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WO1997008531A3 - Detection de genotypes du virus gb de l'hepatite - Google Patents

Detection de genotypes du virus gb de l'hepatite Download PDF

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Publication number
WO1997008531A3
WO1997008531A3 PCT/US1996/013171 US9613171W WO9708531A3 WO 1997008531 A3 WO1997008531 A3 WO 1997008531A3 US 9613171 W US9613171 W US 9613171W WO 9708531 A3 WO9708531 A3 WO 9708531A3
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WO
WIPO (PCT)
Prior art keywords
hepatitis
detection
virus genotypes
virus
genotypes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/013171
Other languages
English (en)
Other versions
WO1997008531A2 (fr
WO1997008531A9 (fr
Inventor
Anthony S Muerhoff
John N Simons
Larry Birkenmeyer
Thomas P Leary
James C Erker
Suresh M Desai
Isa K Mushahwar
Michelle Chalmers
George J Dawson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority to EP96930516A priority Critical patent/EP0845049A2/fr
Priority to JP9510327A priority patent/JPH11511027A/ja
Publication of WO1997008531A2 publication Critical patent/WO1997008531A2/fr
Publication of WO1997008531A3 publication Critical patent/WO1997008531A3/fr
Publication of WO1997008531A9 publication Critical patent/WO1997008531A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des acides nucléiques du virus de l'hépatite C du type GB et notamment des sondes et des amorces oligonucléotidiques, utiles dans la détection de génotypes du virus de l'hépatite C du type GB.
PCT/US1996/013171 1995-08-14 1996-08-14 Detection de genotypes du virus gb de l'hepatite Ceased WO1997008531A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP96930516A EP0845049A2 (fr) 1995-08-14 1996-08-14 Detection de genotypes du virus gb de l'hepatite
JP9510327A JPH11511027A (ja) 1995-08-14 1996-08-14 Ｇｂ型肝炎ウィルス遺伝子型の検出

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60/002,265 1995-08-11
US226595P 1995-08-14 1995-08-14
US08/580,038 1995-12-21
US08/580,038 US5807670A (en) 1995-08-14 1995-12-21 Detection of hepatitis GB virus genotypes

Publications (3)

Publication Number Publication Date
WO1997008531A2 WO1997008531A2 (fr) 1997-03-06
WO1997008531A3 true WO1997008531A3 (fr) 1997-04-17
WO1997008531A9 WO1997008531A9 (fr) 1997-09-18

Family

ID=26670161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/013171 Ceased WO1997008531A2 (fr) 1995-08-14 1996-08-14 Detection de genotypes du virus gb de l'hepatite

Country Status (5)

Country Link
US (1) US5807670A (fr)
EP (1) EP0845049A2 (fr)
JP (1) JPH11511027A (fr)
CA (1) CA2228820A1 (fr)
WO (1) WO1997008531A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981172A (en) * 1994-02-14 1999-11-09 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E Hepatitis reagents and methods for their use
IT1283893B1 (it) * 1996-01-24 1998-05-07 Sorin Biomedica Diagnostics Sp Metodo per rilevare sequenze nucleotidiche di virus associati a epatiti nona-none, peptidi e composizioni
US6436638B1 (en) * 1996-05-09 2002-08-20 Metropolitan Water District Of Southern California Cryptosporidium detection method
US7141405B2 (en) * 1999-06-04 2006-11-28 Board Of Regents, The University Of Texas System Chimeric GB virus B (GBV-B)
US7244585B1 (en) 1999-06-04 2007-07-17 The Board Of Regents Of The University Of Texas System 3′ Sequence of the GB virus B (GBV-B) genome
US20060105365A1 (en) * 2004-09-27 2006-05-18 Annette Martin Chimeric GB virus B (GBV-B)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021922A2 (fr) * 1994-02-14 1995-08-17 Abbott Laboratories Reactifs pour l'hepatite non-a, non-b, non-c, non-d et procede pour leur utilisation
EP0736601A2 (fr) * 1995-04-06 1996-10-09 Abbott Laboratories Réactifs pour la détection associés avec l'hépatite non-A, non-B, non-C, non-D et non-E ainsi que procédés d'utilisation de ces derniers

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US4743535A (en) * 1984-11-07 1988-05-10 Miles Inc. Hybridization assay employing labeled probe and anti-hybrid
US4876187A (en) * 1985-12-05 1989-10-24 Meiogenics, Inc. Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences
CN1074422C (zh) * 1987-11-18 2001-11-07 希龙股份有限公司 制备含有hcv表位的分离多肽的方法
AU4046489A (en) * 1988-07-06 1990-02-05 Genelabs Incorporated Post-transfusion, non-a, non-b hepatitis virus and antigens
JP2696116B2 (ja) * 1988-09-30 1998-01-14 財団法人阪大微生物病研究会 非ａ非ｂ肝炎患者の血清と抗原抗体反応するペプチド、及び該ペプチドをコードするｄｎａ
US5399346A (en) * 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
EP0787807B1 (fr) * 1991-08-27 2003-05-28 F. Hoffmann-La Roche Ag Amorces et sondes pour la détection de l'hépatite C
US5576302A (en) * 1991-10-15 1996-11-19 Isis Pharmaceuticals, Inc. Oligonucleotides for modulating hepatitis C virus having phosphorothioate linkages of high chiral purity
WO1994018217A1 (fr) * 1993-02-03 1994-08-18 Abbott Laboratories Reactifs des hepatites non-a, non-b, non-c, non-d, non-e et leurs procedes d'utilisation
EP0718400A3 (fr) * 1992-09-28 1996-07-03 Chiron Corporation Procédés et compositions pour le contrôle de la traduction des protéines de HCV
ES2113673T3 (es) * 1993-08-24 1998-05-01 Akzo Nobel Nv Lentes oftalmicas.
WO1995032291A2 (fr) * 1994-05-20 1995-11-30 Genelabs Technologies, Inc. Virus de l'hepatite g et son clonage moleculaire
AU2594195A (en) * 1994-05-20 1995-12-18 Genelabs Technologies, Inc. Detection of viral antigens coded by reverse-reading frames
WO1995032290A2 (fr) * 1994-05-20 1995-11-30 Genelabs Technologies, Inc. Agents de l'hepatite non a/non b/non c/non d/non e et leur clonage moleculaire
US6370502B1 (en) * 1999-05-27 2002-04-09 America Online, Inc. Method and system for reduction of quantization-induced block-discontinuities and general purpose audio codec
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Publication number Priority date Publication date Assignee Title
WO1995021922A2 (fr) * 1994-02-14 1995-08-17 Abbott Laboratories Reactifs pour l'hepatite non-a, non-b, non-c, non-d et procede pour leur utilisation
EP0736601A2 (fr) * 1995-04-06 1996-10-09 Abbott Laboratories Réactifs pour la détection associés avec l'hépatite non-A, non-B, non-C, non-D et non-E ainsi que procédés d'utilisation de ces derniers

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SCHLAUDER G G ET AL: "MOLECULAR AND SEROLOGIC ANALYSIS IN THE TRANSMISSION OF THE GB HEPATITIS AGENTS", JOURNAL OF MEDICAL VIROLOGY, vol. 46, no. 1, May 1995 (1995-05-01), pages 81 - 90, XP000612658 *
SIMONS J N ET AL: "ISOLATION OF NOVEL VIRUS-LIKE SEQUENCES ASSOCIATED WITH HUMAN HEPATITIS", NATURE MEDICINE, vol. 1, no. 6, 1 June 1995 (1995-06-01), pages 564 - 569, XP000508526 *
ZUKERMANN A ET AL: "The new GB hepatitis viruses", THE LANCET, vol. 345, 10 June 1995 (1995-06-10), XP002020664 *

Also Published As

Publication number Publication date
WO1997008531A2 (fr) 1997-03-06
JPH11511027A (ja) 1999-09-28
EP0845049A2 (fr) 1998-06-03
CA2228820A1 (fr) 1997-03-06
US5807670A (en) 1998-09-15

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