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WO1996016691A1 - Doseur de medicaments - Google Patents

Doseur de medicaments Download PDF

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Publication number
WO1996016691A1
WO1996016691A1 PCT/US1995/015715 US9515715W WO9616691A1 WO 1996016691 A1 WO1996016691 A1 WO 1996016691A1 US 9515715 W US9515715 W US 9515715W WO 9616691 A1 WO9616691 A1 WO 9616691A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
housing
reservoir
stored energy
flow control
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/015715
Other languages
English (en)
Inventor
Marshall S. Kriesel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Inc
Original Assignee
Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Inc filed Critical Science Inc
Priority to AU44146/96A priority Critical patent/AU704888B2/en
Priority to JP8519127A priority patent/JPH10510450A/ja
Priority to EP95942976A priority patent/EP0796121A4/fr
Publication of WO1996016691A1 publication Critical patent/WO1996016691A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1454—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons spring-actuated, e.g. by a clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14506—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons mechanically driven, e.g. spring or clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic

Definitions

  • the present invention relates generally to fluid medicament dispensers. More particularly, the invention concerns a dispenser for use in controllably dispensing a liquid medicament as, for example, an insulin solution.
  • conventional syringes are used to inject many beneficial agent solutions such as insulin.
  • the prescribed dose is first drawn into the syringe and a visual check is made to make certain that the correct amount of insulin is present in the syringe.
  • air is expelled from the syringe and the dose is injected manually.
  • the Rex, et al device comprises an elongated body formed from two separable sections one of which contains an operating mechanism and the other of which contains a pre-filled cartridge.
  • the operating mechanism of the device mechanically advances an axially movable piston rod which, in turn, drives a piston plug located inside the cartridge so as to expel fluid from the device via a needle located at the bottom end of the body.
  • the piston rod advances in successive axial steps of fixed length through rotation of a rotatable piston rod nut.
  • the piston rod nut is driven by a rotatable worm, which is rotated by the advancing axial movement of a pressure device located at the top of the elongated body.
  • the EPO application discloses a dispensing device somewhat similar to the Rex, et al. device, but embodies an operating mechanism that comprises a pawl which permits relative movement of a ratchet-toothed member in a substantially rectilinear arrangement. As in the Rex, et al. device, the operating mechanism drives the plunger of a medicament vial to expel fluid therefrom.
  • Electrically operated syringe pumps are also well known, however, they are typically of considerable complexity and are designed to inject very small doses of medicine with considerable accuracy over a long period, which may be up to 24 hours. Such syringe pumps do not provide the inexpensive, simple and manually operated device suitable for the slow injection of drugs over a shorter period of time, which may range from one to 15 minutes.
  • the apparatus of the present invention uniquely overcomes the drawbacks of the prior art by providing a novel, disposable dispenser of simple but highly reliable construction.
  • a particularly important aspect of the apparatus of the present invention resides in the provision of a novel, self-contained energy source in the form of a uniquely constructed elastomeric member that provides the force necessary to uniformly and precisely dispense solutions, such as insulin, from standard pre-filled containers that can be conveniently loaded into the apparatus. Because of the simplicity of construction of the apparatus of the invention, and the non-mechanical nature of the energy source, the apparatus can be manufactured at low cost without in any way sacrificing accuracy and reliability.
  • fluid medicaments such as insulin, antibiotics, oncolytics and the like
  • Another object of the invention is to provide a dispenser of the aforementioned character in which a stored energy source is provided in the form of a highly novel, expandable, elastomeric member that provides the force necessary to continuously and uniformly expel fluid from the pre-filled container.
  • Another object of the invention is to provide a dispenser of the character described in the preceding paragraph in which the expandable elastomeric member comprises a polymeric mass which can be controllably deformed and, after being deformed, exhibits a tendency to predictably return toward a non-deformed configura ⁇ tion.
  • Another object of the invention is to provide a fluid dispenser of the class described which is compact, lightweight, is easy for ambulatory patients to use, is fully disposable, and is extremely accurate so as to enable the infusion of precise doses of insulin over prescribed periods of time.
  • Another object of the invention is to provide a self-contained medicament dispenser which is of very simple construction and yet extremely reliable in use.
  • Another object of the invention is to provide a dispenser of the class described which includes means for interconnecting the device with the body or clothing of the patient.
  • Another object of the invention is to provide a fluid dispenser as described in the preceding paragraphs which is easy and inexpensive to manufacture in large quantities.
  • Figure 1 is a generally perspective view of one embodiment of the dispensing apparatus of the present invention for dispensing fluids at a uniform rate.
  • Figure 2 is a generally perspective view showing the appearance of the apparatus of Figure 1 after a portion of the operating member has been threadably advanced into the body portion of the apparatus.
  • Figure 2A is a generally perspective, diagrammatic view illustrating the manner in which a portion of the operating member is advanced by the user into the body of the apparatus.
  • Figure 3 is an enlarged right end view of the apparatus shown in Figures 1 and 2.
  • Figure 4 is a generally perspective, exploded view of the apparatus of Figure 1.
  • Figures 5 is a generally perspective, exploded view of the fluid flow control assembly of the apparatus which functions to control the rate of fluid flow from the apparatus.
  • Figure 6 is an enlarged, cross-sectional view taken along lines 6-6 of Figure 3.
  • Figure 7 is a cross-sectional view taken along lines 7-7 of Figure 6.
  • Figure 8 is a cross-sectional view similar to Figure 7, but illustrating the operation of the housing release mechanism of the base support assembly.
  • Figure 9 is a cross-sectional view taken along lines 9-9 of Figure 6.
  • Figure 10 is a cross-sectional view taken along lines 10-10 of Figure 6.
  • Figure 11 is an enlarged, cross-sectional view similar to Figure 6, but showing the position of the component parts of the apparatus after a portion of the operating member has been threadably advanced into the body.
  • Figure 12 is a fragmentary, cross-sectional view of the dispensing end portion of the apparatus illustrating the position of the cooperating component parts after the cannula has pierced the pierceable septum of the medicament vial.
  • Figure 13 is a development view taken along lines 13-13 of Figure 11 illustrating the manner in which the locking teeth and locking tabs of the device cooperate to lock the operating member to the housing.
  • Figure 14 is a generally perspective view of an alternate embodiment of the dispensing apparatus of the present invention for dispensing fluids at a uniform rate.
  • Figure 15 is a generally perspective view showing the appearance of the apparatus of Figure 14 after a portion of the operating member has been threadably advanced into the body portion of the apparatus.
  • Figure 16 is a generally perspective, exploded view of the apparatus of Figure 14.
  • Figure 17 is a generally perspective, exploded view of the fluid flow control assembly of this latest form of the apparatus which functions to control the rate of fluid flow from the apparatus.
  • Figure 18 is a generally perspective, diagrammatic view illustrating the manner in which a portion of the operating member is threadably advanced by the user into the body of the apparatus.
  • Figure 19 is an enlarged left end view of the apparatus shown in Figures 14 and
  • Figure 20 is an enlarged, cross-sectional view taken along lines 20-20 of Figure
  • Figure 21 is a cross-sectional view taken along lines 21-21 of Figure 20.
  • Figure 22 is a cross-sectional view taken along lines 22-22 of Figure 20.
  • Figure 23 is a cross-sectional view taken along lines 23-23 of Figure 20.
  • Figure 24 is an enlarged, cross-sectional view similar to Figure 20, but showing the position of the component parts of the apparatus after a portion of the operating member has been threadably advanced into the body.
  • Figure 25 is a cross-sectional view similar to Figure 24 but illustrating the position of the cooperating component parts after the cannula has pierced the pierceable septum of the medicament vial.
  • Figure 26 is a cross-sectional view taken along lines 26-26 of Figure 25.
  • Figure 27 is a cross-sectional view taken along lines 27-27 of Figure 25.
  • Figure 28 is an enlarged, fragmentary, cross-sectional view of the dispensing end of the apparatus as shown in Figure 25.
  • Figure 29 is a generally perspective view of an alternate embodiment of the dispensing apparatus of the present invention for dispensing fluids at a uniform rate.
  • Figure 32 is a generally perspective, exploded view of the fluid flow control assembly of this next form of the apparatus which functions to control the rate of fluid flow from the apparatus.
  • Figure 33 is a generally perspective, diagrammatic view illustrating the manner in which a portion of the operating member is advanced by the user into the body of the apparatus.
  • Figure 34 is an enlarged left-end view of the apparatus shown in Figures 29 and 30.
  • Figure 35 is an enlarged, cross-sectional view taken along lines 35-35 of Figure 34.
  • Figure 36 is a cross-sectional view taken along lines 36 : 36 of Figure 35.
  • Figure 37 is a cross-sectional view taken along lines 37-37 of Figure 35.
  • Figure 38 is a cross-sectional view taken along lines 38-38 of Figure 35.
  • Figure 39 is an enlarged, cross-sectional view similar to Figure 35, but showing the position of the component parts of the apparatus after a portion of the operating member has been threadably advanced into the body.
  • Figure 40 is a cross-sectional view similar to Figure 39 but illustrating the position of the cooperating component parts after a portion of the operating member has been further advanced into the body and the cannula has pierced the piercable septum of the medicament vial.
  • Figure 41 is a cross-sectional view taken along lines 41-41 of Figure 40.
  • Figure 42 is a cross-sectional view taken along lines 42-42 of Figure 40.
  • Figure 43 is an enlarged, fragmentary, cross-sectional view of the dispensing end of the apparatus as shown in Figure 41.
  • Figure 44 is a generally perspective view of yet another embodiment of the dispensing apparatus of the present invention for dispensing fluids at a uniform rate.
  • Figure 45 is a generally perspective, diagrammatic view illustrating the manner in which the threaded compression cap is advanced by the user into the body of the apparatus.
  • Figure 46 is a generally perspective, exploded view of the apparatus of Figure 44.
  • Figure 47 is an enlarged left end view of the apparatus shown in Figure 44.
  • Figure 48 is a cross-sectional view taken along lines 48-48 of Figure 47.
  • Figure 49 is a cross-sectional view taken along lines 49-49 of Figure 48.
  • Figure 50 is a cross-sectional view taken along lines 50-50 of Figure 48.
  • Figure 51 is an enlarged, fragmentary view showing the manner in which the locking tabs of the device interlock with the locking teeth.
  • Figure 52 is a cross-sectional view taken along lines 52-52 of Figure 48.
  • Figure 53 is a cross-sectional view taken along lines 53-53 of Figure 48.
  • Figure 54 is a cross-sectional view taken along lines 54-54 of Figure 48.
  • Figure 55 is a cross-sectional view similar to Figure 48, but showing the position of the component parts of the apparatus after the control rod of the device has been threadably advanced into the body.
  • Figure 56 is a generally perspective view of still another embodiment of the dispensing apparatus of the present invention.
  • Figure 57 is a generally perspective, fragmentary view illustrating the appearance of the device after the locking push button has been advanced by the user into the forward portion of the body of the apparatus.
  • Figure 58 is a generally perspective, exploded view of the apparatus shown in Figure 56.
  • Figure 59 is an enlarged left end view of the apparatus shown in Figure 56.
  • Figure 60 is a cross-sectional view taken along lines 60-60 of Figure 59.
  • Figure 62 is a cross-sectional view taken along lines 62-62 of Figure 60.
  • Figure 73 is a generally perspective, exploded view of yet another form of supporting base shown here as comprising a spring loaded clip.
  • the apparatus of this form of the invention comprises an elongated body 14, which is made up of three interconnected, generally tubular shaped portions 16, 18, and 20 respectively, portion 20 comprising the operating means of the invention, the purpose of which will presently be described.
  • portions 16, 18, and 20 are interconnected to form elongated body 14, they define first, second and third communicating interior chambers 22, 24, and 26 respectively.
  • Removably receivable within first chamber 22 is a pre-filled medicament vial
  • plunger engaging means Disposed within second chamber 24 of elongated body 14 is plunger engaging means for moving plunger 34 of the vial assembly axially of chamber 30c. The details of construction and operation of this plunger engaging means and its interrelationship with the operating means will presently be described. Disposed within third chamber
  • This unique stored energy means here comprises a compressively deformable elastomeric, polymeric mass 36 which is movable from a first configuration shown in Figure 6 to a second, more compressed configuration wherein it has a tendency to return toward its first expanded configuration.
  • the method and apparatus for controllably compressively deforming elastomeric member 36, which includes operating member 20 and its finger-engaging portion 20a ( Figure 1), will be described in the paragraphs which follow.
  • flow control means for controlling the outward flow of fluid flowing from the reservoir or internal chamber 30c of vial 30.
  • This flow control means here comprises a body portion provided in the form of an end cap assembly 40 which is threadably interconnectable with body portion 16.
  • cap assembly 40 comprises an internally threaded cap 42 having a fluid outlet
  • a cannula assembly 48 which comprises a hollow cannula 50 and a cannula support plate 52.
  • Cannula 50 can be either a conventional, sharp, hollow needle or a blunt end cannula of a character well known in the art.
  • Cannula assembly 48 is held in position within cap 42 by sonic bonding or the like.
  • a spacer means shown here as a compressible, elastomeric spacer plug assembly 54, which includes a pierceable membrane 54a that is receivable within the mouth of cap chamber 46 in the manner shown in Figure 6.
  • Rate control means Disposed between cannula support plate 52 and an end wall 42a of cap 42 ( Figure 6) is rate control means for controlling the rate of fluid flowing outwardly through outlet 44 of cap 42.
  • This fluid rate control means comprises a part of the fluid flow control means of the invention and, in the form of the invention shown in the drawings, includes a rate control membrane 60.
  • Rate control membrane 60 which can be constructed from any suitable porous material such as a polycarbonate, a metal or a ceramic, is disposed between two fluid distribution plates 62 and 64. These distribution plates, which comprise a part of the fluid distribution means of the invention, function to uniformly distribute fluid flowing through cannula 50 in radially outwardly directions so that the fluid will uniformly flow through the face of the rate control membrane 60.
  • End assembly 42 is then threadably interconnected with body portion 16.
  • the plunger engaging means shown here as an elongated pusher member 70 is inserted into second chamber 24 in the manner shown in Figure 6. This done, the stored energy means, or elastomeric member 36, is inserted into chamber 26 of the third, or operating member, portion of elongated body 14.
  • covering 76 is pealed away from body portion 20 in the manner depicted in Figure 1. This done member 20 is threadably advanced inwardly of body portion 18 using finger-engaging portion 20a in the manner illustrated in
  • FIG. 11 it is to be noted that, as operating member 20 is threaded into body portion 18, the head portion 70a of pusher member 70 will engage and progressively deform elastomeric member 36 between member 70 and the internal end wall 21 of member 20 in the manner indicated by the phantom lines of Figure 11. It is to be understood that member 36 can be deformed at a uniform rate or it can be deformed at a non-uniform rate depending upon the material used to con ⁇ struct the stored energy means and the specific end application to be made of the apparatus. As member 36 is strategically compressively deformed, the opposite end 70b of pusher member 70 will forcefully engage plunger 34 of the vial assembly tending to urge the plunger inwardly of the fluid reservoir in the manner shown in Figure 6.
  • Conduit 80 is typically provided in the form of a microbore, flexible tubing which can be interconnected with a conventional infusion needle or a conventional infusion set (not shown).
  • the stored energy source, or elastomeric member 36 has a tendency to return toward its initial, less deformed starting configuration.
  • member 36 can be either partially compressed, fully extended or strategically elongated. Expansion of compressed member 36 during the stored energy unloading phase causes plunger 34 to move axially of reservoir 30c from a first position shown in Figure 6 to a second position shown in Figures 11 and 12. As the plunger moves within the reservoir, the fluid contained therein will be urged into a central fluid passageway 50a of cannula 50 and toward the flow control means of the apparatus. Fluid flowing from passageway 50a will controllably flow through rate control member 64, outwardly of outlet 44 and into conduit 80.
  • a wide variety of materials can be used to form the stored energy means including rubbers, plastics and other thermoplastic elastomers (TPE) and thermoplastic urethane (TPU).
  • suitable materials include latex rubber, rubber polyolefins, polyisoprene (natural rubber), butyl rubber, nitrile rubber, polyurethane, vinyls, vinyl-end-blocked polydimethylsiloxanes, other homopolymer, copolymers (random alternating, block, graft cross-link and star block), silicones and other flouropolymers, mechanical poly-blends, polymer alloys and interpenetrating polymer networks.
  • porous and cellular systems including open and closed cell products such as highly resilient, flexible polyurethane foams, elastomeric silicone foams, latex rubber foam and other cellular rubber materials such as styrenebutadiene rubber (SBR).
  • open and closed cell products such as highly resilient, flexible polyurethane foams, elastomeric silicone foams, latex rubber foam and other cellular rubber materials such as styrenebutadiene rubber (SBR).
  • SBR styrenebutadiene rubber
  • the stored energy means can be constructed in a wide variety of shaped forms and configurations. It is to be noted that, particularly in latex rubber constructions, coring patterns in shaped form configurations significantly influence the compressive behavior of the cellular polymer.
  • Teeth 84 along with tab-like members 86, comprise the locking means of this form of the invention for irreversibly interlocking the operating means or portion 20, with body portion 18 so as to effectively prevent accidental interruption of the unloading of the stored energy means.
  • Figure 13 in which a segment of the locking means portion of the device shown in a linear portrayal, it can be seen that as member 20 moves into seating engagement with member 18, teeth 84 will yieldably deform flexible locking tabs 86 in the manner shown.
  • the locking tabs will readily pass over the teeth as the operating member is tightened, but then will spring outwardly against the vertical faces of the teeth so as to block rotation in an opposite direction thereby effectively preventing retraction of the operating member once it has been seated.
  • FIG. 14 through 28 of the drawings an alternate form of the dispensing apparatus of the present invention is there illustrated and generally designated by numeral 102.
  • the apparatus of this alternate form of the invention is similar in certain respects to the embodiment just described and like numbers have been used in Figures 14 through 18 to identify like components.
  • a pre- filled medicament vial 120 of the general character previously described having a first end 120a sealed by a piercable member 32 and a second end 120b sealed by an elasto ⁇ meric plunger 34 which is telescopically movable longitudinally of the internal fluid reservoir of chamber 120c of vial 120.
  • pierceable member 32 comprises a part of the outlet means of the reservoir for permitting fluid flow therefrom.
  • plunger engaging means Disposed within second chamber 114 of elongated body 108 is plunger engaging means for moving plunger 34 of the vial assembly axially of chamber 120c. The details of construction and operation of this plunger engaging means will presently be described.
  • the apparatus of this latest form of the invention also includes flow control means for controlling the outward flow of fluid flowing from the reservoir or internal chamber 120c of vial 120.
  • the flow control means here comprises an end cap assembly 124 which is interconnectable with body portion 106 in any appropriate way, such as by adhesive, sonic, or radio frequency bonding.
  • cap assembly 124 comprises a hollow cap 126 having a fluid outlet 128 ( Figure 20) and defining an interior chamber 130.
  • a cannula assembly Disposed within chamber 130 and forming a part of the flow control means of the invention is a cannula assembly
  • cannula 134 which comprises a hollow cannula 134 and a cannula support plate 136.
  • cannula 134 can be either a conventional, sharp, hollow piercing needle or a blunt end cannula mateable with a suitably configured septum 32 of a character well known in the art.
  • Cannula assembly 132 is held in position within cap 126 by appropriate bonding.
  • a compressible, elastomeric spacer plug 138 such as a low durometer silicone foam, is receivable within the mouth of cap chamber 130 in the manner shown in Figure 20.
  • a tear-away cap 140 Prior to the cap assembly being interconnected with body portion 106 interior chamber 130 of the cap assembly is closed and maintained in a sterile configuration by a tear-away cap 140 which is bonded to the cap ( Figures 16 and 17).
  • Rate control means Disposed between cannula support plate 132 and an end wall 126a ( Figure 20) of cap 126 is rate control means for controlling the rate of fluid flowing outwardly through outlet 128 of cap 126.
  • This fluid rate control means comprises a part of the fluid flow control means of the invention and in this latest form of the invention includes a rate control assembly 142.
  • Rate control assembly 142 comprises a laminate, which can be constructed from specially designed wafers 142a and 142b ( Figure 17), one of which comprises a filtering means or filter 145, for filtering particulates from the solution flowing from chamber 120c.
  • the remaining wafers are constructed of porous material such as various polymers with alternate flow control pores of selected diameters and distribution patterns.
  • body 110 of the operating member is provided with threads 154 ( Figure 16) which engage internal threads 156 that are formed internally of second body portion 108 ( Figure 20).
  • member 110 Prior to use of the device, member 110 is connected to, but not fully threaded into body portion 108.
  • the operating member extends outwardly from body portion 108 in the manner shown in Figures 14 and 20.
  • a covering 76 surrounds body portion 110 in the manner shown in Figures 14 and 20.
  • vial assembly 120 will be moved to the right as viewed in Figure 24 causing the compression of elastomeric spacer 138 and simultaneously causing cannula 134 to pierce piercable member 32 of the medicament vial assembly in the manner best seen in Figure 25.
  • a fluid flow path will be opened between the medicament reservoir of the vial and the outlet port 128 of cap assembly 124 permitting the medicament to flow from the reservoir, through the flow control means of the invention and then outwardly of the apparatus through a conduit 163 which is connected to the outlet 128 of the cap assembly in the manner shown in Figure 25.
  • elastomeric spacer plug 138 will once again be compressed from the expanded configuration shown in Figure 24 to the compressed configuration shown in Figures 25 and 28.
  • the plunger engaging means for moving plunger 34 of the vial assembly has been eliminated and movement of the plunger of the vial assembly is accomplished in a different manner presently to be described.
  • This unique stored energy means comprises a generally cylindrically shaped elastomeric plug 197 which is movable from a first configuration shown in Figure 39 to a second, deformed configuration wherein it has a tendency to uniformly return toward its first configuration.
  • the apparatus of this latest form of the invention includes flow control means for controlling the outward flow of fluid flowing from the reservoir or internal chamber 120c of vial 120.
  • the flow control means is essentially identical to that shown in Figure 43, but here comprises an end cap assembly 194 which is threadably interconnectable with body portion 186 rather than being bonded thereto.
  • cap assembly 194 comprises a hollow cap 196 having a fluid outlet 128 ( Figure 43) and defining an interior chamber 198.
  • a cannula assembly 132 Disposed within chamber 198 and forming a part of the flow control means of the invention is a cannula assembly 132 which comprises a hollow cannula 134 and a cannula support plate 136.
  • flow control means Disposed between cannula support plate 136 and an end wall 194a (Figure 39) of cap 194 is flow control means for controlling fluid flowing outwardly through outlet 128 of cap 196.
  • This fluid rate control means is similar to that described in connection with Figures 1 through 5, but includes a combination filter and rate control laminate 60a which functions to control the rate of flow of fluid outwardly of the device.
  • Laminate 60a comprises wafers similar in construction to previously described wafers 142a and 142b.
  • operating member 190 of this latest form of the invention includes a unit condition indicator means for indicating that the apparatus has been placed into an operational condition.
  • This indicator means here comprises an indicator element 202 which is carried within finger-engaging portion 190a of operating member 190.
  • Element 202 includes an elongated, cylindrical body 202a, an enlarged diameter portion 202b, a circumferentially extending groove 202c disposed proximate portion 202b ( Figure 35) and a head portion 202d.
  • Portion 202d is telescopically receivable within an opening 204 of member 190.
  • Resiliently deformable locking tabs 204a are provided in opening
  • the component parts of the apparatus are assembled in the manner previously described and as shown in Figure 35.
  • the body 190 of the operating member is provided with threads 206 ( Figure 31) which engage internal threads 208 that are formed internally of second body portion 188 (see also Figure 39).
  • member 190 Prior to use of the device, member 190 is connected to but not fully threaded into body portion 188. When initially connected, the operating member extends outwardly from body portion
  • a frangible covering 76 is placed around body portion 190 in the manner shown in Figures 29 and 35.
  • a fluid flow path will be opened between the medicament reservoir of the vial and the outlet port 128 of cap assembly 194 permitting the medicament to flow from the reservoir, through the flow control means of the invention and then outwardly of the apparatus through a conduit 163 which is connected to the outlet 128 of the cap assembly in the manner shown in Figure 43.
  • elastomeric spacer plug 138 will be compressed.
  • the stored energy source, or elastomeric member 197 is free to move toward its initial starting configuration.
  • plunger 34 Engagement of plunger 34 by the inboard end of elastomeric member 197 will cause plunger 34 to move axially of reservoir 120c from a first position shown in Figure 36 to a second position shown in Figures 40 and 41.
  • the fluid contained therein will be uniformly urged into the fluid passageway 134a of cannula 134 and toward the flow control means of the apparatus ( Figure 43). The fluid will then flow through rate control assembly 60a, outwardly of outlet 128 and into conduit 163.
  • Detent assembly 168 is of the character previously described and comprises the locking means of this latest form of the invention for locking member 190 to body portion 188. As member 190 moves into seating engagement, detent assembly 168 will move into locking engagement within aperture 209 in the manner shown in Figure 41 thereby effectively preventing removal of the operating member once it has been seated.
  • This latest embodiment of the invention also includes a support means for removably supporting body 182.
  • This support means is of identical construction to that previously described and operates in the same manner. Accordingly, the details of construction of the support means or base assembly will not be here repeated.
  • FIG. 44 through 55 of the drawings yet another form of the dispensing apparatus of the present invention is there illustrated and generally designated by numeral 222.
  • the apparatus of this alternate form of the invention is similar in some respects to the previously described embodiments of the invention and like numbers have been used in Figures 44 through 55 to identify like components.
  • the apparatus of this latest form of the invention comprises an elongated body 224, which is made up of four interconnected, generally tubular shaped portions 226, 228, 230, and 232 respectively, the operating means of the invention being generally designated as 242 ( Figure 48). Portions 226, 228, 230, and 232 are interconnected to form elongated body 224 and, when interconnected, define first, second, third and fourth communicating interior chambers 233, 234, 235 and 236 respectively.
  • a pre-filled medicament vial 120 of the character previously described having a first end 120a sealed by a piercable member 32 ( Figure 48) and a second end 120b sealed by an elastomeric plunger 34 which is telescopically movable longitudinally of the internal fluid reservoir of chamber 120c of vial 120.
  • pierceable member 32 comprises a part of the outlet means of the reservoir for permitting fluid flow therefrom.
  • Receivable within second chamber 234 of elongated body 224 is plunger engaging means, or displacement piston 240 for moving plunger 34 of the vial assembly axially of chamber 120c. The details of construction and operation of displacement piston 240 will presently be described.
  • This unique stored energy means here comprises an elongated, substan ⁇ tially flat member 242 which is provided with a plurality of longitudinally spaced, oval shaped apertures 244.
  • Member 242 is movable from a substantially undeformed condition shown in Figure 48 to a second, more compressively deformed configuration wherein it has a tendency to return toward its first configuration. It should be understood that in some circumstances, it may be desirable to partially load, deform, or compress the stored energy means depending upon the materials used and the flow curve desired.
  • member 242 also has a plurality of longitudinally spaced apart grooves and ridges 242a and 242b respectively.
  • Member 242 can be constructed from materials of the character previously described herein and may be constructed from a polymer foam.
  • the apparatus of this latest form of the invention also includes flow control means for controlling the outward flow of fluid following from the reservoir or internal chamber 120c of vial 120.
  • the flow control means of this embodiment is similar in construction and operation to the flow control means of the previously described embodiment and the details of its construction will not be repeated here.
  • portion 232 here rotatably supports a finger-engaging housing, which is controllably rotated to place the apparatus into a flow discharge condition.
  • the operating means comprises an internally threaded, rotatable, finger-engaging housing 247 and a cooperating, externally threaded control rod 248, a portion of which is receivable within third body portion 230 as the apparatus is placed in the flow discharge mode (see Figure 55).
  • a retaining ring 247a Disposed within member 232 is a retaining ring 247a to which the forwardly extending finger-engaging housing 247 is connected.
  • a fluid flow path will be opened between the medicament reservoir of the vial and the outlet port 128 of cap assembly 124 accommodating fluid flow from the reservoir, through the flow control means of the invention and then outwardly of the apparatus through a conduit 163 which is connected to the outlet 128 of cap assembly by a standard connector, such as a luer connector 163a in the manner shown in Figures 48 and 55.
  • a standard connector such as a luer connector 163a in the manner shown in Figures 48 and 55.
  • the stored energy source or elastomeric member 242
  • the stored energy source is free to return toward its initial starting configuration.
  • This causes plunger 34 to move axially of reservoir 120c from a first position shown in Figure 48 to a second position shown in Figure 55.
  • the fluid contained therein will be uniformly urged into the fluid passageway 134a of cannula 134 and toward the flow control means of the apparatus ( Figure 48). the fluid will then flow through rate control assembly 142, outwardly of outlet 128 and into conduit 163.
  • member 247 is provided with a vent aperture 256 and includes proximate its inboard end a plurality of circumferentially spaced locking tabs 258 which lockably engage circumferentially spaced teeth 260 provided internally of portion 232 (see also Figures 50 and 51).
  • Tabs 258 and teeth 260 comprise the locking means of this latest form of the invention for preventing counter rotation of housing 247. With this construction, once control rod 248 has been fully advanced counterclockwise or loosening rotation of the finger-engaging housing is positively prevented.
  • the apparatus of this latest form of the invention like the embodiment just described, comprises an elongated body 274, which is made up of four interconnected, generally tubular shaped portions 276, 278, 280, and 282 respectively, a portion of the operating means of this form of the invention being designated as 282 ( Figure 56). These portions are interconnected to form elongated body 274 and, when interconnected, define first, second, third and fourth communicating interior chambers 284, 286, 288 and 290 respectively ( Figure 60).
  • a pre-filled medicament vial 120 of the character previously described having a first end 120a sealed by a pierceable member 291 which is retained in position by a crimp cap 139 ( Figure 60).
  • Vial 120 also has a second end 120b which is sealed by an elastomeric plunger 34 which is telescopically movable longitudinally of the internal fluid reservoir of chamber 120c of vial 120.
  • plunger engaging means for moving plunger 34 of the vial assembly axially of chamber 120c.
  • push rod 292 for moving plunger 34 of the vial assembly axially of chamber 120c.
  • this latest form of the invention is of a substantially different construction than that previously described herein and includes a number of special features not found in the previously described embodiments.
  • this latest form of the invention includes different and quite novel operating means for placing the apparatus into an armed, operational condition, that is a condition wherein the stored energy means is placed under load deformation.
  • the operating means here includes tactile sensing means that permits the user to tactilely sense the advance of the control rod portion of the operating means during the loading step.
  • the device includes novel indicator means for indicating the extent of advancement of the control rod during the loading step.
  • control rod 298 moves toward its advanced or extended position, it will controllably compressively deform elastomeric member 294.
  • Member 294 will, in turn, exert a longitudinal force on push rod 292.
  • a va ing means such as a valve 195 in the manner shown in Figure 60
  • the valve means can be used to control fluid flow outwardly of the outlet port. Accordingly, when the valve is closed, the resistance offered by the fluid within the vial reservoir to axial movement of plunger 34 will cause the controlled compression of elastomeric member 294.
  • a non-rotatable locking ring 327 which is affixed to extension 280c as by sonic bonding.
  • ring 327 is provided with circumferentially extending teeth 327a which lockably engage serrations 329 provided within push button 314 when the push button is fully inserted as shown in Figure 67. Because key 326 is locked within keyway 314a, rotation of the push button relative to the finger-engaging member is prevented. Therefore, when the push button is locked against rotation with respect to fixed ring 327, rotation of member 282 is also positively prevented.
  • the apparatus of this latest form of the invention comprises an elongated body 352, which is made up of three interconnected, generally tubular shaped portions which house the medicament vial 120, the push rod 292, and the stored energy means, all of which are identical to those just described.
  • the operating means of this form of the invention is of a different construction and the indicator means provided in the previous embodiment has been eliminated.
  • the apparatus of this latest form of the invention includes flow control means for controlling the outward flow of fluid flowing from the reservoir or internal chamber 120c of vial 120.
  • This flow control means is identical to that shown in Figures 55 through 67 and, therefore, will not here be described.
  • arcuate retaining segments 360 which are engagable with a first collar 320 formed within chamber 318. Also formed within chamber 318 is a second set retention collar 324 which is engagable by retaining segments 360 when push button 314 is pushed inwardly of body portion 354.
  • the push button is provided with a keyway 314a ( Figure 69) which slidably receives a key 364 formed within body portion 354.
  • variable pitch threads is not limited to the construction shown in Figures 55 through 69, but can be employed in the design and construction of the operating means of any of the forms of the invention shown in the drawings and previously described herein.
  • Assembly 380 which is also designed to be lockably interconnected with elongated body 352.
  • Assembly 380 includes a flat base plate 382 which is provided with longitudinally extending channel 384 that slidably receives the flange portion 352a of body 352.
  • base plate 382 is adapted to be removably locked to body 352 by means of locking protuberance 352b provided on flange 352a.
  • base assembly 380 is designed to be interconnected with a section of the belt "B" of the user and includes a forward path-like member 386 which is connected to base plate 382 by a living hinge 388 that bias the outer end 386a of member 388 toward base plate 382.
  • a clip plate is pivotally connected to base plate 392 by biasing means shown where as a metal spring 397 which continuously urges edge portion 396a of clip plate 396 toward base plate 392 in the manner shown. Edge portion 396a can be moved away from plate 392 against the urging of spring 397 by pressing on edge portion 396b.

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Confectionery (AREA)
  • Valve Device For Special Equipments (AREA)

Abstract

Doseur (12) de médicaments injectables servant à débiter de façon régulière et contrôlable des médicaments liquides tels qu'insuline, antibiotiques, oncolytiques et produits semblables. Le doseur comporte une source d'énergie emmagasinée (36) consistant en une pièce en élastomère polymère déformable par compression qui fournit la force nécessaire pour produire un écoulement contrôlable du médicament versé à l'avance dans un récipient.
PCT/US1995/015715 1994-12-02 1995-12-01 Doseur de medicaments Ceased WO1996016691A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU44146/96A AU704888B2 (en) 1994-12-02 1995-12-01 Medicament dispenser
JP8519127A JPH10510450A (ja) 1994-12-02 1995-12-01 薬剤分配装置
EP95942976A EP0796121A4 (fr) 1994-12-02 1995-12-01 Doseur de medicaments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34949694A 1994-12-02 1994-12-02
US08/349,496 1994-12-02

Publications (1)

Publication Number Publication Date
WO1996016691A1 true WO1996016691A1 (fr) 1996-06-06

Family

ID=23372647

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/015715 Ceased WO1996016691A1 (fr) 1994-12-02 1995-12-01 Doseur de medicaments

Country Status (5)

Country Link
EP (1) EP0796121A4 (fr)
JP (1) JPH10510450A (fr)
AU (1) AU704888B2 (fr)
CA (1) CA2206734A1 (fr)
WO (1) WO1996016691A1 (fr)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0836505A4 (fr) * 1995-06-06 2000-01-12 Science Inc Distributeur de medicaments
EP1039947A4 (fr) * 1997-12-16 2001-06-20 Science Inc Distributeur de medicaments et reservoir de remplissage cooperant avec celui-ci
DE20113761U1 (de) * 2001-08-20 2001-12-20 Lohmann & Rauscher GmbH & Co. KG, 56567 Neuwied Wundversorgungsprodukt
WO2003105943A1 (fr) * 2002-06-17 2003-12-24 Scimed Life Systems, Inc. Dispositif a catheter et procede d'administration d'une dose par voie interne pendant une chirurgie invasive minimale
US9415142B2 (en) 2006-04-26 2016-08-16 Micell Technologies, Inc. Coatings containing multiple drugs
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
US9486431B2 (en) 2008-07-17 2016-11-08 Micell Technologies, Inc. Drug delivery medical device
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
US9737642B2 (en) 2007-01-08 2017-08-22 Micell Technologies, Inc. Stents having biodegradable layers
US9789233B2 (en) 2008-04-17 2017-10-17 Micell Technologies, Inc. Stents having bioabsorbable layers
US9827117B2 (en) 2005-07-15 2017-11-28 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US9981072B2 (en) 2009-04-01 2018-05-29 Micell Technologies, Inc. Coated stents
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
US10232092B2 (en) 2010-04-22 2019-03-19 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
US10272606B2 (en) 2013-05-15 2019-04-30 Micell Technologies, Inc. Bioabsorbable biomedical implants
US10835396B2 (en) 2005-07-15 2020-11-17 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
US11039943B2 (en) 2013-03-12 2021-06-22 Micell Technologies, Inc. Bioabsorbable biomedical implants
US11369498B2 (en) 2010-02-02 2022-06-28 MT Acquisition Holdings LLC Stent and stent delivery system with improved deliverability
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
WO2024006163A3 (fr) * 2022-06-27 2024-02-01 Contraline, Inc. Systèmes et procédés de distribution d'une composition
US11904118B2 (en) 2010-07-16 2024-02-20 Micell Medtech Inc. Drug delivery medical device
US11951032B2 (en) 2018-11-13 2024-04-09 Contraline, Inc. Systems and methods for delivering biomaterials

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Publication number Priority date Publication date Assignee Title
CA2395349C (fr) * 1999-12-23 2007-11-06 Arnold Neracher Dispositif d'injection et systeme de propulsion associe
CA2746164C (fr) * 2008-12-09 2019-08-13 Becton, Dickinson And Company Systeme d'administration de medicament a valve ouverte et fermee pour des injections haute pression
AU2010299934B2 (en) * 2009-09-23 2014-08-14 Sanofi-Aventis Deutschland Gmbh Assembly and indicator for a drug delivery device
JP2014528791A (ja) * 2011-09-13 2014-10-30 ユニトラクト シリンジ プロプライエタリイ リミテッドＵｎｉｔｒａｃｔ Ｓｙｒｉｎｇｅ Ｐｔｙ Ｌｔｄ 薬剤送達ポンプ用の薬剤容器に対する滅菌流体経路接続部
US20180311439A1 (en) * 2015-11-27 2018-11-01 Sanofi-Aventis Deutschland Gmbh An injection device with an expandable cavity

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US4209014A (en) * 1977-12-12 1980-06-24 Canadian Patents And Development Limited Dispensing device for medicaments
EP0037696A1 (fr) 1980-04-08 1981-10-14 Greater Glasgow Health Board Distributeur
US4592745A (en) 1984-02-29 1986-06-03 Novo Industri A/S Dispenser
US4636197A (en) * 1985-02-15 1987-01-13 Ping Chu Intravenous fluid infusion device

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DE902776C (de) * 1949-08-17 1954-01-28 August Rooseboom Selbsttaetiger Injektionsapparat mit Ampulle
SE9301494D0 (sv) * 1993-04-30 1993-04-30 Kabi Pharmacia Ab A device for dosing liquid preparation

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US4209014A (en) * 1977-12-12 1980-06-24 Canadian Patents And Development Limited Dispensing device for medicaments
EP0037696A1 (fr) 1980-04-08 1981-10-14 Greater Glasgow Health Board Distributeur
US4592745A (en) 1984-02-29 1986-06-03 Novo Industri A/S Dispenser
US4636197A (en) * 1985-02-15 1987-01-13 Ping Chu Intravenous fluid infusion device

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See also references of EP0796121A4 *

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0836505A4 (fr) * 1995-06-06 2000-01-12 Science Inc Distributeur de medicaments
EP1039947A4 (fr) * 1997-12-16 2001-06-20 Science Inc Distributeur de medicaments et reservoir de remplissage cooperant avec celui-ci
DE20113761U1 (de) * 2001-08-20 2001-12-20 Lohmann & Rauscher GmbH & Co. KG, 56567 Neuwied Wundversorgungsprodukt
WO2003105943A1 (fr) * 2002-06-17 2003-12-24 Scimed Life Systems, Inc. Dispositif a catheter et procede d'administration d'une dose par voie interne pendant une chirurgie invasive minimale
US6802824B2 (en) 2002-06-17 2004-10-12 Scimed Life Systems, Inc. Catheter device and method for delivering a dose internally during minimally-invasive surgery
US7488305B2 (en) 2002-06-17 2009-02-10 Boston Scientific Scimed, Inc. Catheter device and method for delivering a dose internally during minimally-invasive surgery
US10898353B2 (en) 2005-07-15 2021-01-26 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US10835396B2 (en) 2005-07-15 2020-11-17 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
US11911301B2 (en) 2005-07-15 2024-02-27 Micell Medtech Inc. Polymer coatings containing drug powder of controlled morphology
US9827117B2 (en) 2005-07-15 2017-11-28 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US11850333B2 (en) 2006-04-26 2023-12-26 Micell Medtech Inc. Coatings containing multiple drugs
US9737645B2 (en) 2006-04-26 2017-08-22 Micell Technologies, Inc. Coatings containing multiple drugs
US11007307B2 (en) 2006-04-26 2021-05-18 Micell Technologies, Inc. Coatings containing multiple drugs
US9415142B2 (en) 2006-04-26 2016-08-16 Micell Technologies, Inc. Coatings containing multiple drugs
US9737642B2 (en) 2007-01-08 2017-08-22 Micell Technologies, Inc. Stents having biodegradable layers
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
US10617795B2 (en) 2007-01-08 2020-04-14 Micell Technologies, Inc. Stents having biodegradable layers
US9486338B2 (en) 2007-04-17 2016-11-08 Micell Technologies, Inc. Stents having controlled elution
US9775729B2 (en) 2007-04-17 2017-10-03 Micell Technologies, Inc. Stents having controlled elution
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
US9789233B2 (en) 2008-04-17 2017-10-17 Micell Technologies, Inc. Stents having bioabsorbable layers
US10350333B2 (en) 2008-04-17 2019-07-16 Micell Technologies, Inc. Stents having bioabsorable layers
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
US10350391B2 (en) 2008-07-17 2019-07-16 Micell Technologies, Inc. Drug delivery medical device
US9981071B2 (en) 2008-07-17 2018-05-29 Micell Technologies, Inc. Drug delivery medical device
US9486431B2 (en) 2008-07-17 2016-11-08 Micell Technologies, Inc. Drug delivery medical device
US10653820B2 (en) 2009-04-01 2020-05-19 Micell Technologies, Inc. Coated stents
US9981072B2 (en) 2009-04-01 2018-05-29 Micell Technologies, Inc. Coated stents
US11369498B2 (en) 2010-02-02 2022-06-28 MT Acquisition Holdings LLC Stent and stent delivery system with improved deliverability
US10232092B2 (en) 2010-04-22 2019-03-19 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
US11904118B2 (en) 2010-07-16 2024-02-20 Micell Medtech Inc. Drug delivery medical device
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
US10729819B2 (en) 2011-07-15 2020-08-04 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
US11039943B2 (en) 2013-03-12 2021-06-22 Micell Technologies, Inc. Bioabsorbable biomedical implants
US10272606B2 (en) 2013-05-15 2019-04-30 Micell Technologies, Inc. Bioabsorbable biomedical implants
US11951032B2 (en) 2018-11-13 2024-04-09 Contraline, Inc. Systems and methods for delivering biomaterials
US11957616B2 (en) 2018-11-13 2024-04-16 Contraline, Inc. Systems and methods for delivering biomaterials
WO2024006163A3 (fr) * 2022-06-27 2024-02-01 Contraline, Inc. Systèmes et procédés de distribution d'une composition

Also Published As

Publication number Publication date
CA2206734A1 (fr) 1996-06-06
AU704888B2 (en) 1999-05-06
AU4414696A (en) 1996-06-19
EP0796121A1 (fr) 1997-09-24
EP0796121A4 (fr) 1998-08-26
JPH10510450A (ja) 1998-10-13

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