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WO1996037245A1 - Dispositif d'alimentation en liquide a regulation par retroaction - Google Patents

Dispositif d'alimentation en liquide a regulation par retroaction Download PDF

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Publication number
WO1996037245A1
WO1996037245A1 PCT/IE1996/000029 IE9600029W WO9637245A1 WO 1996037245 A1 WO1996037245 A1 WO 1996037245A1 IE 9600029 W IE9600029 W IE 9600029W WO 9637245 A1 WO9637245 A1 WO 9637245A1
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
compartment
gas
reactant
reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IE1996/000029
Other languages
English (en)
Inventor
Joseph Gross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Medical Technologies Ltd
Original Assignee
Elan Medical Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Medical Technologies Ltd filed Critical Elan Medical Technologies Ltd
Priority to AU57015/96A priority Critical patent/AU5701596A/en
Publication of WO1996037245A1 publication Critical patent/WO1996037245A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/60—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant with contents and propellant separated
    • B65D83/62—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant with contents and propellant separated by membranes, bags or the like
    • B65D83/625—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant with contents and propellant separated by membranes, bags or the like the propellant being generated by a chemical or electrochemical reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/155—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J7/00—Apparatus for generating gases
    • B01J7/02—Apparatus for generating gases by wet methods

Definitions

  • This invention relates to liquid delivery devices for delivering a liquid to a subject of the type employing gas generators.
  • it relates to devices in which a gas is generated by means of an effervescent couple.
  • Gravity-controlled systems for the delivery of a nutritive fluid or an intravenous liquid, such as a medicament or a saline drip deliver the liquid at a rate which is controlled by the hydrostatic pressure generated under the force of gravity between the reservoir and the point of administration.
  • a nutritive fluid or an intravenous liquid such as a medicament or a saline drip
  • Such drips are generally placed on a stand at a point approximately 1 meter or so above the point of administration (e.g. a needle in the arm of a subject). They are therefore more suitable for immobile patients, since an ambulatory patient must carry the stand around, and this is clearly impossible if the patient is frail or unsteady.
  • a higher rate of delivery is required, it is necessary to suspend the reservoir 2 or 3 metres above the point of administration. This is clearly impractical.
  • Devices employing gas generators are gravity independent and so can be easily carried by a patient without the use of a stand, and are effective to deliver a liquid at any suitable rate.
  • a liquid delivery device known as the SmartDose Infusion System (SmartDose is a trade mark) is marketed by River Medical Inc., for the intravenous delivery of liquids. It comprises a container which houses a reservoir for the intravenous fluid, the reservoir being separated from a gas generation chamber by a flexible membrane. The gas generation chamber is supplied with a gas generated by the reaction of the components of an effervescent couple.
  • the components of the effervescent couple are separated from one another, but are mixed together upon the depression of a start button.
  • Carbon dioxide is generated when the components are mixed together and the pressure within the gas generation chamber increases, thereby forcing the intravenous fluid from the reservoir by means of an outlet (to which there is typically attached a length of flexible tubing leading to a needle for intravenous delivery).
  • the pressure within the gas generation chamber builds up quickly to the desired level, at which stage a pressure release valve opens to vent the gas and prevent the pressure (and hence the delivery rate) from rising above the desired level.
  • the pressure drops back down to the desired level and the valve closes, reopening again when the gas pressure has built up above the desired level. If for any reason the fluid flow is stopped (e.g. by an accidental tube blockage or a deliberate clamping of the tube when the desired dose has been delivered), the pressure within the gas generation chamber is maintained at the desired level by the venting of the pressure release valve.
  • a problem associated with this type of device is that gas generation cannot be stopped once the start button has been activated.
  • the chemical reaction proceeds to completion whether or not it is desired to deliver all of the liquid within the reservoir in a single infusion.
  • the device cannot be used if one wishes to deliver only a portion of the liquid, cease delivery, wait for a few hours, and then recommence delivery, because by this time, the effervescent reaction will have been completed and the desired pressure will not be available for the delivery of the remainder of the liquid.
  • the effective lifetime of the commercially available device is of the order of 1 hour. Although it would be possible to manufacture a device having a longer lifetime, in order to allow delivery to be interrupted for extended periods, this would be highly inefficient as the system would be generating and venting gas continually throughout the period of interruption.
  • the invention seeks to provide an improved controlled-rate gas generator which can be used for extended periods of time and in which the generation of gas can be interrupted for extended periods of time without the premature completion of the chemical reaction. It is a further object of the invention to provide a gas generator employing an effervescent couple, in which given quantities of the components of the couple will allow an extended period of gas generation when compared with prior art devices.
  • a liquid delivery device for delivering a liquid to a subject, comprising a reservoir for the liquid connected, in use, to a gas generator for supplying a gas to the reservoir to drive the liquid therefrom, the generator comprising first and second compartments, each containing a reactant, said compartments being interconnected in a manner which permits the flow, in use, of a reactant from the first compartment to contact the other reactant, the reactpnts reacting on contact to generate a gas, wherein an increase in gas pressure within the generator reduces the rate of flow of reactant from the first compartment, thereby controlling the rate of gas generation by feedback, and in turn the rate of liquid delivery.
  • the compartments are interconnected via a conduit or an aperture.
  • the compartments are separated by a barrier before use and the aperture or conduit is created in use.
  • the first compartment is bounded by a piercible membrane and an interconnection between the first and second compartments is formed by piercing the membrane prior to delivery.
  • first and second compartments are interconnected by a hollow glass tube extending from the first compartment to the second compartment, one end of the tube being initially closed, which end is broken away from the tube to establish the interconnection prior to delivery. It will be recognised that this arrangement also provides a consistent interconnection through which the rate of flow of reactant can be predictably determined upon manufacture.
  • the reactant flows from the first compartment under an applied pressure.
  • This pressure can be provided by a spring-loaded piston, a stretched membrane, a spring-loaded clip, by gravity, or in any other suitable manner.
  • the first compartment has a boundary which is displaceable under pressure to expand the first compartment, and the rate of flow of reactant from the first compartment is controlled by a valve operatively connected to the displaceable boundary to restrict the rate of flow of reactant therethrough as the boundary is displaced under increasing pressure, the gas pressures in the first and second compartments being equalised by a conduit therebetween.
  • the reactant flows from the first compartment to the second compartment under the pressure of gravity.
  • the reactant in the first compartment is a liquid.
  • liquid as used herein includes liquids, solutions, suspensions, flowable gels and similar materials. In suitable circumstances, materials such as flowable powders may be used instead of a liquid.
  • the reactants comprise an acid and a base which react to produce a gas.
  • the acid is citric acid and the base is sodium bicarbonate.
  • the acid/base couple can be initially be separated from one another, with one reactant in the first compartment and the other reactant in the second compartment, or they can be initially mixed in solid form, for example, as a powder or tablet mixture and the reactant in the first compartment can be water.
  • the effervescent reaction is initiated.
  • this arrangement may not be appropriate in the case of certain components. For example, where citric acid and sodium bicarbonate are used as a solid mixture, water is produced as a by ⁇ product of this reaction. Accordingly, if some water is added to a powder or tablet mixture of citric acid and sodium bicarbonate, the reaction is not easily controllable due to the further reaction of components in the presence of the water produced by the initial reaction.
  • the reactant in the first compartment is a solution of citric acid and the reactant in the second compartment is sodium bicarbonate in powder or tablet form.
  • the reservoir is a rigid bottle having an outlet through which liquid is delivered as gas is fed into the bottle.
  • Such a rigid bottle may be a bottle of the type conventionally used for the delivery of an intravenous liquid to a subject, or it may be particularly adapted for use with the present invention.
  • the device is in the form of a container having a flexible internal wall which defines the reservoir on one side thereof and defines a chamber into which gas is supplied on the other side thereof, such that when gas is supplied to the chamber, the chamber expands, the reservoir is compressed by the movement of the flexible wall, and liquid is delivered from the reservoir via an outlet.
  • the device can be adapted for the delivery of a nutritive liquid or for the delivery of a medicament. Delivery can typically be oral, nasal or intravenous.
  • the liquid is delivered from the reservoir via an outlet which leads to a restrictor which limits the rate of flow of liquid therethrough.
  • the gas generator is removably mounted on the reservoir for the liquid.
  • the reservoir and the gas generator are separately disposable and replaceable independently of one another. Furthermore, this allows a separately supplied gas generator to be used in conjunction with a conventional reservoir.
  • a gas generator adapted for use as part of a device according to the invention.
  • Fig. 1 is a schematic representation of the components of a controlled-rate liquid delivery device according to the invention
  • Fig. 2 is an elevation of a liquid delivery device according to the invention, shown partially in section;
  • Fig. 3 is an elevation of a variation on the device of Fig. 2;
  • Fig. 4 is a sectional elevation illustrating a detail of the device of Fig. 3;
  • Figs. 5-7 are schematic representations of restrictors for use with the invention.
  • Fig. 8 is a sectional side elevation of another liquid delivery device according to the invention, before use;
  • Fig. 9 is a sectional side elevation of the device of Fig. 8, in use;
  • Fig. 10 is a front elevation of the device of Fig. 8.
  • Fig. 11 is a perspective view of a nutritive liquid delivery device according to the invention.
  • Fig. 12 is a schematic representation of a further embodiment of a liquid delivery device according to the invention.
  • Fig. 13 is a side elevation of yet another embodiment of a liquid delivery device according to the invention.
  • Fig. 1 there is illustrated, generally at 10, a schematic representation of a liquid delivery device.
  • the device 10 comprises a gas generator, indicated generally at 11, and a container 12 for a nutritive liquid 13 which is to be pumped via a tube 14 in the direction of arrow 15 for intranasal delivery to a subject.
  • Gas generator 11 comprises an upper compartment 16 and a lower compartment 17 connected by a narrow tube 18.
  • Upper compartment 16 contains a citric acid solution 19 and the lower compartment 17 contains powdered sodium bicarbonate 20. These substances, when mixed, generate carbon dioxide gas.
  • a piston 21 in compartment 16 is compressed by a spring 22 to force the citric acid solution 19 to flow through tube 18 onto sodium bicarbonate 20.
  • Tube 18 is sufficiently narrow to prevent the citric acid solution 19 from flowing therethrough under gravity, i.e. when a positive pressure is not effected by piston 21.
  • the rate at which citric acid solution 19 flows through tube 18 is dependent, in part, on the dimensions of tube 18 and, in part, on the force exerted by spring 22 on piston 21 and the corresponding hydrostatic pressure of citric acid solution 19.
  • the rate at which citric acid solution 19 is added to sodium bicarbonate 20 determines the rate at which gas is generated by the effervescent reaction.
  • the citric acid 19 flows dripwise from tube 18 under normal conditions.
  • the pressure is controlled by a feedback mechanism whereby, in steady state, the reaction only proceeds at a sufficient rate to generate enough gas at constant pressure to replace the volume of liquid leaving container 12 via tube 14.
  • the effervescent reaction will soon stop because the mixing of the components of the effervescent couple 19,20 is cut off by the increased pressure resulting from the effervescent reaction itself. If the flow of liquid through tube 14 is subsequently resumed, the pressure within container 12 drops, as does the pressure in space 23. This allows citric acid solution 19 to resume dropping from tube 18, causing gas generation to recommence at the necessary rate.
  • Figs. 2 and 3 two working embodiments of the device illustrated schematically in Fig. 1 are shown in partially sectional elevation. Common features which can be identified from Fig. 1 are shown by the reference numerals used in Fig. 1.
  • the devices 10 of Figs. 2 and 3 each comprise a container 12 for a liquid 13 to be delivered via a tube 14. Liquid 13 is pumped via a tube 14. Liquid 13 is a nutritive liquid for nasal administration in a hospital situation.
  • Figs. 2 and 3 differ only in the details of tube 24 which connects space 23 in gas generator 11 with space 26 at the top of container 12.
  • tube 24 extends up above the initial height of liquid 13, thereby directly delivering generated gas to space 26; in Fig. 3, tube 24 only extends a small way into container 12, so that gas travelling from space 23 to space 26 bubbles up through liquid 13.
  • tube 24 is provided with a hydrophobic filter 27 which allows gas to travel up from gas generator 11 into container 12 but prevents liquid 13 from travelling back through tube 24 and flooding gas generator 11.
  • gas generator 11 comprises a housing 28 having upper and lower compartments 16,17.
  • Compartment 16 contains citric acid solution 19 and is bounded below by a membrane 29 and above by a piston 21 pressurised by a loaded spring 22.
  • Compartment 17 is provided with sodium bicarbonate powder 20.
  • a plunger 31 having a needle point at the end thereof is depressed to rupture membrane 29 and create a small aperture through which citric acid solution 19 drips under the pressure of spring 22.
  • citric acid solution 19 contacts sodium bicarbonate solution 20, carbon dioxide is generated within space 23, and the pressure in space 23 increases.
  • the gas escapes via filter 27 and tube 24 to bubble through liquid 13 which is held within container 12 (shown in dotted outline). As previously described, this causes the pressure in container 12 to increase, thereby forcing liquid 13 out of tube 14. The rate of delivery of liquid increases to a steady state and the rate of gas generation adjusts to provide a steady state pressure in space 23.
  • FIG. 4 An additional feature illustrated in Fig. 4 is a safety valve comprising a floating ball 32 trapped within space 33.
  • ball 32 When liquid 13 is present within container 12, ball 32 floats within space 33 allowing liquid to flow into tube 14 via aperture 34. As container 12 empties, however, ball 32 drops, thereby cutting off aperture 34 and preventing air or gas from being pumped to the subject via t e 14.
  • a particle filter 35 is fitted at the mouth of tube 14 adjacent to the valve 32,33. Such a filter is desirable where nutritive liquid 13 is liable to contain small particles which might otherwise clog tube 14.
  • a restrictor 36 can be used to control the rate of fluid delivery by providing resistance to the flow of liquid via tube 14.
  • restrictor 36 will be positioned along the length of tube 14, although it may alternatively be provided at the mouth of tube 14, adjacent to filter 35.
  • the restrictor may have a number of different configurations.
  • Fig. 5 shows the first configuration, which is a narrow aperture 40 along the length of a tube 41.
  • Fig. 6 shows the second configuration, which is a narrowed section of tubing 42.
  • Fig. 7 shows a third configuration, which is a tube 43 having internal baffles 44.
  • the configurations of Figs. 5 and 6 are roughly equivalent in that they provide a constriction 40,42 which slows the flow of liquid therethrough.
  • Fig. 7 is slightly different in that the resistance to flow is caused by the baffles 44 which force liquid to follow a convoluted path.
  • Flexible bag 51 has an internal impermeable flexible membrane 52 defining a reservoir 53 on one side thereof and a chamber 54 on the other side thereof.
  • the bag 51 has a pair of external compartments 55,56 one of which 55 contains a citric acid solution 57 and the other of which contains powdered sodium bicarbonate 58.
  • compartments 55,56 are interconnected by means of a hollow glass tube 59 which is initially closed at one end 60 thereof, as illustrated in Fig. 8.
  • Compartment 55 is in the form of an elastically stretched membrane which pressurises solution 57.
  • the top 60 is broken off tube 59, thereby unblocking the hollow section and allowing liquid to drip therethrough under the pressure exerted by the stretched membrane forming compartment 55.
  • carbon dioxide gas is generated as a result of the effervescent reaction.
  • the carbon dioxide gas escapes from compartment 56 through wall 61 which is provided with microscopic holes. Gas begins to fill up chamber 54 thereby exerting a pressure, via membrane 52, onto reservoir 53. A saline solution 62 is held within reservoir 53 and is driven under pressure from reservoir 53 out of bag 51 via outlet tube 63.
  • an increase in pressure within chamber 54 causes a corresponding increase within compartment 56.
  • This increased gas pressure in compartment 56 counteracts the driving pressure exerted by the membrane forming compartment 55.
  • the flow of liquid through tube 59 can be slowed and stopped by a sufficient increase in pressure in chamber 54. In this way, a feedback effect acts to control the rate of mixing of the reactants. If outlet tube 63 is clamped, the reaction will stop.
  • the driving pressure exerted by the flexible membrane forming compartment 55 can be replaced by a spring-loaded clip which can be used to compress compartment 55.
  • Fig. 11 shows a perspective view of a preferred embodiment of a nutrition delivery device similar to the type illustrated in Figs. 1-4.
  • the device indicated generally at 70, comprises a reservoir container 71 for a nutritive liquid.
  • Container 71 is formed of translucent plastic allowing the level of liquid held therein to be visually checked.
  • a gas generator is provided in the base 72.
  • a start button 73 is provided on the external surface of the base. This button actuates a mechanism to pierce a membrane in a citric acid compartment (not shown) allowing citric acid solution to drip onto a sodium bicarbonate tablet thereby generating a gas.
  • the operation of the device can be verified by a transparent window 74 which allows a visual check that citric acid solution 75 is, in fact, dripping at a controlled rate.
  • the reservoir within the reservoir container 71 communicates with an outlet 76 and a delivery tube 77 can be plugged into this outlet. Delivery tube 77 leads to a restrictor (not shown) which provides a control on the rate of liquid delivery.
  • the device 70 can be placed on a bedside table or can be suspended from a hook 78.
  • Fig. 12 there is illustrated, generally at 80, an alternative embodiment of a liquid delivery device, similar in many respects to that illustrated in Fig. 1.
  • the device 80 is distinguished by the gas generator, indicated generally at 81.
  • Generator 81 comprises first and second compartments 82,83, separated by a boundary wall 84 having an aperture 85 which allows a solution of citric acid 86 to drip onto a mass of powdered sodium bicarbonate 87, as previously described.
  • the thus generated gas is fed to a reservoir 88 by means of a connecting tube 89.
  • a conduit 90 leading from connecting tube 89 to first compartment 82 ensures that the gas pressures in the first and second compartments 82,83 are equal at all times. Thus, an increase in gas pressure within the second compartment 83 gives rise to a corresponding increase in gas pressure within first compartment 82.
  • Aperture 85 defines a valve seat which can be sealed by a valve member 91.
  • the valve defined by aperture 85 and valve member 91 is shown in an open position allowing citric acid solution 86 to drip therethrough.
  • a rod 92 connects valve member 91 to roof 93 of first compartment 82.
  • Roof 93 comprises an elastomeric section which imparts a degree of flexibility such that an increase in gas pressure within first compartment 82 causes a section of roof 93 to be expanded upwards. When this occurs, connecting rod 92 moves valve member 91 upwards to shut off the flow of liquid through aperture 85.
  • Fig. 13 is a schematic illustration of a further aspect of the invention, showing a gas generator which can be made and sold separately from a liquid reservoir.
  • a flexible bag 100 is divided by an impermeable membrane 101 into a gas chamber 102 and a liquid reservoir 103.
  • An expansion of gas chamber 102 causes the contraction of reservoir 103 and the consequent ejection of the liquid contained therein through an outlet 104.
  • Gas chamber 102 is provided with an inlet 105 through which pressurised gas can be fed in order to effect delivery of liquid through outlet 104.
  • a delivery unit indicated generally at 106, comprises an outlet tube 107 adapted to be attached to outlet 104, and a gas generator 108, adapted to be attached to inlet 105.
  • Gas generator 108 is the feedback type of gas generator according to the invention, as previously described. Accordingly, gas generator 108 ensures that the rate of delivery of liquid through delivery tube 107 remains constant.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Electrochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

Cette invention concerne un dispositif d'alimentation en liquide (10) permettant d'alimenter un sujet en liquide nutritif (13). Ce dispositif comporte un réservoir (12) de liquide nutritif relié, en cours d'utilisation, à un générateur de gaz (11) qui fournit le réservoir (12) en gaz pour chasser le liquide (13) dudit réservoir. Ledit générateur (11) comporte un premier et un second compartiments (16, 17) qui contiennent chacun un réactif (19, 20), ces compartiments étant reliés entre eux de manière à ce que, en cours d'utilisation, le flux d'un réactif (19) du premier compartiment (16) entre en contact avec l'autre réactif (20), les réactifs sous la forme d'une solution d'acide citrique (19) et de bicarbonate de sodium en poudre (20) réagissant lors de ce contact pour produire un gaz. L'accroissement de la pression du gaz à l'intérieur du générateur (11) réduit le débit du réactif (19) provenant du premier compartiment (16), ce qui permet d'obtenir une régulation du taux de production de gaz par rétroaction et par conséquent du taux d'alimentation en liquide. On peut arrêter l'alimentation en liquide à partir du dispositif (10) en serrant un tube (14) en provenance du réservoir (12), de sorte que l'accroissement de pression résultant dans le réservoir (12) et dans le générateur de gaz (11) arrête le flux de réactif (19) à partir du premier compartiment (16), mettant ainsi fin à la réaction. Ce n'est que lorsqu'on desserre le tube (14) et qu'une diminution de pression résultante se produit à l'intérieur du réservoir (12) que le flux de réactif recommence. Il est ainsi possible d'interrompre l'alimentation pendant des périodes de 20 à 30 heures et de la reprendre ultérieurement avec une efficacité totale.
PCT/IE1996/000029 1995-05-22 1996-05-13 Dispositif d'alimentation en liquide a regulation par retroaction Ceased WO1996037245A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU57015/96A AU5701596A (en) 1995-05-22 1996-05-13 Feedback-controlled liquid delivery device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE950366A IE950366A1 (en) 1995-05-22 1995-05-22 Feedback-controlled liquid delivery device
IE950366 1995-05-22

Publications (1)

Publication Number Publication Date
WO1996037245A1 true WO1996037245A1 (fr) 1996-11-28

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Country Status (5)

Country Link
AU (1) AU5701596A (fr)
IE (1) IE950366A1 (fr)
TW (1) TW323957B (fr)
WO (1) WO1996037245A1 (fr)
ZA (1) ZA963994B (fr)

Cited By (14)

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WO1997036801A3 (fr) * 1996-04-02 1997-12-04 Belgium Spray Accessory Factor Procede et dispositif pour le maintien et la generation d'une pression dans un distributeur de produit
EP0985418A3 (fr) * 1998-09-15 2000-05-03 Alberto Fernandez-Arias Montoya Dispositif pour injection automatique de liquides
WO2008000272A3 (fr) * 2006-06-30 2008-02-14 Carlsberg Breweries As Génération de pression par voie chimique
EP1897572A1 (fr) * 2006-09-11 2008-03-12 Optikon 2000 S.p.a. Récipient pour irrigation forcée, en particulier pour l'intervention en chirurgie oculaire
WO2009137438A3 (fr) * 2008-05-06 2010-01-21 Wilson-Cook Medical Inc. Appareil et procédés pour administrer des agents thérapeutiques
CN101479169B (zh) * 2006-06-30 2012-03-07 嘉士伯酿酒有限公司 用于化学产生压力的系统和在系统中化学产生压力的方法
JP2014014589A (ja) * 2012-07-11 2014-01-30 Fumakilla Ltd 気体放散装置
US9101744B2 (en) 2009-05-29 2015-08-11 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
EP3290070A1 (fr) * 2016-09-06 2018-03-07 Fritz Ruck Ophthalmologische Systeme GmbH Recipient pour un liquide
US10675248B2 (en) 2018-08-14 2020-06-09 Alma Therapeutics Ltd. Expandable pill
JP2021533048A (ja) * 2018-07-27 2021-12-02 シンプリー・ブリーズ・ホールディングス・リミテッド バッグオンバルブ技術
US11931227B2 (en) 2013-03-15 2024-03-19 Cook Medical Technologies Llc Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding
US12226568B2 (en) 2020-06-05 2025-02-18 Cook Medical Technologies Llc Medical scopes for delivering therapeutic agents

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US3178075A (en) * 1964-03-19 1965-04-13 George M Riedl Pressurized container
US4861560A (en) * 1987-07-16 1989-08-29 Nakajima Doko Company Limited Liquid supply device
EP0439287A1 (fr) * 1990-01-26 1991-07-31 Ccl Industries Inc. Méthode et dispositif pour maintenir une pression à l'intérieur d'un dispensateur
WO1993025269A1 (fr) * 1992-06-15 1993-12-23 Abbott Laboratories Systeme de recipient alimente ambulatoire

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US3178075A (en) * 1964-03-19 1965-04-13 George M Riedl Pressurized container
US4861560A (en) * 1987-07-16 1989-08-29 Nakajima Doko Company Limited Liquid supply device
EP0439287A1 (fr) * 1990-01-26 1991-07-31 Ccl Industries Inc. Méthode et dispositif pour maintenir une pression à l'intérieur d'un dispensateur
WO1993025269A1 (fr) * 1992-06-15 1993-12-23 Abbott Laboratories Systeme de recipient alimente ambulatoire

Cited By (30)

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IE950366A1 (en) 1996-11-27
ZA963994B (en) 1996-11-27
AU5701596A (en) 1996-12-11
TW323957B (en) 1998-01-01

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