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WO1997015585A1 - Fucose derivatives, drugs containing the same as active ingredient, and intermediates for producing the same - Google Patents

Fucose derivatives, drugs containing the same as active ingredient, and intermediates for producing the same Download PDF

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Publication number
WO1997015585A1
WO1997015585A1 PCT/JP1996/003081 JP9603081W WO9715585A1 WO 1997015585 A1 WO1997015585 A1 WO 1997015585A1 JP 9603081 W JP9603081 W JP 9603081W WO 9715585 A1 WO9715585 A1 WO 9715585A1
Authority
WO
WIPO (PCT)
Prior art keywords
same
intermediates
producing
active ingredient
drugs containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1996/003081
Other languages
English (en)
French (fr)
Inventor
Takahiro Tsukida
Takao Kiyoi
Toshio Achiha
Hideki Moriyama
Kiriko Kurokawa
Hiroshi Ohmoto
Kenji Nakamura
Hirosato Kondo
Yukihisa Wada
Tadayuki Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to US09/051,846 priority Critical patent/US5919769A/en
Priority to EP96935412A priority patent/EP0859005A1/en
Publication of WO1997015585A1 publication Critical patent/WO1997015585A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/JP1996/003081 1995-10-26 1996-10-23 Fucose derivatives, drugs containing the same as active ingredient, and intermediates for producing the same Ceased WO1997015585A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US09/051,846 US5919769A (en) 1995-10-26 1996-10-23 Fucose derivatives, drugs containing the same as active ingredient, and intermediates for producing the same
EP96935412A EP0859005A1 (en) 1995-10-26 1996-10-23 Fucose derivatives, drugs containing the same as active ingredient, and intermediates for producing the same

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP7/303476 1995-10-26
JP30347695 1995-10-26
JP17548796 1996-06-13
JP8/175487 1996-06-13
JP8/231482 1996-08-12
JP23148296 1996-08-12

Publications (1)

Publication Number Publication Date
WO1997015585A1 true WO1997015585A1 (en) 1997-05-01

Family

ID=27324111

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1996/003081 Ceased WO1997015585A1 (en) 1995-10-26 1996-10-23 Fucose derivatives, drugs containing the same as active ingredient, and intermediates for producing the same

Country Status (3)

Country Link
US (1) US5919769A (ja)
EP (1) EP0859005A1 (ja)
WO (1) WO1997015585A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000009546A1 (fr) * 1998-08-10 2000-02-24 Hokkaido Electric Power Company, Incorporated Preparation de glycopeptides ordinaires
US6229008B1 (en) * 1994-08-25 2001-05-08 Saischek Joern α-D-pentofuranosides, and a process for preparing the same

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329344B1 (en) * 1998-10-22 2001-12-11 Ranbaxy Laboratories Limited Derivatives of monosaccharides as cell adhesion inhibitors
WO2003097658A2 (en) 2002-05-16 2003-11-27 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
US20040096396A1 (en) * 2002-07-03 2004-05-20 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
DE602004011272T2 (de) * 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
JP2007524658A (ja) * 2003-11-19 2007-08-30 グリコミメティクス， インコーポレイテッド Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト
US8201377B2 (en) * 2004-11-05 2012-06-19 Faus Group, Inc. Flooring system having multiple alignment points
WO2006127906A1 (en) * 2005-05-25 2006-11-30 Glycomimetics, Inc. Heterobifunctional compounds for selectin inhibition
US7517980B2 (en) * 2005-08-09 2009-04-14 Glycomimetics, Inc. Glycomimetric inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas
PL2264043T3 (pl) * 2005-09-02 2018-04-30 Glycomimetics, Inc. Heterobifunkcyjne inhibitory pan-selektyny
WO2007143052A1 (en) * 2006-06-01 2007-12-13 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
EP2074132B1 (en) 2006-10-12 2013-05-15 GlycoMimetics, Inc. Glycomimetic replacements for hexoses and n-acetyl hexosamines
CA2677747A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
KR100882505B1 (ko) 2007-05-04 2009-02-06 한국과학기술연구원 아토피성 피부질환 마우스 및 이를 이용한 아토피성피부질환 예방제, 치료제 또는 화장료 조성물의 스크리닝방법
US8039442B2 (en) * 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
US8895510B2 (en) * 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
EP2318015B1 (en) * 2008-06-13 2013-08-07 GlycoMimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
AU2010241807B2 (en) 2009-05-01 2014-08-14 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
CN104039805B (zh) 2011-12-22 2016-11-16 糖模拟物有限公司 E-选择蛋白拮抗剂化合物、组合物及使用方法
PL2928476T3 (pl) 2012-12-07 2018-07-31 Glycomimetics, Inc. Związki, kompozycje i sposoby wykorzystujące antagonistów e-selektyny do mobilizacji komórek hematopoietycznych
KR102542750B1 (ko) 2014-12-03 2023-06-12 글리코미메틱스, 인크. E-셀렉틴 및 cxcr4 케모카인 수용체의 헤테로이작용성 억제제
CA3009836A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
WO2018031445A1 (en) 2016-08-08 2018-02-15 Glycomimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4
BR112019006642A2 (pt) 2016-10-07 2019-07-02 Glycomimetics Inc antagonistas multiméricos de e-selectina altamente potentes
US11197877B2 (en) 2017-03-15 2021-12-14 Glycomimetics. Inc. Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
WO2019133878A1 (en) 2017-12-29 2019-07-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
US11707474B2 (en) 2018-03-05 2023-07-25 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004751A1 (en) * 1993-08-04 1995-02-16 Glycomed Incorporated Selectin binding glycopeptides
WO1995010296A1 (en) * 1993-10-12 1995-04-20 Glycomed Incorporated A library of glyco-peptides useful for identification of cell adhesion inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444050A (en) * 1994-04-29 1995-08-22 Texas Biotechnology Corporation Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004751A1 (en) * 1993-08-04 1995-02-16 Glycomed Incorporated Selectin binding glycopeptides
WO1995010296A1 (en) * 1993-10-12 1995-04-20 Glycomed Incorporated A library of glyco-peptides useful for identification of cell adhesion inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6229008B1 (en) * 1994-08-25 2001-05-08 Saischek Joern α-D-pentofuranosides, and a process for preparing the same
WO2000009546A1 (fr) * 1998-08-10 2000-02-24 Hokkaido Electric Power Company, Incorporated Preparation de glycopeptides ordinaires

Also Published As

Publication number Publication date
US5919769A (en) 1999-07-06
EP0859005A1 (en) 1998-08-19

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