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WO1996011709B1 - Synthese du vaccin antityphoidique a partir d'un polysaccharide de plante ou de fruit - Google Patents

Synthese du vaccin antityphoidique a partir d'un polysaccharide de plante ou de fruit

Info

Publication number
WO1996011709B1
WO1996011709B1 PCT/US1995/012585 US9512585W WO9611709B1 WO 1996011709 B1 WO1996011709 B1 WO 1996011709B1 US 9512585 W US9512585 W US 9512585W WO 9611709 B1 WO9611709 B1 WO 9611709B1
Authority
WO
WIPO (PCT)
Prior art keywords
carrier
modified
oligogalacturonate
polygalacturonate
acetylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/012585
Other languages
English (en)
Other versions
WO1996011709A1 (fr
Filing date
Publication date
Priority claimed from US08/323,918 external-priority patent/US5738855A/en
Application filed filed Critical
Priority to AU37607/95A priority Critical patent/AU3760795A/en
Priority to AT95935689T priority patent/ATE213647T1/de
Priority to DE69525638T priority patent/DE69525638T2/de
Priority to EP95935689A priority patent/EP0787015B1/fr
Publication of WO1996011709A1 publication Critical patent/WO1996011709A1/fr
Publication of WO1996011709B1 publication Critical patent/WO1996011709B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

La présente invention concerne un oligosaccharide ou un polysaccharide modifié extrait de plante ou de fruit ou obtenu par synthèse et qui a été structurellement modifié pour rende le saccharide modifié antigéniquement semblable au polysaccharide capsulaire (Vi) de Salmonella Typhi. Le saccharide modifié peut se conjuguer avec un vecteur pour former un conjugué immunogène contre Salmonella Typhi. Les anticorps produits en réponse au conjugué immunogène apportent une protection contre la fièvre typhoïde. L'invention concerne également des procédés de fabrication du saccharide modifié et du conjugué immunogène.
PCT/US1995/012585 1994-10-17 1995-09-28 Synthese du vaccin antityphoidique a partir d'un polysaccharide de plante ou de fruit Ceased WO1996011709A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU37607/95A AU3760795A (en) 1994-10-17 1995-09-28 Synthesis of typhoid fever vaccine from a plant or fruit polysaccharide
AT95935689T ATE213647T1 (de) 1994-10-17 1995-09-28 Synthese eines typhusimpfstoffes unter verwendung eines polysaccharids aus einer pflanze oder einer frucht
DE69525638T DE69525638T2 (de) 1994-10-17 1995-09-28 Synthese eines typhusimpfstoffes unter verwendung eines polysaccharids aus einer pflanze oder einer frucht
EP95935689A EP0787015B1 (fr) 1994-10-17 1995-09-28 Synthese du vaccin antityphoidique a partir d'un polysaccharide de plante ou de fruit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/323,918 1994-10-17
US08/323,918 US5738855A (en) 1994-10-17 1994-10-17 Synthesis of typhoid fever vaccine from a plant or fruit polysaccharide

Publications (2)

Publication Number Publication Date
WO1996011709A1 WO1996011709A1 (fr) 1996-04-25
WO1996011709B1 true WO1996011709B1 (fr) 1996-06-13

Family

ID=23261276

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/012585 Ceased WO1996011709A1 (fr) 1994-10-17 1995-09-28 Synthese du vaccin antityphoidique a partir d'un polysaccharide de plante ou de fruit

Country Status (7)

Country Link
US (1) US5738855A (fr)
EP (1) EP0787015B1 (fr)
KR (1) KR100433986B1 (fr)
AT (1) ATE213647T1 (fr)
AU (1) AU3760795A (fr)
DE (1) DE69525638T2 (fr)
WO (1) WO1996011709A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT848011E (pt) * 1996-12-16 2001-08-30 Staat Nl Verteg Door Min Welzi Metodo para acoplar polisacaridos a proteinas
DE69830326T2 (de) * 1997-10-03 2006-02-02 Galenica Pharmaceuticals, Inc. Iminbildende polysaccharide, deren herstellung und verwendung als zusatzmittel und immunstimulierende mittel
US6258774B1 (en) * 1998-03-19 2001-07-10 University Of Medicine And Dentistry Of New Jersey Carrier for in vivo delivery of a therapeutic agent
US6797275B1 (en) * 1998-12-04 2004-09-28 The United States Of America As Represented By The Department Of Health And Human Services Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine
JP2003512812A (ja) 1998-12-23 2003-04-08 ボイス トンプソン インステイテュート フォア プラント リサーチ トランスジェニック植物における免疫原性ｂ型肝炎表面抗原の発現
CA2434668A1 (fr) 2003-07-04 2005-01-04 Laurence Mulard Nouvelle approche pour concevoir des glycopeptides a base de o-specifique polysaccharide de shigella flexneri serotype 2a
CN1645104B (zh) * 2004-12-21 2011-03-16 兰州生物制品研究所 伤寒Vi-rEPA结合疫苗中高分子结合物含量的测定方法
US8426567B2 (en) * 2005-08-26 2013-04-23 Econugenics, Inc. Method for enhancing mammalian immunological function
GB0810894D0 (en) 2008-06-13 2008-07-23 Novartis Vaccines & Diagnostic Conjugated saccharide
EP2386563A1 (fr) 2010-05-12 2011-11-16 Institut Pasteur Nouveaux décasaccharides O-acétylés
AU2014313699B2 (en) 2013-08-24 2019-12-19 Bharat Biotech International Limited A bacterial vaccine and methods for manufacture thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204098A (en) * 1988-02-16 1993-04-20 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-protein conjugates
FR2682388B1 (fr) * 1991-10-10 1995-06-09 Pasteur Merieux Serums Vacc Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal.
IL102687A (en) * 1992-07-30 1997-06-10 Yeda Res & Dev Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them

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