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WO1996016684A1 - Pompe centrifuge integree a faible volume d'amorçage et oxygenateur a membrane - Google Patents

Pompe centrifuge integree a faible volume d'amorçage et oxygenateur a membrane Download PDF

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Publication number
WO1996016684A1
WO1996016684A1 PCT/US1994/013763 US9413763W WO9616684A1 WO 1996016684 A1 WO1996016684 A1 WO 1996016684A1 US 9413763 W US9413763 W US 9413763W WO 9616684 A1 WO9616684 A1 WO 9616684A1
Authority
WO
WIPO (PCT)
Prior art keywords
fibers
ring
mass transfer
fluid
transfer bed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1994/013763
Other languages
English (en)
Inventor
Wilfred Mathewson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Priority to PCT/US1994/013763 priority Critical patent/WO1996016684A1/fr
Publication of WO1996016684A1 publication Critical patent/WO1996016684A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1623—Disposition or location of membranes relative to fluids
    • A61M1/1625—Dialyser of the outside perfusion type, i.e. blood flow outside hollow membrane fibres or tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/262—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving rotating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/267—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving used for pumping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
    • A61M60/232—Centrifugal pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/38—Blood oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/403—Details relating to driving for non-positive displacement blood pumps
    • A61M60/408—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
    • A61M60/411—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
    • A61M60/416—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted directly by the motor rotor drive shaft
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/0232—Manufacturing thereof using hollow fibers mats as precursor, e.g. wound or pleated mats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/025—Bobbin units
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/034—Lumen open in more than two directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means

Definitions

  • U.S. Patent No. 3,841,837 discloses a blood oxygenator or dialyzer that achieves enhanced transfer through rotation of a cylindrically mounted membrane placed eccentrically inside a stator housing. Blood flows in the annular space between the rotor and the stator. Rotation causes a pumping action, thus causing pumping and oxygenation to occur simultaneously. All of these prior art devices have required relatively large amounts of fluid to prime the pump and oxygenator. There have also been difficulties with the safety and ease of use by the perfusionist. Furthermore, these devices can be quite costly to manufacture.
  • the low priming volume integrated centrifugal pump and membrane oxygenator of the present invention comprises housing 10 containing impeller 30 surrounded by mass transfer bed 40.
  • the top and bottom of the mass transfer bed 40 are sealed to the upper and lower internal faces of housing 10.
  • Fluid entering housing 10 through fluid inlet 12 is pumped by impeller 30 through mass transfer bed 40.
  • mass transfer bed 40 the fluid is oxygenated and the carbon dioxide is removed.
  • the fluid is then collected and discharged through a tapered exit manifold 14 located around the outer diameter of mass transfer bed 40.
  • impeller 30 has flow channels 32 that act to force the fluid through the mass transfer bed 40.
  • flow channels 32 deliver uniform radial flow to the mass transfer bed 40 in the course of its 360 degree rotation. This uniform radial flow enhances oxygenation by insuring that the mass transfer bed 40 is uniformly perfused with blood to be oxygenated.
  • the rotation of the impeller 30 insures true and uniform radial flow over the entire circumference and height of the mass transfer bed 40.
  • a local flow pulse is created followed by a quiescent period until the next flow channel 32 arrives. This pulse enhances mass transfer, in particular, oxygenation and carbon dioxide removal.
  • the flow channel volume of flow channels 32 is relatively small compared with the envelope of the impeller 30. This is in direct contrast to conventional radial impellers for centrifugal pumps. Conventional centrifugal pumps generally operate in a region of higher flow rates for a given required delivery pressure. Typical impellers have thin vanes with wide flow channels between the vanes to keep the flow channel volume as close to the maximum volume available as possible to create high flow rates. However, in extracorporeal cardiopulmonary support, relatively low flow and high pressure is required. Thus the impeller diameter and RPM requirements are dictated more by delivery pressure than flow demands.
  • the small flow channel volume of the present invention results in high fluid delivery pressures at adequate flow rates, and thus allows the priming volume to be reduced. Another effect of the small flow channel volume is reduced turbulence in the pumping portion of the integrated pump and oxygenator.
  • the volume of flow channels 32 should be of a size to permit relatively laminar flow of the fluid in the impeller 8
  • the flow channel volume is from about 5% to about 60% of the total envelope volume. More preferably the flow channel volume is less than 50% of the total envelope volume. Most preferably the flow channel volume is from about 5% to about 30% of the total envelope volume.
  • the flow channel volume can be altered by any means such as adjusting the size, shape and number of the flow channels.
  • Impeller 30 should be of a size sufficient to force the fluid through the mass transfer bed 40 and to return it to the patient without the need for an external pump. Preferably, the impeller 30 has a diameter of from about 2 inches to about 6 inches.
  • the pump, including impeller and housing can be made from any inert material that will not react with the blood or the oxygen.
  • the pump, impeller and housing may be molded from plastic materials such as polycarbonate and the like.
  • the mass transfer bed 40 has a gas inlet header 60 and gas inlet manifold 62 to allow the passage of a second fluid, the oxygen gas, into the lumens 46 of the fibers 38.
  • the second fluid exits the lumens 46 by means of gas outlet manifold 64 and gas outlet header 66, while maintaining separation of the second fluid from the first fluid.
  • Manifold partition 68 separates the gas inlet header 60 and gas inlet manifold 62 from gas outlet header 66 and gas outlet manifold 64.
  • the headers 60 and 66 are aligned at an angle to the fibers 38 of the mass transfer bed 40.
  • the mass transfer bed 40 is of a sufficient size to permit it to be sealed to the upper and lower internal faces of housing 10.
  • the mass transfer bed 40 has a radial thickness ranging from about 1/10 inch to about 1.5 inches.
  • the mass transfer bed 40 may be bonded 11
  • An engineering model of the integrated pump and membrane oxygenator of the present invention was constructed to test the fluid dynamics.
  • the inside of the housing was 6 inches in diameter and 1 1/2 inches high.
  • the impeller had 4 grooved flow channels and was powered by means of a drillpress motor.
  • the engineering model had a ring 17

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Manufacturing & Machinery (AREA)
  • External Artificial Organs (AREA)

Abstract

Pompe centrifuge intégrée à faible volume d'amorçage et oxygénateur à membrane comprenant un boîtier (10) qui contient un lit (40) à transfert de matière constitué de fibres creuses (38) de membrane perméables au gaz placées circonférentiellement en anneau autor d'une roue hélice (30). Le lit (40) à transfert de matière est formé d'un enroulement d'un ruban (42) de fibres comprenant au moins deux couches de fibres (38) collées ensemble suivant une orientation précise telle que les fibres des couches alternées soient positionnées en ligne, les ouvertures entre les fibres étant situées dans les couches supérieure et inférieure. Des dispositifs de fixation assurent l'orientation précise des fibres (38). Le volume d'amorçage est encore réduit par un volume de canal d'écoulement déterminé par une petite roue hélice.
PCT/US1994/013763 1994-11-28 1994-11-28 Pompe centrifuge integree a faible volume d'amorçage et oxygenateur a membrane Ceased WO1996016684A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US1994/013763 WO1996016684A1 (fr) 1994-11-28 1994-11-28 Pompe centrifuge integree a faible volume d'amorçage et oxygenateur a membrane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/013763 WO1996016684A1 (fr) 1994-11-28 1994-11-28 Pompe centrifuge integree a faible volume d'amorçage et oxygenateur a membrane

Publications (1)

Publication Number Publication Date
WO1996016684A1 true WO1996016684A1 (fr) 1996-06-06

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Country Status (1)

Country Link
WO (1) WO1996016684A1 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003018088A1 (fr) * 2001-08-23 2003-03-06 Michigan Critical Care Consultants, Inc. Appareil assurant un echange de gaz dans un liquide
WO2006118817A1 (fr) 2005-04-21 2006-11-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education Poumon-para-corporel d'assistance respiratoire
US8585968B2 (en) 2006-04-21 2013-11-19 Scott W. Morley Method and system for purging moisture from an oxygenator
US10722631B2 (en) 2018-02-01 2020-07-28 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US11185677B2 (en) 2017-06-07 2021-11-30 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11511103B2 (en) 2017-11-13 2022-11-29 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
US11964145B2 (en) 2019-07-12 2024-04-23 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use
US12102815B2 (en) 2019-09-25 2024-10-01 Shifamed Holdings, Llc Catheter blood pumps and collapsible pump housings
US12121713B2 (en) 2019-09-25 2024-10-22 Shifamed Holdings, Llc Catheter blood pumps and collapsible blood conduits
US12161857B2 (en) 2018-07-31 2024-12-10 Shifamed Holdings, Llc Intravascular blood pumps and methods of use
US12220570B2 (en) 2018-10-05 2025-02-11 Shifamed Holdings, Llc Intravascular blood pumps and methods of use
US12409310B2 (en) 2019-12-11 2025-09-09 Shifamed Holdings, Llc Descending aorta and vena cava blood pumps
US12465748B2 (en) 2019-08-07 2025-11-11 Supira Medical, Inc. Catheter blood pumps and collapsible pump housings

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031012A (en) * 1975-09-17 1977-06-21 Gics Pharmaceuticals, Inc. Separatory apparatus
EP0187708A2 (fr) * 1985-01-08 1986-07-16 Medtronic, Inc. Appareil de transfert de masse à membrane microporeuse sous forme de fibre creuse enroulée en spirale
US4906581A (en) * 1988-10-20 1990-03-06 Minntech Corporation Method of quality control for hollow fiber gas transfer cells
US5043140A (en) * 1989-05-26 1991-08-27 A. Jorrdan Medical, Inc. Blood oxygenator
WO1993005828A2 (fr) * 1991-09-25 1993-04-01 Baxter International Inc. Pompe centrifuge integree et oxygenateur a membrane
WO1994002187A1 (fr) * 1992-07-21 1994-02-03 Baxter International Inc. Pompe a sang du type centrifuge

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031012A (en) * 1975-09-17 1977-06-21 Gics Pharmaceuticals, Inc. Separatory apparatus
EP0187708A2 (fr) * 1985-01-08 1986-07-16 Medtronic, Inc. Appareil de transfert de masse à membrane microporeuse sous forme de fibre creuse enroulée en spirale
US4906581A (en) * 1988-10-20 1990-03-06 Minntech Corporation Method of quality control for hollow fiber gas transfer cells
US5043140A (en) * 1989-05-26 1991-08-27 A. Jorrdan Medical, Inc. Blood oxygenator
WO1993005828A2 (fr) * 1991-09-25 1993-04-01 Baxter International Inc. Pompe centrifuge integree et oxygenateur a membrane
WO1994002187A1 (fr) * 1992-07-21 1994-02-03 Baxter International Inc. Pompe a sang du type centrifuge

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003018088A1 (fr) * 2001-08-23 2003-03-06 Michigan Critical Care Consultants, Inc. Appareil assurant un echange de gaz dans un liquide
WO2006118817A1 (fr) 2005-04-21 2006-11-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education Poumon-para-corporel d'assistance respiratoire
EP2295133A1 (fr) * 2005-04-21 2011-03-16 University of Pittsburgh of the Commonwealth System of Higher Education Poumon d'assistance respiratoire extracorporel
US7927544B2 (en) 2005-04-21 2011-04-19 Alung Technologies, Inc. Paracorporeal respiratory assist lung
AU2006242663B2 (en) * 2005-04-21 2012-01-19 Alung Technologies, Inc. Paracorporeal respiratory assist lung
US8585968B2 (en) 2006-04-21 2013-11-19 Scott W. Morley Method and system for purging moisture from an oxygenator
US11717670B2 (en) 2017-06-07 2023-08-08 Shifamed Holdings, LLP Intravascular fluid movement devices, systems, and methods of use
US11185677B2 (en) 2017-06-07 2021-11-30 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11511103B2 (en) 2017-11-13 2022-11-29 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11229784B2 (en) 2018-02-01 2022-01-25 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US10722631B2 (en) 2018-02-01 2020-07-28 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US12076545B2 (en) 2018-02-01 2024-09-03 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US12161857B2 (en) 2018-07-31 2024-12-10 Shifamed Holdings, Llc Intravascular blood pumps and methods of use
US12220570B2 (en) 2018-10-05 2025-02-11 Shifamed Holdings, Llc Intravascular blood pumps and methods of use
US11964145B2 (en) 2019-07-12 2024-04-23 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US12465748B2 (en) 2019-08-07 2025-11-11 Supira Medical, Inc. Catheter blood pumps and collapsible pump housings
US12121713B2 (en) 2019-09-25 2024-10-22 Shifamed Holdings, Llc Catheter blood pumps and collapsible blood conduits
US12102815B2 (en) 2019-09-25 2024-10-01 Shifamed Holdings, Llc Catheter blood pumps and collapsible pump housings
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
US12409310B2 (en) 2019-12-11 2025-09-09 Shifamed Holdings, Llc Descending aorta and vena cava blood pumps

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