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WO1997034627A3 - Protection de cellules hematopoietiques durant une chimiotherapie ou une radiotherapie - Google Patents

Protection de cellules hematopoietiques durant une chimiotherapie ou une radiotherapie Download PDF

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Publication number
WO1997034627A3
WO1997034627A3 PCT/IB1997/000499 IB9700499W WO9734627A3 WO 1997034627 A3 WO1997034627 A3 WO 1997034627A3 IB 9700499 W IB9700499 W IB 9700499W WO 9734627 A3 WO9734627 A3 WO 9734627A3
Authority
WO
WIPO (PCT)
Prior art keywords
radiotherapy
hemopoietic cells
cells during
protection
during chemotherapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB1997/000499
Other languages
English (en)
Other versions
WO1997034627A2 (fr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of WO1997034627A2 publication Critical patent/WO1997034627A2/fr
Publication of WO1997034627A3 publication Critical patent/WO1997034627A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur un procédé permettant de stimuler la régénération de cellules hématopoïétiques chez un patient soumis à une chimiothérapie ou à une radiothérapie. Ce procédé consiste à administrer à ce patient un inhibiteur de l'enzyme de conversion de l'angiotensine, ceci sous un volume propre à réduire la prolifération de cellules hématopoïétiques durant la chimiothérapie ou la radiothérapie ou à la suite de celles-ci.
PCT/IB1997/000499 1996-03-19 1997-03-19 Protection de cellules hematopoietiques durant une chimiotherapie ou une radiotherapie Ceased WO1997034627A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61648996A 1996-03-19 1996-03-19
US08/616,489 1996-03-19

Publications (2)

Publication Number Publication Date
WO1997034627A2 WO1997034627A2 (fr) 1997-09-25
WO1997034627A3 true WO1997034627A3 (fr) 1997-12-18

Family

ID=24469683

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1997/000499 Ceased WO1997034627A2 (fr) 1996-03-19 1997-03-19 Protection de cellules hematopoietiques durant une chimiotherapie ou une radiotherapie

Country Status (1)

Country Link
WO (1) WO1997034627A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852316B2 (en) 1998-08-18 2005-02-08 Queen Mary & Westfield College Cancer treatment

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335195B1 (en) 1997-01-28 2002-01-01 Maret Corporation Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
US6455500B1 (en) 1998-03-10 2002-09-24 University Of Southern California Radiation therapy methods
US7173011B2 (en) 2000-11-20 2007-02-06 University Of Southern California Radiation therapy methods
JP3728400B2 (ja) * 1998-03-10 2005-12-21 ユニヴァースティ オブ サザーン カリフォルニア 改良型放射線治療の諸方法
WO1999058140A1 (fr) * 1998-05-11 1999-11-18 University Of Southern California Procede d'augmentation du taux de survie des globules blancs apres une chimiotherapie
US6762167B1 (en) 1998-05-11 2004-07-13 University Of Southern California Methods for treating a patient undergoing chemotherapy
US7338938B2 (en) 1999-05-10 2008-03-04 University Of Southern California Methods for treating a patient undergoing chemotherapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114926A (en) * 1986-07-18 1992-05-19 Institut National De La Sante Et De La Recherche Medicale Tetrapeptide inhibiting the entry into cycle of hemopoietic stem cells processes for its preparation, and its uses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114926A (en) * 1986-07-18 1992-05-19 Institut National De La Sante Et De La Recherche Medicale Tetrapeptide inhibiting the entry into cycle of hemopoietic stem cells processes for its preparation, and its uses

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AZIZI M ET AL: "Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline", JOURNAL OF CLINICAL INVESTIGATION, 97 (3). 1996. 839-844., XP002042150 *
MOORE M A S ET AL: "SYNERGY OF INTERLEUKIN 1 AND GRANULOCYTE COLONY-STIMULATING FACTOR IN-VIVO STIMULATION OF STEM-CELL RECOVERY AND HEMATOPOIETIC REGENERATION FOLLOWING 5 FLUOROURACIL TREATMENT OF MICE", PROC NATL ACAD SCI U S A, 84 (20). 1987. 7134-7138., XP002042152 *
MOULDER, JOHN E. ET AL: "Prophylaxis of bone marrow transplant nephropathy with captopril, an inhibitor of angiotensin-converting enzyme", RADIAT. RES., 1993, 136, 404-7, XP002042154 *
RIEGER K-J ET AL: "Involvement of human plasma angiotensin I-converting enzyme in the degradation of the haemoregulatory peptide N-acetyl-seryl-aspartyl-lysyl-proline", BIOCHEMICAL JOURNAL, 296 (2). 1993. 373-378., XP002042151 *
ROUSSEAU A ET AL: "The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme", JOURNAL OF BIOLOGICAL CHEMISTRY, 270 (8). 1995. 3656-3661., XP002042153 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852316B2 (en) 1998-08-18 2005-02-08 Queen Mary & Westfield College Cancer treatment

Also Published As

Publication number Publication date
WO1997034627A2 (fr) 1997-09-25

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