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WO1996037206A1 - Compositions orales de rehydratation a base de farine de riz pour animaux de ferme - Google Patents

Compositions orales de rehydratation a base de farine de riz pour animaux de ferme Download PDF

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Publication number
WO1996037206A1
WO1996037206A1 PCT/NZ1996/000050 NZ9600050W WO9637206A1 WO 1996037206 A1 WO1996037206 A1 WO 1996037206A1 NZ 9600050 W NZ9600050 W NZ 9600050W WO 9637206 A1 WO9637206 A1 WO 9637206A1
Authority
WO
WIPO (PCT)
Prior art keywords
day
calves
animals
grams
riceflour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NZ1996/000050
Other languages
English (en)
Inventor
Alan Moana Alexander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virbac Laboratories NZ Ltd
Original Assignee
Virbac Laboratories NZ Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virbac Laboratories NZ Ltd filed Critical Virbac Laboratories NZ Ltd
Priority to AU58475/96A priority Critical patent/AU5847596A/en
Publication of WO1996037206A1 publication Critical patent/WO1996037206A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/22—Compounds of alkali metals

Definitions

  • This invention relates to the treatment of diarrhoea in animals.
  • Diarrhoea in farm animals can arise through infection or as a result of stress, for example weaning, transportation etc.
  • Conventional treatment of diarrhoea and the prevention of dehydration in farm animals required starvation or the withdrawal of all food for its resolution.
  • Glucose was previously orally given with electrolytes. Solutions of bentonite or kaolin have also been used in treating diarrhoea, as they are absorbents.
  • LectadePlus® is a commercial formulation comprising dextrose and a mixture of electrolytes.
  • the glucose and glycine are actively absorbed from the intestine and thus energises the absorption of sodium and water. The effect is to rapidly dehydrate the animal whilst supplying nutrients and electrolytes. This may even occur against an osmotic pressure gradient between the gut and body fluids.
  • the present invention seeks to provide an improved treatment of diarrhoea in animals or one which will at least provide farmers and veterinarians with a useful choice.
  • the invention provides a formulation comprising complex carbohydrates, monosaccharides and optionally electrolytes in a pharmaceutically acceptable carrier.
  • the invention provides a method of treating diarrhoea in animals suffering therefrom by administering to such animal an oral solution containing complex carbohydrates, monosaccharides and optionally electrolytes in a pharmaceutically acceptable carrier.
  • the complex carbohydrate is riceflour, while the pharmaceutically acceptable carrier is water and the monosaccharide is glucose.
  • the riceflour is milled to a substantially average micron size of 150 microns with substantially no particle being larger than 250 microns.
  • the electrolytes are selected from sodium and potassium salts of chloride, citrate, acetate, bicarbonate and phosphate.
  • ingredients may include lactose and alanine.
  • the above active ingredients are diluted with warm water and mixed until the contents are well suspended.
  • the formulations given in the above examples supply immediate energy to the animal from glucose; plus sustained energy from either lactose or riceflour and starch - sources of energy which can be utilised during the treatment of diarrhoea.
  • Glucose supports rapid absorption of electrolytes, including sodium and bicarbonate. This is necessary so that water can be absorbed by the animal to reverse dehydration.
  • the formulations of the examples provide energy for maintenance of the central body functions in the absence of food or milk.
  • the amino acid alanine assists in the sodium uptake.
  • calves (35) qualifying to enter the trial were first drenched with 4 g of sodium bicarbonate in 60ml of water to overcome the protection of abomasal acidity against ingested pathogenic organisms. Calves were then orally dosed with a mixture of 5.6 - 6 x 10 enterotoxigenic Escherichia coli (K99) and 30 mis of faeces collected from clinical cases of calf diarrhoea identified as having a rotavirus aetiology. Faeces were tested and presence of rotavirus confirmed using a Murex Rotavirus Latex Testkit in the Virology Laboratory, Massey University. Stock culture was prepared from E.
  • the calves (32) were assigned to three different treatment groups based on their immunoglobulin status assessed by the zinc sulfate turbidity test.
  • the two deliveries of calves were given either the test product (Example 1) with LectadePlus® as a control.
  • the further deliveries of calves were given either (Example 1), (Example 3) or LectadePlus®.
  • Table 2 gives a composition of the three different treatments. All calves received four feeds of the oral rehydration solution (ORS) dissolved in two litres of luke warm water starting in the afternoon of Day T. After these four feeds the ORS's were replaced with two feeds of two litres of 50% milk substitute before being placed on milk substitute feeds for the rest of the trial. Calves which did not drink voluntarily were stomach tubed.
  • ORS oral rehydration solution
  • Fluid volumes were measured in the morning of Days I, T, U, V, and W. Blood samples were taken at the same intervals for determination of plasma sodium, potassium, albumin, urea, creatinine and glucose. Blood biochemistry was done at MAF Batchelar Laboratories, Palmerston North, New Zealand. Blood samples were also taken into heparinized syringe for blood gas analyses. Syringes were kept on ice for transport to the laboratory. Blood gases were analysed within two hours in the Department of Veterinary Clinical Sciences, Massey University using a blood gas analyser except for those occasions when bloods had to be submitted in the clinical pathology laboratories of the Palmerston North Hospital due to breakdown of the gas analyser in the Veterinary Clinic.
  • Haemoglobin concentration, HCO 3 , pH, TCO 2 , actual base excesses were measured.
  • PCV's were calculated from haemoglobin concentrations by dividing with the factor 3.3.
  • Results were analysed with emphasis on Day U and Day V, as data obtained on these days were collected before the re-introduction of dietary milk. Any observed changes on Day W cannot be solely attributed to the ORS. Statistically significant differences between the three treatment groups were absent before the induction of diarrhoea.
  • the example 1 group showed the highest percentage of fully restored fluid components with 64% of the test animals having a restored plasma volume and 50% of the tested animals a restored ECF volume on Day V (Table 3).
  • the percentages for the control group (Lectade Plus®) treated groups were 62.5% and 50% and for the example 3 treated group 50% and 17% for plasma volume and ECF respectively.
  • the improvement in glucose levels were significantly better in the example 3 group than in the example 1 group or in the control group.
  • the serum glucose levels continued to drop after two feeds in the example 1 group before improving on Day V.
  • example 3 and example 1 ORS's were reflected by the higher serum sodium concentrations in these groups after treatment. Plasma and ECF volumes were also restored more quickly and effectively in the group receiving the example 1 ORS and initially the example 3 group than in the control group.
  • example 1 ORS and example 3 ORS had a beneficial effect in restoring fluid compartments more quickly than in LectadePlus®.
  • the high available energy and bi-carbonate sources in example 3 group were more effective in rapidly restoring and maintaining serum bi-carbonate levels than in the control group.
  • the inclusion of lactose in example 3 ORS in combination with its hypertonicity had a negative therapeutic effect and a majority of calves in this group suffered a relapse. In contrast there were no relapses in either the example 1 group nor the control group after treatment started.
  • example 1 ORS enabled isotonicity to be maintained as well as providing a high energy source utilisable by calves as demonstrated by rising serum glucose and sodium and bicarbonate levels.
  • the combination of the high energy level and the high sodium concentration in the example 1 ORS had a faster and better effect in restoring fluid volume.
  • example 1 produced an undigested residue at the flour/starch tested. Although the effect of the this was benign, dosages of these starch sources can be lowered to about 70% of those tested to reduce this effect.
  • Example 2 formulation has a lowered riceflour content, being replaced by lactose. Lactose as a natural food constituent for the neo-natal calf, can be expected to enhance digestibility.
  • diarrhoea scours
  • dairy feeds can given with either example 1 ORS or example 2 ORS for one or two days.
  • milk can be mixed with example 1 ORS or example 2 ORS prepared solutions for 2-4 meals.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)

Abstract

Cette invention concerne des compositions permettant de traiter la diarrhée chez des animaux, lesquelles comprennent au moins un hydrate de carbone complexe, l'un d'entre eux au moins étant de la farine de riz, et au moins un monosaccharide dans un véhicule acceptable sur le plan pharmaceutique. Sous un autre aspect, cette invention concerne un procédé de traitement de la diarrhée chez les animaux, lequel procédé consiste à administrer à un animal une solution orale contenant une quantité efficace d'au moins un hydrate de carbone complexe, l'un d'entre eux au moins étant de la farine de riz, et d'au moins un monosaccharide dans un véhicule acceptable sur le plan pharmaceutique.
PCT/NZ1996/000050 1995-05-26 1996-05-24 Compositions orales de rehydratation a base de farine de riz pour animaux de ferme Ceased WO1996037206A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU58475/96A AU5847596A (en) 1995-05-26 1996-05-24 Rice flour based oral rehydration compositions for farm anim als

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ272226 1995-05-26
NZ27222695 1995-05-26

Publications (1)

Publication Number Publication Date
WO1996037206A1 true WO1996037206A1 (fr) 1996-11-28

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Family Applications (1)

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PCT/NZ1996/000050 Ceased WO1996037206A1 (fr) 1995-05-26 1996-05-24 Compositions orales de rehydratation a base de farine de riz pour animaux de ferme

Country Status (2)

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AU (1) AU5847596A (fr)
WO (1) WO1996037206A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998009669A1 (fr) * 1996-09-03 1998-03-12 The Royal Children's Hospital Foundation Solution rehydratante per os a base de riz
AU709607B2 (en) * 1996-09-03 1999-09-02 Royal Children's Hospital Foundation, The Rice-based oral rehydration solution
EP0910359A4 (fr) * 1996-03-20 2003-03-05 Univ New South Wales Selection et/ou renforcement de populations de micro-organismes residents dans le tractus gastro-intestinal
EP2659787A1 (fr) * 2012-05-04 2013-11-06 BENEO-Orafti S.A. Procédé d'alimentation d'un porcelet ou d'un veau
WO2021018938A1 (fr) * 2019-07-29 2021-02-04 Nutreco Ip Assets B.V. Composition d'électrolyte et procédés d'utilisation

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5112945A (en) * 1974-07-19 1976-01-31 Soji Iwadare Chuchoshokuno seiho
JPS56148242A (en) * 1980-03-18 1981-11-17 Nippon Haigou Shiryo Kk Half wetted feed for domestic animals and poultry
WO1991015199A1 (fr) * 1990-04-09 1991-10-17 Medicis Corporation Composition et procede antidiarrheique
EP0459108A2 (fr) * 1990-04-03 1991-12-04 Bristol-Myers Squibb Company Solution de réhydration orale contenant de la dextrine de riz
US5120539A (en) * 1991-01-22 1992-06-09 Doyle W. Boatwright Amylase-electrolyte oral rehydration method and composition
JPH05286863A (ja) * 1992-03-24 1993-11-02 Sandoz Nutrition Ltd 有機化合物に関する改良
US5489440A (en) * 1995-03-06 1996-02-06 Abbott Laboratories Rice flour-based oral rehydration solution
US5498408A (en) * 1992-09-21 1996-03-12 Sandoz Nutrition Ltd. Oral rehydration composition

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5112945A (en) * 1974-07-19 1976-01-31 Soji Iwadare Chuchoshokuno seiho
JPS56148242A (en) * 1980-03-18 1981-11-17 Nippon Haigou Shiryo Kk Half wetted feed for domestic animals and poultry
EP0459108A2 (fr) * 1990-04-03 1991-12-04 Bristol-Myers Squibb Company Solution de réhydration orale contenant de la dextrine de riz
WO1991015199A1 (fr) * 1990-04-09 1991-10-17 Medicis Corporation Composition et procede antidiarrheique
US5120539A (en) * 1991-01-22 1992-06-09 Doyle W. Boatwright Amylase-electrolyte oral rehydration method and composition
WO1992012721A1 (fr) * 1991-01-22 1992-08-06 Boatwright, Doyle, W. Procede et appareil de rehydratation orale a base d'electrolyte/une amylase
JPH05286863A (ja) * 1992-03-24 1993-11-02 Sandoz Nutrition Ltd 有機化合物に関する改良
US5498408A (en) * 1992-09-21 1996-03-12 Sandoz Nutrition Ltd. Oral rehydration composition
US5489440A (en) * 1995-03-06 1996-02-06 Abbott Laboratories Rice flour-based oral rehydration solution

Non-Patent Citations (19)

* Cited by examiner, † Cited by third party
Title
ARCHIVES OF DISEASE IN CHILDHOOD, (1982), Vol. 57, PATRA F.C. et al., "Is Oral Rice Electrolyte Solution Superior to Glucose Electrolyte Solution in Infantile Diarrhoea?", pages 910-12. *
BMJ, (1992), Vol. 304, GORE S.M. et al., "Impact of Rice Based Oral Rehydration Solution on Stool Output and Duration of Diarrhoea: Meta-Analysis of 13 Clinical Trials", pages 287-91. *
BRITISH VETERINARY JOURNAL, (1992), Vol. 148, No. 6, MITCHELL A.R. et al., "The Comparitive Effectiveness of Three Commercial Oral Solutions in Correcting Fluid, Electrolyte and Acid Base Disturbances Caused by Calf Diarrhoea", pages 507-22. *
BULLETIN OF THE WORLD HEALTH ORGANISATION, (1985), Vol. 63, No. 4, MOLLA A.M. et al., "Rice-Based Oral Rehydration Solution Decreases the Stool Volume in Acute Diarrhoea", pages 751-6. *
DERWENT ABSTRACT, No. 19973X; & JP,A,51 012 945 (IWADARE S), 31 January 1976. *
DERWENT ABSTRACT, No. 90-013297; & SE,A,88 01143 (JUNGVID H AB), 29 September 1989. *
DERWENT ABSTRACT, No. 93-383004; & JP,A,05 286 863 (SANDOZ NUTRITION LTD.), 2 November 1993. *
DISEASE IN CHILDHOOD, (1994), Vol. 71, ISLAM A. et al., "Is Rice Based Oral Rehydration Therapy Effective in Young Infants", pages 19-23. *
GASTROENTEROLOGY, (1991), Vol. 101, RABBANI G.H. et al., "Short-Chain Glucose Polymer and Anthracene-9-Carboxylic Acid Inhibit Water and Electrolyte Secretion Induced by Dibutyryl Cyckic AMP in the Small Intestine", pages 1046-53. *
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, (1987), Vol. 6, BHAN M.K. et al., "Efficacy of Mung Bean (Lentil) and Pop Rice Based Rehydration Solutions in Comparison with the Standard Glucose Electrolyte Solution", pages 392-9. *
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, (1988), Vol. 7, EL-MOUGI et al., "Controlled Clinical Trial on the Efficacy of Rice Powder-Based Oral Rehydration Solution on the Outcome of Acute Diarrhea in Infants", pages 572-6. *
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, (1989), Vol. 8, MOLLA A.M. et al., "Turning off the Diarrhea: The Role of Food and ORS", pages 81-4. *
NEW ENGLAND JOURNAL OF MEDICINE, (1988), Vol. 319, No. 20, CARPENTER C.C.J. et al., "Oral-Rehydration Therapy - The Role of Polymeric Substrates", pages 1346-8. *
NEW ENGLAND JOURNAL OF MEDICINE, (1991), Vol. 324, No. 8, PIZZARRO D. et al., "Rice Based Oral Electrolyte Solutions for the Management of Infantile Diarrhea", pages 517-21. *
PATENT ABSTRACTS OF JAPAN, Vol. 6, No. 31; & JP,A,56 148 242 (NIPPON HAIGOU SHIRIYOU K.K.), 17 November 1981. *
THE JOURNAL OF PEDIATRICS, (1990), Vol. 116, No. 6, SLOVEN D.G. et al., "Hydrolysis and Absorption of Glucose Polymers from Rice Compared with Corn in Chronic Diarrhea of Infancy", pages 876-81. *
THE JOURNAL OF PEDIATRICS, (1991), Vol. 118, No. 4, LEBENTHAL E. and LU R., "Glucose Polymers as an Alternative to Glucose in Oral Rehydration Solutions", pages S62-S69. *
THE LANCET, 12 June 1982, MOLLA A.M. et al., "Rice Powder Electrolyte Solution as Oral Therapy in Diarrhoea Due to Vibrio Cholerae and Escherichia Coli", pages 1317-19. *
THE LANCET, 25 January 1992, Vol. 339, "Editorial: Cereal Based Oral Rehydration Solutions - Bridging the Gap Between Fluid and Food", pages 219-20. *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0910359A4 (fr) * 1996-03-20 2003-03-05 Univ New South Wales Selection et/ou renforcement de populations de micro-organismes residents dans le tractus gastro-intestinal
WO1998009669A1 (fr) * 1996-09-03 1998-03-12 The Royal Children's Hospital Foundation Solution rehydratante per os a base de riz
AU709607B2 (en) * 1996-09-03 1999-09-02 Royal Children's Hospital Foundation, The Rice-based oral rehydration solution
EP2659787A1 (fr) * 2012-05-04 2013-11-06 BENEO-Orafti S.A. Procédé d'alimentation d'un porcelet ou d'un veau
WO2014000839A1 (fr) * 2012-05-04 2014-01-03 Beneo-Orafti S.A. Procédé pour nourrir un porcelet, un agneau ou un veau
WO2021018938A1 (fr) * 2019-07-29 2021-02-04 Nutreco Ip Assets B.V. Composition d'électrolyte et procédés d'utilisation
CN114269353A (zh) * 2019-07-29 2022-04-01 纽崔克Ip资产有限公司 电解质组合物及使用方法

Also Published As

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