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WO1997032998A3 - Materials and methods relating to the identification of a polymorphism associated with disease susceptibility - Google Patents

Materials and methods relating to the identification of a polymorphism associated with disease susceptibility Download PDF

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Publication number
WO1997032998A3
WO1997032998A3 PCT/GB1997/000637 GB9700637W WO9732998A3 WO 1997032998 A3 WO1997032998 A3 WO 1997032998A3 GB 9700637 W GB9700637 W GB 9700637W WO 9732998 A3 WO9732998 A3 WO 9732998A3
Authority
WO
WIPO (PCT)
Prior art keywords
vdr
gene
common allele
polymorphism
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1997/000637
Other languages
French (fr)
Other versions
WO1997032998A2 (en
Inventor
Adrian Hill
Richard Bellamy
Cyril Ruwende
Hilton Whittle
Suchismita Roy
Mark Thursz
Suleman Ali
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9604985.3A external-priority patent/GB9604985D0/en
Priority claimed from GBGB9621866.4A external-priority patent/GB9621866D0/en
Priority claimed from GBGB9701919.4A external-priority patent/GB9701919D0/en
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Priority to AU21019/97A priority Critical patent/AU2101997A/en
Publication of WO1997032998A2 publication Critical patent/WO1997032998A2/en
Publication of WO1997032998A3 publication Critical patent/WO1997032998A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The inventors have found a highly significant association between homozygotes (designated tt) for the less common allele t of the Taq1 VDR polymorphism and susceptibility to autoimmune infectious diseases such as tuberculosis, hepatitis B, leprosy, HIV-1. There is provided a method for the determination of an individual's susceptibility level to autoimmune disease or infectious disease which comprises obtaining a sample of tissue from the individual; obtaining from the tissue sample a test sample comprising nuclear material from cells of the tissue sample; establishing the individuals vitamin D receptor (VDR) genotype, namely establishing whether or not the individual is: homozygous or heterozygous for a less common allele of the gene for the vitamin D receptor (VDR) and wherein said less common allele of the VDR gene comprises the polymorphisms B and A in intron 8 of the VDR gene and the polymorphism t in exon 9 of the VDR gene; or homozygous for a more common allele of the VDR gene and wherein said more common allele of the VDR gene comprises the polymorphisms b and a in intron 8 of the VDR gene and the polymorphism T in exon 9 of the VDR gene and wherein the genotype in relation to the VDR is specifically associated with susceptibility level to one or more autoimmune or infectious diseases.
PCT/GB1997/000637 1996-03-08 1997-03-10 Materials and methods relating to the identification of a polymorphism associated with disease susceptibility Ceased WO1997032998A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU21019/97A AU2101997A (en) 1996-03-08 1997-03-10 Materials and methods relating to the identification of a polymorphism associated with disease susceptibility

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9604985.3A GB9604985D0 (en) 1996-03-08 1996-03-08 Materials and methods relating to the diagnosis of susceptibility to and the prophylactic and therapeutic treatment of certain diseases
GB9604985.3 1996-03-08
GB9621866.4 1996-10-21
GBGB9621866.4A GB9621866D0 (en) 1996-10-21 1996-10-21 Materials and methods relating to the diagnosis and prophylactic and therapeutic treatment of hepatitis B virus infection and leprosy
GBGB9701919.4A GB9701919D0 (en) 1997-01-30 1997-01-30 Materials and methods relating to the diagnosis of susceptibility to HIV-1 infection and to treatment methods related to HIV-1
GB9701919.4 1997-01-30

Publications (2)

Publication Number Publication Date
WO1997032998A2 WO1997032998A2 (en) 1997-09-12
WO1997032998A3 true WO1997032998A3 (en) 1997-10-30

Family

ID=27268174

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/000637 Ceased WO1997032998A2 (en) 1996-03-08 1997-03-10 Materials and methods relating to the identification of a polymorphism associated with disease susceptibility

Country Status (2)

Country Link
AU (1) AU2101997A (en)
WO (1) WO1997032998A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000015836A2 (en) * 1998-09-15 2000-03-23 Signalgene Inc. Combination of markers at the estrogen- and vitamin d-receptor genes or equivalents thereof to prognose a response to osteoporosis therapy
WO2006094103A2 (en) * 2005-03-01 2006-09-08 President And Fellows Of Harvard College Methods for treating and diagnosing susceptibility to cytosolic pathogens

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006754A1 (en) * 1988-12-14 1990-06-28 Teijin Limited Active vitamin d for chronic hepatitis treatment
WO1994003633A1 (en) * 1992-07-31 1994-02-17 Garvan Institute Of Medical Research Assessment of trans-acting factors allelic variation
WO1994007853A1 (en) * 1992-10-06 1994-04-14 Schering Aktiengesellschaft 25-carboxylic acid derivatives in the vitamin d series, method of producing them, intermediate products for this method, pharmaceutical preparations containing these derivatives and their use in the manufacture of medicines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006754A1 (en) * 1988-12-14 1990-06-28 Teijin Limited Active vitamin d for chronic hepatitis treatment
WO1994003633A1 (en) * 1992-07-31 1994-02-17 Garvan Institute Of Medical Research Assessment of trans-acting factors allelic variation
WO1994007853A1 (en) * 1992-10-06 1994-04-14 Schering Aktiengesellschaft 25-carboxylic acid derivatives in the vitamin d series, method of producing them, intermediate products for this method, pharmaceutical preparations containing these derivatives and their use in the manufacture of medicines

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MORRISON ET AL.: "PREDICTION OF BONE DENSITY FROM VITAMIN D RECEPTOR ALLELES", NATURE, vol. 367, 1994, pages 284 - 287, XP002040320 *
MORRISON N A ET AL: "CONTRIBUTION OF TRANS-ACTING FACTOR ALLELES TO NORMAL PHYSIOLOGICAL VARIABILITY: VITAMIN D RECEPTOR GENE POLYMORPHISMS AND CIRCULATING OSTEOCALCIN", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 89, no. 15, 1 August 1992 (1992-08-01), pages 6665 - 6669, XP000569585 *
ROOK ET AL.: "THE ROLE OF GAMMA-INTERFERON, VITAMIN D3 METABOLITES AND TUMOUR NECROSIS FACTOR IN THE PATHOGENESIS OF TUBERCULOSIS", IMMUNOLOGY, vol. 62, 1987, pages 229 - 234, XP002040321 *

Also Published As

Publication number Publication date
WO1997032998A2 (en) 1997-09-12
AU2101997A (en) 1997-09-22

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