[go: up one dir, main page]

WO1996032137B1 - Techniques de declenchement d'une tolerance immunitaire a l'aide d'immunotoxine - Google Patents

Techniques de declenchement d'une tolerance immunitaire a l'aide d'immunotoxine

Info

Publication number
WO1996032137B1
WO1996032137B1 PCT/US1996/005087 US9605087W WO9632137B1 WO 1996032137 B1 WO1996032137 B1 WO 1996032137B1 US 9605087 W US9605087 W US 9605087W WO 9632137 B1 WO9632137 B1 WO 9632137B1
Authority
WO
WIPO (PCT)
Prior art keywords
immunotoxin
donor
recipient
cell
crm9
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/005087
Other languages
English (en)
Other versions
WO1996032137A2 (fr
WO1996032137A3 (fr
Filing date
Publication date
Priority to CA2218166A priority Critical patent/CA2218166C/fr
Priority to AU56637/96A priority patent/AU5663796A/en
Priority to DE69638145T priority patent/DE69638145D1/de
Priority to EP96913790A priority patent/EP0830146B1/fr
Priority to AT96913790T priority patent/ATE460179T1/de
Application filed filed Critical
Publication of WO1996032137A2 publication Critical patent/WO1996032137A2/fr
Publication of WO1996032137A3 publication Critical patent/WO1996032137A3/fr
Publication of WO1996032137B1 publication Critical patent/WO1996032137B1/fr
Anticipated expiration legal-status Critical
Priority to AU39405/00A priority patent/AU762197B2/en
Priority to US09/810,999 priority patent/US7288254B2/en
Ceased legal-status Critical Current

Links

Abstract

L'invention porte sur une technique de traitement de troubles du système immunitaire, n'entraînant pas de prolifération de lymphocytes thymodépendants, qui consiste à administrer à l'animal une immunotoxine, comportant une fraction de toxine diphtérique mutante liée à une fraction d'anticorps s'acheminant par la voie d'un anti-CD3, ou un dérivé de celle-ci, dans des conditions telles que les troubles sont traités. Il est donc possible, grâce à la présente technique, de traiter une réaction du greffon contre l'hôte. L'invention porte également sur une technique visant à l'inhibition d'un phénomène du rejet de greffe par déclenchement d'une tolérance immunitaire chez un receveur vis-à-vis d'un tissu ou de cellules de donneur mammalien étranger; cette technique consiste, a), à soumettre le receveur à une immunotoxine de façon à diminuer de 80 % au moins la population de lymphocytes thymodépendants circulant chez des receveurs, l'immunotoxine étant un anticorps anti-CD3 lié à une toxine de protéine diphtérique et la protéine présentant une mutation du site de liaison et b), à transplanter les cellules du donneur chez le receveur, ce qui a pour effet d'inhiber un phénomène du rejet de greffe de la part du receveur vis-à-vis de la cellule d'organe du donneur et rendre l'hôte tolérant à la cellule du donneur.
PCT/US1996/005087 1995-04-14 1996-04-12 Techniques de declenchement d'une tolerance immunitaire a l'aide d'immunotoxine Ceased WO1996032137A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2218166A CA2218166C (fr) 1995-04-14 1996-04-12 Techniques de declenchement d'une tolerance immunitaire a l'aide d'immunotoxine
AU56637/96A AU5663796A (en) 1995-04-14 1996-04-12 Methods of inducing immune tolerance using immunotoxins
DE69638145T DE69638145D1 (de) 1995-04-14 1996-04-12 Verfahren zur herbeiführung einer immuntoleranz mit hilfe von immuntoxinen
EP96913790A EP0830146B1 (fr) 1995-04-14 1996-04-12 Techniques de declenchement d'une tolerance immunitaire a l'aide d'immunotoxine
AT96913790T ATE460179T1 (de) 1995-04-14 1996-04-12 Verfahren zur herbeiführung einer immuntoleranz mit hilfe von immuntoxinen
AU39405/00A AU762197B2 (en) 1995-04-14 2000-06-12 Methods of inducing immune tolerance using immunotoxins
US09/810,999 US7288254B2 (en) 1995-10-30 2001-03-16 Use of immunotoxins to induce immune tolerance to pancreatic islet transplantation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42210095A 1995-04-14 1995-04-14
US08/422,100 1995-04-14
US8810495P 1995-10-30 1995-10-30
US60/088,104 1995-10-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US62874596A A-371-Of-International 1995-10-30 1996-11-18
US87837897A Continuation 1995-10-30 1997-06-18

Publications (3)

Publication Number Publication Date
WO1996032137A2 WO1996032137A2 (fr) 1996-10-17
WO1996032137A3 WO1996032137A3 (fr) 1997-01-09
WO1996032137B1 true WO1996032137B1 (fr) 1997-02-20

Family

ID=26778277

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/005087 Ceased WO1996032137A2 (fr) 1995-04-14 1996-04-12 Techniques de declenchement d'une tolerance immunitaire a l'aide d'immunotoxine

Country Status (6)

Country Link
EP (1) EP0830146B1 (fr)
AT (1) ATE460179T1 (fr)
AU (2) AU5663796A (fr)
CA (1) CA2218166C (fr)
DE (1) DE69638145D1 (fr)
WO (1) WO1996032137A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696338B2 (en) 1995-10-30 2010-04-13 The United States Of America As Represented By The Department Of Health And Human Services Immunotoxin fusion proteins and means for expression thereof
US7288254B2 (en) 1995-10-30 2007-10-30 The United States Of America As Represented By The Secretary, Department Of Health And Human Services, Nih Use of immunotoxins to induce immune tolerance to pancreatic islet transplantation
US7517527B2 (en) 1995-10-30 2009-04-14 The United States Of America As Represented By The Department Of Health And Human Services Immunotoxin with in vivo T cell suppressant activity and methods of use
US7125553B1 (en) 1996-04-15 2006-10-24 The United States of America as represented by the Department of Health and Human Services c/o Centers for Disease Control and Prevention Methods of inducing immune tolerance using immunotoxins
CA2284079C (fr) * 1997-03-05 2009-05-12 David M. Neville Nouvelles immunotoxines et nouveaux procedes d'induction de tolerance immunitaire
WO1998039425A2 (fr) * 1997-03-05 1998-09-11 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nouveaux vecteurs et procedes d'expression utiles pour produire des proteines mutantes
DE60034428T2 (de) * 1999-01-08 2008-01-03 Wisconsin Alumni Research Foundation, Madison Vorbeugung der kronischen transplantat-abstossung durch eine kombination von immuntoxinen und kostimulationblocker
CA2409746C (fr) * 2000-05-18 2014-11-25 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Proteines de fusion d'immunotoxines et leurs moyens d'expression
WO2014138486A1 (fr) * 2013-03-06 2014-09-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ganglion lymphatique comme site de transplantation, organogenèse et fonctionnement pour de multiples tissus et organes
WO2009111778A2 (fr) 2008-03-07 2009-09-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Ganglions lymphatiques comme site de régénération
WO2025050404A1 (fr) * 2023-09-08 2025-03-13 成都维瑾柏鳌生物医药科技有限公司 Composition pharmaceutique et utilisation associée

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520226A (en) * 1982-07-19 1985-05-28 The United States Of America As Represented By The Department Of Health And Human Services Treatment of graft versus host disease using a mixture of T-lymphocyte specific monoclonal antibody: ricin conjugates
US5167956A (en) * 1991-02-11 1992-12-01 The United States Of America As Represented By The Department Of Health And Human Services Immunotoxin with in-vivo t cell suppressant activity
ES2231770T3 (es) * 1993-03-05 2005-05-16 Wyeth Holdings Corporation Nuevos plasmidos para la produccion de proteina crm y toxina difterica.

Similar Documents

Publication Publication Date Title
Inamura et al. Prolongation of skin allograft survival in rats by a novel immunosuppressive agent, FK 506
Kupiec-Weglinski et al. Sparing of suppressor cells: a critical action of cyclosporine
Ricordi et al. Low-temperature culture of human islets or in vivo treatment with L3T4 antibody produces a marked prolongation of islet human-to-mouse xenograft survival.
CA2284079A1 (fr) Nouvelles immunotoxines et nouveaux procedes d'induction de tolerance immunitaire
EP0621786B1 (fr) Procede servant a induire la tolerance aux xenorogreffes
WO1996032137B1 (fr) Techniques de declenchement d'une tolerance immunitaire a l'aide d'immunotoxine
CA2218166A1 (fr) Techniques de declenchement d'une tolerance immunitaire a l'aide d'immunotoxine
Prigozhina et al. PERMANENT AND SPECIFIC TRANSPLANTATION TOLERANCE INDUCED BY A NONMYELOABLATIVE TREATMENT TO A WIDE VARIETY OF ALLOGENEIC TISSUES: I. Induction of Tolerance by a Short Course of Total Lymphoid Irradiation and Selective Elimination of the Donor-Specific Host Lymphocytes: 1
Siemionow et al. Advances in the development of experimental composite tissue transplantation models
JP2002541195A (ja) 移植片に対する免疫寛容を誘導するための、免疫毒素および樹状細胞の成熟を阻害する作用剤を含有する組成物
US5885570A (en) Induction of tolerance with modified immunogens
Barriga Depression of cell-mediated immunity following inoculation of Trichinella spiralis extract in the mouse
WO1998039016A1 (fr) Inducteurs de tolerance immunitaire
Guenther et al. Advances in strategies for inducing central tolerance in organ allograft recipients
Gill et al. The role of islet transplantation in the treatment of insulin-dependent diabetes mellitus
Ricordi et al. Induction of pancreatic islet graft acceptance: the role of antigen presenting cells
DE69431184T2 (de) Ein thymus-fremdtransplantat
DE69816812T2 (de) Non myeloablative therapie für toleranzinduktion
JPH06298654A (ja) 抗原特異的免疫抑制剤
Mullen et al. Use of total lymphoid irradiation in transplantation of rat fetal pancreases
Slavin et al. Induction of Bilateral Transplantation Tolerance to Cellular and Perfused Allografts and Xenografts with Donor Hematopoietic Cells a
EDELMAN et al. Fetal islet allotransplantation in rabbits
Shankarkumar Xenotransplantation ethics and immunological hurdles!
AU1372192A (en) Protein production from immortal cells grown in vivo
Faustman Antibodies for transplantation