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WO1996012737A3 - Compositions and treatment for multiple sclerosis - Google Patents

Compositions and treatment for multiple sclerosis Download PDF

Info

Publication number
WO1996012737A3
WO1996012737A3 PCT/US1995/013682 US9513682W WO9612737A3 WO 1996012737 A3 WO1996012737 A3 WO 1996012737A3 US 9513682 W US9513682 W US 9513682W WO 9612737 A3 WO9612737 A3 WO 9612737A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
multiple sclerosis
compositions
autoantigen
myelin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/013682
Other languages
French (fr)
Other versions
WO1996012737A2 (en
WO1996012737A9 (en
Inventor
Dawn Smilek
Michael Samson
Malcolm Gefter
Di-Hwei Hsu
Jia-Dong Shi
Xavier Paliard
Brigitte Devaux
Jonathan Rothbard
Henry Franzen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immulogic Pharmaceutical Corp
Original Assignee
Immulogic Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP95941330A priority Critical patent/EP0787147A1/en
Priority to BR9509438A priority patent/BR9509438A/en
Priority to JP8514109A priority patent/JPH10504039A/en
Priority to SI9520118A priority patent/SI9520118A/en
Priority to SK512-97A priority patent/SK51297A3/en
Priority to CZ971226A priority patent/CZ122697A3/en
Priority to AU42782/96A priority patent/AU4278296A/en
Application filed by Immulogic Pharmaceutical Corp filed Critical Immulogic Pharmaceutical Corp
Publication of WO1996012737A2 publication Critical patent/WO1996012737A2/en
Publication of WO1996012737A9 publication Critical patent/WO1996012737A9/en
Publication of WO1996012737A3 publication Critical patent/WO1996012737A3/en
Priority to IS4466A priority patent/IS4466A/en
Priority to FI971750A priority patent/FI971750A7/en
Priority to NO971900A priority patent/NO971900L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Rehabilitation Therapy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides isolated peptides and combinations of peptides derived form myelin autoantigens such as MBP, MOG, PLP, and MAG suitable for treating multiple sclerosis, including prophylactic and therapeutic compositions and methods for preventing or treating multiple sclerosis. Preferred compositions of the invention comprise at least one isolated, purified peptide, free from all other polypeptides or contaminants, the peptide comprising an amino acid sequence, the myelin autoantigen which has T cell activity. A therapeutic composition of the invention is capable of down regulating the autoantigen specific immune response to the myelin autoantigen in a population of humans suffering from, or susceptible to multiple sclerosis, such that disease symptoms are reduced, eliminated, or reversed and/or the onset or progression of disease symptoms is prevented or slowed. Additionally, compositions and methods of the instant invention when administered in an advanced stage of disease, reverse ongoing paralysis or other signs of disease when administered during the acute phase of disease or prevents relapse when administered during remission.
PCT/US1995/013682 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis Ceased WO1996012737A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP95941330A EP0787147A1 (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis
BR9509438A BR9509438A (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis
JP8514109A JPH10504039A (en) 1994-10-25 1995-10-25 Compositions and treatments for multiple sclerosis
SI9520118A SI9520118A (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis
SK512-97A SK51297A3 (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis
CZ971226A CZ122697A3 (en) 1994-10-25 1995-10-25 Preparations and methods of treating disseminated sclerosis
AU42782/96A AU4278296A (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis
IS4466A IS4466A (en) 1994-10-25 1997-04-17 Composition and treatment for multiple sclerosis
NO971900A NO971900L (en) 1994-10-25 1997-04-24 Mixtures and treatment of multiple sclerosis
FI971750A FI971750A7 (en) 1994-10-25 1997-04-24 Compositions for multiple sclerosis and its treatment

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32822494A 1994-10-25 1994-10-25
US08/328,224 1994-10-25
US40422895A 1995-03-15 1995-03-15
US08/404,228 1995-03-15

Publications (3)

Publication Number Publication Date
WO1996012737A2 WO1996012737A2 (en) 1996-05-02
WO1996012737A9 WO1996012737A9 (en) 1996-07-18
WO1996012737A3 true WO1996012737A3 (en) 1996-10-10

Family

ID=26986277

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/013682 Ceased WO1996012737A2 (en) 1994-10-25 1995-10-25 Compositions and treatment for multiple sclerosis

Country Status (15)

Country Link
EP (1) EP0787147A1 (en)
JP (1) JPH10504039A (en)
AU (1) AU4278296A (en)
BR (1) BR9509438A (en)
CA (1) CA2203629A1 (en)
CZ (1) CZ122697A3 (en)
FI (1) FI971750A7 (en)
HU (1) HUT77047A (en)
IL (1) IL115766A0 (en)
IS (1) IS4466A (en)
NO (1) NO971900L (en)
PL (1) PL324091A1 (en)
SI (1) SI9520118A (en)
SK (1) SK51297A3 (en)
WO (1) WO1996012737A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6252040B1 (en) * 1991-10-22 2001-06-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US6156535A (en) 1995-08-04 2000-12-05 University Of Ottawa Mammalian IAP gene family, primers, probes, and detection methods
JP4340329B2 (en) 1996-03-21 2009-10-07 サーカッシア リミテッド Latent peptides and methods for identifying them
AU3825497A (en) * 1996-08-15 1998-03-06 Agrivax Incorporated Delivery of tolerogenic antigens via edible plants or plant-derived products
CA2494338C (en) * 1997-04-04 2007-07-17 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
SE9703287D0 (en) * 1997-09-11 1997-09-11 Astra Ab Peptides
HK1039636A1 (en) * 1998-05-05 2002-05-03 科里克萨公司 Myelin basic protein peptides and uses thereof
US20020072493A1 (en) 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
WO1999060021A2 (en) * 1998-05-19 1999-11-25 Yeda Research And Development Co. Ltd. Use of activated t cells, nervous system-specific antigens for treating disorders of the nevrous system
EP1288226A1 (en) * 2001-09-03 2003-03-05 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Modification of the expression levels of Toll-like receptor familiy members for influencing neurodegeneration and neuroprotection in the human central nervous system
GB0202399D0 (en) * 2002-02-01 2002-03-20 Univ Bristol Peptide
WO2003080638A2 (en) 2002-03-27 2003-10-02 Aegera Therapeutics, Inc. Antisense iap nucleobase oligomers and uses thereof
DE10230381A1 (en) 2002-07-05 2004-01-22 Institut für Medizintechnologie Magdeburg GmbH, IMTM Use of inhibitors of alanyl aminopeptidases and pharmaceutical compositions comprising them
US8012944B2 (en) 2003-10-30 2011-09-06 Pharmascience Inc. Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
EP2572734B1 (en) 2006-10-31 2016-04-06 East Carolina University Cytokine-based fusion proteins for treatment of immune disorders
WO2010024927A2 (en) * 2008-08-28 2010-03-04 The Research Foundation Of State University Of New York Treatment of amyloidoses using myelin basic protein and fragments thereof
CA2757287C (en) 2009-03-31 2019-09-10 East Carolina University Cytokines and neuroantigens for treatment of immune disorders
DK2488196T3 (en) 2009-10-12 2016-03-14 Lifebio Lab Llc A composition for treating multiple sclerosis
RU2448685C2 (en) * 2009-11-30 2012-04-27 Российская Федерация в лице Министерства промышленности и торговли Российской Федерации Liposomes containing oligopeptides - fragments of myelin basic protein, pharmaceutical composition and method of treating multiple sclerosis
BR112013023978B1 (en) 2011-03-21 2021-09-08 Atlantic Cancer Research Institute POLYPEPTIDE WITH AFFINITY FOR THERMAL SHOCK PROTEINS AND THEIR USE IN INFECTIOUS DISEASE DIAGNOSIS, IMMUNE RESPONSE PRODUCTION AND CANCER TREATMENT, AS WELL AS NUCLEIC ACID, COMPOSITION AND METHOD OF FRACTIONATION OF ALOGIC SUBSTANCE OR CLINICAL ANALYSIS
CN112336851A (en) 2014-01-13 2021-02-09 博格有限责任公司 Enolase 1(ENO1) compositions and uses thereof
CA3007262A1 (en) 2015-12-03 2017-06-08 Lucas James Thompson Modified chimeric receptors and related compositions and methods

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Publication number Priority date Publication date Assignee Title
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Patent Citations (21)

* Cited by examiner, † Cited by third party
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WO1991008760A1 (en) * 1989-12-20 1991-06-27 Brigham And Women's Hospital Improved treatment of autoimmune diseases by aerosol administration of auto antigens
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VALLI ET AL: "BINDING OF MYELIN BASIC PROTEIN PEPTIDES TO HUMAN HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN CLASS II MOLECULES AND THEIR RECOGNITION BY T CELLS FROM MULTIPLE SCLEROSIS PATIENTS", J.CLIN.INVEST., vol. 91, 1993, pages 616 - 628, XP000567819 *

Also Published As

Publication number Publication date
IS4466A (en) 1997-04-17
BR9509438A (en) 1997-12-23
WO1996012737A2 (en) 1996-05-02
CA2203629A1 (en) 1996-05-02
FI971750A0 (en) 1997-04-24
FI971750A7 (en) 1997-06-24
PL324091A1 (en) 1998-05-11
JPH10504039A (en) 1998-04-14
AU4278296A (en) 1996-05-15
EP0787147A1 (en) 1997-08-06
CZ122697A3 (en) 1997-09-17
SI9520118A (en) 1998-08-31
SK51297A3 (en) 1998-03-04
NO971900D0 (en) 1997-04-24
NO971900L (en) 1997-06-25
IL115766A0 (en) 1996-01-19
HUT77047A (en) 1998-03-02

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