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WO1997030085B1 - Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese - Google Patents

Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese

Info

Publication number
WO1997030085B1
WO1997030085B1 PCT/US1997/002439 US9702439W WO9730085B1 WO 1997030085 B1 WO1997030085 B1 WO 1997030085B1 US 9702439 W US9702439 W US 9702439W WO 9730085 B1 WO9730085 B1 WO 9730085B1
Authority
WO
WIPO (PCT)
Prior art keywords
fact
troponin subunit
peptide
subunit
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/002439
Other languages
English (en)
Other versions
WO1997030085A1 (fr
Filing date
Publication date
Priority claimed from US08/602,941 external-priority patent/US5837680A/en
Application filed filed Critical
Priority to AU22753/97A priority Critical patent/AU707262B2/en
Priority to DE69729125T priority patent/DE69729125T2/de
Priority to AT97905992T priority patent/ATE266675T1/de
Priority to EP97905992A priority patent/EP1007556B1/fr
Priority to JP52953997A priority patent/JP3990456B2/ja
Priority to CA2247247A priority patent/CA2247247C/fr
Publication of WO1997030085A1 publication Critical patent/WO1997030085A1/fr
Publication of WO1997030085B1 publication Critical patent/WO1997030085B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

Des procédés permettent d'inhiber l'angiogénèse atopique à l'aide de sous-unités de troponine et de leurs fragments peptidiques. On décrit aussi des compositions pharmaceutiques comprenant une sous-unité de troponine ou un de ses fragments. Ces compositions et procédés permettent de traiter des tumeurs solides, particulièrement celles du système nerveux central et de l'oeil.
PCT/US1997/002439 1996-02-16 1997-02-14 Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese Ceased WO1997030085A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU22753/97A AU707262B2 (en) 1996-02-16 1997-02-14 Troponin subunits and fragments useful as angiogenesis inhibitors
DE69729125T DE69729125T2 (de) 1996-02-16 1997-02-14 Troponin untereinheiten und fragmente zur verwendung als inhibitoren der angiogenese
AT97905992T ATE266675T1 (de) 1996-02-16 1997-02-14 Troponin untereinheiten und fragmente zur verwendung als inhibitoren der angiogenese
EP97905992A EP1007556B1 (fr) 1996-02-16 1997-02-14 Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese
JP52953997A JP3990456B2 (ja) 1996-02-16 1997-02-14 血管形成の阻害剤として有用なトロポニンのサブユニットおよびフラグメント
CA2247247A CA2247247C (fr) 1996-02-16 1997-02-14 Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/602,941 US5837680A (en) 1996-02-16 1996-02-16 Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis
US08/602,941 1996-02-16

Publications (2)

Publication Number Publication Date
WO1997030085A1 WO1997030085A1 (fr) 1997-08-21
WO1997030085B1 true WO1997030085B1 (fr) 1997-09-25

Family

ID=24413387

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/002439 Ceased WO1997030085A1 (fr) 1996-02-16 1997-02-14 Sous-unites et fragments de troponine utiles comme inhibiteurs de l'angiogenese

Country Status (8)

Country Link
US (4) US5837680A (fr)
EP (1) EP1007556B1 (fr)
JP (1) JP3990456B2 (fr)
AT (1) ATE266675T1 (fr)
AU (1) AU707262B2 (fr)
CA (1) CA2247247C (fr)
DE (1) DE69729125T2 (fr)
WO (1) WO1997030085A1 (fr)

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US6586401B1 (en) * 1996-02-16 2003-07-01 Children's Medical Center Corporation Troponin subunit I fragment and homologs thereof
US6589936B1 (en) * 1996-02-16 2003-07-08 Children's Medical Center Corporation Pharmaceutical compositions comprising recombinant troponin subunits
US5837680A (en) 1996-02-16 1998-11-17 Children's Medical Center Corporation Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis
US6465431B1 (en) * 1999-11-17 2002-10-15 Boston Life Sciences, Inc. Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis
US20030166065A1 (en) * 1997-04-24 2003-09-04 Human Genome Sciences, Inc. Novel integrin ligand ITGL-TSP
US7220557B2 (en) 1997-04-24 2007-05-22 Human Genome Sciences, Inc. METH1 polynucleotides
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US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
AU9673998A (en) * 1997-10-01 1999-04-23 G.D. Searle & Co. Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment
KR100335397B1 (ko) * 1998-05-25 2002-09-05 주식회사 하이닉스반도체 센스앰프순차구동장치
AU756370B2 (en) * 1998-07-17 2003-01-09 Licentia Ltd Myotilin, an actin-organizing protein
US6378526B1 (en) * 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
AU6117099A (en) * 1998-10-21 2000-05-08 Spectral Diagnostics Inc. Cardiac troponin i polypeptide fragments and uses in diagnostics
JP2002539161A (ja) * 1999-03-15 2002-11-19 ボストン ライフ サイエンシズ，インコーポレーテッド． トロポニンサブユニット、それらの断片および相同体を含む医薬組成物ならびに血管形成を抑制するためのそれらの使用方法
CA2382774A1 (fr) * 1999-05-25 2000-11-30 Human Genome Sciences, Inc. Polynucleotides et polypeptides meth1 et meth2
US20020142982A1 (en) * 1999-09-02 2002-10-03 Timothy Hla Method for regulating angiogenesis
JP2004511219A (ja) 2000-07-12 2004-04-15 アジェンシス，インコーポレイテッド 膀胱癌、卵巣癌、肺癌、および腎臓癌の診断および治療に有用な腫瘍抗原
US20030236188A1 (en) * 2001-05-03 2003-12-25 Spytek Kimberly A. Novel human proteins, polynucleotides encoding them and methods of using the same
JP4214397B2 (ja) * 2002-02-04 2009-01-28 秀男 吉田 変異ベロ毒素を用いた抗癌剤
US8623822B2 (en) * 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
WO2004065621A1 (fr) 2002-03-01 2004-08-05 Dyax Corp. Peptides de liaison kdr et vegf/kdr et leur utilisation a des fins diagnostiques et therapeutiques
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
JP2006514915A (ja) 2002-03-01 2006-05-18 ダイアックス、コープ Ｋｄｒおよびｖｅｇｆ／ｋｄｒ結合ペプチドならびに診断および治療におけるその使用
EP1490107A4 (fr) 2002-03-21 2005-11-09 Univ Florida Modulation de l'angiogenese
AU2003275259A1 (en) * 2002-09-26 2004-04-19 Northwestern University Anti-angiogenic fragments of pigment epithelium-derived factor (pedf)
DK2284180T3 (en) 2003-03-03 2015-12-21 Dyax Corp Uses of peptides that specifically bind to the HGF receptor (cMET)
CN1294987C (zh) * 2003-04-15 2007-01-17 刘凤鸣 心肌肌钙蛋白i在制备抑制肿瘤药物中的应用
CA2820537C (fr) 2003-04-23 2015-10-20 Valeritas, Inc. Pompe activee hydrauliquement pour l'administration de fluide
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US7265248B1 (en) 2005-04-29 2007-09-04 Technology Innovations, Llc Compositions and methods for the treatment of malaria
US20070130009A1 (en) * 2005-06-01 2007-06-07 Chad Steelberg System and method for media play pricing
WO2007067611A2 (fr) * 2005-12-07 2007-06-14 The Brigham And Women's Hospital, Inc. Méthodes pour traiter une maladie de reperfusion cardiaque
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Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
AU652744B2 (en) * 1990-01-25 1994-09-08 Children's Medical Center Corporation Method and compositions for inhibiting angiogenesis
FR2701954B1 (fr) * 1993-02-23 1995-07-07 Pasteur Sanofi Diagnostics Composition stabilisée de troponine pour immunoessais et procédé de stabilisation de troponine pour immunoessais.
US5837680A (en) * 1996-02-16 1998-11-17 Children's Medical Center Corporation Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis

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