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WO1997028265A1 - Immunisation contre la rougeole par inoculation d'unites de transcription de l'adn - Google Patents

Immunisation contre la rougeole par inoculation d'unites de transcription de l'adn Download PDF

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Publication number
WO1997028265A1
WO1997028265A1 PCT/US1997/001982 US9701982W WO9728265A1 WO 1997028265 A1 WO1997028265 A1 WO 1997028265A1 US 9701982 W US9701982 W US 9701982W WO 9728265 A1 WO9728265 A1 WO 9728265A1
Authority
WO
WIPO (PCT)
Prior art keywords
dna
antigen
measles virus
transcription unit
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/001982
Other languages
English (en)
Other versions
WO1997028265A9 (fr
Inventor
Harriet L. Robinson
Diane E. Griffin
Alexandra Valsamakis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
UMass Memorial Medical Center
University of Massachusetts Chan Medical School
Original Assignee
Johns Hopkins University
UMass Memorial Medical Center
University of Massachusetts Chan Medical School
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University, UMass Memorial Medical Center, University of Massachusetts Chan Medical School filed Critical Johns Hopkins University
Priority to AU21189/97A priority Critical patent/AU2118997A/en
Publication of WO1997028265A1 publication Critical patent/WO1997028265A1/fr
Publication of WO1997028265A9 publication Critical patent/WO1997028265A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Definitions

  • Figure 3A is a graph depicting temporal curves of neutralization titers of antibodies raised in mice by gene gun inoculation of H DNA. DNA deliveries are indicated on dotted lines. Each curve represents data for an individual animal.
  • the macaques were anaesthetized with Ketaset/Rompun (ketamine) and their target areas were prepared. Each macaque was either inoculated intradermally in the back or inoculated with a gene gun at the abdominal epidermis. The gene gun method used is described in Example 3 above, with each macaque receiving 1 ⁇ g DNA per delivery at a pressure of 400 p.s.i.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des procédés et des compositions utilisés pour immuniser un mammifère contre le virus de la rougeole. Ledit procédé consiste à introduire dans le mammifère au moins un produit de transcription de l'ADN comprenant de l'ADN codant pour un antigène du virus de la rougeole lié activement à l'ADN qui est une région de promotrice, et ce afin de produire l'expression de l'antigène et de provoquer une réponse immunitaire. La réponse immunitaire ainsi provoquée peut assurer une protection contre la maladie due au virus de la rougeole. L'hôte peut être n'importe quel mammifère dont l'humain.
PCT/US1997/001982 1996-02-05 1997-02-05 Immunisation contre la rougeole par inoculation d'unites de transcription de l'adn Ceased WO1997028265A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU21189/97A AU2118997A (en) 1996-02-05 1997-02-05 Measles immunization by dna transcription unit inoculation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59697796A 1996-02-05 1996-02-05
US08/596,977 1996-02-05

Publications (2)

Publication Number Publication Date
WO1997028265A1 true WO1997028265A1 (fr) 1997-08-07
WO1997028265A9 WO1997028265A9 (fr) 1997-10-30

Family

ID=24389529

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/001982 Ceased WO1997028265A1 (fr) 1996-02-05 1997-02-05 Immunisation contre la rougeole par inoculation d'unites de transcription de l'adn

Country Status (2)

Country Link
AU (1) AU2118997A (fr)
WO (1) WO1997028265A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7750005B2 (en) 2003-02-13 2010-07-06 Sanofi-Aventis Deutschland Gmbh Substituted hexahydropyrazino [1,2-A] pyrimidine-4,7-dione derivatives, process for their preparation and their use as medicaments

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008789A1 (fr) * 1990-11-20 1992-05-29 Virogenetics Corporation Vaccin contenant un poxvirus recombine renfermant de l'adn de virus morbilleux
WO1993019183A1 (fr) * 1992-03-23 1993-09-30 University Of Massachusetts Medical Center Procede d'immunisation par inoculation d'une unite de transcription d'adn
WO1995020660A2 (fr) * 1994-01-27 1995-08-03 University Of Massachusetts Medical Center Immunisation par inoculation d'une unite de transcription d'adn

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008789A1 (fr) * 1990-11-20 1992-05-29 Virogenetics Corporation Vaccin contenant un poxvirus recombine renfermant de l'adn de virus morbilleux
WO1993019183A1 (fr) * 1992-03-23 1993-09-30 University Of Massachusetts Medical Center Procede d'immunisation par inoculation d'une unite de transcription d'adn
WO1995020660A2 (fr) * 1994-01-27 1995-08-03 University Of Massachusetts Medical Center Immunisation par inoculation d'une unite de transcription d'adn

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FOOKS A R ET AL: "High-level expression of the measles virus nucleocapsid protein by using a replication-deficient adenovirus vector: Induction of an MHC-1-restricted CTL response and protection in a murine model.", VIROLOGY 210 (2). 1995. 456-465. ISSN: 0042-6822, XP000652343 *
GELDER, C. M. ET AL: "Human CD4+ T-cell recognition of influenza A virus hemagglutinin after subunit vaccination", J. VIROL. (1996), 70(7), 4787-4790 CODEN: JOVIAM;ISSN: 0022-538X, July 1996 (1996-07-01), XP000655051 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7750005B2 (en) 2003-02-13 2010-07-06 Sanofi-Aventis Deutschland Gmbh Substituted hexahydropyrazino [1,2-A] pyrimidine-4,7-dione derivatives, process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
AU2118997A (en) 1997-08-22

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