WO1996021615B1 - Coupling assembly for the sterile transfer of sterile materials between a transportable container and a sterile enclosure - Google Patents
Coupling assembly for the sterile transfer of sterile materials between a transportable container and a sterile enclosureInfo
- Publication number
- WO1996021615B1 WO1996021615B1 PCT/IE1996/000001 IE9600001W WO9621615B1 WO 1996021615 B1 WO1996021615 B1 WO 1996021615B1 IE 9600001 W IE9600001 W IE 9600001W WO 9621615 B1 WO9621615 B1 WO 9621615B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- assembly according
- sterilising
- coupling member
- container
- enclosure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
A coupling assembly for the sterile transfer of sterile materials between a transportable container (1, 201) and a sterile enclosure (P) includes a closable dock (20, 220) of the enclosure (P) which seals with a closable mouth (2, 202) of the container (1, 201) to define between them a sealed connecting chamber (24, 281). A UV light source (26, 226) mounted within the chamber (24, 281) is activated to generate UV light to sterilise the interior of the chamber (24, 281). Closures (4, 204) of the container mouth (2, 202) and dock (20, 220) are then displaced to provide a communication path between the interiors of the container (1, 201) and enclosure (P).
Claims
1. A coupling assembly for use in the sterile transfer of sterile materials between a transportable container and a sterile enclosure, the assembly comprising sterilising means (26, 226), a first coupling member (2, 202) on the container engageable with a second coupling member (20, 220) on the enclosure and engaging means (5, 25, 250, 251, 243, 253) associated with each of the coupling members for sealmgly mterengaging the container and the enclosure, the first coupling member (2, 202) including a removable container closure (4, 204) and the second coupling member including a removable closure (20, 221) for the enclosure so that on interengagement the closures define between tnem a sealed connecting chamber (24, 281), the sterilising means (26, 226) comprising means for generating sterilising ultravviolet (UV) or pulsed light radiation and being contained substantially within the sealed connecting chamber (24, 281 ) and being operable to generate in the chamber UV or pulsed light radiation for sterilising the chamber and its internal surfaces.
2. An assembly according to Claim 1, in which the second coupling member (20, 220) includes the sterilising means (26, 226), the sterilising means being mounted so as to face toward the first coupling member (2, 202).
3. An assembly according to Claim 2, in which the second coupling member (20, 220) includes a docking element (23, 220) for releasably engaging the first coupling member (2, 202), the docking element (23, 220) surrounding the closure (4, 204) and the closure comprising a door (21, 221) which is openable inwardly into the enclosure to permit communication between the interiors of a docked container and enclosure on displacement of the closures (4, 204), the sterilising means (26, 226) being mounted on the door (21, 221) .
4. An assembly according to Claim 3, in which a Darner means (27, 227) is provided between the door (21, 221) and the docking element (23, 220) and about the door (21, 221) to form a seal between tne door (21, 221) and the docking element (23, 220), and the sterilising means (26, 226) is arranged to sterilise any exposed surfaces of the barrier means (27, 227).
5. An assembly according to Claim 4, in which the sterilising means comprises at least one source of UV light (26, 226)
6. An assembly according to Claim 5, in which the sterilising means comprises between 3 and 7 UV light sources (26, 226) arranged in parallel.
7. An assembly according to Claim 5 or Claim 6, in which the sterilising means (26, 226) includes a deflector element (291) for reflecting UV light toward the first coupling member (2, 202).
8. An assembly according to Claim 7, in which the deflector element (291) is formed with at least one elongate trough and each UV light source (226) is mounted to lie substantially within the trough.
9. An assembly according to Claim 7 or Claim 8, in which the sterilising means includes a diffuser element (293) and the light source (226) is located between the deflector element (291) and the diffuser element (293).
0 10. An assembly according to Claim 9, in which the diffuser element (293) comprises a sheet of quartz glass.
11. An assembly according to any of Claims 3 to 10, in which the docking element (23, 220) includes at least one sealing means (5, 25, 250, 251) for -> sealmgly interengaging the first and second coupling members ((2, 202), (20, 220)).
12. An assembly according to Claim 11, in which the at least one sealing means (250, 251) comprises an expandable seal which on expansion, bears 0 tightly between the docking element (220) and the first coupling member (202) to lock the enclosure and the container together.
13. An assembly according to Claim 12, in which the docking element (220; comprises a female element of substantially circular cross-section for 5 receiving a correspondingly shaped male element of the first coupling member (202) and in which the sealing means (250, 251) bears radially on the male element to seal and lock the first coupling member (202) and the docking element (220) together.
14. An assembly according to any of Claims 3 to 13, m which the docking element (220) includes supplementary locking means (253) for locating the first coupling member (202) in the docking element (220) and for co-operating with locking formations (243) of the first coupling member (202) to lock the first coupling member (202) and the docking element (220) together.
15. An assembly according to Claim 1 , in which the locking formation comprises a circumferentially extending groove (243).
16. An assembly according to any preceding claim, including sensor means (280) for detecting when the first and second coupling members ((2, 202), (20, 220)) are engaged.
17. An assembly according to Claim 16, in which the sensor means (280) includes means for effecting locking together of the first and second coupling members ((2, 202), (20, 220)).
18. An assembly according to Claim 16 or Claim 17, in which the sensor means (280) includes actuating means for operating the sterilising means.
19. An assembly according to any preceding claim, including means for removing particulate material from the vicinity of the sterilising means (26, 226) before or after engaging the first and second coupling members ((2, 202), (20, 220)).
20. An assembly according to any preceding claim, including a protector (260) for engaging the second coupling member (220) in the absence of a first coupling member (202).
21. An assembly according to any preceding claim, m which the first coupling member (202) includes a removable cover (241) which fits about the closure (204) to protect the closure (204) from damage during transport or storage.
22. An assembly according to any preceding claim, in which the first coupling member (2, 202) comprises a collar of substantially rigid plastics material.
23. An assembly according to any preceding claim, m which the first coupling member (2, 202) includes walls (202b) which taper inwardly toward a sealable mouth of the closure (4, 204) so that the external surfaces of the closure (4, 204) and of the walls (202b) are presented in the path of the sterilising radiation without shadowing.
24. An assembly according to any preceding claim, including a container (1, 201) and an enclosure (P), the container (1, 201) and/or the enclosure (P) being so formed or arranged that contents of the container (1, 201) can be fed between the interiors of the container (1, 201) and the enclosure (P) under the influence of gravity.
25. An assembly according to any preceding claim, including a container (1) which is provided with a sealable opening (3) for charging the container with contents, the opening (3) being separate from the removable closure (4).
26. A transportable container for use with the coupling assembly according to any of Claims 1 to 23.
27. An enclosure for use with the coupling assembly according to any of Claims 1 to 25.
28. A process for conducting a sterile transfer of sterile materials between a transportable container and a sterile enclosure, comprising sealingly interengaging respective closures of each of the container and the enclosure to define between the closures a sealed connecting chamber, sterilising the sealed chamber and its internal surfaces by generating in the chamber sterilising ultraviolet (UV) or pulsed light radiation produced by sterilising means contained substantially within the chamber and thereafter removing the closures of the container and enclosure to provide a path communicating between the interiors of the container and the enclosure.
STATEMENT UNDER ARTICLE 19
Claim 1 has been amended by the insertion of "comprising means for generating sterilising ultraviolet (UV) or pulsed light radiation and" after sterilising means (26, 226) at line 13 and the insertion of "UV or pulsed light radiation" in place of "a sterilising medium" at line 15.
Claim 28 has been amended by the substitution of "sterilising ultraviolet (UV) or pulsed light radiation" for "a sterilising medium" .
Claim 5 has been deleted and new Claim 15 has been introduced which is based on the circumferential groove 243 of Figure 3 (correction from radial groove 243).
The amended claims distinguish the invention from the prior art cited in the International Search Report and additionally from US-A-5,446,289 (Shodeen et al) and US-A-5, 447, 699 (Papciak et al) .
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/860,911 US6030578A (en) | 1995-01-13 | 1996-01-15 | Coupling assembly for the sterile transfer of sterile materials between a transportable container and a sterile enclosure |
| DK96900419T DK0800480T3 (en) | 1995-01-13 | 1996-01-15 | Coupling assembly for sterile transfer of sterile materials between a portable container and a sterile enclosure |
| EP96900419A EP0800480B1 (en) | 1995-01-13 | 1996-01-15 | Coupling assembly for the sterile transfer of sterile materials between a transportable container and a sterile enclosure |
| AU43996/96A AU4399696A (en) | 1995-01-13 | 1996-01-15 | Coupling assembly for the sterile transfer of sterile materials between a transportable container and a sterile enclosure |
| DE69602251T DE69602251T2 (en) | 1995-01-13 | 1996-01-15 | COUPLING ARRANGEMENT FOR THE STERILE TRANSFER OF STERILE MATERIALS BETWEEN A TRANSPORTABLE CONTAINER AND A STERILE HOUSING |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE950020 | 1995-01-13 | ||
| IES950020 | 1995-01-13 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1996021615A2 WO1996021615A2 (en) | 1996-07-18 |
| WO1996021615A3 WO1996021615A3 (en) | 1996-09-19 |
| WO1996021615B1 true WO1996021615B1 (en) | 1996-10-31 |
Family
ID=11040623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IE1996/000001 Ceased WO1996021615A2 (en) | 1995-01-13 | 1996-01-15 | Coupling assembly for the sterile transfer of sterile materials between a transportable container and a sterile enclosure |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6030578A (en) |
| EP (1) | EP0800480B1 (en) |
| AT (1) | ATE179393T1 (en) |
| AU (1) | AU4399696A (en) |
| DE (1) | DE69602251T2 (en) |
| DK (1) | DK0800480T3 (en) |
| WO (1) | WO1996021615A2 (en) |
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| IES80564B2 (en) * | 1997-02-04 | 1998-09-23 | Duras Trading Limited | A removable closure for a container |
| FR2788048B1 (en) | 1999-01-04 | 2001-03-23 | Calhene | METHOD AND DEVICE FOR TRANSFERRING STERILE PRODUCTS BETWEEN A CONTAINER AND AN INSULATOR |
| DE19916720B4 (en) * | 1999-04-13 | 2005-05-04 | Smeja Gmbh & Co Kg | Cleaning and sterilizing machine |
| US8754385B1 (en) * | 1999-06-01 | 2014-06-17 | Jose Gutman | Advanced system and method for ozone containing packaging for sanitizing application |
| SE521881C2 (en) * | 1999-06-09 | 2003-12-16 | Getinge Sterilization Aktiebol | Clutch unit, sterilization system and method of transferring sterilized goods |
| WO2001070621A1 (en) * | 2000-03-23 | 2001-09-27 | Lynn Buckner | Beverage storage and dispensing container |
| US6849233B2 (en) * | 2001-02-26 | 2005-02-01 | Purepulse Technologies, Inc. | Vacuum sterilized sealing of passthrough light treatment devices |
| GB0108850D0 (en) * | 2001-04-07 | 2001-05-30 | Bergin Brian | Apparatus for sterile transfer |
| US20030030011A1 (en) * | 2001-05-17 | 2003-02-13 | Purepulse Technologies, Inc. | Light treatment control in a fluid treatment system using light for the treatment of fluid products |
| EP1499382B1 (en) | 2002-04-26 | 2006-12-27 | GL Tool and Manufacturing Co. Inc. | A valve |
| JP2006503666A (en) * | 2002-10-29 | 2006-02-02 | ミリポア・コーポレイション | Aseptic transfer bag that can be integrity tested and autoclaved |
| US7293477B2 (en) | 2003-12-23 | 2007-11-13 | Millipore Corporation | Disposable, pre-sterilized fluid receptacle sampling device |
| US9511344B2 (en) | 2007-12-18 | 2016-12-06 | Ultraviolet Sciences, Inc. | Ultraviolet light treatment chamber |
| US7511281B2 (en) * | 2005-08-31 | 2009-03-31 | Ultraviolet Sciences, Inc. | Ultraviolet light treatment chamber |
| US9808544B2 (en) | 2005-08-31 | 2017-11-07 | Ultraviolet Sciences, Inc. | Ultraviolet light treatment chamber |
| FR2896992A1 (en) * | 2006-02-09 | 2007-08-10 | Gred Sa | Reutilizable medical device e.g. endoscope, disinfection enclosure, has outer case acting as trap to block radiation emitted by source and incident on orifice, when endoscope`s part is partially introduced in disinfection space via orifice |
| EP1982920A1 (en) * | 2007-04-19 | 2008-10-22 | Krones AG | Device for sterilising containers |
| US7938454B2 (en) | 2007-04-24 | 2011-05-10 | Hyclone Laboratories, Inc. | Sterile connector systems |
| CA2682650A1 (en) * | 2007-04-24 | 2008-10-30 | Hyclone Laboratories, Inc. | Sterile connector systems |
| SG153002A1 (en) | 2007-11-16 | 2009-06-29 | Millipore Corp | Fluid transfer device |
| FR2940440B1 (en) | 2008-12-18 | 2010-12-24 | Millipore Corp | DEVICE FOR TRANSFERRING A MEDIUM |
| FR2940439B1 (en) | 2008-12-18 | 2011-02-11 | Millipore Corp | DEVICE FOR TRANSFERRING A MEDIUM |
| FR2942777B1 (en) | 2009-03-06 | 2016-02-05 | Sartorius Stedim Biotech Sa | SELF-TIGHTENING SKIRT MOUNTING FOR THE FITTING OF, OR CONNECTION TO, AN ANNULAR, QUICK-SETTING AND REMOVAL COLLAR, INTENDED FOR BIOPHARMACEUTICALS |
| FR2942778B1 (en) | 2009-03-06 | 2016-02-05 | Sartorius Stedim Biotech Sa | MOUNTING WITH A CONTINUOUS TORQUE ENCLOSURE FOR FASTENING, OR CONNECTING TO, AN ANNULAR COLLAR WITH RAPID PLACEMENT AND REMOVAL, INTENDED FOR THE BIOPHARMACEUTICAL FIELD |
| CA2761077A1 (en) * | 2009-05-05 | 2010-11-11 | Sidel S.P.A. Con Socio Unico | A unit and a method for sterilizing container closures |
| US8544497B2 (en) | 2009-10-30 | 2013-10-01 | Emd Millipore Corporation | Fluid transfer device and system |
| FR2952988B1 (en) * | 2009-11-23 | 2012-02-03 | Sartorius Stedim Aseptics | IMPROVEMENTS TO THE SEALED JUNCTION AND THE SEALED TRANSFER BETWEEN TWO ENCLOSURES FOR ASEPTIC TRANSFER BETWEEN THEM. |
| FR2952989B1 (en) | 2009-11-23 | 2012-02-03 | Sartorius Stedim Aseptics | SPEAKER FOR SEAL JUNCTION DEVICE AND ASEPTIC TRANSFER DEVICE. |
| US8591486B2 (en) | 2010-11-17 | 2013-11-26 | Kci Licensing, Inc. | Reduced-pressure systems and methods employing an ultraviolet light source for reducing bioburden |
| US8828193B2 (en) * | 2011-09-06 | 2014-09-09 | Indian Institute Of Technology Madras | Production of graphene using electromagnetic radiation |
| CH711666A1 (en) * | 2015-10-20 | 2017-04-28 | Netzhammer Eric | Container for small parts in the pharmaceutical industry. |
| JP6591932B2 (en) * | 2016-06-09 | 2019-10-16 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
| GB201702910D0 (en) * | 2017-02-23 | 2017-04-12 | Ezidock Systems Ltd | Contained transfer of sterile or aseptic materials |
| US11305026B2 (en) | 2017-11-03 | 2022-04-19 | Amgen Inc. | Systems and approaches for sterilizing a drug delivery device |
| CH715184A1 (en) | 2018-07-18 | 2020-01-31 | Pharma Integration S R L | Arrangement for the contamination-free introduction of a sterile object from a container into a containment and method therefor. |
| CN109520789B (en) * | 2018-11-20 | 2023-08-11 | 南京南华航空产业有限公司 | Be applied to environmental protection field mill waste gas collection unmanned aerial vehicle |
| GB201909315D0 (en) * | 2019-06-28 | 2019-08-14 | Ge Healthcare Bio Sciences Ab | Improvements in and relating to steriliasation of fluid-guiding elements |
| US11007292B1 (en) | 2020-05-01 | 2021-05-18 | Uv Innovators, Llc | Automatic power compensation in ultraviolet (UV) light emission device, and related methods of use, particularly suited for decontamination |
| US12252451B2 (en) * | 2020-05-06 | 2025-03-18 | Green Logic, LLC | Dual chamber disinfection system |
| CN118742357B (en) | 2022-02-21 | 2026-02-03 | 拜耳医药保健有限责任公司 | Systems, methods, and devices for delivery of therapeutic or diagnostic agents |
| US12364778B1 (en) * | 2023-09-06 | 2025-07-22 | Kreative Zeno Systems, Inc. | Portable disinfection apparatus, and system and method for tracking disinfection |
| DE102023209418A1 (en) * | 2023-09-27 | 2025-03-27 | Carl Zeiss Smt Gmbh | Device and method for detachably connecting at least one mobile cleanroom with at least one second cleanroom, cleanroom, cleanroom system and lithography system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1017454B (en) * | 1954-05-18 | 1957-10-10 | Allgaeuer Alpenmilch | Method and device for the sterile packaging of liquids, in particular milk |
| US3769517A (en) * | 1972-01-21 | 1973-10-30 | Ppg Industries Inc | Controlled atmosphere chamber |
| US4710634A (en) * | 1986-04-14 | 1987-12-01 | Brookes Richard L | Sanitary door handle having an upper housing and a spacer element |
| FR2613526B1 (en) * | 1987-04-02 | 1989-06-16 | Euritech | DISCONNECTABLE DEVICE FOR COMMUNICATING TWO CLOSED VOLUMES |
| DE3931368A1 (en) * | 1989-09-20 | 1991-03-28 | Smeja Gmbh & Co Kg | CLEANING AND STERILIZING MACHINE FOR SMALL OBJECTS, LIKE LOCKING ELEMENTS OF PHARMACEUTICAL VESSELS |
| GB2237816A (en) * | 1989-11-09 | 1991-05-15 | Cambridge Isolation Tech | Isolator transfer containers |
| US5425400A (en) * | 1993-03-29 | 1995-06-20 | Lee A. Francis | Transfer port apparatus and method |
| FR2703340B1 (en) * | 1993-04-01 | 1995-06-30 | Elveco Msj Sa | INSTALLATION AND METHOD FOR TRANSFERRING GRAVITY FLOWING PRODUCTS. |
| US5447699A (en) * | 1993-11-17 | 1995-09-05 | The West Company | Combination container for holding sterilized elements and a sterilizable transfer port |
| US5446289A (en) * | 1994-04-15 | 1995-08-29 | Despatch Industries Limited Partnership | Ultraviolet passthrough sterilization device |
-
1996
- 1996-01-15 AT AT96900419T patent/ATE179393T1/en active
- 1996-01-15 WO PCT/IE1996/000001 patent/WO1996021615A2/en not_active Ceased
- 1996-01-15 AU AU43996/96A patent/AU4399696A/en not_active Abandoned
- 1996-01-15 DE DE69602251T patent/DE69602251T2/en not_active Expired - Lifetime
- 1996-01-15 DK DK96900419T patent/DK0800480T3/en active
- 1996-01-15 US US08/860,911 patent/US6030578A/en not_active Expired - Lifetime
- 1996-01-15 EP EP96900419A patent/EP0800480B1/en not_active Expired - Lifetime
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