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WO1996016679B1 - Complexes paramagnetiques de n-alkyl-n-hydroxylamides d'acides organiques et emulsions pour imagerie rmn les contenant - Google Patents

Complexes paramagnetiques de n-alkyl-n-hydroxylamides d'acides organiques et emulsions pour imagerie rmn les contenant

Info

Publication number
WO1996016679B1
WO1996016679B1 PCT/US1995/014508 US9514508W WO9616679B1 WO 1996016679 B1 WO1996016679 B1 WO 1996016679B1 US 9514508 W US9514508 W US 9514508W WO 9616679 B1 WO9616679 B1 WO 9616679B1
Authority
WO
WIPO (PCT)
Prior art keywords
group
hydroxyl
physiologically acceptable
metal ion
acceptable emulsion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/014508
Other languages
English (en)
Other versions
WO1996016679A1 (fr
Filing date
Publication date
Priority claimed from US08/346,885 external-priority patent/US5614170A/en
Application filed filed Critical
Priority to JP8518809A priority Critical patent/JPH11500413A/ja
Priority to EP95942846A priority patent/EP0794801A1/fr
Priority to AU44060/96A priority patent/AU4406096A/en
Publication of WO1996016679A1 publication Critical patent/WO1996016679A1/fr
Publication of WO1996016679B1 publication Critical patent/WO1996016679B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention porte sur des émulsions d'agents de contraste paramagnétiques et leurs procédés d'obtention et d'utilisation. Lesdites émulsions contiennent de l'eau, une phase huileuse dispersée et un complexe d'ion métallique paramagnétique et d'un chélateur d'acide organique, par exemple du DTPA (acide diéthylèntriaminepentaacétique) comportant un groupe aliphatique saturé C10-C30 et un groupe hydroxyle lié à l'atome d'azote. Ces émulsions très stables et thérapeutiquement acceptables s'administrent per voie intraveineuse pour améliorer l'imagerie par RMN.
PCT/US1995/014508 1994-11-30 1995-11-09 Complexes paramagnetiques de n-alkyl-n-hydroxylamides d'acides organiques et emulsions pour imagerie rmn les contenant Ceased WO1996016679A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP8518809A JPH11500413A (ja) 1994-11-30 1995-11-09 有機酸のｎ−アルキル−ｎ−ヒドロキシルアミドの常磁性錯体及びそれを含有する磁気共鳴影像（ｍｒｉ）のためのエマルジョン
EP95942846A EP0794801A1 (fr) 1994-11-30 1995-11-09 Complexes paramagnetiques de n-alkyl-n-hydroxylamides d'acides organiques et emulsions pour imagerie rmn les contenant
AU44060/96A AU4406096A (en) 1994-11-30 1995-11-09 Paramagnetic complexes of N-alkyl-N-hydroxylamides of organicacids and emulsions containing same for magnetic resonance imaging (MRI)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/346,885 US5614170A (en) 1994-11-30 1994-11-30 Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI)
US08/346,885 1994-11-30

Publications (2)

Publication Number Publication Date
WO1996016679A1 WO1996016679A1 (fr) 1996-06-06
WO1996016679B1 true WO1996016679B1 (fr) 1996-08-01

Family

ID=23361430

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/014508 Ceased WO1996016679A1 (fr) 1994-11-30 1995-11-09 Complexes paramagnetiques de n-alkyl-n-hydroxylamides d'acides organiques et emulsions pour imagerie rmn les contenant

Country Status (6)

Country Link
US (1) US5614170A (fr)
EP (1) EP0794801A1 (fr)
JP (1) JPH11500413A (fr)
AU (1) AU4406096A (fr)
CA (1) CA2205232A1 (fr)
WO (1) WO1996016679A1 (fr)

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Publication number Priority date Publication date Assignee Title
US6028108A (en) * 1998-10-22 2000-02-22 America Home Products Corporation Propofol composition comprising pentetate
CN100356984C (zh) * 2002-01-24 2007-12-26 巴内斯－朱威胥医院 整联蛋白靶向的影像剂
US7279150B2 (en) * 2002-01-24 2007-10-09 Barnes-Jewish Hospital Chelating agents with lipophilic carriers
US6869591B2 (en) * 2002-03-26 2005-03-22 Barnes-Jewish Hospital Paramagnetic particles that provide improved relaxivity
WO2005122891A1 (fr) 2004-06-09 2005-12-29 Kereos, Inc. Derives lipophiles de monoamides chelates
FR2883562B1 (fr) 2005-03-24 2009-02-27 Guerbet Sa Chelates lipophiles et leur utilisation en imagerie
LU503039B1 (en) * 2022-11-11 2024-05-13 Teresa Carlomagno Novel photocleavable spin-labels
CN115947672B (zh) * 2023-01-04 2024-02-27 成都威斯津生物医药科技有限公司 用于递送药物的化合物、脂质体及药物载体

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993581A (en) * 1973-10-05 1976-11-23 The Green Cross Corporation Process for preparing stable oxygen transferable emulsion
JPS5331209B2 (fr) * 1973-10-05 1978-09-01
US4187252A (en) * 1977-08-26 1980-02-05 Suntech, Inc. Tetramethylpentane blood substitutes
US4110474A (en) * 1977-08-26 1978-08-29 Suntech, Inc. Tetramethylpentane blood substitutes
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
US4252827A (en) * 1979-05-23 1981-02-24 The Green Cross Corporation Oxygen-transferable fluorocarbon emulsion
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
CA1187882A (fr) * 1981-11-27 1985-05-28 Kazumasa Yokoyama Compose perfluore et emulsion de ce compose
US4443480A (en) * 1982-04-12 1984-04-17 Children's Hospital Medical Center Artificial blood and other gas transport agents
US4423077A (en) * 1982-07-27 1983-12-27 The University Of Pennsylvania Perfluorochemical emulsion artificial blood
DE3366683D1 (de) * 1982-08-07 1986-11-13 Green Cross Corp Perfluoro-1-azatricyclic amine compound
US4534978A (en) * 1982-12-28 1985-08-13 The Green Cross Corporation Perfluorocycloamines
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
CA1257828A (fr) * 1984-04-16 1989-07-25 William Mccormick Dispersions de compose perfluore renfermant des quantites reduites de surfactif; methode de preparation
US4859451A (en) * 1984-10-04 1989-08-22 Salutar, Inc. Paramagnetic contrast agents for MR imaging
US4826673A (en) * 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
US4686024A (en) * 1985-02-01 1987-08-11 The Green Cross Corporation Novel perfluoro chemicals and polyfluorinated compounds and process for production of the same
US5399340A (en) * 1987-09-24 1995-03-21 Schering Aktiengesellschaft Use of amide complex compounds
US5064636A (en) * 1989-10-19 1991-11-12 Li King C P Paramagnetic oil emulsions as enteric MRI contrast agents
US5120527A (en) * 1989-10-19 1992-06-09 King Chuen Peter Li Paramagnetic oil emulsions as mri contrast agents
US5154914A (en) * 1990-03-12 1992-10-13 Research Corporation Technologies, Inc. Methods of diagnostic image analysis using lipophilic contrast agents
US5217706A (en) * 1990-11-21 1993-06-08 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging
CA2102605A1 (fr) * 1991-05-23 1992-11-24 Evan C. Unger Substances liposolubles pour l'imagerie a resonance magnetique
US5571498A (en) * 1994-06-02 1996-11-05 Hemagen/Pfc Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).

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