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WO1997032885B1 - Synthese de l'isoimide de substances chlorees et bacteriochlorees et leur utilisation pour le diagnostic et le traitement du cancer - Google Patents

Synthese de l'isoimide de substances chlorees et bacteriochlorees et leur utilisation pour le diagnostic et le traitement du cancer

Info

Publication number
WO1997032885B1
WO1997032885B1 PCT/US1997/003891 US9703891W WO9732885B1 WO 1997032885 B1 WO1997032885 B1 WO 1997032885B1 US 9703891 W US9703891 W US 9703891W WO 9732885 B1 WO9732885 B1 WO 9732885B1
Authority
WO
WIPO (PCT)
Prior art keywords
purpurin
imide
group
alkyl
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/003891
Other languages
English (en)
Other versions
WO1997032885A1 (fr
WO1997032885A9 (fr
Filing date
Publication date
Priority claimed from US08/613,134 external-priority patent/US5770730A/en
Application filed filed Critical
Publication of WO1997032885A1 publication Critical patent/WO1997032885A1/fr
Publication of WO1997032885B1 publication Critical patent/WO1997032885B1/fr
Publication of WO1997032885A9 publication Critical patent/WO1997032885A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

Composés pouvant servir de composés absorbant la lumière, tout particulièrement utiles dans le domaine de la thérapie photodynamique. De tels composés ont la formule (I) où z désigne =O ou NR14; où R14 représente alkyle ou alkyle substitué; où R1 est un groupe amino-acide, polyamine, polyéther ou bien OR13, où R13 est alkyle; R4 à R11 représentent -H, -OH, alkyle, alkylène ou bien -OR16, où R16 est H, alkyle, aryle, carbonyle ou bien un groupe contenant un carbonyle, à condition que R4 puisse être pris avec R5 pour former =O; que R6 puisse être pris avec R7 pour former =O; que R8 puisse être pris avec R9 pour former =O; que R10 puisse être pris avec R11 pour former =O; que R4 et R7 puissent former une liaison chimique; que R8 et R11 puissent former une liaison chimique; que R12 soit l'hydrogène ou un alkyle de faible masse moléculaire; et que si le premier z représente 0, le deuxième est NR14.
PCT/US1997/003891 1996-03-08 1997-03-07 Synthese de l'isoimide de substances chlorees et bacteriochlorees et leur utilisation pour le diagnostic et le traitement du cancer Ceased WO1997032885A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/613,134 US5770730A (en) 1996-03-08 1996-03-08 Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer
US08/613,134 1996-03-08
US08/812,029 1997-03-06

Publications (3)

Publication Number Publication Date
WO1997032885A1 WO1997032885A1 (fr) 1997-09-12
WO1997032885B1 true WO1997032885B1 (fr) 1997-11-06
WO1997032885A9 WO1997032885A9 (fr) 1997-12-18

Family

ID=24456008

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/003891 Ceased WO1997032885A1 (fr) 1996-03-08 1997-03-07 Synthese de l'isoimide de substances chlorees et bacteriochlorees et leur utilisation pour le diagnostic et le traitement du cancer

Country Status (2)

Country Link
US (2) US5770730A (fr)
WO (1) WO1997032885A1 (fr)

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USRE38994E1 (en) 1988-07-20 2006-02-28 Health Research, Inc. Pyropheophorbides conjugates and their use in photodynamic therapy
USRE39094E1 (en) 1988-07-20 2006-05-09 Health Research, Inc. Pyropheophorbides and their use in photodynamic therapy
US5952366A (en) * 1996-03-08 1999-09-14 Health Research, Inc. Alkyl ether analogs of chlorins having an N-substituted imide ring
JP3613599B2 (ja) * 1996-10-01 2005-01-26 ワイス株式会社 イミノクロリンアスパラギン酸誘導体
CA2221912A1 (fr) * 1997-11-21 1999-05-21 David Dolphin Agents photosensibilisants dont les proprietes de biodistribution et d'absorption de lumiere sont ameliorees
DE19814405C2 (de) 1998-03-31 2000-03-02 Schastak Astrid Porphyrine und ihre Verwendung als Photosensitizer
US6454789B1 (en) * 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
DE60001629T2 (de) * 1999-01-15 2003-12-18 Light Sciences Corp., Issaquah Therapeutische zusammensetzungen fur knochenstoffwechselstörungen oder knochenmetastasen enthaltend einen photosensitizer und ein bisphosphonat
AU2412800A (en) * 1999-01-15 2000-08-01 Light Sciences Corporation Noninvasive vascular therapy
US6602274B1 (en) * 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
US6376483B1 (en) 1999-05-27 2002-04-23 Miravant Pharmaceuticals, Inc. Bacteriochlorins and bacteriopurpurins useful as photoselective compounds for photodynamic therapy and a process for their production
US6534040B2 (en) 1999-12-23 2003-03-18 Health Research, Inc. Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US7078014B2 (en) * 1999-12-23 2006-07-18 Health Research, Inc. Method for using chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US7097826B2 (en) 1999-12-23 2006-08-29 Health Research, Inc. Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
JP2003519670A (ja) * 2000-01-12 2003-06-24 ライト サイエンシーズ コーポレイション 眼疾患の新規処置
US6624187B1 (en) * 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
CA2473924A1 (fr) * 2002-01-23 2003-07-31 Light Sciences Corporation Systemes et procedes pour une therapie photodynamique
EP1517684B1 (fr) * 2002-06-27 2009-07-22 Health Research, Inc. Photosensibilisants fluores associes a des chlores et des bacteriochlores pour la therapie photodynamique
EP1606291A2 (fr) * 2002-07-02 2005-12-21 Health Research, Inc. Synthese efficace de pyropheophorbide a et ses derives
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
US7057100B2 (en) * 2003-06-26 2006-06-06 The J.C. Robinson Seed Co. Inbred corn line W23129
DK1753457T3 (en) * 2004-06-07 2016-12-05 Yeda Res & Dev Cationic bakterieklorofylderivater and uses
US7147840B2 (en) * 2004-11-24 2006-12-12 Health Research, Inc. Oxo-bacteriopyropheophorbide-a carboxylic acid and esters thereof
CA2632183A1 (fr) 2005-08-25 2007-03-01 Philip R. Houle Solutions sensibilisantes ameliorees, systemes, et procedes d'utilisation
WO2009105210A2 (fr) * 2008-02-19 2009-08-27 Health Research, Inc. Photosensibilisateurs tétrapyrolliques à anneau b réduit-anneau d oxydé pour une thérapie photodynamique et une imagerie de tumeur
US20110092961A1 (en) * 2008-08-13 2011-04-21 Searete Llc Artificial cells
GB0819594D0 (en) 2008-10-24 2008-12-03 Univ Coimbrra Process

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
US5002962A (en) * 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US5591847A (en) * 1994-05-23 1997-01-07 Health Research, Inc. Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages

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