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WO1996039425A3 - Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity - Google Patents

Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity Download PDF

Info

Publication number
WO1996039425A3
WO1996039425A3 PCT/US1996/008923 US9608923W WO9639425A3 WO 1996039425 A3 WO1996039425 A3 WO 1996039425A3 US 9608923 W US9608923 W US 9608923W WO 9639425 A3 WO9639425 A3 WO 9639425A3
Authority
WO
WIPO (PCT)
Prior art keywords
activity
compounds
bradykinin antagonistic
opioid
bradykinin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/008923
Other languages
French (fr)
Other versions
WO1996039425A2 (en
Inventor
John C Cheronis
Albert Gyorkos
Lyle W Spruce
Eric T Whalley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cortech Inc
Original Assignee
Cortech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/465,672 external-priority patent/US5843900A/en
Application filed by Cortech Inc filed Critical Cortech Inc
Priority to AU60444/96A priority Critical patent/AU6044496A/en
Priority to EP96918098A priority patent/EP0832106A2/en
Publication of WO1996039425A2 publication Critical patent/WO1996039425A2/en
Publication of WO1996039425A3 publication Critical patent/WO1996039425A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to pharmaceutically effective heterodimers comprising a bradykinin antagonist component covalently linked to a mu-opioid agonist component.
PCT/US1996/008923 1995-06-05 1996-06-04 Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity Ceased WO1996039425A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU60444/96A AU6044496A (en) 1995-06-05 1996-06-04 Compounds having bradykinin antagonistic activity and mu-opi oid agonistic activity
EP96918098A EP0832106A2 (en) 1995-06-05 1996-06-04 Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/465,672 US5843900A (en) 1991-04-01 1995-06-05 Bradykinin antagonists
US08/465,672 1995-06-05
US64716096A 1996-05-21 1996-05-21
US08/647,160 1996-05-21

Publications (2)

Publication Number Publication Date
WO1996039425A2 WO1996039425A2 (en) 1996-12-12
WO1996039425A3 true WO1996039425A3 (en) 1997-01-30

Family

ID=27041368

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/008923 Ceased WO1996039425A2 (en) 1995-06-05 1996-06-04 Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity

Country Status (4)

Country Link
EP (1) EP0832106A2 (en)
AU (1) AU6044496A (en)
TW (1) TW407159B (en)
WO (1) WO1996039425A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262265B1 (en) * 1999-06-18 2001-07-17 Microgenics Corporation Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay
EP1312923B1 (en) * 2001-11-16 2007-03-28 Randox Laboratories Ltd. Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs
ES2284783T3 (en) * 2001-11-16 2007-11-16 Randox Laboratories Ltd. METHOD AND CASE FOR DETECTING, OR DETERMINING THE AMOUNT OF, FENTANIL METABOLITES AND METABOLITES OF FENTANIL ANALOGS.
WO2006055321A2 (en) * 2004-11-10 2006-05-26 Boehringer Ingelheim Chemicals, Inc. Process of making fentanyl intermediates
US7238791B1 (en) * 2005-12-16 2007-07-03 Roche Diagnostics Operations, Inc. 6-monoacetylmorphine derivatives useful in immunoassay
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
EP2628489B1 (en) * 2009-07-21 2017-03-01 Nektar Therapeutics PEG oligomer-fentanyl conjugates

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370453A2 (en) * 1988-11-24 1990-05-30 Hoechst Aktiengesellschaft Peptides having a Brady kinine-inhibiting activity
WO1992017201A1 (en) * 1991-04-01 1992-10-15 Cortech, Inc. Bradykinin antagonists
WO1992018156A1 (en) * 1991-04-19 1992-10-29 Nova Technology Limited Partnership Bradykinin antagonist peptides
WO1994011021A1 (en) * 1992-11-10 1994-05-26 Cortech, Inc. Bradykinin antagonists
WO1995024422A1 (en) * 1994-03-09 1995-09-14 Cortech, Inc. Bradykinin antagonist peptides incorporating n-substituted glycines
WO1996016081A1 (en) * 1994-11-18 1996-05-30 University Technology Corporation Bradykinin antagonist peptides containing indane-substituted amino acids

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370453A2 (en) * 1988-11-24 1990-05-30 Hoechst Aktiengesellschaft Peptides having a Brady kinine-inhibiting activity
WO1992017201A1 (en) * 1991-04-01 1992-10-15 Cortech, Inc. Bradykinin antagonists
WO1992018156A1 (en) * 1991-04-19 1992-10-29 Nova Technology Limited Partnership Bradykinin antagonist peptides
WO1994011021A1 (en) * 1992-11-10 1994-05-26 Cortech, Inc. Bradykinin antagonists
WO1995024422A1 (en) * 1994-03-09 1995-09-14 Cortech, Inc. Bradykinin antagonist peptides incorporating n-substituted glycines
WO1996016081A1 (en) * 1994-11-18 1996-05-30 University Technology Corporation Bradykinin antagonist peptides containing indane-substituted amino acids

Also Published As

Publication number Publication date
EP0832106A2 (en) 1998-04-01
AU6044496A (en) 1996-12-24
WO1996039425A2 (en) 1996-12-12
TW407159B (en) 2000-10-01

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