WO1997032891B1 - Conjugue pour influer sur les interactions entre des proteines - Google Patents
Conjugue pour influer sur les interactions entre des proteinesInfo
- Publication number
- WO1997032891B1 WO1997032891B1 PCT/DE1997/000458 DE9700458W WO9732891B1 WO 1997032891 B1 WO1997032891 B1 WO 1997032891B1 DE 9700458 W DE9700458 W DE 9700458W WO 9732891 B1 WO9732891 B1 WO 9732891B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- conjugate
- receptor
- polypeptides
- conjugate according
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
La présente invention concerne un conjugué comprenant deux polypeptides qui présentent une affinité mutuelle et sont reliées l'une à l'autre par un segment de liaison. L'invention concerne en outre l'utilisation d'un tel conjugué pour influer sur les interactions entre des protéines.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53135697A JP4301575B2 (ja) | 1996-03-07 | 1997-03-07 | 蛋白質間の相互作用に影響を及ぼすためのコンジュゲート |
| AT97919258T ATE229542T1 (de) | 1996-03-07 | 1997-03-07 | Fusionspolypeptid zur beeinflussung von wechselwirkungen zwischen proteinen |
| DE59708952T DE59708952D1 (de) | 1996-03-07 | 1997-03-07 | Fusionspolypeptid zur beeinflussung von wechselwirkungen zwischen proteinen |
| DK97919258T DK0888384T3 (da) | 1996-03-07 | 1997-03-07 | Fusionspolypeptid til påvirkning af vekselvirkninger mellem proteiner |
| EP97919258A EP0888384B1 (fr) | 1996-03-07 | 1997-03-07 | Polypeptide de fusion pour influer sur les interactions entre des proteine |
| US09/142,471 US7112436B1 (en) | 1996-03-07 | 1997-03-07 | Conjugate for modifying interactions between proteins |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19608813.5 | 1996-03-07 | ||
| DE19608813A DE19608813C2 (de) | 1996-03-07 | 1996-03-07 | Konjugat zur Beeinflussung von Wechselwirkungen zwischen Proteinen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1997032891A2 WO1997032891A2 (fr) | 1997-09-12 |
| WO1997032891A3 WO1997032891A3 (fr) | 1998-02-05 |
| WO1997032891B1 true WO1997032891B1 (fr) | 1998-03-19 |
Family
ID=7787490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/DE1997/000458 Ceased WO1997032891A2 (fr) | 1996-03-07 | 1997-03-07 | Conjugue pour influer sur les interactions entre des proteines |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7112436B1 (fr) |
| EP (1) | EP0888384B1 (fr) |
| JP (1) | JP4301575B2 (fr) |
| AT (1) | ATE229542T1 (fr) |
| DE (2) | DE19608813C2 (fr) |
| DK (1) | DK0888384T3 (fr) |
| ES (1) | ES2188935T3 (fr) |
| PT (1) | PT888384E (fr) |
| WO (1) | WO1997032891A2 (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6217858B1 (en) | 1997-02-11 | 2001-04-17 | Hadasit & Medical Research Services & Development Company, Ltd. | Pharmaceutical composition for treating hepatitis B virus (HBV) infection |
| IL122818A0 (en) * | 1997-07-10 | 1998-08-16 | Yeda Res & Dev | Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof |
| WO2001096565A2 (fr) * | 2000-06-16 | 2001-12-20 | Asterion Limited | Liant |
| DE10107737A1 (de) * | 2001-02-16 | 2002-09-05 | S Rose John Christian Albrecht | Verwendung eines Konjugats aus IL-6 und einem IL-6 Rezeptor zur Tumortherapie |
| EP1499332A4 (fr) * | 2002-04-29 | 2006-12-06 | Hadasit Med Res Service | Compositions et methodes de traitement du cancer avec un agent oncolytique viral |
| EP1400587A1 (fr) * | 2002-09-19 | 2004-03-24 | MainGen Biotechnologie GmbH | Utilisation de polypeptide de fusion pour l'obtention de cellules souches pluripontentes non embryonales |
| IL161672A0 (en) | 2004-04-29 | 2004-09-27 | Yeda Res & Dev | Compositions and methods for therapy of chemotherapy-induced neuropathy |
| EP1598364A1 (fr) * | 2004-05-21 | 2005-11-23 | AGIRx Limited | Recepteur chimérique soluble hyper IL-11 et son utilisation |
| DE102004033122A1 (de) * | 2004-07-08 | 2006-02-09 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Vorrichtung und Verfahren zur Analyse von Wechselwirkungen zwischen Biomolekülen |
| CA2608474C (fr) | 2005-05-17 | 2019-11-12 | University Of Connecticut | Compositions et methodes d'immunomodulation d'un organisme |
| WO2006134601A2 (fr) | 2005-06-16 | 2006-12-21 | Hadasit Medical Research Services And Development Ltd. | Procedes pour le traitement d'insuffisance renale |
| EP1777294A1 (fr) * | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Le domaine sushi de IL-15Ralpha comme enhancer sélectif et efficace de l'action de f IL-15 grâce à IL-15Rbeta/gamma, et l' hyperagoniste (IL15Ralpha sushi -IL15) comme protéine fusion |
| JP5709356B2 (ja) | 2006-01-13 | 2015-04-30 | アメリカ合衆国 | 哺乳動物細胞における発現のためのコドン最適化IL−15およびIL−15R−α遺伝子 |
| EP2097517B1 (fr) | 2006-10-16 | 2014-06-04 | Genelux Corporation | Virus recombinant de la vaccine de souche Lister codant pour un anticorps anti-VEGF à chaîne unique |
| US9931377B2 (en) | 2007-06-27 | 2018-04-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cell expressing complexes of IL-15 and IL-15Ralpha |
| CN101827857A (zh) * | 2007-08-03 | 2010-09-08 | 埃斯特瑞恩有限公司 | 粒细胞集落刺激因子 |
| GB0715213D0 (en) * | 2007-08-06 | 2007-09-12 | Asterlon Ltd | Igf-1 |
| EP2217264B8 (fr) * | 2007-11-28 | 2013-02-27 | Hadasit Medical Research Services and Development Ltd. | UTILISATION D'UN COMPLEXE iIL-6/RÉCEPTEUR D'IL-6 POUR PRÖVENIR LA XÉROSTOMIE INDUITE PAR LA RADIOTHÉRAPIE OU LA CHIMIOTHÉRAPIE |
| EP2300023A2 (fr) * | 2008-05-16 | 2011-03-30 | Genelux Corporation | Microorganismes pour la prévention et le traitement de néoplasmes accompagnant une thérapie cellulaire |
| EP2387415A1 (fr) * | 2009-01-16 | 2011-11-23 | AGIRx Limited | Compositions vaccinales |
| US8871191B2 (en) | 2009-08-14 | 2014-10-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of IL-15 preparations to treat lymphopenia |
| WO2011151716A1 (fr) | 2010-06-04 | 2011-12-08 | Lupin Limited | Procédé de purification d'il-11 humaine recombinante |
| JP6280031B2 (ja) | 2012-03-29 | 2018-02-14 | 中外製薬株式会社 | 抗lamp5抗体およびその利用 |
| JP2016518361A (ja) | 2013-04-19 | 2016-06-23 | シーチューヌ ファルマCytune Pharma | 血管漏出症候群の発生を抑制するサイトカイン治療 |
| EP2915569A1 (fr) | 2014-03-03 | 2015-09-09 | Cytune Pharma | Procédé de purification de conjugués à base Il -15/IL-15Ralpha |
| EP2992898A1 (fr) | 2014-09-04 | 2016-03-09 | Klinikum rechts der Isar der Technischen Universität München | Adjuvant pour lymphocyte T utiles pour la vaccination thérapeutique ou prophylactique |
| CN110055224B (zh) * | 2019-04-03 | 2023-06-30 | 深圳市体内生物医药科技有限公司 | 一种基因修饰的免疫细胞及其制备方法和应用 |
| EP3875111A1 (fr) | 2020-03-05 | 2021-09-08 | Poznan University Of Medical Sciences | Composition de vaccin contre le cancer de cellules souches |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| GB9324807D0 (en) * | 1993-12-03 | 1994-01-19 | Cancer Res Campaign Tech | Tumour antibody |
| ES2152424T5 (es) * | 1994-07-29 | 2010-07-05 | Sunol Molecular Corporation | Complejos del mhc y usos de los mismos. |
-
1996
- 1996-03-07 DE DE19608813A patent/DE19608813C2/de not_active Expired - Fee Related
-
1997
- 1997-03-07 EP EP97919258A patent/EP0888384B1/fr not_active Expired - Lifetime
- 1997-03-07 DK DK97919258T patent/DK0888384T3/da active
- 1997-03-07 ES ES97919258T patent/ES2188935T3/es not_active Expired - Lifetime
- 1997-03-07 JP JP53135697A patent/JP4301575B2/ja not_active Expired - Fee Related
- 1997-03-07 WO PCT/DE1997/000458 patent/WO1997032891A2/fr not_active Ceased
- 1997-03-07 US US09/142,471 patent/US7112436B1/en not_active Expired - Fee Related
- 1997-03-07 DE DE59708952T patent/DE59708952D1/de not_active Expired - Lifetime
- 1997-03-07 PT PT97919258T patent/PT888384E/pt unknown
- 1997-03-07 AT AT97919258T patent/ATE229542T1/de active
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