WO1997033622B1 - Apport d'acides nucleiques par des porphyrines - Google Patents
Apport d'acides nucleiques par des porphyrinesInfo
- Publication number
- WO1997033622B1 WO1997033622B1 PCT/US1997/004000 US9704000W WO9733622B1 WO 1997033622 B1 WO1997033622 B1 WO 1997033622B1 US 9704000 W US9704000 W US 9704000W WO 9733622 B1 WO9733622 B1 WO 9733622B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- poφhyrin
- oligonucleotide
- composition
- macrocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
L'invention porte sur d'utiles méthodes et compositions d'apport ciblé de concentrations efficaces de composés comprenant des molécules d'acides nucléiques et d'oligonucléotides tels que des séquences guides extérieures (EGS), des ribozymes et des oligonucléotides antisens, des protéines, des peptides, des hydrates de carbone, des molécules organiques ou non organiques de synthèse, ou leurs combinaisons, à des cellules et en particulier à des hépatocytes. Dans le mode de réalisation préféré, le composé est un oligonucléotide chargé négativement qui se fixe dans un rapport stoechiométrique à un macrocycle hydrosoluble chargé positivement tel qu'une porphyrine, ciblant et protégeant l'oligonucléotide. La porphyrine protège le composé à apporter et apporte le composé de préférence à certains types de cellules et de tissus. Dans une variante, la porphyrine qui agit contre le virus de l'hépatite humain lorsqu'on l'administre seule, voit son activité substantiellement augmentée lorsqu'elle est administrée en combinaison avec un composé antiviral, en particulier un oligonucléotide.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU23244/97A AU2324497A (en) | 1996-03-14 | 1997-03-14 | Delivery of nucleic acids by porphyrins |
| EP97915946A EP0894011A2 (fr) | 1996-03-14 | 1997-03-14 | Apport d'acides nucleiques par des porphyrines |
| US08/912,378 US6610478B1 (en) | 1996-08-16 | 1997-08-15 | Phenotypic conversion of cells mediated by external guide sequences |
| US09/627,562 US6558954B1 (en) | 1996-08-16 | 2000-07-28 | Phenotypic conversion of cells mediated by external guide sequences |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/616,141 US6620805B1 (en) | 1996-03-14 | 1996-03-14 | Delivery of nucleic acids by porphyrins |
| US08/616,141 | 1996-03-14 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US08/912,378 Continuation-In-Part US6610478B1 (en) | 1996-08-16 | 1997-08-15 | Phenotypic conversion of cells mediated by external guide sequences |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1997033622A2 WO1997033622A2 (fr) | 1997-09-18 |
| WO1997033622A3 WO1997033622A3 (fr) | 1998-02-26 |
| WO1997033622B1 true WO1997033622B1 (fr) | 1998-04-16 |
Family
ID=24468218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/004000 Ceased WO1997033622A2 (fr) | 1996-03-14 | 1997-03-14 | Apport d'acides nucleiques par des porphyrines |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6620805B1 (fr) |
| EP (1) | EP0894011A2 (fr) |
| AU (1) | AU2324497A (fr) |
| WO (1) | WO1997033622A2 (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6610478B1 (en) | 1996-08-16 | 2003-08-26 | Yale University | Phenotypic conversion of cells mediated by external guide sequences |
| AU4071197A (en) * | 1996-08-16 | 1998-03-06 | Yale University | Phenotypic conversion of drug-resistant bacteria to drug-sensitivity |
| AU3984497A (en) * | 1996-08-16 | 1998-03-06 | Innovir Laboratories, Inc. | Phenotypic conversion of cells mediated by external guide sequences |
| EP0855184A1 (fr) * | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Composition pharmaceutique comprenant un polynucléotide et un antigène notamment pour la vaccination |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US20020155999A1 (en) * | 1998-04-30 | 2002-10-24 | Han In Suk | Method of using a porphyrin-like molecule conjugated with an anti-cancer drug for the treatment of cancer |
| US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| JP4308015B2 (ja) * | 2001-12-20 | 2009-08-05 | サソル テクノロジー （ピーティーワイ）リミテッド | クロムを主成分とした触媒を使用したオレフィン類の三量化およびオリゴマー化 |
| US20050048641A1 (en) * | 2002-11-26 | 2005-03-03 | Medtronic, Inc. | System and method for delivering polynucleotides to the central nervous system |
| WO2004053104A2 (fr) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | Acides nucleiques 5'cpg et leurs methodes d'utilisation |
| GB2397067B (en) * | 2002-12-23 | 2005-05-11 | Destiny Pharma Ltd | Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation |
| US7109173B1 (en) | 2004-03-16 | 2006-09-19 | Wilbert Gamble | Transport of nucleotides, oligonucleotides and polynucleotides into the cytoplasm and nucleus of cells by peptides |
| GB2415372A (en) | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
| US20070036740A1 (en) * | 2004-10-06 | 2007-02-15 | Reed Kenneth C | Modulation of hair growth |
| AU2005299672A1 (en) * | 2004-10-22 | 2006-05-04 | Benitec, Inc. | Therapeutic RNAi agents for treating psoriasis |
| US20070004040A1 (en) * | 2005-01-06 | 2007-01-04 | Brashears Sarah J | RNAi agents for maintenance of stem cells |
| US20070128116A1 (en) * | 2005-07-27 | 2007-06-07 | Wang Zheng J | Multifunctional core for molecular imaging and targeted delivery of macromolecules and drugs |
| GB0519169D0 (en) * | 2005-09-21 | 2005-10-26 | Leuven K U Res & Dev | Novel anti-viral strategy |
| CA2628300C (fr) | 2005-11-02 | 2018-04-17 | Protiva Biotherapeutics, Inc. | Molecules d'arnsi modifiees et utilisations de celles-ci |
| WO2009082817A1 (fr) | 2007-12-27 | 2009-07-09 | Protiva Biotherapeutics, Inc. | Silençage de l'expression de la polo-like kinase à l'aide d'un arn interférent |
| AU2009236219B8 (en) | 2008-04-15 | 2015-06-25 | Arbutus Biopharma Corporation | Silencing of CSN5 gene expression using interfering RNA |
| US20130164380A1 (en) | 2010-06-17 | 2013-06-27 | Actogenix Nv | Compositions and methods for treating inflammatory conditions |
| US20150240238A1 (en) | 2011-11-17 | 2015-08-27 | The Regents Of The University Of California | Therapeutic rna switches compositions and methods of use |
| US9035039B2 (en) | 2011-12-22 | 2015-05-19 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing SMAD4 |
| MX2014010016A (es) | 2012-02-21 | 2015-06-05 | Inst Nat Sante Rech Med | Receptores de mucina de inmunoglobulina de celula t (tim) como co-factores de entrada del virus. |
| US20160015808A1 (en) | 2012-02-21 | 2016-01-21 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Tam receptors as virus entry cofactors |
| CN104736563A (zh) | 2012-07-27 | 2015-06-24 | 国家健康与医学研究院 | Cd147作为受体用于脑膜炎球菌至血管内皮的菌毛介导的粘附 |
| WO2015019548A1 (fr) * | 2013-08-05 | 2015-02-12 | パナソニック株式会社 | Procédé permettant d'inhiber la réaction de dégradation de l'adn, et inhibiteur de la réaction de dégradation de l'adn |
| EP3201338B1 (fr) | 2014-10-02 | 2021-11-03 | Arbutus Biopharma Corporation | Compositions et méthodes d'extinction de l'expression du gène du virus de l'hépatite b |
| WO2016197132A1 (fr) | 2015-06-04 | 2016-12-08 | Protiva Biotherapeutics Inc. | Traitement d'une infection à virus de l'hépatite b à de l'aide de crispr |
| HK1248278A1 (zh) | 2015-07-29 | 2018-10-12 | Arbutus Biopharma Corporation | 用於使乙型肝炎病毒基因表达沉默的组合物及方法 |
| US20210284733A1 (en) | 2016-08-22 | 2021-09-16 | Arbutus Biopharma Corporation | Anti-pd-1 antibodies, or fragments thereof, for treating hepatitis b |
| WO2018038155A1 (fr) * | 2016-08-23 | 2018-03-01 | 国立大学法人東京大学 | Micelle et utilisation de cette dernière |
| US20200352913A1 (en) | 2017-11-23 | 2020-11-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating dengue virus infection |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4104466A (en) | 1974-03-13 | 1978-08-01 | Eishun Tsuchida | Polymeric metal complex and method of manufacturing the same |
| IL69720A (en) | 1983-09-14 | 1987-08-31 | Univ Ramot | Anti-tumor pharmaceutical compositions comprising liposome-bound porphyrins |
| FR2567892B1 (fr) | 1984-07-19 | 1989-02-17 | Centre Nat Rech Scient | Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| GB2213684A (en) | 1987-12-11 | 1989-08-16 | Philips Electronic Associated | Data demodulator baud clock phase locking |
| ATE115999T1 (de) | 1987-12-15 | 1995-01-15 | Gene Shears Pty Ltd | Ribozyme. |
| US5192788A (en) * | 1988-05-23 | 1993-03-09 | Georgia State University Foundation, Inc. | Porphyrin antiviral compositions |
| FR2632187B1 (fr) | 1988-06-02 | 1990-09-14 | Centre Nat Rech Scient | Derives de metalloporphyrines, leur preparation, leur application en therapeutique et leur utilisation pour la preparation de molecules hybrides |
| US5225337A (en) | 1989-09-25 | 1993-07-06 | Innovir Laboratories, Inc. | Ribozyme compositions and methods for use |
| AU659482B2 (en) | 1991-06-28 | 1995-05-18 | Massachusetts Institute Of Technology | Localized oligonucleotide therapy |
| US5607924A (en) | 1992-01-21 | 1997-03-04 | Pharmacyclics, Inc. | DNA photocleavage using texaphyrins |
| FR2697254A1 (fr) | 1992-10-22 | 1994-04-29 | Genset Sa | Conjugués constitués par un oligonucléotide lié à des dérivés de métalloporphyrine cationique, leur préparation et leur utilisation. |
| US6012375A (en) | 1993-07-06 | 2000-01-11 | Eckstein; Donald B. | Aircraft infrared guided defense missile system |
| CA2183992A1 (fr) | 1994-02-23 | 1995-08-31 | Dan T. Stinchcomb | Procede et reactif inhibiteur de l'expression de genes concernant une affection |
| US5691316A (en) | 1994-06-01 | 1997-11-25 | Hybridon, Inc. | Cyclodextrin cellular delivery system for oligonucleotides |
| AU2816195A (en) | 1994-06-02 | 1996-01-04 | Bar-Ilan University | Synergistic antibiotic compositions containing a perphyrin and an antibiotic |
-
1996
- 1996-03-14 US US08/616,141 patent/US6620805B1/en not_active Expired - Lifetime
-
1997
- 1997-03-14 AU AU23244/97A patent/AU2324497A/en not_active Abandoned
- 1997-03-14 EP EP97915946A patent/EP0894011A2/fr not_active Withdrawn
- 1997-03-14 WO PCT/US1997/004000 patent/WO1997033622A2/fr not_active Ceased
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