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WO1997007139A3 - Stabilized chitin derivative compounds - Google Patents

Stabilized chitin derivative compounds Download PDF

Info

Publication number
WO1997007139A3
WO1997007139A3 PCT/EP1996/003474 EP9603474W WO9707139A3 WO 1997007139 A3 WO1997007139 A3 WO 1997007139A3 EP 9603474 W EP9603474 W EP 9603474W WO 9707139 A3 WO9707139 A3 WO 9707139A3
Authority
WO
WIPO (PCT)
Prior art keywords
polysaccharide
stabilized
chitin derivative
derivative compounds
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1996/003474
Other languages
French (fr)
Other versions
WO1997007139A2 (en
Inventor
Shau-Fong Yen
Mary Sou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/675,748 external-priority patent/US5773608A/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Priority to AU67426/96A priority Critical patent/AU6742696A/en
Publication of WO1997007139A2 publication Critical patent/WO1997007139A2/en
Publication of WO1997007139A3 publication Critical patent/WO1997007139A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Inorganic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

A process for sterilizing a polysaccharide composition containing chitosan, a chitosan derivative or a chitin derivative without substantially degrading the polysaccharide. The process has the steps of blending the polysaccharide in a solvent to form a solution or suspension; sterilizing the solution or suspension; dissolving suspended particles, if present; and then aseptically adjusting the pH of the sterilized solution. There is additionally provided a polyol stabilizing agent suitable for the polysaccharide composition.
PCT/EP1996/003474 1995-08-17 1996-08-06 Stabilized chitin derivative compounds Ceased WO1997007139A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU67426/96A AU6742696A (en) 1995-08-17 1996-08-06 Stabilized chitin derivative compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51642095A 1995-08-17 1995-08-17
US08/516,420 1995-08-17
US08/675,748 US5773608A (en) 1995-08-17 1996-07-03 Process for preparing stabilized chitin derivative compounds
US08/675,748 1996-07-03

Publications (2)

Publication Number Publication Date
WO1997007139A2 WO1997007139A2 (en) 1997-02-27
WO1997007139A3 true WO1997007139A3 (en) 1997-04-10

Family

ID=27058839

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/003474 Ceased WO1997007139A2 (en) 1995-08-17 1996-08-06 Stabilized chitin derivative compounds

Country Status (2)

Country Link
AU (1) AU6742696A (en)
WO (1) WO1997007139A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005030011A1 (en) * 2005-06-17 2006-12-21 Aesculap Ag & Co. Kg Process for the preparation of sterile polysaccharide solutions
WO2016066195A1 (en) * 2014-10-29 2016-05-06 Laboratoire Medidom Sa Heat-sterilized formulation comprising chitosan and process of preparation thereof
CN114652866A (en) * 2020-12-23 2022-06-24 上海其胜生物制剂有限公司 A kind of moist heat sterilization method of carboxymethyl chitin solution

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0180934A2 (en) * 1984-11-06 1986-05-14 DECHEMA Deutsche Gesellschaft für Chemisches Apparatewesen, Chemische Technik und Biotechnologie e.V. Use of coarse granules of layered silicates as adsorbents for proteins
GB2179043A (en) * 1985-08-09 1987-02-25 British Food Manufacturing Ind Foamed products
EP0356060A2 (en) * 1988-08-18 1990-02-28 Minnesota Mining And Manufacturing Company Wound filling compositions
WO1994007999A1 (en) * 1992-09-28 1994-04-14 Brown University Research Foundation Chitosan matrices for encapsulated cells
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
EP0665022A1 (en) * 1994-01-28 1995-08-02 Prodex, Inc. Viscoelastic solution of N,O-carboxymethyl chitosan for ophthalmic use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0180934A2 (en) * 1984-11-06 1986-05-14 DECHEMA Deutsche Gesellschaft für Chemisches Apparatewesen, Chemische Technik und Biotechnologie e.V. Use of coarse granules of layered silicates as adsorbents for proteins
GB2179043A (en) * 1985-08-09 1987-02-25 British Food Manufacturing Ind Foamed products
EP0356060A2 (en) * 1988-08-18 1990-02-28 Minnesota Mining And Manufacturing Company Wound filling compositions
WO1994007999A1 (en) * 1992-09-28 1994-04-14 Brown University Research Foundation Chitosan matrices for encapsulated cells
EP0665022A1 (en) * 1994-01-28 1995-08-02 Prodex, Inc. Viscoelastic solution of N,O-carboxymethyl chitosan for ophthalmic use
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system

Also Published As

Publication number Publication date
WO1997007139A2 (en) 1997-02-27
AU6742696A (en) 1997-03-12

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