treads are aligned, for example, as shown in Figure 1.
  • the belts will retain their synchronization indefinitely.
  • Figure 4 shows the apparatus and method for loading the transport device of Figure 1.
  • An introducer apparatus 20 is shown at the moment when it is injecting a slide into the region between the belts.
  • the in ⁇ troducer apparatus includes a carriage portion 25 and tongue 28.
  • the tongue holds slide 9 which is cradled in a depression between lips 21 and 29.
  • the carriage includes bearing 23 which is mounted around bar 22, so that the carriage travels horizontally along the bar.
  • the carriage can P T/ S97/0 01
  • Figure 3 shows that the introduction of the slide is per ⁇ formed when the opposing treads 8A and 8B are located slightly below the bottom surface of slide 9.
  • Figure 5 shows how the slide is lifted away from the tongue.
  • the belts are simply rotated in the directions indicated by arrows 25 and 26. This rotation lifts slide 9 away from lip 21, and thus from the tongue.
  • slide 9 will not move when the tongue is withdrawn.
  • Carriage 20 is now free to retract, by moving to the left.
  • the tongue is constructed so that it fits within the space between facing outer treads. Also, the width of the tongue is less than the length of the slide, so that the slide will overhang the tongue, as is visible in Figures 3 and 5. Thus, the tongue can simply deposit the slide onto a pair of outer treads. The tongue need not ever be in direct contact with the outer treads.
  • Figure 8 shows an embodiment of the present invention which includes the transport device described above, in combination with an automated smear making apparatus.
  • the smear making apparatus is similar to what is described in U.S. Patent Application Serial No. 08/477,980, cited above.
  • the latter apparatus includes magazine 32 containing microscope slides 9, a module 33 which prints identifying indicia on the slide, and a smearing element 35 which spreads blood across the slide.
  • the smear making appa ⁇ ratus also includes a carriage which transports the slides horizontally from the smear making area to the vertical transport.
  • Reference numeral IA indicates a slide on which a smear has just been made.
  • Reference numeral IB indicates a slide bearing a smear, the slide IB having been pushed onto the vertical transport of the present invention.
  • the slides are exposed to heated air, blown by fan 114, and are dried as they travel.
  • the drying of the slides is an example of how the slides can be processed while they are being conveyed by the transport device. Other forms of processing can be per ⁇ formed while the slides are in transit.
  • the slides are deposited in a tray IF.
  • Figure 9 shows another embodiment of the present invention which includes the slide transport device described above, in combination with both an automated smearing apparatus and a commercially available stainer.
  • the slides are first prepared in the smearing apparatus, as described above, and are delivered automatically to the vertical trans ⁇ port device, which carries them to the stainer, and deposits them upside- down onto a horizontal surface.
  • the stainer indicated generally by ref ⁇ erence numeral 303, includes a worm drive, defined by cylindrical members 304 and 305 having helical protrusions, which transport slides 9 across the horizontal surface.
  • the slides are then subjected to various chemicals as they move along that surface.
  • the length of the belt and the spacing of the treads determines the capacity of the device to store slides, and to act as a buffer between components of a larger system.
  • buffering is useful because the processes of smearing and staining are non-synchro ⁇ nous.
  • the capacity of the belt allows time for the drying of slides, which may be enhanced by the use of heated air.
  • Figure 10 shows an alternative embodiment which includes a device that flips the slides upside-down, and deposits them onto a target sur ⁇ face, which, in the example of Figure 9, can be the platen of the stainer.
  • the device includes pivoting shelf 70 which has a protrusion at one end, the protrusion defining notch 71.
  • the shelf is attached to bracket 72 which pivots about axle 74, which is connected to motor 73.
  • Motor 73 is attached to base 75 which rests on target surface 77.
  • Pin 76 is affixed to the base, and protrudes therefrom, in a direction toward the reader.
  • the invention is especially useful in transporting flat objects such as microscopic slides, it is not limited to use with flat objects.
  • Objects having a significant vertical dimension can also be transported by the present invention, as long as the vertical dimension of the objects is less than the distance between adjacent treads of a particular belt.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Structure Of Belt Conveyors (AREA)

Abstract

Le dispositif de transport décrit amène des objets, par exemple des lames (9) de microscope d'un niveau à un autre. Le dispositif de transport comporte une paire de courroies (1, 2), ces courroies (1, 2) présentant une pluralité de pas fixés à la surface extérieure des courroies (1,2). Les courroies (1, 2) se déplacent en sens contraire, de sorte que les pas qui se font face se déplacent dans le même sens, vers le haut ou vers le bas. Chaque lame (9) est maintenue par une paire de pas, et est transportée vers le haut ou vers le bas, tout en restant dans une position générale horizontale. Le dispositif de transport peut relier deux éléments ou plus de l'équipement de laboratoire, de façon à s'intégrer dans un système plus important qui peut être totalement automatisé. Par exemple, le dispositif de transport peut acheminer les lames depuis un appareil à frottis automatisé jusqu'à un dispositif de coloration, sans nécessité d'intervention manuelle. L'invention concerne également des éléments de chargement des lames sur le dispositif de transport, et d'inversion des lames après leur transport.
PCT/US1997/005301 1996-04-15 1997-04-08 Systeme de transport de lames Ceased WO1997039348A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU26008/97A AU2600897A (en) 1996-04-15 1997-04-08 Slide transport system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63207996A 1996-04-15 1996-04-15
US08/632,079 1996-04-15

Publications (1)

Publication Number Publication Date
WO1997039348A1 true WO1997039348A1 (fr) 1997-10-23

Family

ID=24533987

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/005301 Ceased WO1997039348A1 (fr) 1996-04-15 1997-04-08 Systeme de transport de lames

Country Status (2)

Country Link
AU (1) AU2600897A (fr)
WO (1) WO1997039348A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2782800A1 (fr) * 1998-09-01 2000-03-03 Abx Sa Dispositif pour la preparation automatique d'etalements sanguins sur des lames
WO2001002867A1 (fr) * 1999-07-03 2001-01-11 Janssen Pharmaceutica N.V. Dispositif servant a transporter des supports vers un poste de traitement et son procede de mise en service
WO2008068525A1 (fr) * 2006-12-06 2008-06-12 Thomas Fergus Hughes Dispositif et procédé pour orienter une pluralité de cassettes pour des échantillons de laboratoire
WO2008149169A1 (fr) * 2007-06-08 2008-12-11 3Dhistech Kft. Système pour manipuler des diapositives
EP2787339A3 (fr) * 2013-04-05 2015-02-11 GG&B Company Appareil de traitement de lames multiples
CN114506668A (zh) * 2022-02-18 2022-05-17 赛轮集团股份有限公司 运输装置及具有其的存放设备
RU2820112C1 (ru) * 2020-01-15 2024-05-29 Филип Моррис Продактс С.А. Способ формирования пар пачек
IT202300015078A1 (it) * 2023-07-18 2025-01-18 Cheddite Italy S R L Un dispositivo per l’avanzamento di cartucce sotto una stazione di lavorazione

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857272A (en) * 1985-06-21 1989-08-15 Fuji Photo Film Co., Ltd. Chemical assay system
US4857471A (en) * 1987-07-20 1989-08-15 Eastman Kodak Company Analyzer with wash station separate from incubator
US5149654A (en) * 1989-11-21 1992-09-22 Hoechst Aktiengesellschaft Incubation device for microtiter plates
US5209903A (en) * 1989-09-06 1993-05-11 Toa Medical Electronics, Co., Ltd. Synthetic apparatus for inspection of blood
US5324957A (en) * 1993-06-30 1994-06-28 Eastman Kodak Company Belt position sensor
US5419871A (en) * 1994-04-29 1995-05-30 Muszak; Martin F. Analyzer elevator assembly
US5447690A (en) * 1992-01-16 1995-09-05 Fuji Photo Film Co., Ltd. Chemical analysis system

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857272A (en) * 1985-06-21 1989-08-15 Fuji Photo Film Co., Ltd. Chemical assay system
US4857471A (en) * 1987-07-20 1989-08-15 Eastman Kodak Company Analyzer with wash station separate from incubator
US5209903A (en) * 1989-09-06 1993-05-11 Toa Medical Electronics, Co., Ltd. Synthetic apparatus for inspection of blood
US5149654A (en) * 1989-11-21 1992-09-22 Hoechst Aktiengesellschaft Incubation device for microtiter plates
US5447690A (en) * 1992-01-16 1995-09-05 Fuji Photo Film Co., Ltd. Chemical analysis system
US5324957A (en) * 1993-06-30 1994-06-28 Eastman Kodak Company Belt position sensor
US5419871A (en) * 1994-04-29 1995-05-30 Muszak; Martin F. Analyzer elevator assembly

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2782800A1 (fr) * 1998-09-01 2000-03-03 Abx Sa Dispositif pour la preparation automatique d'etalements sanguins sur des lames
EP0984263A1 (fr) * 1998-09-01 2000-03-08 A B X Dispositif pour la préparation automatique d'étalements sanguins sur des lames
US6319470B1 (en) 1998-09-01 2001-11-20 Abx Device for automatic preparation of blood smears on plates
WO2001002867A1 (fr) * 1999-07-03 2001-01-11 Janssen Pharmaceutica N.V. Dispositif servant a transporter des supports vers un poste de traitement et son procede de mise en service
US8651045B2 (en) 2006-12-06 2014-02-18 Raymond A. Lamb Limited Device and method for orientating a plurality of cassettes for laboratory samples
WO2008068525A1 (fr) * 2006-12-06 2008-06-12 Thomas Fergus Hughes Dispositif et procédé pour orienter une pluralité de cassettes pour des échantillons de laboratoire
WO2008149169A1 (fr) * 2007-06-08 2008-12-11 3Dhistech Kft. Système pour manipuler des diapositives
EP2787339A3 (fr) * 2013-04-05 2015-02-11 GG&B Company Appareil de traitement de lames multiples
US9091621B2 (en) 2013-04-05 2015-07-28 GGB Company Multiple slide processing apparatus
US9435720B2 (en) 2013-04-05 2016-09-06 Hardy Diagnostics Multiple slide processing apparatus
RU2820112C1 (ru) * 2020-01-15 2024-05-29 Филип Моррис Продактс С.А. Способ формирования пар пачек
CN114506668A (zh) * 2022-02-18 2022-05-17 赛轮集团股份有限公司 运输装置及具有其的存放设备
CN114506668B (zh) * 2022-02-18 2024-03-22 赛轮集团股份有限公司 运输装置及具有其的存放设备
IT202300015078A1 (it) * 2023-07-18 2025-01-18 Cheddite Italy S R L Un dispositivo per l’avanzamento di cartucce sotto una stazione di lavorazione

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Publication number Publication date
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