WO1996033651B1 - Apparatus for sensing bodily conditions - Google Patents
Apparatus for sensing bodily conditionsInfo
- Publication number
- WO1996033651B1 WO1996033651B1 PCT/US1996/005331 US9605331W WO9633651B1 WO 1996033651 B1 WO1996033651 B1 WO 1996033651B1 US 9605331 W US9605331 W US 9605331W WO 9633651 B1 WO9633651 B1 WO 9633651B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- test
- biopotential
- sensors
- digital
- signals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
A method and apparatus for screening or sensing disease states, injury sites or bodily conditions in a human or animal subject by separately detecting the DC biopotential of the electromagnetic field at a plurality of test points in a test area. The DC biopotentials are converted by analog-to-digital converters (36, 38) connected to DC biopotential test sensors (12) at the test points into digital test signals, and the DC biopotential test sensors (12) and analog-to-digital converters (36, 38) form a biopotential sensing section (48) which is separate from a processing section (46) that receives and processes the test signals. Signals between the processing section (46) and the biopotential sensing section (48) are transmitted by a transmission network which electrically isolates the two sections. The conversions performed by the analog-to-digital converters (36, 38) are synchronized with the AC line frequency of the apparatus power supply (42), and the digital test signals are filtered in the processing section (46) by digital filters (68), each of which is dedicated to an individual DC biopotential test sensor (12).
Claims
1. An apparatus for sensing a condition at a test site on a human or animal subject by detecting DC biopotentials during a test period which are a function of the electromagnetic field present in the subject at the test site, said apparatus being powered by an AC power supply having an AC line frequency and comprising: at least one DC biopotential reference sensor for contacting the subject at a reference location, a plurality of DC biopotential test sensors for contacting the subject at spaced locations at the test site, each said test sensor operating with a reference sensor to detect DC biopotentials which are present in the area of said test site and to provide DC test potentials as a function thereof, an analog to digital converter operably connected to said test sensors for receiving said DC test potentials and for performing conversion operations for converting said analog DC test potentials to digital test signals, a timing circuit for sensing said AC line frequency and controlling said analog to digital converter to synchronize the conversion operations of said analog to digital converter with said AC line frequency.
2. The apparatus of claim 1 wherein said timing circuit causes said analog to digital converter to provide two conversion operations for each half cycle of AC line frequency.
3. The apparatus of claim 2 wherein said timing circuit causes said analog to digital converter to provide a conversion operation at points on each half cycle of AC line frequency which are substantially equidistant -34- from a peak 90 degree point of such half cycle and are on opposite sides of said peak point.
4. The apparatus of claim 1 which includes a digital processor connected to receive said digital test signals from said analog to digital converter, said processor operating during a test period to sample a plurality of digital test signals which are a function of a plurality of DC test potentials from each test sensor and to identify potential relationships therebetween.
5. The apparatus of claim 4 wherein said processor provides control signals to control a sampling of DC test potentials during a test period, said processor including said timing circuit for providing conversion timing signals to control the conversion operations of said analog to digital converter.
6. An apparatus for sensing a condition at a test site on a human or animal subject by detecting DC biopotentials during a test period at the test site, said apparatus being powered by an AC power supply having an AC line frequency and comprising: a biopotential sensing section including at least one DC biopotential reference sensor for contacting the subject at a reference location, a plurality of DC biopotential test sensors for contacting the subject at spaced locations at the test site, each said test sensor operating with a reference sensor to detect DC biopotentials and to provide DC test potentials as a function thereof, and an analog to digital converter connected to said test sensors for receiving said DC test potentials and for performing conversion operations for converting said DC test potentials to digital test signals, a processing section connected to said AC power supply and including a digital processor operative during a test period to sample digital test signals which are a function of a plurality of DC test potentials from each test sensor and to identify potential relationships therebetween, said processor operating to provide control signals to said biopotential sensing section during said test period, and an isolation circuit connected between said biopotential sensing section and said processing section to transmit control signals to said biopotential sensing section and digital test signals to said processing section, said isolation circuit operating to electrically isolate said biopotential sensing section from said processing section and including test signal conversion means to convert digital test signals from said analog to digital converter to test optical signals and reconvert said test optical signals to electrical digital test signals at said processing section and control conversion means to convert said control signals from said processing section to optical control signals and reconvert said optical control signals to electrical signals at said biopotential sensing section.
7. The apparatus of claim 6 wherein said processor senses said AC line frequency and provides control signals to said analog to digital converter to synchronize the conversion operations of said analog to digital converter with said AC line frequency.
8. An apparatus for sensing a condition at a test site on a human or animal subject by detecting DC biopotentials during a test period, said apparatus being powered by an AC power supply having an AC line frequency and comprising: -36- at least one DC biopotential reference sensor for contacting the subject at a reference location, a plurality of DC biopotential test sensors for contacting the subject at spaced locations at the test site, each said test sensor having a signal output and operating with a reference sensor to detect DC biopotentials which are present in the area of said test site and to provide DC test potentials as a function thereof, an analog to digital converter connected to said test sensors for converting DC test potentials to digital test signals, a multiplexor connected between said test sensors and said analog to digital converter for sequentially switching among said test sensors during a test period and performing a parallel to serial conversion, a de-multiplexor connected to the output of said analog to digital converter for decommutating said digital test signals and performing a serial to parallel conversion, and a plurality of separate digital filters connected to said de-multiplexor for receiving said digital test signals from said analog to digital converter, said de-multiplexor providing digital test signals from each of said test sensors to one of said plurality of separate digital filters dedicated to receiving digital test signals from DC test potentials received from only that test sensor.
9. The apparatus of claim 8 which includes a signal ranging circuit connected to said digital filters for passing test signals within a predetermined millivolt range and rejecting test signals outside such predetermined range. -37-
10. The apparatus of claim 8 which includes at least first and second separate sensor arrays, each of said sensor arrays including a plurality of said DC biopotential test sensors, said multiplexer operating during a test period to simultaneously provide DC test potentials from individual test sensors in said first and second sensor arrays, at least one analog to digital converter for each sensor array, each analog to digital converter operating during a test period to receive DC test potentials from its associated sensor array.
11. The apparatus of claim 10 which includes a digital processor operating during a test period to sample a plurality of said digital test signals which are a function of a plurality of DC test potentials from each test sensor, said processor including said digital filters and operating to demultiplex the serial test signals from the analog to digital converter and connect the decommutated digital test signals to said separate digital filters.
12. The apparatus of claim 11 wherein said digital processor senses said AC line frequency and synchronizes the conversion operations of said analog to digital converters with said AC line frequency.
13. An apparatus for sensing a condition at a test site on a human or animal subject by detecting DC biopotentials during a test period at the test site comprising: a biopotential section including at least one reference sensor for contacting the subject at a reference location and a plurality of test sensors for contacting the subject at spaced locations at the test site, each test sensor having a signal output and operating with a reference sensor to detect DC biopotentials which are present at the test site and to provide DC test -38- potentials as a function thereof, an analog to digital converter for converting said DC test potentials to digital test signals which are indicative of said DC test potentials, and a multiplexer connected between said test sensors and said analog to digital converter for providing serial DC test potentials to said analog to digital converter by switching between individual test sensors during a test period and a processing section including a digital processor operating during a test period to sample and process only digital test signals indicative of DC test potentials which are within a range of from -30 mv to +100 mv and to identify potential relationships therebetween.
14. The apparatus of claim 13 wherein said biopotential sensing section includes at least first and second separate sensor arrays, each of said sensor arrays including a plurality of test sensors, said multiplexer operating during a test period to simultaneously provide DC test potentials from individual test sensors in said first and second sensor arrays, at least one analog to digital converter for each sensor array, each analog to digital converter operating during a test period to receive DC test potentials from its associated sensor array.
15. The apparatus of claim 14 wherein said processor provides control signals to said biopotential sensing section during said test period, said apparatus including an isolation circuit means connected between said biopotential sensing section and said processing section to transmit control signals to said biopotential sensing section and digital test signals to said processing section, said isolation circuit means operating to electrically isolate said biopotential sensing section from said processing section. -39-
16. The apparatus of claim 15 wherein said isolation circuit means converts digital test signals from said analog to digital converter to optical signals and reconverts said digital test signals to electrical signals at said processing section and converts said control signals from said processing section to optical signals and reconverts said control signals to electrical signals at said biopotential sensing section.
17. The apparatus of claim 16 wherein said processing section is connected to an AC power supply having an AC line frequency.
18. The apparatus of claim 17 wherein said processor senses said AC line frequency and synchronizes the conversion operations of said analog to digital converter with said AC line frequency.
19. The apparatus of claim 18 wherein said processing section includes a de-multiplexor for decommutating the serial digital test signals received from said analog to digital converter for performing a serial parallel conversion and separate digital filters being connected to the separate parallel outputs from said de-multiplexor for filtering said individual digital test signals.
20. A method for bodily condition sensing at one or more test sites on a human or animal subject as a function of DC biopotentials present at the test site by a plurality of spaced DC biopotential sensors in contact with the skin surface of the subject including one or more DC biopotential reference sensors and a plurality of DC biopotential test sensors which includes: -40- selecting during a test period a first pair and a second pair of DC biopotential sensors from said plurality of spaced DC biopotential sensors, each said first and second pairs of DC biopotential sensors including a reference and a test sensor, detecting a plurality of times during the test period the biopotential present in the subject between said first pair of DC biopotential sensors and the biopotential present in the subject between said second pair of DC biopotential sensors to obtain a plurality of detected biopotentials from each said first and second pair of sensors, and obtaining a plurality of differential values from said plurality of detected biopotentials from said first and second DC biopotential sensor pairs by comparing each biopotential detected by the first pair of DC biopotential sensors with a biopotential detected by said second pair of DC biopotential sensors to obtain a differential value indicative of the potential difference therebetween.
21. The method of claim 20 which includes averaging said plurality of differential values to obtain an average differential value.
22. The method of claim 20 which includes selecting, during a test period, X number of first and second pairs of DC biopotential sensors, obtaining a plurality of biopotentials during the test period from each first and second pair of DC biopotential sensors in said X number of pairs of first and second DC biopotential sensors, obtaining a plurality of differential values from said plurality of biopotentials from each of said X number of pairs of said first and second DC biopotential sensors, -41 - averaging said plurality of differential values from each of said X number of pairs of first and second DC biopotential sensors to obtain X number of average differential values, comparing the X number of average differential values to identify a high and a low level differential value, obtaining a final differential value indicative of the difference between said high and low level differential values, comparing said final differential value to a predetermined reference value to obtain a relationship therebetween, and obtaining an indication of the presence or absence of a disease, an injury or a bodily condition from the relationship of said final differential value to said reference value.
23. The method of claim 20 which includes simultaneously and sequentially detecting biopotentials between said first pair and second pair of DC biopotential sensors and obtaining said differential values by comparing simultaneously detected biopotentials from said first and second pair of DC biopotential sensors.
24. The method of claim 23 which includes selecting, during a test period, X number of first and second pairs of DC biopotential sensors, sequentially obtaining a plurality of biopotentials during the test period from each first and second pair of DC biopotential sensors in said X number of pairs of first and second biopotential sensors, and obtaining a plurality of differential values from said plurality of biopotentials from each of said X number of pairs of said first and second DC biopotential sensors.
-42- 25. The method of claim 24 which includes averaging the differential values obtained from each of said X numbers of pairs of first and second DC biopotential sensors to obtain X number of average differential values.
26. A method for bodily condition sensing at one or more test sites on a human or animal subject as a function of DC biopotentials present at the test site by a plurality of spaced DC biopotential sensors in contact with the skin surface of the subject including one or more DC biopotential reference sensors and a plurality of DC biopotential test sensors, said DC biopotential sensors contacting the skin of the subject at spaced measurement points at the test site which includes: detecting during the test period the biopotential between a DC biopotential reference sensor and each of a plurality of DC biopotential sensors at different measurement points to obtain a biopotential value for each measurement point, and inferring a biopotential value for an interpolation point at the test site not contacted by a DC biopotential test sensor by comparing a distance from each measurement point to the interpolation point to the biopotential value for each measurement point.
27. The method of claim 26 which includes inferring a biopotential value for a plurality of interpolation points and subsequently generating an image using the biopotential values detected for each measurement point and the biopotential values inferred for each interpolation point.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU55531/96A AU702900B2 (en) | 1995-04-26 | 1996-04-25 | Apparatus for sensing bodily conditions |
| BR9608524A BR9608524A (en) | 1995-04-26 | 1996-04-25 | Process and apparatus for selection or detection of body conditions using cc biopotentials |
| DK96912853T DK0831741T3 (en) | 1995-04-26 | 1996-04-25 | Apparatus for detecting DC biopotentials |
| AT96912853T ATE255362T1 (en) | 1995-04-26 | 1996-04-25 | DEVICE FOR DETECTING DC BIOPOTENTIALS |
| DE69630952T DE69630952T2 (en) | 1995-04-26 | 1996-04-25 | DEVICE FOR DETECTING DC BIOPOTENTIALS |
| JP8532603A JPH11504236A (en) | 1995-04-26 | 1996-04-25 | Method and apparatus for screening or detecting body condition using DC biopotential |
| EP96912853A EP0831741B1 (en) | 1995-04-26 | 1996-04-25 | Apparatus for detecting dc biopotentials |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/429,138 US5678547A (en) | 1988-12-22 | 1995-04-26 | Method and apparatus for screening or sensing bodily conditions using DC biopotentials |
| US429,138 | 1995-04-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996033651A1 WO1996033651A1 (en) | 1996-10-31 |
| WO1996033651B1 true WO1996033651B1 (en) | 1996-12-05 |
Family
ID=23701954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1996/005331 Ceased WO1996033651A1 (en) | 1995-04-26 | 1996-04-25 | Apparatus for sensing bodily conditions |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5678547A (en) |
| EP (2) | EP0831741B1 (en) |
| JP (1) | JPH11504236A (en) |
| AT (1) | ATE255362T1 (en) |
| AU (1) | AU702900B2 (en) |
| BR (1) | BR9608524A (en) |
| CA (1) | CA2218870A1 (en) |
| DE (1) | DE69630952T2 (en) |
| DK (1) | DK0831741T3 (en) |
| ES (1) | ES2208741T3 (en) |
| PT (1) | PT831741E (en) |
| WO (1) | WO1996033651A1 (en) |
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| US6208983B1 (en) | 1998-01-30 | 2001-03-27 | Sarnoff Corporation | Method and apparatus for training and operating a neural network for detecting breast cancer |
| WO1999053627A1 (en) | 1998-04-10 | 1999-10-21 | Chrimar Systems, Inc. Doing Business As Cms Technologies | System for communicating with electronic equipment on a network |
| IL125053A (en) * | 1998-06-22 | 2004-07-25 | Sorin T Teich | Method for the detection of inflammatory processes and malignancies in mammals |
| ID29282A (en) * | 1998-07-06 | 2001-08-06 | Pastor Aleksander Cs | EQUIPMENT FOR EVALUATION OF SKIN IMPEDANCE VARIATIONS |
| ATE392180T1 (en) | 1999-01-13 | 2008-05-15 | Cytyc Corp | IDENTIFICATION OF DUCTAL OPENINGS USING CHARACTERISTIC ELECTRICAL SIGNAL |
| US6488689B1 (en) | 1999-05-20 | 2002-12-03 | Aaron V. Kaplan | Methods and apparatus for transpericardial left atrial appendage closure |
| US7499745B2 (en) * | 2000-02-28 | 2009-03-03 | Barbara Ann Karmanos Cancer Institute | Multidimensional bioelectrical tissue analyzer |
| DE10119527A1 (en) * | 2001-04-12 | 2002-11-07 | Sitec Sensortechnik Gmbh | Method for the mobile or stationary acquisition of body function and metabolic data of a living body and device for carrying out the method |
| US7044911B2 (en) * | 2001-06-29 | 2006-05-16 | Philometron, Inc. | Gateway platform for biological monitoring and delivery of therapeutic compounds |
| US7610104B2 (en) | 2002-05-10 | 2009-10-27 | Cerebral Vascular Applications, Inc. | Methods and apparatus for lead placement on a surface of the heart |
| US7630759B2 (en) | 2002-05-20 | 2009-12-08 | Epi-Sci, Llc | Method and system for detecting electrophysiological changes in pre-cancerous and cancerous breast tissue and epithelium |
| US6866639B2 (en) * | 2002-09-23 | 2005-03-15 | Everest Biomedical Instruments | Handheld low voltage testing device |
| US8594764B2 (en) * | 2003-03-07 | 2013-11-26 | Jon Rice | Device and method for assessing the electrical potential of cells and method for manufacture of same |
| WO2005034802A2 (en) | 2003-10-09 | 2005-04-21 | Sentreheart, Inc. | Apparatus and method for the ligation of tissue |
| WO2006110734A2 (en) | 2005-04-07 | 2006-10-19 | Sentreheart, Inc. | Apparatus and method for the ligation of tissue |
| US7738951B2 (en) | 2006-07-28 | 2010-06-15 | Medtronic, Inc. | Prioritized multicomplexor sensing circuit |
| PT2574287E (en) | 2007-03-30 | 2015-07-22 | Sentreheart Inc | Devices for closing the left atrial appendage |
| WO2009039191A2 (en) | 2007-09-20 | 2009-03-26 | Sentreheart, Inc. | Devices and methods for remote suture management |
| CN102448383B (en) | 2009-04-01 | 2015-03-04 | 森特莱哈尔特公司 | Tissue ligation device and controller thereof |
| WO2011129894A2 (en) | 2010-04-13 | 2011-10-20 | Sentreheart, Inc. | Methods and devices for accessing and delivering devices to a heart |
| US9061140B2 (en) | 2010-10-13 | 2015-06-23 | Boston Scientific Neuromodulation Corporation | Sample and hold circuitry for monitoring voltages in an implantable neurostimulator |
| AU2012267914B2 (en) | 2011-06-08 | 2016-11-17 | Atricure, Inc. | Tissue ligation devices and tensioning devices therefor |
| EP3378416B1 (en) | 2013-03-12 | 2020-07-29 | Sentreheart, Inc. | Tissue ligation devices |
| US20150335288A1 (en) | 2013-06-06 | 2015-11-26 | Tricord Holdings, Llc | Modular physiologic monitoring systems, kits, and methods |
| US10258408B2 (en) | 2013-10-31 | 2019-04-16 | Sentreheart, Inc. | Devices and methods for left atrial appendage closure |
| DE102013022090A1 (en) * | 2013-12-16 | 2015-06-18 | Seca Ag | Multifunction measuring device and method for determining and evaluating various measurement signals of a biological subject |
| DE102014015896A1 (en) * | 2014-10-28 | 2016-04-28 | Drägerwerk AG & Co. KGaA | Device for detecting electrical potentials |
| CA3209783A1 (en) | 2015-03-24 | 2016-09-29 | Atricure,Inc. | Devices and methods for left atrial appendage closure |
| PL3273870T3 (en) | 2015-03-24 | 2024-04-29 | Atricure, Inc. | Tissue ligation devices |
| CA3015804A1 (en) | 2016-02-26 | 2017-08-31 | Sentreheart, Inc. | Devices and methods for left atrial appendage closure |
| EP3553538B1 (en) | 2018-04-13 | 2021-03-10 | Nokia Technologies Oy | An apparatus, electronic device and method for estimating impedance |
| US11571159B1 (en) * | 2020-07-23 | 2023-02-07 | Meta Platforms Technologies, Llc | Floating biopotential samplings |
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| US4328809A (en) * | 1976-09-24 | 1982-05-11 | Barry Herbert Hirschowitz | Device and method for detecting the potential level of the electromagnetic field of a living organism |
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| US4416288A (en) * | 1980-08-14 | 1983-11-22 | The Regents Of The University Of California | Apparatus and method for reconstructing subsurface electrophysiological patterns |
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-
1995
- 1995-04-26 US US08/429,138 patent/US5678547A/en not_active Expired - Fee Related
-
1996
- 1996-04-25 AU AU55531/96A patent/AU702900B2/en not_active Ceased
- 1996-04-25 WO PCT/US1996/005331 patent/WO1996033651A1/en not_active Ceased
- 1996-04-25 ES ES96912853T patent/ES2208741T3/en not_active Expired - Lifetime
- 1996-04-25 EP EP96912853A patent/EP0831741B1/en not_active Expired - Lifetime
- 1996-04-25 CA CA002218870A patent/CA2218870A1/en not_active Abandoned
- 1996-04-25 DK DK96912853T patent/DK0831741T3/en active
- 1996-04-25 JP JP8532603A patent/JPH11504236A/en not_active Ceased
- 1996-04-25 BR BR9608524A patent/BR9608524A/en not_active Application Discontinuation
- 1996-04-25 EP EP03000224A patent/EP1308127A1/en not_active Withdrawn
- 1996-04-25 AT AT96912853T patent/ATE255362T1/en not_active IP Right Cessation
- 1996-04-25 PT PT96912853T patent/PT831741E/en unknown
- 1996-04-25 DE DE69630952T patent/DE69630952T2/en not_active Expired - Fee Related
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